• Journal of Korean Society of Industrial and Systems Engineering
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• v.37 no.4
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• pp.90-97
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• 2014

The mobile SNS is a promising e-service platform of the future. However, measuring its service quality is a challenge. An appropriate model for measuring service quality is required. This paper proposes e-service quality models for analyzing mobile SNS platform quality, based on previous service quality researches. An empirical study is performed on the proposed models. The results show that constructs of existing e-service models such as responsiveness and assurance do not fit the mobile SNS platform, and that loyalty and value are better measures for mobile service quality.

• Proceedings of the IEEK Conference
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• summer
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• pp.57-60
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• 2004

Next generation wireless network is evolving toward IP-based network that can various provide multimedia services. A challenge in wireless mobile Internet is support of quality of service over wireless access networks. DiffServ architecture is proposed for evolving wireless mobile Internet. In this paper we propose an algorithm for optimal buffer partitioning which requires the minimal channel capacity to satisfy the QoS requirements of input traffic. We used a partitioned buffer with size B to serve a layered traffic at each DiffServ router. We consider a traffic model with a single source generates traffic having J $(J\geq2)$ quality of service (QoS) classes. QoS in this case is described by loss probability $\varepsilon_j$. for QoS class j. Traffic is admitted or rejected based on the buffer occupancy and its service class. Traffic is generated by heterogeneous Markov-modulated fluid source (MMFS).

• IMMUNE NETWORK
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• v.2 no.1
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• pp.1-5
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• 2002

Estimated number of adults and children newly infected with HIV-1 during 2001 alone is 5 million in total. An effective vaccine, in addition to education & public health approaches, has been believed to be the best option to stop the HIV-1 transmission, especially for developing countries. Among AIDS vaccine candidates, DNA vaccine is relatively safe and, in a certain extent, mimics some attributes of live attenuated vaccine, with regard to in vivo gene expression & the type of immunity induced. We recently demonstrated that DNA vaccines expressing SIVmac239 structural and regulatory genes, augmented with coadministration of IL-12 mutant induced the strongest T cell responses, resulting in low to undetectable setpoint viral loads, stable $CD4^+$ T cell counts, and no evidence of clinical diseases or mortality by day 420 after challenge. This finding is the second demonstration, following the protective result of live attenuated SIV vaccine in SIVmac-rhesus monkey model, which was known to have safety problem. So, our DNA vaccines could give a significant impact on HIV-1 epidemic by slowing or stopping the spread of HIV-1, leading to eventual eradication of HIV-1 and AIDS in the population.

• Korean Journal of Agricultural Science
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• v.44 no.3
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• pp.424-439
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• 2017

This study was undertaken to examine the profit efficiency and its determining factors, the investment opportunity, and the challenges of shea butter producers in the northern region of Ghana. The methods employed in this research were the Stochastic Profit Frontier (SPF) model, gain-cost and investment return analyses, as well as Kendall's W statistic using primary data collected from 120 purposively-selected respondents. Results from the analysis indicated that profit efficiency was positively influenced by sex, household size, marital status, educational level, transportation cost, store rent, and price of shea nut with a gain in profit efficiency of 58.5%. The investment analysis demonstrated a net gain per person of $8,077 equivalent to GH₵ 28,270 Ghanaian cedi (GH₵) using 2016 exchange rate (GH₵ 3.5 = $1). Among the challenges identified, the poor quality of shea nuts was the most prioritised challenge with 72.8% agreement among the respondents. Based on these findings, it was recommended that proper training and education, as well as improvement in shea nut quality, should be promoted to improve the profit efficiency of shea butter producers.

• Archives of Pharmacal Research
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• v.19 no.1
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• pp.66-70
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• 1996

Aliphatic esters of protocatechuic acid (PA, 1), vanillic acid (VA, 9) and gallic acid (GA, 18) were prepared and their anti-thrombotic effects were evaluated in the mouse model of thrombosis. The aliphatic groups included methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl, n-amyl and cyclohexyl. n-Amyl ester of PA (7), i-propyl and cyclohexyl esters of VA (13 and 17 respectively) and ethyl ester of GA (20) treatment significantly lowered the death rate and increased the recovery from paralysis due to the thrombotic challenge. From the limited analogs available, it was tentatively concluded that the structural conformation, where carboxy oxygen (=O or -O) of the carboxyl group (COOH) at $C_1$ and the oxygen function at $C_3(either\; OH\; or\; OCH_3)$ are closely situated, is favorable for the esters of PA, VA and GA to be more antithrombotic.

• JSTS:Journal of Semiconductor Technology and Science
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• v.15 no.3
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• pp.356-364
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• 2015

The transmission performance of TSV considering the effect of electronic-thermal coupling is an new challenge in three dimension integrated circuit. This paper presents the thermal equivalent circuit (TEC) model of the TSV, and discussed the thermal equivalent parameters for TSV. Si layer is equivalent to transmission line according to its thermal characteristic. Thermal transient response (TTR) of TSV considering electronic-thermal coupling effects are proposed, iteration flow electronic-thermal coupling for TSV is analyzed. Furthermore, the influences of TTR are investigated with the non-coupling and considering coupling for TSV. Finally, the relationship among temperature, thickness of $SiO_2$, radius of via and frequency of excitation source are addressed, which are verified by the simulation.

• Steel and Composite Structures
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• v.10 no.4
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• pp.331-348
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• 2010

Ample research effort has been oriented into developing damage indices with the aim of estimating in a reasonable manner the consequences, in terms of structural damage and deterioration, of severe plastic cycling. Although several studies have been devoted to calibrate damage indices for steel and reinforced concrete members; currently, there is a challenge to study and calibrate the use of such indices for the practical evaluation of complex structures. The aim of this paper is to introduce an energy-based damage index for multi-degree-of-freedom steel buildings that accounts explicitly for the effects of cumulative plastic deformation demands. The model has been developed by complementing the results obtained from experimental testing of steel members with those derived from analytical studies regarding the distribution of plastic demands on several steel frames designed according to the Mexico City Building Code. It is concluded that the approach discussed herein is a promising tool for practical structural evaluation of framed structures subjected to large energy demands.

• Journal of Information Technology Applications and Management
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• v.18 no.1
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• pp.75-100
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• 2011

For decades, thousands of corporation introduced knowledge management systems to respond knowledge-based society. However, it seems that the systems merely focusing on knowledge accumulation and its sharing have been bounded by many restrictions in terms of new knowledge creation based on the life cycle of knowledge management systems. Moreover, recently, a variety of knowledge management activities regarding organization, systems, and process is emphasized as a strategic asset for a corporation to create core knowledge. Therefore, this study adopted the Csikszentmihalyi's flow theory to investigate the factors affecting knowledge creation and the success factors of knowledge management systems in virtual space. Prior studies argued that flow experience should be a prerequisite for creative knowledge creation. In that vein, this research revealed the causal relationships for flow experience between the determinants of clear goal, immediate feedback, congruence of challenge and skill. Additionally, it empirically examined how flow experience affected the exploratory behavior of knowledge creation.

• Proceeding of EDISON Challenge
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• 2016.03a
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• pp.55-61
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• 2016

$A{\beta}_{40}$ peptides form oligomers that later aggregate into a plaque, which is deemed to be a leading cause of Alzheimer's Disease. Its non-crystalline morphology has limited an understanding of comprehensive structural study. In this research, computational biomolecular simulations were performed in the following order: solvent and ion addition in a box, energy minimization of protein, equilibration, and periodic boundary condition disaggregation of a monomer from fibril. The result founded the two-fold model is 25% more stable in the simulation environment, and the steric zippers held on most tightly until 220 ps of simulation. The study supports the previous findings that two-fold aggregate $A{\beta}_{40}$ is more stable at 310 K and discusses further how much contribution steric-zipper and hydrogen bonding are making.

• Proceeding of EDISON Challenge
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• 2013.04a
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• pp.13-24
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• 2013

Dopamine agonists and antagonists and its receptor play a critical role in the information transfer in the nervous system, and dopamine receptor-ligands interactions are deeply related to Parkinson's disease, schizophrenia and some other mental diseases. However, the only experimental 3D structure available for dopamine receptors is human D3 dopamine receptor. Therefore, it is important to create model of subtype dopamine receptor-ligands interactions. We report here the 3D structures of the human D1 and D2 dopamine receptor predicted by using GalaxyTBM, and its predicted binding site determined by using GalaxyDock. The highly conserved Asp on TM 3 and Phe on TM 6 have critical role in ligand binding. Also, highly conserved serines on TM 5 are essential for binding agonists and some kinds of antagonists. We identify differences between binding sites of agonists and antagonists of human D1 and D2 dopamine receptor, and find the reasons of selective binding of antagonists.