• Journal of Mechanical Science and Technology
• /
• v.16 no.4
• /
• pp.557-563
• /
• 2002

In this paper, the characteristics of flow and spray motions affected by from piston head configurations were investigated numerically. Calculations were carried out from intake process to the end of compression. GTT (Generalized Tank and Tube method) code, which includes a third order upwind Chakravarthy-Osher TVD scheme and k-$\varepsilon$ turbulence model with fuel spray analysis was used for the calculations. As a results, piston heads with smaller radii of curvature were found to give stronger reverse tumble than those with larger radii of curvature. Similar results are shown in the convection and diffusion of fuel sprays.

• Journal of applied mathematics & informatics
• /
• v.39 no.1_2
• /
• pp.173-196
• /
• 2021

This paper treats a retrial queue with phase type retrial times and a threshold type-policy, where each server is subject to breakdowns and repairs. Upon a server failure, the customer whose service gets interrupted will be handed over to another available server, if any; otherwise, the customer may opt to join the retrial orbit or depart from the system according to a Bernoulli trial. We analyze such a multi-server retrial queue using the recently introduced threshold-based retrial times for orbiting customers. Applying the matrix-analytic method, we carry out the steady-state analysis and report a few illustrative numerical examples.

• 한국전산유체공학회:학술대회논문집
• /
• 2001.05a
• /
• pp.189-194
• /
• 2001

In this paper, non-reacting and reacting flowfields were computed using a preconditioned Navier-Stokes solver. The preconditioning technique of Merkle et al. and TVD scheme or Chakravarthy and Osher was employed and the results obtained using developed code have a good agreement with the previous results and experimental data. The preconditioned Wavier-Stokes equation set with low Reynolds number $\kappa-\epsilon$ equation and species continuity equations, are discretized with strongly implicit manner and time integrated with LU-SSOR scheme. For the purpose of treating unsteady problem the duel-time stepping scheme was employed. For the validation of the code in incompressible flow regime, steady driven square cavity flow was considered and calculation result shows reasonably good agreement with the result of incompressible code. Shock wave/boundary layer interaction problem was considered to show the shock capturing performance of preconditioned-TVD scheme. To validate unsteady flow, acoustic oscillation problem was calculated, and supersonic premix flame of $H_2$-air reaction problem which is calculated with turbulence model, 9-species/18-reaction step reaction model, shows reasonable agreement with the previous results. As a result, the preconditioning method has an advantage to calculate incompressible and compressible flow through one code and preconditioned solver easily developed from standard compressible code with minor efforts. But additional computational time and computer memory is required due to preconditioning matrix.

• Asian Pacific Journal of Cancer Prevention
• /
• v.14 no.2
• /
• pp.727-731
• /
• 2013

Background: The aim of this study was to analyze the clinicopathological and immunohistochemical features of primary central nervous system lymphoma (PCNSL) cases occurring in Indian patients and also study the utility of the crush smear preparation in intraoperative diagnosis. Materials and Methods: The immune status, clinical, radiological details, immunohistochemical profile, histopathological findings and cytological features in smear preparation of 32 cases of PCNSL were analyzed. Patients with systemic NHL and skull-base lymphomas were excluded. Results: The mean age of our patients was 52 years with a male: female ratio 1:1. A periventricular location was found in 62.5% of patients. None of our PCNSL cases were associated with AIDS. All cases except one were diffuse large B-cell lymphomas. Intraoperative diagnosis using crush smears allowed correct prediction in 93% of cases. Conclusions: Our study shows that PCNSL is seen predominantly in immunocompetent patients in India. The age of presentation is relatively young as compared to the West. Our study also stresses the utility of crush smear preparation in establishing an intraoperative diagnosis.

• Journal of applied mathematics & informatics
• /
• v.39 no.5_6
• /
• pp.601-616
• /
• 2021

Retrial queueing models have been studied extensively in the literature. These have many practical applications, especially in service sectors. However, retrial queueing models have their own limitations. Typically, analyzing such models involve level-dependent quasi-birth-and-death processes, and hence some form of a truncation or an approximate method or simulation approach is needed to study in steady-state. Secondly, in general, the customers are not served on a first-come-first-served basis. The latter is the case when a new arrival may find a free server while prior arrivals are waiting in the retrial orbit due to the servers being busy during their arrivals. In this paper, we take a different approach to the study of multi-server retrial queues in which the signals are generated in such a way to provide a reasonably fair treatment to all the customers seeking service. Further, this approach makes the study to be level-independent quasi-birth-and-death process. This approach is different from any considered in the literature. Using matrix-analytic methods we analyze MAP/M/c-type retrial queueing models along with Poisson signals in steady-state. Illustrative numerical examples including a comparison with previously published retrial queues are presented and they show marked improvements in providing a quality of service to the customers.

• CELLMED
• /
• v.3 no.4
• /
• pp.32.1-32.6
• /
• 2013

Plectranthus amboinicus Benth (Lamiaceae) is a medicinal plant native to India, and its leaves are widely used in several traditional medicinal preparations. The purpose of this study was to detect and quantify phenolics present in ethyl acetate and acetone extracts of P. amboinicus leaves, and evaluate their antioxidant, antibacterial, antimutagenic and anticancer activities. The HPLC chromatograms of crude leaf extracts indicated the presence of phenolics like caffeic acid, coumaric acid, rutin, quercetin and gallic acid, which were present in the range of 0.01 - 1.41 mg/g in ethyl acetate and 0.03 - 1.93 mg/g in the acetone extract. The acetone extract showed statistically (p < 0.05) higher antioxidant activity ($IC_{50}$, 99.59 ${\mu}g/ml$) than ethyl acetate extract ($IC_{50}$, 149.96 ${\mu}g/ml$). Statistically (p < 0.05) higher antimutagenicity was shown by acetone extract (46.16%) as compare to ethyl acetate extract (12.16%) at 500 ${\mu}g/plate$ concentration. The acetone extract showed higher antibacterial activity than ethyl acetate extract, and both the extracts showed highest activity against B. cereus (375 and 625 ${\mu}g/ml$, respectively) and lowest activity against Y. enterocolitica (1000 and 1125 ${\mu}g/ml$, respectively). Both the extracts also showed inhibitory effect on cancer cell lines HCT-15 and MCF-7. These results suggest that the leaves of P. amboinicus possess various biological activities, and validate the traditional use of the leaves of P. amboinicus against cold, infection and ulceration.

• Journal of Information Processing Systems
• /
• v.6 no.3
• /
• pp.335-346
• /
• 2010

The present study investigates the difficulty of solving the mathematical problem, namely the DLP (Discrete Logarithm Problem) for ephemeral keys. The DLP is the basis for many public key cryptosystems. The ephemeral keys are used in such systems to ensure security. The DLP defined on a prime field $Z^*_p of random prime is considered in the present study. The most effective method to solve the DLP is the ICM (Index Calculus Method). In the present study, an efficient way of computing the DLP for ephemeral keys by using a new variant of the ICM when the factors of p-1 are known and small is proposed. The ICM has two steps, a pre-computation and an individual logarithm computation. The pre-computation step is to compute the logarithms of a subset of a group and the individual logarithm step is to find the DLP using the precomputed logarithms. Since the ephemeral keys are dynamic and change for every session, once the logarithms of a subset of a group are known, the DLP for the ephemeral key can be obtained using the individual logarithm step. Therefore, an efficient way of solving the individual logarithm step based on the newly proposed precomputation method is presented and the performance is analyzed using a comprehensive set of experiments. The ephemeral keys are also solved by using other methods, which are efficient on random primes, such as the Pohlig-Hellman method, the Van Oorschot method and the traditional individual logarithm step. The results are compared with the newly proposed individual logarithm step of the ICM. Also, the DLP of ephemeral keys used in a popular password key exchange protocol known as Chang and Chang are computed and reported to launch key recovery attack.

• Journal of Periodontal and Implant Science
• /
• v.43 no.3
• /
• pp.121-129
• /
• 2013

Purpose: The present study has two aims; firstly, it attempts to verify the presence of oxidative stress by estimating the reactive oxygen species (ROS) levels in periodontal pockets ${\geq}5$ mm as compared to controls. The second aim is to evaluate the effect of lycopene as a locally delivered antioxidant gel on periodontal health and on the gingival crevicular fluid (GCF) levels of 8-hydroxydeoxyguanosine (8-OHdG), a marker of oxidative injury. Methods: Thirty-one subjects participated in this study. In the pretreatment phase, the ROS levels in pockets ${\geq}5$ mm were measured by flow cytometry. Three sites in each subject were randomly assigned into each of the following experimental groups: sham group, only scaling and root planing (SRP) was done; placebo group, local delivery of placebo gel after SRP; and lycopene group, local delivery of lycopene gel after SRP. Clinical parameters included recording site-specific measures of GCF 8-OHdG, plaque, gingivitis, probing depth, and clinical attachment level. Results: The gel, when delivered to the sites with oxidative stress, was effective in increasing clinical attachment and in reducing gingival inflammation, probing depth, and 8-OHdG levels as compared to the placebo and sham sites. Conclusions: From this trial conducted over a period of 6 months, it was found that locally delivered lycopene seems to be effective in reducing the measures of oxidative stress and periodontal disease.

• Proceedings of the Korean Vacuum Society Conference
• /
• 2013.08a
• /
• pp.142.2-142.2
• /
• 2013

The effect of substrate on catalytic activity of CO oxidation with transition metal Platinum nanoparticles on doped and undoped TiO2 was investigated. Titanium dioxide was doped chemically with non-metal anions including nitrogen and fluorine. Undoped TiO2 was synthesized via simple conventional sol-gel route. Thin films of titania were developed by spin coating technique and the characterization techniques SEM, XRD, UV-Vis Absorption Spectroscopy and XPS were carried out to examine the morphology of films, crystal phase, crystallites, optical properties and elemental composition respectively. XPS analysis from doped TiO2 confirmed that the nitrogen site were interstitial whereas fluorine was doped into TiO2 lattice substitutionally. Catalytic activity systems of Pt/doped-TiO2 and Pt/undoped-TiO2 were fabricated to reveal the strong metal-support interaction effect during catalytic activity of CO oxidation reactions. By arc plasma deposition technique, platinum nanoparticles with mean size of 2.7 nm were deposited on the thin films of doped and undoped titanium dioxide. The CO oxidation was performed with 40 Torr CO and 100 Torr O2 with 620 Torr He carrier gas. Turn over frequency was observed two to three folds enhancement in case of Pt/doped TiO2 as compared to Pt/TiO2. The electronic excitation and the oxygen vacancies that were formed with the doping process were the plausible reasons for the enhancement of catalytic activity.

• Asian Pacific Journal of Cancer Prevention
• /
• v.16 no.16
• /
• pp.7071-7076
• /
• 2015

Epidermal growth factor receptor (EGFR) is one of the targeted molecular markers in many cancers including lung malignancies. Gefitinib and erlotinib are two available therapeutics that act as specific inhibitors of tyrosine kinase (TK) domains. We performed a case-control study with formalin-fixed paraffin-embedded tissue blocks (FFPE) from tissue biopsies of 167 non-small cell lung carcinoma (NSCLC) patients and 167 healthy controls. The tissue biopsies were studied for mutations in exons 18-21 of the EGFR gene. This study was performed using PCR followed by DNA sequencing. We identified 63 mutations in 33 men and 30 women. Mutations were detected in exon 19 (delE746-A750, delE746-T751, delL747-E749, delL747-P753, delL747-T751) in 32 patients, exon 20 (S786I, T790M) in 16, and exon 21 (L858R) in 15. No mutations were observed in exon 18. The 63 patients with EFGR mutations were considered for upfront therapy with oral tyrosine kinase inhibitor (TKI) drugs and have responded well to therapy over the last 15 months. The control patients had no mutations in any of the exons studied. The advent of EGFR TKI therapy has provided a powerful new treatment modality for patients diagnosed with NSCLC. The study emphasizes the frequency of EGFR mutations in NSCLC patients and its role as an important predictive marker for response to oral TKI in the south Indian population.