• 센서학회지
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• 제13권1호
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• pp.47-55
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• 2004

This paper presents drug release properties of active drug delivery system (DDS) using volume change of polypyrrole (PPy). The incorporation of various chemical substances into the PPy and controlling its release with the externally applied voltage to the PPy are possible. In order to confirm possibility for drug delivery system qualitatively, indicator(phenol red) was examined as a dopant of PPy. The applied voltage to the PPy electrode was set to -2 V and this negative voltage makes the anionic indicator released in saline solution. After qualitative analysis, in order to confirm quantitative drug release characteristic of PPy, salicylate which is one of the aspirin substance was used as a dopant of PPy. As a result, the salicylate release characteristics with time was thoroughly investigated while varying the electrode area, polymerization time, the applied voltage for drug release. Based on these quantitative results, a preliminary experiment was carried out to check the feasibility of the PPy applicable to the neuronal system.

• Nuclear Engineering and Technology
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• 제25권3호
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• pp.447-456
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• 1993

중저준위 방사성폐기물처분장 인공방벽의 핵종유출 저지능을 평가할 수 있는 단순 모델이 제안되었다. 이 모델은 현재 우리나라에서 제안되고 있는 처분장 개념을 고려하여 고안되었으며, 인공방벽의 설계에 적합한 설계 기준 유출 과 인공방벽 성능평가에 적합한 현실적 유출 두 가지 경우를 다루고 있다. 모델의 유용성을 보이기 위해 화학적 특성이 다른 다섯 핵종에 대해 모의 계산을 수행하고 그 결과를 분석하였다.

• Biotechnology and Bioprocess Engineering:BBE
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• 제9권6호
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• pp.476-481
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• 2004

The aim of this study was to formulate a sustained release system for indomethacin (IND) with rosin gum obtained from a pine tree. Rosin microparticles were prepared by a disper­sion and dialysis method without the addition of surfactant. In order to investigate the influence of solvents on the formation of colloidal microparitcles, various solvents like ethanol, DMF, DMAc, and acetone were used. The rosin microparticles containing IND were characterized by X­ray differactometry (XRD) and differential scanning calorimetry (DSC). The morphologies of rosin microparticles observed by scanning electron microscopy (SEM) were spherical. The solvents used to dissolve rosin significantly affected the drug content and drug release rate of IND. The release behaviors of IND from the rosin microparticles were dependent on the drug content and size of the particles. Rosin micorparticles with a higher drug content and of a larger particle size had a slower drug release rate. Also, the IND release rate from the rosin microparticles could be regulated by the rosin content in the microparticles. From these results, rosin microparticles have the potential of being used as a sustained release system of IND.

• 한국약용작물학회지
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• 제11권3호
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• pp.190-194
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• 2003

두물차의 수량은 관행시비 (4회 분시)에 비해 완효성 비료 9월, 3월 분시 2회 와 3월 1회 분시는 수량차가 없었으나 9월 1회 분시는 감수되었다. 관행시비에 비해 완효성비료 2회 분시가 총 질소, 총 아미노산은 많았고, tannin과 caffeine 함량은 적은 경향이었으며 엽록소, 비타민 C, 유리당 함량과 감칠맛 주성분인 theanine 함량은 차이가 없었다. 형상, 향, 맛 등 제다품질은 완효성 비료 2회 분시가 1회 분시나 관행 시비 (4회 분시)에 비해 우수하였다. 그러나 완효성 비료처리는 토양비료성분 중 질소, 인산, 칼리의 효율성을 향상시켜 차잎 수량 및 품질을 증가시킨다고 생각된다.

• 한국물환경학회지
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• 제25권5호
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• pp.742-749
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• 2009

To examine the characteristics of the nutrient release from the sediments in two reservoirs, Lake Paldang and Lake Cheungpyeung, we analyzed physical and chemical properties of the sediments and calculated the nutrient release rates from the sediments. The particle properties of sediments in Lake Paldang changed from silt to sand after summer rainy season, especially in the water area of the Kyeungan River where the water depth was shallow and the width of river was narrow. The sediments in Lake Cheungpyeung had higher contents of silt and clay than in Lake Paldang, and the particle size was not much different before and after rainfall. The release rates of nutrients in two lakes varied with the kind of nutrients and the season. The release rates of DTN and ${NH_4}^+-N$ in Lake Paldang were faster in spring than autumn. But the Lake Cheungpyeung showed similar values of release rates before and after summer rainy season. ${NO_3}^--N$ and phosphorous were not released from sediments or were absorbed into sediments all the time in two lakes. Compared with other lakes, the sediments of two lakes consisted of bigger particles and had a lower organic matters content than other lake-type reservoirs. Due to the short hydraulic retention time and no stratification throughout the year in Lake Paldang and Lake Cheungpyeung, the release rates of nutrients from sediment in these reservoirs were lower than other lakes and this seems to be a typical characteristic of river-type reservoirs.

• Macromolecular Research
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• 제16권5호
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• pp.429-433
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• 2008

Alginate/carboxymethyl scleroglucan (CMSG) hydrogels were suggested as a novel carrier for the controlled release of protein drugs. The drug release characteristics of alginate hydrogels were improved by CMSG addition. Scleroglucan (Sclg) was carboxymethylated using monochloroacetic acid in aqueous alkaline medium. Alginate/CMSG hydrogels were prepared by dropping the mixture solution of alginate/CMSG into calcium chloride solution. The swelling behaviors and drug release characteristics of the hydrogels were investigated in the buffers of pH 1.2 or 7.4. As the CMSG content increased in the hydrogels, the swelling ratio of the alginate/CMSG hydrogel increased rapidly in the buffer of pH 7.4. At pH 1.2, however, the swelling ratio significantly decreased compared to that at pH 7.4. According to in vitro release tests, only 15% of ovalbumin, investigated as a model protein drug, was released from the alginate/CMSG hydrogels at pH 1.2 within 6 h. At pH 7.4, however, the drug release significantly increased due to the rapid swelling of the hydrogels. The release and swelling behaviors of the hydrogels could be controlled by changing the CMSG content in the hydrogels. These results supported the use of alginate/CMSG hydrogels as a suitable carrier for the controlled release of protein drugs in a pH responsive manner.

• 한국화재소방학회논문지
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• 제31권5호
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• pp.19-27
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• 2017

밀폐된 구획실 화재에서 화원의 면적 및 위치, 화재성장률, 구획 체적의 변화가 열발생률을 포함한 주요 화재특성에 미치는 영향이 검토되었다. 이를 위해 닫힌 개구부가 적용된 ISO 9705 화재실을 대상으로 Fire Dynamics Simulator (FDS)를 활용한 화재시뮬레이션이 수행되었다. 주요 결론으로서, 화원의 면적 및 위치의 변화는 최대 열발생률, 총 열량, 상층부의 최대 온도 및 화학종 농도를 포함한 구획 내의 열적 특성과 화학적 특성에 큰 영향을 주지 않음을 확인하였다. 그러나 화재성장률과 구획 체적의 증가는 최대 열발생률 및 총 열량의 증가를 가져오며, 한계산소농도의 감소 및 최대 CO 농도의 증가를 발생시킨다. 마지막으로 화재성장률과 구획 체적의 함수로 표현된 최대 열발생률의 상관식을 도출하여, 밀폐된 구획실 화재에 대한 화재성장곡선의 적용을 위한 방법론이 제안되었다.

• 한국토양비료학회지
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• 제48권1호
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• pp.1-7
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• 2015

Global population is expected to reach nine billion in 2050 and the total demand for food is expected to increase approximately by 60 percent by 2050 as compared to 2005. Therefore, it is important to increase crop production in order to meet the global demand for food. Slow release fertilizers have been developed and designed in order to improve the efficiency of fertilizers. Mineral-based slow release fertilizers are useful because the minerals have a crystalline structure and are environmentally friendly in a soil. This review focuses on slow release fertilizers based on montmorillonite, zeolite, and layered double hydroxide phases as a host for nutrients, especially N. Urea was successfully stabilized in the interlayer space of montmorillonite by the formation of urea-Mg or Ca complex, $[(Urea)_6Mg\;or\;Ca]^{2+}$ protecting its rapid degradation in soils. Naturally occurring zeolites occluded with ammonium nitrate and potassium nitrate by molten salt treatment could be used as slow release fertilizer because the occlusion process increased the capacity of zeolites to store nutrients in addition to exchangeable cations. Additionally, surface-modified zeolites could also be used as slow release fertilizer because the modified surface showed high affinity for anionic nutrients such as nitrate and phosphate. Moreover, there were attempts to develop and use synthetic layered double hydroxide as a carrier of nitrate because it has positively charged layers which electrostatically bond nitrate anions. Kaolin was also tested by combining with a polymer or through the mechanical-chemical process for slow release of nutrients.

• 한국토양비료학회지
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• 제49권6호
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• pp.651-654
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• 2016

A number of accidents relating to highly toxic hydrogen fluoride (HF) or hydrofluoric acid (HA) release have occurred over fast few decades in Korea. Thus, this study was conducted to investigate the fluoride (F) concentrations in paddy soil and brown rice from 2 different areas where the soils were exposed to HF and HA. In the first case, the HF leakage accident that occurred in 2012 affected the surrounding soils and crops and consequently, crops (rice) affected by HF were unavailable for forage even though F did not accumulate in the soil. For example, at the time of accident, F concentrations in brown rice samples were $33.0-1,395mg\;kg^{-1}$, while F concentrations in soil samples were $155-295mg\;kg^{-1}$ which were less than the Korean standard guideline values of $400mg\;kg^{-1}$. However, after a year, F concentrations in brown rice were observed below the detection limit ($1mg\;kg^{-1}$), although F concentrations in soils were similar with those in 2012. Also, large amounts of wastewater discharges containing HA occurred in 2013 and some agricultural soils exceeded the Korean standard guideline values for F ($400mg\;kg^{-1}$), but soil-plant F transfer was not observed. In conclusion, it was observed that soil to plant transfer of F is unlikely although HF and HA as gas or liquid form can cause direct damage to plants.

• Bulletin of the Korean Chemical Society
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• 제30권9호
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• pp.1985-1988
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• 2009

Poly (lactic-co-glycolic acid) (PLGA) nanoparticles loading paclitaxel have been deposited on coronary stents by self-assembling properties of colloidal particles. The layers of the nanoparticles were enhanced to a sufficient mechanical strength by a thermal process under the proper temperature and humidity conditions. In vitro release studies proved the controlled paclitaxel release of the nanoparticle layers. This technique gives rise to a new range of applications for nanoparticles and drug-eluting stents.