• Journal of the Korean Chemical Society
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• v.48 no.4
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• pp.427-435
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• 2004

Characteristics of chemistry education during the enlightenment period in Korea are examined by analyzing chemistry textbooks used in the period. Specifically, the analysis is made from the aspects of science, students and teachers. As a result it is found that; first, scientific knowledge itself is emphasized, contrary to those described in the curriculum of chemistry used in the period, and it consists of introduction, non-metals, metals and organic chemistry in chemistry textbook, second, the level of chemistry is similar with that in present high schools, and its technical constitution might have been difficult for a student to study with an experiment, third, terminology lacks consistency and some textbooks include contents of other subject. It is therefore believed that the chemistry textbooks of the enlightenment period is scientifically incomplete and would not have been easy for the teachers to use them to teach the students. In addition, considering the students as a beginner of modern sciences, study level could have been too difficult for them to follow. In conclusion, it appears that chemistry education during the enlightenment period in Korea was not so successful.

• Journal of the Korean Chemical Society
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• v.49 no.6
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• pp.584-590
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• 2005

• Journal of the Korean Chemical Society
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• v.49 no.1
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• pp.105-111
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• 2005

• Journal of The Korean Association For Science Education
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• v.27 no.6
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• pp.477-487
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• 2007

Previous studies show that students have difficulties in understanding and using molecular visualization tools. This study focuses on the ways in which first year chemistry undergraduates use ball-and-stick molecular models to explain the concept of addition reaction and the difficulties that they face using the models. Video recordings of interviews with undergraduates manipulating ball-and-stick models to solve problems related to reaction mechanisms are analysed to determine if they are able to elucidate their understanding with use of models. The results showed that students have difficulties with viewing the ball-and-stick models from the proper perspective and understanding the relationship between the various structures that they have created using the models. They also find the use of ball-and-stick models tedious and prefer drawing molecular structures on paper to explain their ideas. Implications for the teaching using ball-and-stick molecular models are discussed.

• Journal of the Korean Chemical Society
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• v.54 no.6
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• pp.787-798
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• 2010

We compared the understanding of 4 pre-service teachers of chemistry education major and 2 pre-service teachers of chemistry major related to conceptions of "properties of dilute solutions" chapter in high school Chemistry II textbooks. As results, few pre-service teachers understood fully the concepts of high school Chemistry II textbooks. Some pre-service teachers had misconceptions related to properties of dilute solutions. We found that few differences existed between the pre-service teachers' understanding regardless of whether they took a major in chemistry education of a education college or a major in chemistry of noneducation college. Most of the pre-service teachers who attended this research recognized the lack of practical knowledge in their pre-service teacher curriculum.

• Bulletin of the Korean Chemical Society
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• v.34 no.11
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• pp.3257-3260
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• 2013

Two new diphenylethylenes, gramniphenols H and I (1 and 2), together with six known diphenylethylenes (3-8), were isolated from Arundina graminifolia. The structures of 1-8 were elucidated by spectroscopic methods including extensive 1D- and 2D-NMR techniques. Compounds 1 and 2 were evaluated for their cytotoxicity against five human tumor cell lines. Compound 1 showed cytotoxicity against PC3 cells with $IC_{50}$ value of 3.5 ${\mu}M$. Compound 2 showed cytotoxicity against NB4 and PC3 cells with $IC_{50}$ values of 3.6 and 3.8 ${\mu}M$, respectively.

• Journal of the Korean Chemical Society
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• v.37 no.2
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• pp.265-268
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• 1993

• Bulletin of the Korean Chemical Society
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• v.28 no.6
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• pp.911-912
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• 2007

• Molecules and Cells
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• v.26 no.5
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• pp.443-453
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• 2008

The Bric-a-brac, Tramtrack, Broad-complex (BTB) domain is a protein-protein interaction domain that is found in many zinc finger transcription factors. BTB containing proteins play important roles in a variety of cellular functions including regulation of transcription, regulation of the cytoskeleton, protein ubiquitination, angiogenesis, and apoptosis. Here, we report the cloning and characterization of a novel human gene, KLHL31, from a human embryonic heart cDNA library. The cDNA of KLHL31 is 5743 bp long, encoding a protein product of 634 amino acids containing a BTB domain. The protein is highly conserved across different species. Western blot analysis indicates that the KLHL31 protein is abundantly expressed in both embryonic skeletal and heart tissue. In COS-7 cells, KLHL31 proteins are localized to both the nucleus and the cytoplasm. In primary cultures of nascent mouse cardiomyocytes, the majority of endogenous KLHL31 proteins are localized to the cytoplasm. KLHL31 acts as a transcription repressor when fused to GAL4 DNA-binding domain and deletion analysis indicates that the BTB domain is the main region responsible for this repression. Overexpression of KLHL31 in COS-7 cells inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). KLHL31 also significantly reduces JNK activation leading to decreased phosphorylation and protein levels of the JNK target c-Jun in both COS-7 and Hela cells. These results suggest that KLHL31 protein may act as a new transcriptional repressor in MAPK/JNK signaling pathway to regulate cellular functions.

• Journal of the Korean Chemical Society
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• v.40 no.8
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• pp.13-594
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• 1996