• The Journal of Korean Medicine
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• v.26 no.4
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• pp.87-97
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• 2005

Backgrounds: Intracerebral hemon-hage is one of the most devastating types of stroke. Ginseng radix, the root of Panax Ginseng, C. A. MEYER (Araliaceae), is one of the most famous medicinal herbs with various therapeutic applications. Objectives: In the present study, the effect of aqueous extract of Ginseng radix on intracerebral hemorrhage-induced neuronal cell death in rats was investigated. Materials and Methods: Step-down avoidance task, Nissl staining, immunohistochemistry for caspase-3 and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay were used for this study. Results: The present results show that hemorrhage-induced lesion volume and apoptotic neuronal cell death in the striatum were significantly suppressed by treatment with Ginseng radix, resulting in enhancement of short-ten-n memory. Conclusions: We have shown that Ginseng radix has a neuroprotective effect on stroke, and aids the recovery from central nervous system sequelae following stroke.

• Communications for Statistical Applications and Methods
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• v.24 no.4
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• pp.367-382
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• 2017

We consider an infinite-order long-memory heterogeneous autoregressive (HAR) model, which is motivated by a long-memory property of realized volatilities (RVs), as an extension of the finite order HAR-RV model. We develop bootstrap tests for structural mean or variance changes in the infinite-order HAR model via stationary bootstrapping. A functional central limit theorem is proved for stationary bootstrap sample, which enables us to develop stationary bootstrap cumulative sum (CUSUM) tests: a bootstrap test for mean break and a bootstrap test for variance break. Consistencies of the bootstrap null distributions of the CUSUM tests are proved. Consistencies of the bootstrap CUSUM tests are also proved under alternative hypotheses of mean or variance changes. A Monte-Carlo simulation shows that stationary bootstrapping improves the sizes of existing tests.

• The Transactions of the Korean Institute of Electrical Engineers
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• v.40 no.8
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• pp.836-844
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• 1991

PLC(programmable logic controller) system is widely used for the control of factory. PLC system receives ladder diagram which is drawn by the user to implement hardware logic, converts the ladder diagram into sequence program which is executable in the PLC system, and executes the sequence program indefinitely unless user breaks. The sequence program processes the data of on/off signal, and endures 1 scan delay and missing of pulse-type signal shorter than a scan time. So, data dependency doesn't exist. By applying theis characteristics to multiprocessor architecture, we design parellel PLC functionally and evaluate performance upgrade. Parallel PLC consists of central processing module, N general processing unit, and a shared memory by master-slave type. Each module executes allocated sequence program by the control of central processing module. We can expect performance upgrade by parallel processing, and reliability by relocation of sequence program when error occurs in processing module.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 1998.04a
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• pp.165-172
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• 1998

The development of Reinforced Concrete member design modules is necessary for user to design structures easily. The purpose of this paper is to be available for a integrated system used structure design. This module is linked with central database for the benefit of minimizing time of design and user's efforts. In order to minimize memory space, all of data is stored in central database. Member design modules applied Object-Oriented concepts are possible to be reusible, flexible for member functions in classes. This modules can be operated both independent member design modules and a part of integrated system. Sooner or later, this modules will be related to member grouping modules by data.

• The Journal of Information Technology
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• v.10 no.3
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• pp.77-92
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• 2007

This study aims to suggest an implementation methodology of security module for data integrity of mobile internet terminal. This is based on the WTLS(Wileless Transport Layer Security) of WAP Protocol. This security module is expected to achieve central role in conversion of wireless internet environment and emphasis of encryption technology and safe and calculable wireless communication environment construction.

• Proceedings of the CALSEC Conference
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• 2002.01a
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• pp.233-237
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• 2002

The smartcard is a processing platform ＆ a store or data it can perform calculations and run programs It contains its own memory (RAM), storage (ROM and EEPROM). and (Central Processing Unit) CPU like a PC If it had its own power supply. keyboard and screen. it would be a fully independent computer Requires an Interface Device (IFD) to supply the power and provide suitable input and display mechanisms. Some examples of IFDs are: point of sale terminal(POS) telephone ATM etc.(omitted)

• Journal of the Korean Society of Safety
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• v.10 no.3
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• pp.42-46
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• 1995

To purpose of this study is to model design and motion analysis of tangential cam mechanism using personal computer system. The CAD(Computer Aided Design) system used in this study was constructed with CPU(Central Processing Unit) 80486, RAM(Random Access Memory) 8M, CGA graphic card. By using developed program for tangential cam mechanism, we designed tangential cam models and analysed displacement, velocity, acceleration of follower.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.34 no.3B
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• pp.311-317
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• 2009

The traditional network anomaly detection systems execute the threshold-based detection without considering dynamic network environments, which causes false positive and limits an effective resource utilization. To overcome the drawbacks, we present the adaptive network anomaly detection model based on artificial immune system (AIS) in centralized network. AIS is inspired from human immune system that has learning, adaptation and memory. In our proposed model, the interaction between dendritic cell and T-cell of human immune system is adopted. We design the main components, such as central node and router node, and define functions of them. The central node analyzes the anomaly information received from the related router nodes, decides response policy and sends the policy to corresponding nodes. The router node consists of detector module and responder module. The detector module perceives the anomaly depending on learning data and the responder module settles the anomaly according to the policy received from central node. Finally we evaluate the possibility of the proposed detection model through simulation.

• Journal of Physiology & Pathology in Korean Medicine
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• v.17 no.1
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• pp.57-63
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• 2003

Background: Rehmanniae radix preparata is a medicinal herb widely used in Asian countries, to replenish Yin and Vital Essence through strengthen the kidney function. In Oriental Medicine the brain has physiological relationship with the Vital Essence. And central nerve system (CNS) is also refered to as 'Sea of the Vital Essence'. So if the Vital Essence is strong it will nourish the brain and memory will all be keen. The purpose of this study was to investigate the effect of 7 to 14 days treatment with Rehmanniae radix preparata (3.4 g /100 g, per os) on retention performance of rats in a passive avoidance situation. Methods: Male Sprague-Dawley rats were trained on a one-trial passive avoidance task using a two-way shuttle box by giving a foot shock. They were tested for retention of 6h, 24h, 72h, 168h, and 336h after training. Results: Rehmanniae radix preparata treated rats showed a increased performance in retention test as compared to saline at 6hr (P<0.05) and 24hr (P<0.05). Conclusion: These data suggest that Rehmanniae radix preparata treatment can improve memory in the rat.

• 한국약용작물학회:학술대회논문집
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• 2011.09a
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• pp.31-45
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• 2011

The amyloid ${\beta}$-peptide ($A{\beta}$), which originates from the proteolytic cleavage of amyloid precursor protein (APP), plays a central role in the pathogenesis of Alzheimer's disease (AD). Mounting evidence indicates that different species of $A{\beta}$, such as $A{\beta}$ oligomers and fibrils, may contribute to AD pathogenesis via distinct mechanisms at different stages of the disease. Importantly, elevation and accumulation of soluble $A{\beta}$ oligomers closely correlate with cognitive decline and/or disease progression in animal models of AD. In agreement with these studies, oligomers of $A{\beta}$ have been shown to directly affect synaptic plasticity, a neuronal process that is known to be essential for memory formation. Our previous studies showed that $A{\beta}$ induces the breakdown of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), a phospholipid that regulates key aspects of neuronal function. PI(4,5)P2 breakdown was found to be a key step toward synaptic and memory dysfunction in a mouse model of AD. To this end, we seek to identify small molecules that could elevate the levels of PI(4,5)P2 and subsequently block $A{\beta}$ oligomer-induced breakdown of PI(4,5)P2 and synaptic dysfunction.. We found that (20S)Rg3, an active triterpene glycoside from heat-processed ginseng, serves as an agonist for phosphatidylinositol 4-kinase IIalpha (PI4KIIalpha), which is a lipid kinase that mediates a rate-limiting step in PI(4,5)P2 synthesis. Consequently, (20S)Rg3 stimulates PI(4,5)P2 synthesis by directly stimulating the activity of PI4KIIalpha. Interestingly, treatment of a mouse model of AD with (20S)Rg3 leads to reversal of memory deficits. Our data suggest that the PI(4,5)P2-promoting effects of (20S)Rg3 may help mitigate the cognitive symptoms associated with AD.