Journal of the Korean Academy of Child and Adolescent Psychiatry

Korean Academy of Child and Adolescent Psychiatry (대한소아청소년정신의학회)
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Prenatal, Perinatal and Infancy History of Autism Spectrum Disorder

자폐 스펙트럼 장애의 산전 및 주산기 합병증

  • Nam, Bo-Ra (Department of Psychiatry, Seoul National University Hospital) ;
  • Yoo, Hee-Jeong (Department of Neuropsychiatry, Seoul National University Bungdang Hospital) ;
  • Cho, In-Hee (Department of Psychiatry, Gachon University of Medicine and Science) ;
  • Park, Tae-Won (Department of Psychiatry, Chungbuk National University Hospital) ;
  • Son, Jung-Woo (Department of Psychiatry, Chonbuk National University Hospital) ;
  • Chung, Un-Sun (Department of Psychiatry, Kyungpook National University) ;
  • Shin, Min-Sup (Department of Psychiatry, Seoul National University Hospital) ;
  • Kim, Bung-Nyun (Department of Psychiatry, Seoul National University Hospital) ;
  • Kim, Jae-Won (Department of Psychiatry, Seoul National University Hospital) ;
  • Yang, Young-Hui (Department of Psychiatry, Seoul National University Hospital) ;
  • Kang, Je-Wook (Department of Neuropsychiatry, School of Medicine and Institute of Neuroscience, Inje University) ;
  • Song, Sook-Hyung (Department of Psychiatry, Seoul National University Hospital) ;
  • Cho, Soo-Churl (Department of Psychiatry, Seoul National University Hospital)
  • 남보라 (서울대학교병원 신경정신과) ;
  • 유희정 (분당서울대학교병원 신경정신과) ;
  • 조인희 (가천의과대학병원 정신과) ;
  • 박태원 (충북대학교병원 정신과) ;
  • 손정우 (전북대학교병원 정신과) ;
  • 정운선 (경북대학교병원 정신과) ;
  • 신민섭 (서울대학교병원 신경정신과) ;
  • 김붕년 (서울대학교병원 신경정신과) ;
  • 김재원 (서울대학교병원 신경정신과) ;
  • 양영희 (서울대학교병원 신경정신과) ;
  • 강제욱 (인제대학교병원 신경정신과) ;
  • 송숙형 (서울대학교병원 신경정신과) ;
  • 조수철 (서울대학교병원 신경정신과)
  • Received : 2010.05.24
  • Accepted : 2010.08.16
  • Published : 2010.10.30
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Abstract

Objectives: The purpose of this study was to evaluate the prenatal, perinatal, and infancy history of children with autism spectrum disorder (ASD) as compared to unaffected siblings (SIB) and typically developing children (TC). Methods: Subjects with ASD, their SIB, and TC were recruited. All subjects were assessed using both the Korean version of Autism Diagnostic Interview-Revised (K-ADI-R) and the Korean version of Autism Diagnostic Observation Schedule (K-ADOS) and were subsequently identified as affected or unaffected. Prenatal, perinatal, and infancy history was obtained from the primary caregivers and each facet was compared in those with ASD, the SIB, and the TC groups using SPSS ver. 17.0 (p<.05). Results: 70 individuals with ASD (63 males, 87.94${\pm}$37.8months), 53 SIB (27 males, 85.4087.94${\pm}$48.06 months), and 32 TC (19 males, 104.1987.94${\pm}$23.409 months) were analyzed. The ASD group showed significantly higher rates of insufficient vaccination as they aged age ($x^2$=15.54, p=.000). Among the scheduled vaccinations, the DPT vaccination ($x^2$=10.08, p=.006) was insufficient in ASD groups. The ASD group also showed higher rates of sleep disturbances from infancy. Differences in maternal/paternal age at conception, gestational age, and growth parameters at birth were not significantly difference among the three groups. Conclusion: These results do not support the previous controversies regarding the relationship between prenatal/perinatal complications and ASD. However, these results indicate that perinatal and prenatal factors may contribute to the development of ASD.

Keywords

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