Biotechnology and Bioprocess Engineering:BBE

The Korean Society for Biotechnology and Bioengineering (한국생물공학회)
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Rosin Microparticles as Drug Carriers: Influence of Various Solvents on the Formation of Particles and Sustained-release of Indomethacin

  • Lee Chang Moon (Interdisciplinary Program of Biomedical Engineering, Chonnam National University) ;
  • Lim Seung (Ecobio Inc., Business Incubation Center, Chonnam National University) ;
  • Kim Gwang Yun (Ecobio Inc., Business Incubation Center, Chonnam National University) ;
  • Kim Do Man (School of biological Sciences and Technology and Research Institute for Catalysis, Chonnam National University) ;
  • Kim Dong Woon (Department of Health and Hygiene, Gwang-Yang Health College) ;
  • Lee Hyun Chul (Department of Microbiology, Chonnam National University Medical School) ;
  • Lee Ki Young (Department of Applied Chemical Engineering & The Research Institute for Catalysis, Chonnam National University)
  • Published : 2004.11.01
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Abstract

The aim of this study was to formulate a sustained release system for indomethacin (IND) with rosin gum obtained from a pine tree. Rosin microparticles were prepared by a disper­sion and dialysis method without the addition of surfactant. In order to investigate the influence of solvents on the formation of colloidal microparitcles, various solvents like ethanol, DMF, DMAc, and acetone were used. The rosin microparticles containing IND were characterized by X­ray differactometry (XRD) and differential scanning calorimetry (DSC). The morphologies of rosin microparticles observed by scanning electron microscopy (SEM) were spherical. The solvents used to dissolve rosin significantly affected the drug content and drug release rate of IND. The release behaviors of IND from the rosin microparticles were dependent on the drug content and size of the particles. Rosin micorparticles with a higher drug content and of a larger particle size had a slower drug release rate. Also, the IND release rate from the rosin microparticles could be regulated by the rosin content in the microparticles. From these results, rosin microparticles have the potential of being used as a sustained release system of IND.

Keywords

References

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