• Molecular & Cellular Toxicology
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• 제5권4호
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• pp.310-316
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• 2009

Some environmental chemicals have been shown to cause liver-toxicity as the result of bioaccumulation. Particularly, fungicides have been shown to cause varying degrees of hepatictoxicity and to disrupt steroid hormone homeostasis in in vivo models. The principal objective of this study was to evaluate the liver-toxic responses of environmental chemicals-in this case selected fungicides and parasiticides-in order to determine whether or not this agent differentially affected its toxicogenomic activities in hepatic tumor cell lines. To determine the gene expression profiles of 3 fungicides (triadimefon, myclobutanil, vinclozolin) and 1 parasiticide (dibutyl phthalate), we utilized a modified HazChem human array V2. Additionally, in order to observe the differential alterations in its time-dependent activities, we conducted two time (3 hr, 48 hr) exposures to the respective IC20 values of four chemicals. As a result, we analyzed the expression profiles of a total of 1638 genes, and we identified 70 positive significant genes and 144 negative significant genes using four fungicidic and parasiticidic chemicals, using SAM (Significant Analysis of Microarray) methods (q-value<0.5%). These genes were analyzed and identified as being related to apoptosis, stress responses, germ cell development, cofactor metabolism, and lipid metabolism in GO functions and pathways. Additionally, we found 120 genes among those time-dependently differentially expressed genes, using 1-way ANOVA (P-value<0.05). These genes were related to protein metabolism, stress responses, and positive regulation of apoptosis. These data support the conclusion that the four tested chemicals have common toxicogenomic effects and evidence respectively differential expression profiles according to exposure time.

• 항공우주시스템공학회지
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• 제12권5호
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• pp.32-39
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• 2018

본 논문에서는 소형 압전유압펌프에 적용된 박판 스프링 형 체크밸브의 변형에 의한 이론적인 압력전달 비율을 계산하였다. 박판 체크밸브는 외력에 의해 변형이 발생하는 유연체이며, 체크밸브의 변형은 챔버 압력이 부하 압력으로 전달되는 비율에 영향을 미친다. 박판 체크밸브를 강체로 가정하였을 때와 유연체 모델일 때의 차이를 비교하기 위해 각각의 모델에 대한 이론적인 압력 전달 비율을 계산하였고, 유연체 체크밸브 모델의 압력 전달 비율 계산을 위해 P-delta 효과를 고려하였다. 또한, 유연체 체크밸브 모델의 변형을 고려하여 계산된 압력 전달 비율의 검증 실험을 수행하였다. 실험에는 박판 스프링 형의 체크밸브와 볼-박판 스프링 형의 체크밸브를 각각 적용하여 부하 압력을 측정하였다. 실험을 통해 얻어진 각각의 부하 압력을 이용하여 실험적인 압력 전달 비율을 계산하였다. 실험으로 얻어진 결과를 이론적으로 계산된 압력 전달 비율과 비교하여 P-delta 효과를 고려한 박판형 체크밸브 압력전달 해석의 타당성을 검증하였다.

• 대한방사선치료학회:학술대회논문집
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• 대한방사선치료학회 2005년도 춘계학술대회 초록집
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• pp.19-22
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• 2005

방사선 종양학과에서 실시하고 있는 일일 정도관리 항목인 out put laser alignment, field size, SSD indicator 점검을 간편하고 정확하게 할 수 있도록 phantom 모양의 daily check device를 설계하고 제작하였다. 본 장치를 사용하여 4개월(2005. $2\~5$)월 동안 4대의 선형가속기 일일 정도관리에 사용한 곁과 측정과정이 편리하고 시간이 단축되어 일일점검의 효율성이 향상 되었고, 출력선량 측정은 각 장비별로 ${\pm}\;2\%$ 이내였으며 laser, field size, SSD indicator 는 ${\pm}\;1mm$ 이내의 범위에서 측정되었다. 일일 정도관리 기록을 기초로 하여 월간, 연간 정도관리의 객관적인 기초 자료로 활용할 수 있었다. 제작된 daily check device는 기존 상품화된 고가의 측정 장비를 대체 사용가능하게 함으로써 비용절감 효과가 기대되며, 향후 장치 재질의 견고성 및 가벼운 소재의 개발이 필요할 것으로 사료된다.

• Molecular & Cellular Toxicology
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• 제3권3호
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• pp.208-213
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• 2007

With the help of a development and popularization of microarray technology that enable to us to simultaneously investigate the expression pattern of thousands of genes, the toxicogenomics experimenters can interpret the genome-scale interaction between genes exposed in toxicant or toxicant-related environment. The ultimate and primary goal of toxicogenomics identifies functional context among the group of genes that are differentially or similarly coexpressed under the specific toxic substance. On the other side, public reference databases with transcriptom, proteom, and biological pathway information are needed for the analysis of these complex omics data. However, due to the heterogeneous and independent nature of these databases, it is hard to individually analyze a large omics annotations and their pathway information. Fortunately, several web sites of the public database provide information linked to other. Nevertheless it involves not only approriate information but also unnecessary information to users. Therefore, the systematically integrated database that is suitable to a demand of experimenters is needed. For these reasons, we propose SOP (Search of Omics Pathway) database system which is constructed as the integrated biological database converting heterogeneous feature of public databases into combined feature. In addition, SOP offers user-friendly web interfaces which enable users to submit gene queries for biological interpretation of gene lists derived from omics experiments. Outputs of SOP web interface are supported as the omics annotation table and the visualized pathway maps of KEGG PATHWAY database. We believe that SOP will appear as a helpful tool to perform biological interpretation of genes or proteins traced to omics experiments, lead to new discoveries from their pathway analysis, and design new hypothesis for a next toxicogenomics experiments.

• 한국산업경영시스템학회:학술대회논문집
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• 한국산업경영시스템학회 2002년도 춘계학술대회
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• pp.403-412
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• 2002

Machine condition diagnosis is the technique to perceive the machine errors and the abrasion online without overhaul. We need the steps to predict the life span and reliability of a machine for the abrasion as with perceiving the degree of the abrasion of certain machine parts to make errors. In this study we deals with the methods to check and manage periodically and to configure the judgement criteria for the state of a machine. For the applications of CDT(Condition Diagnosis Technique) we also suggest the methods to check comparing the measured vibration values with the absolute criteria and to check the abnormality by vibration level.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2000년도 추계학술대회논문집
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• pp.145-149
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• 2000

In this paper, Firstly, it is shown that the bending mode vibration of check valve is comparatively large because resonance. Secondly in order to decrese the bending mode vibration of check valve, some practical dynamic vibration absorber have been developed and its effectiveness is investigated as installing it at the check valve of piping system practically.

• 한국기계가공학회지
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• 제20권11호
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• pp.100-107
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• 2021

The use of new and renewable energy is essential to solve the problem of increasing fossil fuel use due to industrial development. The paradigm of the automobile industry has changed due to the strengthening of environmental regulations in developed countries, and the development of eco-friendly cars is underway. Fuel cell electric vehicles (FCEVs), which use hydrogen as fuel, require strict standards for fuel-related components. In particular, check valves for FCEV control high-pressure hydrogen and thus, must be sufficiently strong for the challenging environment caused by high-pressure hydrogen. Therefore, this study used DEFORM 3D, a regular finite element analysis program, to check the moldability of check valves for FCEV, design the process, verify reliability through single streamline analysis, tensile tests, and ANSYS simulations, and identify suitable materials for the high-pressure hydrogen environment.

• 한국군사과학기술학회지
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• 제26권1호
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• pp.64-71
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• 2023

In the recent defence industries, it is required to develop the small and low cost embedded systems for guided missiles. According to the characteristics of guided missiles, the mission is conducted with multiple phases, which include a squib activation phase. By considering the unexpected squib activation, the squib system should be disabled after the launch of a guided missile. Therefore, the squib system needs to include the functions of the safe ignition and status check. This paper presents the squib ignition and status check circuits design for the compact embedded systems in guided missiles. Validation results show that for the functions of the squib ignition and status check, the presented circuits design performs well. The designed circuits also were implemented with various electronic devices and validated by the ground and flight tests.

• ETRI Journal
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• 제46권3호
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• pp.485-500
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• 2024

A hardware architecture is presented to decode (N, K) polar codes based on a low-density parity-check code-like decoding method. By applying suitable pruning techniques to the dense graph of the polar code, the decoder architectures are optimized using fewer check nodes (CN) and variable nodes (VN). Pipelining is introduced in the CN and VN architectures, reducing the critical path delay. Latency is reduced further by a fully parallelized, single-stage architecture compared with the log N stages in the conventional belief propagation (BP) decoder. The designed decoder for short-to-intermediate code lengths was implemented using the Virtex-7 field-programmable gate array (FPGA). It achieved a throughput of 2.44 Gbps, which is four times and 1.4 times higher than those of the fast-simplified successive cancellation and combinational decoders, respectively. The proposed decoder for the (1024, 512) polar code yielded a negligible bit error rate of 10^-4 at 2.7 E_b/N_o (dB). It converged faster than the BP decoding scheme on a dense parity-check matrix. Moreover, the proposed decoder is also implemented using the Xilinx ultra-scale FPGA and verified with the fifth generation new radio physical downlink control channel specification. The superior error-correcting performance and better hardware efficiency makes our decoder a suitable alternative to the successive cancellation list decoders used in 5G wireless communication.

• 한국정보통신설비학회:학술대회논문집
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• 한국정보통신설비학회 2009년도 정보통신설비 학술대회
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• pp.387-390
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• 2009

Wireless Sensor Network (WSN) can easily compromised from attackers because it has the limited resource and deployed in exposed environments. When the sensitive packets are occurred such as enemy's movement or fire alarm, attackers can selectively drop them using a compromised node. It brings the isolation between the basestation and the sensor fields. To detect selective forwarding attack, Xiao, Yu and Gao proposed checkpoint-based multi-hop acknowledgement scheme (CHEMAS). The check-point nodes are used to detect the area which generating selective forwarding attacks. However, CHEMAS has static probability of selecting check-point nodes. It cannot achieve the flexibility to coordinate between the detection ability and the energy consumption. In this paper, we propose the control method for the number fo check-point nodes. Through the control method, we can achieve the flexibility which can provide the sufficient detection ability while conserving the energy consumption.