• Title/Summary/Keyword: Cervix

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High versus Low Dose-Rate Intracavitary Irradiation for Adenocarcinoma of the Uterine Cervix (자궁경부 선암 환자에서 고선량률 강내치료와 저선량률 강내치료의 비교)

  • Kim Woo Chul;Kim Gwi Eon;Chung Eun Ji;Suh Chang Ok;Hong Soon Won;Cho Young Kap;Loh JK
    • Radiation Oncology Journal
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    • v.18 no.1
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    • pp.32-39
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    • 2000
  • Purpose :The incidence of adenocarcinoma of the uterine cervix is low. Traditionally, Low Dose Rate (LDR) brachytherapy has been used as a standard modality in the treatment for patients with carcinoma of the uterine cervix. The purpose of this report is to evaluate the effects of the High dose rate (HDR) brachytherapy in the patients with adenocarcinoma of the uterine cervix compared with the LDR. : From January 1971 to December 1992, 106 patients of adenocarcinoma of uterine cervix were treated with radiation therapy in the Department of Radiation Oncology, Yonsei University with curative intent. LDR brachytherapy was carried out on 35 patients and 71 patients were treated with HDR brachytherapy. In LDR Group, 8 patients were in stage I, 18 in stage II and 9 in stage III. External radiation therapy was delivered with 10 MV X-ray, daily 2 Gy fractionation, total dose 40$\~$46Gy (median 48 Gy). And LDR Radium intracavitary irradiation was peformed with Henschke applicator, 22$\~$59 Gy to point A (median 43 Gy). In HDR Group, there were 16 patients in stage 1, 38 in stage II and 17 in stage III. The total dose of external radiation was 40$\~$61 Gy(median 45 Gy), daily 1.8$\~$2.0 Gy. HDR Co-60 intracavitary irradiation was peformed with RALS (Remote Afterloading System), 30 $\~$ 57 Gy(median 39 Gy) to point A, 3 times a week, 3 Gy per fraction. Conclusion : The 5-year overall survival rate in LDR Group was 72.9$\%$, 61.9$\%$, 45.0$\%$ in stage I, II, III, respectively and corresponding figures for HDR were 87.1$\%$, 58.3$\%$, 41.2$\%$, respectively (p>0.05). There was no statistical difference in terms of the 5-year overall survival rate between HDR Group and LDR Group in adenocarcinoma of the uterine cervix. There was 11$\%$ of late complication rates in LDR Group and 27$\%$ in HDR Group. There were no prognostic factors compared HDR with LDR group. The incidence of the late complication rate in HDR Group stage II, III was higher than that in LDR Group(16.7$\%$ vs. 31.6$\%$ in stage II, 11.1$\%$ vs. 35.3$\%$ In stage III, p>0.05). Although the incidence of radiation induced late complication rate was higher in HDR Group stage II and III patients than that in the LDR Group, statistical significance was not detected and within acceptable level. Conclusion : There was no difference in terms of 5-year survival rate and failure pattern in the patients with adenocarcinoma of the uterine cervix treated with HDR and LDR brachytherapy. Even late complication rates were higher in the HDR group It was an acceptable range. This retrospective study suggests that HDR brachytherapy seems to replace the LDR brachytherapy in the adenocarcinoma of the uterine cervix. However, further studies will be required to refine the dose rate effects.

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Lack of Participation of the GSTM1 Polymorphism in Cervical Cancer Development in Northeast Thailand

  • Natphopsuk, Sitakan;Settheetham-Ishida, Wannapa;Settheetham, Dariwan;Ishida, Takafumi
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.5
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    • pp.1935-1937
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    • 2015
  • The potential association between the GSTM1 deletion polymorphism and risk of cervical cancer was investigated in Northeastern Thailand. DNA was extracted from buffy coat specimens of 198 patients with squamous cell carcinoma of the cervix and 198 age-matched healthy controls. Genotyping of the GSTM1 was conducted by using two PCR methods, a short- and a long-PCR. Distribution of the GSTM1 genotypes in between the cases and the controls was not significantly different (p>0.5 by ${\chi}^2$ test). The results suggest that the GSTM1 deletion polymorphism is not a risk factor for squamous cell carcinoma of the cervix in the northeast Thai women.

A Comparision of Mghr Prescription to Doses at Ponts A and B in Intracavitary Radiotherapy of Cervix Cancer (자궁경구암(子宮頸口癌) 강내조사치료시(腔內照射治療時) A점(點) B점(點) 선량계산방법(線量計算方法)과 mghr 단위(單位) 방법(方法)의 비교(比較))

  • Park, Charn-Il;Ha, Sung-Whan;Kang, Wee-Saing
    • Journal of Radiation Protection and Research
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    • v.6 no.1
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    • pp.31-33
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    • 1981
  • The 42 patients with carcinoma of the cervix, performed intracavitary radiotherapy, were analysed the doses at points A and B comparing to the mghr prescription. The doses at points A and B were calculated by PC-12 computer planning system. Correlation coefficienty between doses at points A and B and the mghr prescription are 0.82 (p<0.001) and 0.90 (p<0.001) respectively. The slope of the point A line is 0.70 and the slope of the point B is 0.21. Therefore, the dose at point A is approximately 3/4 the mghr prescription and the dose at point B is approximately 1/4 the mghr precription.

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A Study on Specificity of Cancer Incidence in Daegu-Kyungbuk Area (일부 지역의 암발생 특성에 관한 조사연구)

  • 김진모;민경진
    • Korean Journal of Health Education and Promotion
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    • v.6 no.1
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    • pp.60-65
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    • 1989
  • A statistical analysis was made on 15,971 surgically operated patients at D-Medical Center in the year of 1978 and 1988. 1,416 cancer patients among them were classified by sex, age, and malignant tumor site. The obtained results indicated that trend of male cancer was generally similar to the results of nation wide study. But, specific phenomenon was found in the case of female cancer in Daegu-Kyungbuk area. Among females the frequency rank was uterine cervix (35.77%), breast (17.97%), stomach (11.65%) in 1988. The frequency of uterine cervix was higher than other area. Breast cancer was highly ranked tumor compare with other area, and its age distribution also appeared in much younger decade.

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Effect on Conception for Insemination Method of Frozen Semen in Cheju Native Cattle. II. Effect of time and site of insemination (제주한우에 있어서 동결정액 수정방법이 수태에 미치는 영향 제II보 동결정액의 수정시기와 주입부위가 수태에 미치는 영향)

  • 김중규;장덕지
    • Korean Journal of Animal Reproduction
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    • v.8 no.2
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    • pp.87-91
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    • 1984
  • This study was conducted to determine the optimum time and the insemination site of frozen in Cheju native cows, and 660 cows first service inseminated with rectovaginal methods by 3 skillful technicians as 3 districts near Cheju City and Sogwipo City areas obtained the following results. Optimum time for insemination was 16-20 hours after the onset of estrus and 80.6% of 67 conceived to first insemination. In the rectovaginal technique used widely at present conception rate for the palpation of ovaries showed 6.6% (index) higher than that of non-palpation. Conception rate of the insemination site; the intra-uterine horn, intra-uterus, just inside the cervix and depositing in mid-cervix were 62.5, 78.4, 74.6, and 80.9% respectively, however, there was no difference in conception rate between cervical and uterine deposition of forzon semen except for the intra-uterine horn.

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Reasons for Variation in Sensitivity and Specificity of Visual Inspection with Acetic Acid (VIA) for the Detection of Pre-Cancer and Cancer Lesions of Uterine Cervix

  • Parashari, Aditya;Singh, Veena
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.12
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    • pp.7761-7762
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    • 2013
  • Alternative strategies such as visual inspection of cervix with acetic acid, are real time, economical and easily implemented methods for cervical cancer screening. However, variable sensitivity and specificity have been observed in various community based studies. The possible reasons could include variation in man power training, light source used for visualization, and preparation of diluted (4-5%) acetic acid and its storage. A standardized protocol for training, teaching material (easy to understand in the local language) for trainees, supervision and reinforcement by intermittent and supplementary training to check the quality of their observation, a standard protocol for preparation dilute acetic acid and its storage and a standard good light source (equivalent to day light) are needed to minimize the variation in sensitivity and specificity of VIA in community settings.

Endometrial Polyps with Open-Cervix Pyometra in a Cat

  • Lee, Sang-Ho;Park, Chul-Ho;Son, Chang-Ho
    • Journal of Veterinary Clinics
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    • v.35 no.5
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    • pp.222-225
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    • 2018
  • The current study describes a case of endometrial polyps accompanied by an open-cervix pyometra in a 15-year-old female Chinchilla Persian cat. The cat was presented with a history of a large mass in the endometrium and purulent discharge from the vulva. Ovariohysterectomy was performed and pedunculated polypoid mass on the endometrium was seen protruded into the uterine cavity. Histologically, the mass was composed of multiple cystically dilated glands surrounded by fibrous stroma. Based on gross and histologic findings, the diagnosis for this case was concluded.

Economic Consideration of Mass Screening Program for Early Detection of Carcinoma of the Uterine Cervix (자궁부암의 조기발견을 위한 집단 적격 검사 계획의 경제학적 고려)

  • Yang, Dal-Sun
    • Journal of Preventive Medicine and Public Health
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    • v.7 no.2
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    • pp.367-372
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    • 1974
  • Authors reviewed 2,362 cases of consecutive vaginal and cervical smears submitted to the Department of Pathology, Pusan Gospel Hospital during one year period from Jan. 1, 1974 to Dec. 31, 1974. Prevalence of dysplasia, carcinoma in situ and invasive carcinoma of the uterine cervix was analyzed, and cost per a lesion was calculated. The followings are conclusions: 1. Prevalence of dysplasia, carcinoma in situ and invasive carcinoma was 2.88%, 0.34% and 2.58% restectively. 2. Cost per a lesion for dysplasia was calculated as 34,735 Won, for carcinoma in situ, as 295,250 Won and for invasive carcinoma as 38,721 Won. Cost per a lesion for dysplasia and carcinoma in situ was calculated as 31,079 Won and for dysplasia and for all the lesions as 17,248 Won. 3. The results obtained suggested that mass cytologic screeiding for detection of dysplasia, carcinoma in situ and invasive carcinoma was reasonable in the present status of economy.

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Cevix Cancer Associated with Pregnancy - A Case Report and Review of the Literature- (임신중 자궁 경부암)

  • Lee, Tae-June;Kwon, Hyung-Cheol
    • Radiation Oncology Journal
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    • v.7 no.1
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    • pp.77-80
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    • 1989
  • Invasive carcinoma of the cervix during the pregnancy is relatively uncommon. It must be considered fetal viability, tumor control as well. If the carcinoma is diagnosed in the first or second trimester, treatment should be undertaken immediately. At the third trimester, treatment should be deferred until the fetus is viable.

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