• Macromolecular Research
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• v.14 no.1
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• pp.87-93
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• 2006

Copolymers composed of hyaluronic acid (HA) and poly(N-isopropylacrylamide) (PNIPAAm) were prepared to create temperature-sensitive injectable gels for use in controlled drug delivery applications. Semi-telechelic PNIPAAm, with amino groups at the end of each main chain, was synthesized by radical polymerization using 2-aminoethanethiol hydrochloride (AESH) as the chain transfer agent, and was then grafted onto the carboxyl groups of HA using carbodiimide chemistry. The result of the thermo-optical analysis revealed that the phase transition of the PNIPAAm-grafted HA solution occurred at around 30$\∼$33$^{circ}C$. As the graft yield of PNIPAAm onto the HA backbone increased, the HA-g-PNIPAAm copolymer solution exhibited sharper phase transition. The short chain PNIPAAm-grafted HA ($M_{w}$=6,100) showed a narrower temperature range for optical turbidity changes than the long chain PNIPAAm-grafted HA ($M_{w}$=13,100). PNIPAAm-grafted HA exhibited an increase in viscosity above 35$^{circ}C$, thus allowing the gels to maintain their shape for 24 h after in vivo administration. From the in vitro riboflavin release study, the HA-g-PNIPAAm gel showed a more sustained release behavior when the grafting yield of PNIPAAm onto the HA backbone was increased. In addition, BSA released from the PNIPAAm-g-HA gels showed a maximum concentration in the blood 12 h after being injected into the dorsal surface of a rabbit, followed by a sustained release profile after 60 h.

• Bulletin of the Korean Chemical Society
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• v.32 no.11
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• pp.4021-4026
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• 2011

Functions of the luteinizing hormone releasing hormone (LHRH) and its induced release by divalent metal ions have received great attention because this neurotransmitter subsequently regulates the secretion of luteinizing hormone (LH). Metal-LHRH complexes were synthesized by addition of various Cu(II),Ni(II),Zn(II) ions into LHRH in order to understand how the induced release of LHRH is possible. The degree of complexation was monitored by $^1H$, $^{13}C$-NMR chemical shifts, and final products were identified by Mass spectrometry. Solutionstate structure determination of Zn(II)-LHRH out of metal-complexes was accomplished by using NMR and NMR-based distance geometry (DG). Interproton distance information from nuclear Overhauser effect spectroscopy was utilized for structure determination. Structure obtained in this study has a cyclic conformation exhibiting a specific ${\alpha}$-helical turn with residue numbers His[2]-Leu[7] out of 10 amino acids. Comparison of chemical shifts and EPR studies of Ni(II),Cu(II)-LHRH complexes exhibit that these metal complexes have 4-coordination geometry.

• Korean Chemical Engineering Research
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• v.54 no.6
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• pp.781-785
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• 2016

Chloric acid is a toxic chemical and the risk of facility handling chloric acid was assessed from the list of accident scenario to provide countermeasure to keep the vicinity safe. Accident scenarios were listed by using MSDS and process safety information. The scenarios having effect to the off-site were selected and assessed further according to guideline provided by Korea government. Worst case and alternative scenarios including other interested scenarios were evaluated using ALOHA. Each evaluated scenario was assessed further considering countermeasures. The results showed that the facility handling chloric acid is safe enough and needed no further protections at the moment.

• Smart Structures and Systems
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• v.7 no.3
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• pp.199-211
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• 2011

Using computational modeling, we design a pair of biomimetic microcapsules that exploit chemical mechanisms to communicate and alter their local environment. As a result, these synthetic objects can undergo autonomous, directed motion. In the simulations, signaling microcapsules release "agonist" particles, while target microcapsules release "antagonist" particles and the permeabilities of both capsule types depend on the local particle concentration in the surrounding solution. Additionally, the released nanoscopic particles can bind to the underlying substrate and thereby create adhesion gradients that propel the microcapsules to move. Hydrodynamic interactions and the feedback mechanism provided by the dissolved particles are both necessary to achieve the cooperative behavior exhibited by these microcapsules. Our model provides a platform for integrating both the spatial and temporal behavior of assemblies of "artificial cells", and allows us to design a rich variety of structures capable of exhibiting complex dynamics. Due to the cell-like attributes of polymeric microcapsules and polymersomes, material systems are available for realizing our predictions.

• Solar Energy
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• v.9 no.2
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• pp.22-30
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• 1989

Since the energy storage method by means of the thermochemical reaction has no heat loss by separating the reactants under the storage period, it is remarked as one of promising means particularly for long-term heat storage. In this study, the heat-storage/-release characteristics of the reversible chemical reaction cycle, $Ca(OH)_2/CaO$, is numerically analysed by a mathematical modelling. As a result, the effectiveness of the heat exchanger by the chemical heat storage method is considerably higher than that by the sensible heat storage method. It is found that the major parameters, which determines the effectiveness of the heat exchanger, are the mass flow rate and inlet temperature of fluid, the residence time, etc.. The heat-storage/-release period can be controlled by changing the operation conditions. It is expected that the results obtained here will supply useful informations in designing a regenerative heat exchanger utilizing the thermochemical reaction.

• Journal of Korean Society on Water Environment
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• v.32 no.6
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• pp.546-551
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• 2016

In this study, capping with recycled aggregate and natural zeolite in marine sediment was performed to investigate its inhibitory effect on pollutants released from sediment to seawater. An experiment was performed by capping with amendments for 60 days, and concentrations of organic matter (COD), nitrate, phosphate and metallic elements (Ni, Zn, Cu, Pb, Cd, As, and Cr) were measured. Two capping materials effectively suppressed pollutant release. Recycled aggregate showed better effectiveness for organic pollutant, nitrate and phosphate release. Meanwhile, natural zeolite was effective for metallic elements. As a result, recycled aggregate and natural zeolite can be considered as cost-effective/inexpensive capping material candidates. Also, the capping material can be selected according to the target pollutant.

• Proceedings of the KSR Conference
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• 2009.05a
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• pp.206-212
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• 2009

Chemical behaviors of each surface material for interior facilities affect to fire initiation and growth in general fire situation. These chemical behaviors were characterized by thermal properties (Heat release rate, Pyrolysis rate, specific heat, etc) which could be derived from experimental test. Especially, Heat release rate which indicates aspect of fire size is one of the most important property to asses fire hazard and protection needs. The cone calorimeter test (ISO 5660) has recently assumed to a dominant role in bench scale fire testing to obtain the Heat release rate of materials. This value could be calculated by the 'Oxygen Consumption Method' under various producing irradiances to each surface of materials. In this study, Process of the cone calorimeter test was simulated by Pyrolysis model of FDS (Fire Dynamics Simulator by NIST) base on the ISO 5660 international standard. Then, we could estimate the simulation method of FDS in case of single materials through the comparative study with test results.

• Journal of Forest and Environmental Science
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• v.35 no.3
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• pp.141-149
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• 2019

Nanocellulose, which can exist as either cellulose nanocrystals or cellulose nanofibrils, has been used as a biomaterial for drug delivery owing to its non-immunogenicity, biocompatibility, high specific area, good mechanical properties, and variability for chemical modification. Various water-soluble drugs can be bound to and released from nanocelluloses through electrostatic interactions. The high specific surface area of nanocellulose allows for high specific drug loading. Additionally, a broad spectrum of drugs can bind to nanocellulose after facile chemical modifications of its surface. Controlled release can be achieved for various pharmaceuticals when the nanocellulose surface is chemically modified or physically formulated in an adequate manner. This review summarizes the potential applications of nanocelluloses in drug delivery according to published studies on drug delivery systems.

• Bulletin of the Korean Chemical Society
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• v.7 no.3
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• pp.213-217
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• 1986

A series of copolypeptides of glutamic acid and leucine have been synthesized by N-carboxy-${\alpha}$-amino acid anhydride procedure and cast to form injectable microparticulate monolithic devices in which indomethacin was physically dispersed. With these devices, various release properties and possible clinical application were studied. The release rate of the drug had a close relationship with the monomer composition of the copolymer matrix as well as the environmental pH condition. The monolithic device of glutamic acid/leucine = 50/50 was found to be the most promising one as a ploymeric delivery system of indomethacin. The intrinsic viscosity of this copolymer was 4.35 dl/g and the release rate was 18.5${\mu}g/g/day$.

• Korean Chemical Engineering Research
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• v.61 no.4
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• pp.570-575
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• 2023

Targeted anticancer drug delivery systems are needed to enhance therapeutic efficacy by selectively delivering drugs to tumor cells while minimizing off-target effects, improving treatment outcomes and reducing toxicity. In this study, a silica-based nanocarrier capable of targeting drug delivery to cancer cells was developed. First, silica nanoparticles were synthesized by the Stöber method using the surfactant cetyltrimethylammonium bromide (CTAB). Increasing the ratio of EtOH in the solvent produced uniformly spherical silica nanoparticles. Washing the nanoparticles removed unreacted residues, resulting in a non-toxic carrier for drug delivery in cells. Upon surface modification, the pH-responsive polymer, polyethyleneimine (PEI) exhibited slow doxorubicin release at pH 7.4 and accelerated release at pH 5.5. By exploiting this feature, we developed a system capable of targeted drug release in the acidic tumor microenvironment.