• 한국치위생학회지
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• 제18권5호
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• pp.621-630
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• 2018

Objectives: The purpose of this study was to investigate the smoking status and related factors among adolescents in Korea. Methods: We used data from the 5-7th Korea National Health and Nutrition Examination Survey. The distribution of smokers and smoking status according to general characteristics was analyzed using complex chi-square tests. Multiple logistic regression was used to analyze the relationship between smoking experience and general characteristics by calculating the 95% confidence intervals. Results: There were 618 subjects who had experience smoking one or two puffs, the starting age of one or two puffs on smoking was 14.37 years old, the number of smoking days per month was 12.42 days, and the amount of smoking per day in a month was 7.59. Gender, residential area, income level, drinking experience, subjective health status, perceived stress level, continuous depression for more than 2 weeks, suicidal thoughts within a year, and age were significantly related to smoking experience. Conclusions: It is necessary to understand the smoking behavior of adolescents. It is important to lower the smoking rate among adolescents through the development and operation of systematic smoking prevention and smoking cessation policies at the national level, as well as the efforts of youth themselves to quit smoking.

• 한국치위생학회지
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• 제18권5호
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• pp.631-641
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• 2018

Objectives: The purpose of this study was to confirm the relationship between socioeconomic characteristics and the prevalence of periodontal disease, with a focus on employment status, in a representative sample of Korean adults aged 19-39 years. Methods: Data were obtained from 3,178 adults who completed the Korean National Health and Nutrition Examination Survey, health-related questionnaires, and an oral examination. Socioeconomic, demographic, and oral health-related behavior data were adopted as independent variables. The chi-square test was used to assess differences in the distribution of socioeconomic status, oral health behavior, and nutrition factors according to employment status. Logistic regression analysis was performed to confirm the relationships between the prevalence of periodontitis and the related variables. Results: Significant differences in sex, educational level, income, marital status, smoking status, prevalence of periodontitis, number of dental check-ups in a year, and unmet dental care were confirmed according to employment status. The prevalence of periodontal disease was not significantly related to employment status. Conclusions: These results suggest a significant difference in periodontal disease according to socioeconomic factors in Korean adults. However, the prevalence of periodontal disease was not related to employment status. To prevent the progression of periodontal disease, attention should be paid to oral health, time available for dental treatment, smoking cessation, and use of floss.

• 한국미생물·생명공학회지
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• 제15권6호
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• pp.414-419
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• 1987

Saccharomycopsis lipolytica의 isocitrate lyase에 대한 온도감수성 변이의 특성과 이 효소의 생화학적성질을 조사하기 위한 기초연구로서 isocitrate lyase 결손변이 균주인 MX9-11(Icl-)로부터 온도감수성을 나타내는 복귀 변이균주를 3균주 분리하고 그중 활성의 회복이 가장 높은 MX9-11RX8 균주의 성질을 조사하였다. MX9-11RX8 복귀 변이균주는 탄소원으로서 초산을 사용하였을 때 온도의 증가에 따라서 isocitrate lyase의 생성량과 비생성 속도가 감소하여 33$^{\circ}C$에서는 거의 효소를 합성하지 않았으며, 온도를 23$^{\circ}C$에서 33$^{\circ}C$로 올렸을 때 효소의 합성은 바로 정지하였지만 균체증식은 계속되었다. 한편 n-hexadecane을 탄소원으로 사용하였을 때에도 온도감수성을 나타내었으며, 온도의 shift up 후에도 isocitric acid 생산은 거의 변화가 없었다.

• The Korean Journal of Physiology and Pharmacology
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• 제15권2호
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• pp.67-81
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• 2011

Epilepsy is a chronic disease occurring in approximately 1.0% of the world's population. About 30% of the epileptic patients treated with availably antiepileptic drugs (AEDs) continue to have seizures and are considered therapy-resistant or refractory patients. The ultimate goal for the use of AEDs is complete cessation of seizures without side effects. Because of a narrow therapeutic index of AEDs, a complete understanding of its clinical pharmacokinetics is essential for understanding of the pharmacodynamics of these drugs. These drug concentrations in biological fluids serve as surrogate markers and can be used to guide or target drug dosing. Because early studies demonstrated clinical and/or electroencephalographic correlations with serum concentrations of several AEDs, It has been almost 50 years since clinicians started using plasma concentrations of AEDs to optimize pharmacotherapy in patients with epilepsy. Therefore, validated analytical method for concentrations of AEDs in biological fluids is a necessity in order to explore pharmacokinetics, bioequivalence and TDM in various clinical situations. There are hundreds of published articles on the analysis of specific AEDs by a wide variety of analytical methods in biological samples have appears over the past decade. This review intends to provide an updated, concise overview on the modern method development for monitoring AEDs for pharmacokinetic studies, bioequivalence and therapeutic drug monitoring.

• 터널과지하공간
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• 제22권6호
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• pp.373-382
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• 2012

폐광된 광산에서는 채광장으로 유입되는 지하수의 펌핑 작업을 더 이상 수행하지 않기 때문에, 채광 공동이나 채광장 주변 지층에서 지하수위가 점진적으로 상승하는 지하수 리바운드 현상이 발생한다. 그동안 폐광산 지역의 지하수 리바운드 현상을 분석할 수 있는 다양한 수치모델들이 개발되었다. 본 논문에서는 폐탄광지역의 지하수 리바운드 현상 분석시 활용할 수 있는 VSS-NET, GRAM, MODFLOW 모델에 대해 조사하고, 공간적/시간적 규모에서 각 모델의 적용 범위에 대해 소개하였다. 특히, GRAM 모델에 대해서는 상세한 분석을 수행하였으며 포트란 언어를 이용하여 프로그램을 구현하였다. GRAM 모델을 이용하여 국내 동원탄광 수갱의 지하수 리바운드 현상을 분석하였으며, 현장의 지하수위 계측 결과와 GRAM 모델의 분석 결과가 유사한 것으로 나타났다.

• 한국임상수의학회지
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• 제11권2호
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• pp.585-592
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• 1994

A consecutive Jiao Chio acupuncture therapy was performed for 3 days in the 45-90 days old 11 calves of which have been shown severe watery diarrhea. The discharge of the infected calves was yellowish brown in color. Two calves of these patients were infected wi pulmonary disease as well as diarrhea. Thus, Su Qi and Fei Yu acupuncture therapy was carried out additionally after dosing with antibiotics twice for The two infected calves. Blood chemical values and serum neutralizing antibody titers were checked, and total blood cell count was also carried out to know the therapeutic effect before and after(21 days) acupuncture therapeutics. The results are as follows ; 1, The diarrhea has ceased one day after begining of the acupuncture therapy in 5 calves, and the cessation of the diarrhea in remaining calves occurred in 1 calf each on 3rd and 4th day, and 2 calves on 6th day, respectively. Two calves infected with pulmonary disease as well diarrhea were cured 8 days after the begining of the therapcutics. 2. Rotaviruses wire detected in the feces of 2 calves, and bovine diarrhea viruses were detected in the 8 calves by the test for serum neutralizing antibody titers, and bovine coronaviruses were also detected in 5 calves. Four calves of the 5 bovine coronavirus infected calves were also infected with bovine diarrhea viruses. 3. Total leucocyte number, total amount of serum protein, and amount of fibringen were slightly increased, while total erythrocyte number, and erythrocyte packed cell volume were slightly decreased. These valucs were statistically not significant. Electrolytes of Na/sup +/, K/sup +/ and Cl/sup -/ were slightly decreased but these values also were not significant. These results indicate that the acupuncture therapeutics arc significantly effective to remove the viral diarrhea in the young calves.

• 동의생리병리학회지
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• 제23권3호
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• pp.700-703
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• 2009

The present study investigated whether electroacupuncture (EA) can alleviate hypertension and concomitant disorders such as decreased kidney weight and elevation of serum creatinine in spontaneous hypertensive rats. EA (2 Hz, 3 mA, 10 min) was applied to Joksamni (ST36) once daily for 7 days. Body weight, blood pressure and heart rate were measured on Day 0, 2, 6, 8, 10 and 12, and kidney weight and serum creatinine levels were examined after sacrifice (on Day 12 after last examination). In the ST36 group, the blood pressure were significantly decreased from 6thdays and its effects lasted up to Day12 (up to 5days after cessation of acupuncture), compared to control. And, significant decreases of the heart rates after EA at ST36 were also observed on Day 2, 6, and 8. However, there were no significant differences in daily body weight, kidney weight and serum creatinine between acupuncture and control group. These results showed that EA at ST36 caused anti-hypertension by decreasing blood pressure and heart rates in spontaneous hypertenstive rats, although it failed to alleviate concomitant disorders such as the decreased kidney weight and elevation of serum creatinine shown in hypertensive rats.

• 수산해양교육연구
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• 제26권1호
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• pp.98-107
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• 2014

As part of a series of studies about improving yellow croaker drift gill net fishing gear and the development of a labor-saving fishing system, we installed a labor-saving-type, five-step-drum net hauler, and a triple-V-type net hauler in 108 Daeheung-ho, a fishing boat which operates drift gill nets for yellow croakers mainly in the sea near Chu-ja Island. Net damage with the labor-saving-type, five-step-drum net hauler is lower than for the triple-V-type net hauler. In addition, there was a reduction in the standard operational crew of two people. The lead time for hauling the labor-saving net was approximately 10% and 19.2% less than for hauling the triple-V-type net hauler and for hauling by hand, respectively. It was found that there were fewer slip in fishing gear and less damage to the wing of the drum as well as less damage to the fish when the labor-saving-type, five-step-drum net hauler was used than when the triple-V-type net hauler was used. In the survey, the lead time for hauling the net was approximately 21.6% and 45.2% more effective than hauling with the triple-V-type net hauler and hauling by hand, respectively. The crew was reduced by approximately 18.2% and 25% than when hauling with the triple-V-type net hauler and hauling by hand, respectively. In addition, cessation of operation and damage to the fish were reduced when compared to the triple-V-type net hauler and hauling by hand.

• Journal of Preventive Medicine and Public Health
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• 제41권3호
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• pp.136-146
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• 2008

Objectives : The purpose of this study was to estimate the willingness to quit cigarette price among Korean male adults, and to examine the factors affecting the willingness to quit cigarette price. Methods : The data was collected by a random digit dial telephone survey. 702 samples were analyzed by using t-tests, ANOVA and OLS regression analysis. To estimate the willingness to quit cigarette price, smokers were asked dichotomous questions with open-ended follow-up and the starting point of the price was randomized by one of 5 bid prices elicited from a pilot study. Results : The mean of the willingness to quit cigarette price was 4,287 Won per package, which was about 2,000 Won higher than the mean of the actual price the smokers now paid. About 41% of respondents were willing to quit smoking if the price of cigarette would be increased by 3,000 Won, and if the price would be increased by 20,000 Won, all respondents were willing to quit smoking. The factors associated with the willingness to quit cigarette price were the place of residence, the amount of smoking and the degree of exposure to smoking through the mass media. Conclusions : The results showed that to get people to quit smoking, increasing the cigarette price would obviously be effective and much higher prices have a greater effect. Furthermore, to enlarge the effect of increased cigarette prices, providing more cessation programs to small towns, reducing the amount of smoking and decreasing or prohibiting advertisements of cigarettes and smoking in the mass media will be efficient.

• 대한지역사회영양학회지
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• 제3권5호
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• pp.685-694
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• 1998

This cross-sectional study was conducted to describe the changes of plasma cardiovascular disease(CVD) risk factors in Korea. Overnight fasting plasma levels of total cholesterol, high density lipoprotein(HDL)-cholesterol, triacylglycerol and glucose were analyzed. Blood pressure and anthropometric data were also measured. Health practice factors such as smoking status, alcohol consumption and frequency fo exercise were evaluated by a self-administered questionnaire. Questions regarding dietary habits and food preferences were also asked. Seventy eight percent of the subjects had more than one CVD risk factor. Plasma total cholesterol, triacylglycerol, and fasting blood glucose were significantly increased according to the subjects body mass index$(kg/m^2$, BMI), whereas HDL-cholesterol, low density lipoprotein(LDL)-cholesterol and blood pressure showed no significant differences with BMI. Current smokers had significantly high plasma total cholesterol, LDL-cholesterol and triacylglycerol levels. Alcohol consumption significantly increased plasma total cholesterol and fasting blood sugar, but regular exercise had no effects on the plasma CVD risk factors. Overeating and frequency of fast food consumption were positively correlated with the CVD risk score, whereas intake of grains, meats and vegetables were negatively correlated with that score. A stepwise multiple regression analysis was performed to examine the effects of specific dietary factors on plasma lipid levels. For plasma total cholesterol level, the frequency of fast food intake explained 8% of the variance, followed by habitual overeating, frequency of grain intake and high cholesterol food intake(Model $R^2$=22.4%). For plasma triacylglycerol level, preference of oily foods accounted for 7.5% of the variance, followed by eating breakfast, preference of fruit and frequency of grain intake(Model $R^2$=22.0%). The findings suggest that intervention programs to reduce the risk of CVD should focus on health practice through reducing BMI, smoking cessation and moderate or no alcohol drinking. Moreover, desirable dietary habits such as eating breakfast, not overeating and reduced intake of fast food may improve CVD risk.