• 대한이식학회지
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• 제31권4호
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• pp.157-169
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• 2017

Regulatory T cells (Treg) naturally rein in immune attacks, and they can inhibit rejection of transplanted organs and even reverse the progression of autoimmune diseases in mice. The initial safety trials of Treg against graft-versus-host disease (GVHD) provided evidence that the adoptive transfer of Treg is safe and capable of limiting disease progression. Supported by such evidence, numerous clinical trials have been actively investigating the efficacy of Treg targeting autoimmune diseases, type I diabetes, and organ transplant rejection, including kidney and liver. The limited quantity of Treg cells harvested from peripheral blood and subsequent in vitro culture have posed a great challenge to large-scale clinical application of Treg; nevertheless, the concept of CAR (chimeric antigen receptor)-Treg has emerged as a potential resolution to the problem. Recently, two CAR-T therapies, tisagenlecleucel and axicabtagene ciloleucel, were approved by the US FDA for the treatment of refractory or recurrent acute lymhoblastic leukemia. This approval could serve as a guideline for the production protocols for other genetically engineered T cells for clinical use as well. The phase I and II clinical trials of these agents has demonstrated that genetically engineered and antigen-targeting T cells are safe and efficacious in humans. In conclusion, both the promising results of Treg cell therapy from the clinical studies and the recent FDA approval of CAR-T therapies are paving the way for CAR-Treg therapy in clinical use.

• Smart Structures and Systems
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• 제31권3호
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• pp.229-245
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• 2023

The absence of excitation measurements may pose a big challenge in the application of structural damage identification owing to the fact that substantial effort is needed to reconstruct or identify unknown input force. To address this issue, in this paper, an iterative strategy, a synergy of Tikhonov regularization method for force identification and modified Jaya algorithm (M-Jaya) for stiffness parameter identification, is developed for damage identification with partial output-only responses. On the one hand, the probabilistic clustering learning technique and nonlinear updating equation are introduced to improve the performance of standard Jaya algorithm. On the other hand, to deal with the difficulty of selection the appropriate regularization parameters in traditional Tikhonov regularization, an improved L-curve method based on B-spline interpolation function is presented. The applicability and effectiveness of the iterative strategy for simultaneous identification of structural damages and unknown input excitation is validated by numerical simulation on a 21-bar truss structure subjected to ambient excitation under noise free and contaminated measurements cases, as well as a series of experimental tests on a five-floor steel frame structure excited by sinusoidal force. The results from these numerical and experimental studies demonstrate that the proposed identification strategy can accurately and effectively identify damage locations and extents without the requirement of force measurements. The proposed M-Jaya algorithm provides more satisfactory performance than genetic algorithm, Gaussian bare-bones artificial bee colony and Jaya algorithm.

• Asian Pacific Journal of Cancer Prevention
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• 제13권12호
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• pp.6073-6076
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• 2012

Discovery of anticancer drugs that kill or disable tumor cells in the presence of normal cells without undue toxicity is a potential challenge for therapeutic care. Several papers in the literature have emphasized the potential implications of marine products such as seaweeds which exhibit antitumor activity. Study attempts to screen the antitumor effect of Sargassum sp, against chosen cell lines such as MCF-7 (Breast cancer) and Hep-2 (Liver Cancer). Ethanol extract of Sargassum sp. was concentrated using a Soxhlet apparatus and dissolved in DMSO. In vitro cytotoxic activity of Sargassum sp at various concentrations ($100{\mu}g/ml-300{\mu}g/ml$) screened for antitumor effect against the chosen cell lines using MTT assay (3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide, a yellow tetrazole). The study documented that the percentage of cell viability has been reduced with increased concentration, as evidenced by cell death. Sargassum sp extract shows potential cytotoxic activity ($P{\leq}0.05$) with $IC_{50}$ of $200{\mu}g/ml$ and $250{\mu}g/ml$ against Hep-2 and MCF-7 cell lines respectively. The ethanol fraction of Sargassum sp induced cell shrinkage, cell membrane blebbing and formation of apoptotic bodies with evidence of bioactive components as profound influencing factors for anti-tumor effects. Further research need to be explored for the successful application of Sargassum sp as a potent therapeutic tool against cancer.

• International Journal of Automotive Technology
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• 제8권1호
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• pp.27-31
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• 2007

The number of vehicles employing diesel engines is rapidly rising. Accompanying this trend, application of an after-treatment system is strictly required as a result of reinforced exhaust regulations. The Diesel Particulate Filter (DPF) system is considered as the most efficient method to reduce particulate matter (PM), but the improvement of a regeneration performance at any engine operation point presents a considerable challenge by itself. Therefore, the present study evaluates the effect of fuel injection characteristics on regeneration performance in a DOC and a catalyzed CR-DPF system. The temperature distribution on the rear surface of the DOC and the exhaust gas emission were analyzed in accordance with fuel injection strategies and engine operating conditions. A temperature increase more than BPT of DPF system was obtained with a small amount fuel injection although the exhaust gas temperature was low and flow rate was high. This increase of temperature at the DPF inlet cause PM to oxidize completely by oxygen. In the case of multi-step injection, the abrupt temperature changes of DOC inlet didn't occur and THC slip also could not be observed. However, in the case of pulse type injection, the abrupt injection of much fuel results in the decrease of DOC inlet temperatures and the instantaneous slip of THC was observed.

• Journal of Biosystems Engineering
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• 제40권2호
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• pp.124-136
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• 2015

Purpose: Grain quality is a general concept that covers many characteristics, ranging from physical to biochemical and physiochemical properties. Rice aging during storage is currently a challenge in the rice industry, and is a complicated process involving changes in all of the above properties. Spectroscopic techniques can be used to obtain information on the quality of rice samples in a non-destructive manner. Methods: The objective of this review was to highlight the factors that contribute to rice quality and aging, and to describe various spectroscopic modalities, particularly vibrational and hyperspectral imaging, for the assessment of rice quality. Results: Starch and protein are the main components of the rice endosperm, and are therefore key factors contributing to eating and cooking quality. While the overall starch, protein, and lipid content in the rice grain remains essentially unchanged during storage, structural changes do occur. These changes affect pasting and gel properties, and ultimately the flavor of cooked rice. In addition, grain quality is significantly affected by growing and environmental conditions, such as water availability, temperature, fertilizer application, and salinity stress. These properties can be evaluated using spectroscopic techniques, and rice samples can be discriminated by using multivariate statistical analysis methods. Conclusion: Hyperspectral imaging and vibrational spectroscopy techniques have good potential for determining rice quality properties in a non-invasive manner, i.e., not requiring the introduction of instruments into the rice grain.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 2001년도 가을 학술발표회 논문집
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• pp.29-62
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• 2001

Based on the results from investigation of behaviour of pulverized fly ashes (PFA) at laboratory and field, the way how to reduce the environmental impacts to geotechnical practices Is considered and described. In order to reduce discharged industrial by-products, it should primarily be emphasized that an effort are made as much as possible not to put into homing. Secondarily, an effort must be made to increase amount of utilization to geotechnical engineering practices. In addition, from an environmental point of view, we should challenge to create innovative materials which are eligible for controlling other wastes and remedying contamination m soils by using industrial byproducts which belong to wastes This Is a new concept in which the polluting materials can be eliminated by making use of wastes. Based on the above-stated concept, the previous and possible utilization of PFA is classified into: (1 ) reclamation, embankment or backfill material, (2) light weight geo-material, (8) soil stabilization/improvement, and (4) environmental material. The reason why PFA, in particular, slurry PFA has been used and will possibly be used more widely is due to the fact that PFA has the advantages : (i) low specific gravity leading to a light weight geomaterial, (ii) high pozzolanic activity enhancing strength, especially due to cement addition, and (iii) spherical shape of particles producing isotropy and then pumpability. As well as the concept of reducing geo-environmental impacts, the present text mainly describes the successful results at laboratory and field which have been obtained by the authors. The most important issue hi application of byproducts including PFA for geotechnical practices is to prevent leakage of polluted substances from sedimentary deposits, ground and earth structures. As one of possible techniques far achieving this purpose, a method of washing off the polluted substances by hot water is described.

• Wind and Structures
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• 제13권5호
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• pp.413-431
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• 2010

The focus of this article is on the assessment of vertical wind vector components and their aerodynamic impact on lattice framework, specifically two distinct sections of a guyed transmission tower. Thunderstorm winds, notably very localized events such as convective downdrafts (including downbursts) and tornadoes, result in a different load on a tower's structural system in terms of magnitude and spatial distribution when compared to horizontal synoptic winds. Findings of previous model-scale experiments are outlined and their results considered for the development of a testing rig that allows for rotation about multiple body axes through a series of wind tunnel tests. Experimental results for the wind loads on two unique experimental models are presented and the difference in behaviour discussed. For a model cross arm with a solidity ratio of approximately 30%, the drag load was increased by 14% when at a pitch angle of $20^{\circ}$. Although the effects of rotation about the vertical body axis, or the traditional 'angle of attack', are recognized by design codes as being significant, provisions for vertical winds are absent from each set of wind loading specifications examined. The inclusion of a factor to relate winds with a vertical component to the horizontal speed is evaluated as a vertical wind factor applicable to load calculations. Member complexity and asymmetric geometry often complicate the use of lattice wind loading provisions, which is a challenge that extends to future studies and codification. Nevertheless, the present work is intended to establish a basis for such studies.

• 한국콘텐츠학회논문지
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• 제19권5호
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• pp.74-81
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• 2019

본 연구의 목적은 국내에서 수행된 플립드러닝 관련 연구의 현황과 동향을 정리하는 것이다. 이를 위해 RISS의 학술 논문 검색 기능을 활용하여 총 680 편의 논문을 분석 대상으로 수집, 선정하였고, RISS에서 제공하는 기본 서지 정보와 분석 과정에서 도출한 분류 유목을 기반으로 내용분석을 실시하였다. 분석 유목은 논문 성격, 연구 방법, 연구 대상, 학문 분야, 연구 주제, 논문 주제어 분류로 하였다. 분석 결과, 국내에 학술논문형식으로 플립드러닝이 다루어진 것은 2013년부터다. 이후 급격한 증가 추세를 보였으며, 학문 분야, 논의 주제, 관련 변인 등에 있어서도 다양하게 확산되어 나갔음을 알 수 있었다. 연구의 목적이나 주제 측면에서도, 플립드러닝의 소개와 기초 논의, 탐색적 적용, 심화 및 확장의 순으로 점차 발전해 왔다. 양적 성장의 과제가 충분히 달성된 지금, 플립드러닝 연구의 이론적 기초와 토대를 점검하고 공고히 할 것을 제안하였다.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2012년도 제42회 동계 정기 학술대회 초록집
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• pp.245-245
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• 2012

Syntheses of oxide supported metal catalysts by wet-chemical routes have been well known for their use in heterogeneous catalysis. However, uniform deposition of metal nanoparticles with controlled size and shape on the support with high reproducibility is still a challenge for catalyst preparation. Among various synthesis methods, arc plasma deposition (APD) of metal nanoparticles or thin films on oxide supports has received great interest recently, due to its high reproducibility and large-scale production, and used for their application in catalysis. In this work, Au and Pt nanoparticles with size of 1-2 nm have been deposited on titania powder by APD. The size of metal nanoparticles was controlled by number of shots of metal deposition and APD conditions. These catalytic materials were characterized by x-ray diffraction (XRD), inductively coupled plasma (ICP-AES), CO-chemisorption and transmission electron microscopy (TEM). Catalytic activity of the materials was measured by CO oxidation using oxygen, as a model reaction, in a micro-flow reactor at atmospheric pressure. We found that Au/$TiO_2$ is reactive, showing 100% conversion at $110^{\circ}C$, while Pt/$TiO_2$ shows 100% conversion at $200^{\circ}C$. High activity of metal nanoparticles suggests that APD can be used for large scale synthesis of active nanocatalysts. We will discuss the effect of the structure and metal-oxide interactions of the catalysts on catalytic activity.

• 한국중재학회지:중재연구
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• 제14권1호
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• pp.133-156
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• 2004

The rapid development of the internet may not have occurred without techniques of linking and framing, which provide users flexible and easy access to other website. These techniques have enabled internet users to navigate the internet efficiently and sort through the products, services and information available on the internet. The Advent of the global information structure and the do-called EC revolution raise countless new issues and questions. There are no limitations regulating the expressions on the cyberspace due to internet's of quality anonymity? diversity? spontaneity. Therefore, the freedom of speech is expanded in both areas of time and space, which was impossible with the old communicating system. Although online technology raises many new legal issues, the law available to help us resolve them, at least today, is largely based on the world as it existed before online commerce became a reality. Thus the challenge is to predict how these new legal issues may be resolved using the current law. As a result of the drastic change of the environment for international trade of which that has taken took place in parallel with the global information technology revolution on a global basis, the scope of issues to be addressed which should be resolved by the conflict of laws principles has been remarkably expanded, and various new issues of an entirely which are quite new in its type and nature have arisen been raised. Further more in addition, the old act prior act was regarded as insufficient in that it lacked rules on international governing law to adjudicate, or international adjudicatory governing law, where as the expectation of the public was that the private international law should function as the basic law of the legal relational encompassing rules on governing law given the increase of It international disputes. for the move the private international law has also attracted more attention from the korean.