• Molecules and Cells
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• 제41권7호
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• pp.646-652
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• 2018

Neurodegeneration can result in memory loss in the central nervous system (CNS) and impairment of taste and smell in the peripheral nervous system (PNS). The neurodegeneration seen in Parkinson's disease (PD) is characterized by functional loss of dopaminergic neurons. Recent studies have also found a role for dopaminergic neurons in regulating taste memory rewards in insects. To investigate how taste memories and sugar sensitivity can be affected in PD, we utilized the $DJ-1{\beta}$ mutant fruit fly, $DJ-1{\beta}^{ex54}$, as a PD model. We performed binary choice feeding assays, electrophysiology and taste-mediated memory tests to explore the function of the $DJ-1{\beta}$ gene in terms of sugar sensitivity as well as associative taste memory. We found that PD flies exhibited an impaired ability to discriminate sucrose across a range of sugar concentrations, with normal responses at only very high concentrations of sugar. They also showed an impairment in associative taste memory. We highlight that the taste impairment and memory defect in $DJ-1{\beta}^{ex54}$ can be recovered by the expression of wild-type $DJ-1{\beta}$ gene in the dopaminergic neurons. We also emphasized the role of dopaminergic neurons in restoring taste memory function. This impaired memory property of $DJ-1{\beta}^{ex54}$ flies also allows them to be used as a model system for finding supplementary dietary foods that can improve memory function. Here we provide evidence that the associative taste memory of both control and $DJ-1{\beta}^{ex54}$ flies can be enhanced with dietary supplementation of the medicinal plant, omija.

• 한국수학교육학회지시리즈A:수학교육
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• 제52권1호
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• pp.19-41
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• 2013

What is the foundation of mathematical thinking? Is it logic based symbolic language system? or does it rely more on mental imagery and visuo-spatial abilities? What kind of neural changes happen if someone's mathematical abilities improve through practice? To answer these questions, basic cognitive processes including long term memory, working memory, visuo-spatial perception, number processes are considered through neuropsychological outcomes. Neuronal changes following development and practices are inspected and we can show there are neural networks critical for the mathematical thinking and development: prefrontal-anterior cingulate-parietal network. Through these inquiry, we can infer the answer to our question.

• 감성과학
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• 제5권1호
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• pp.79-90
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• 2002

기억은 상황인식을 개발하고 유지하는 데 중요한 역할을 한다. 본 연구에서는 비행상황 인식의 민감도에 영향을 주는 기억과정들이 조종사의 전문성 정도에 따라 어떻게 다른지를 조사하였다. 실험 1에서는 조종사가 상황정보를 회상하기 위해 사용하는 여러 기억과정들을 비교하였다. 즉, 조종실 계기판에 제시되는 상이한 형태(공간적 및 언어적)의 상황정보에 관한 조종사의 기억을 즉각회상과 지연 회상법으로 평가하였다. 실험 2에서는 조종사의 상황인식 민감도를 측정하였고, 그 민감도와 실험 1에서 수집한 여러 회상기억 측정치들과의 상관관계를 조사하였다. 두 실험결과를 요약하면, 전문성 효과가 상황정보의 활동기억보다는 장기기억에서 나타났고, 상황인식 민감도를 높이는 데 요구되는 상황정보의 기억표상이 전문성 정도에 따라 달랐다. 실험결과의 이론적 설명이 심리학의 전문성 이론을 중심으로 논의되었다.

• 헤리티지:역사와 과학
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• 제48권3호
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• pp.154-165
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• 2015

유라시아의 문화유산에 대한 연구와 정책 동향을 조명한다면 그 범위가 너무 넓어 한두 가지 맥락으로 일목요연하게 정리할 수는 없지만 그래도 나름대로 공통적 특성은 발견할 수 있을 것이다. 특히 중앙아시아 국가들을 중심으로 살펴보면 일부 국가들의 경우 정책수단의 근본이 되는 문화유산 관련 법령이 잘 갖추어지지 않은 것을 발견할 수 있다. 이들이 독립국가가 된 것이 오래되지 않았고 일부 국가들에서 볼 수 있듯이 경제적 어려움 속에서 법령을 정교하게 다듬어 집행할 여력이 없었기 때문이다. 문화유산에 대한 연구도 자체 능력보다는 외국과의 협력을 통해 진행하는 경우가 많은데 발굴사업의 예에서 보듯이 유럽을 중심으로 한 외국 연구기관과의 협력 아래 진행하는 연구가 다수를 차지한다. 유네스코에서도 중앙아시아 실크로드 문화유산의 일련번호 지정사업을 통해 중앙아시아 및 실크로드 국가들이 문화유산을 보호하고 향후 잠정목록에 올릴 수 있도록 지원하고 있다. 문화유산의 보호 활동은 국가별 차이는 있으나 전반적으로 보아 예산과 전문 인력 등의 부족으로 효과적인 활동을 하지 못하고 있는 실정이다. 특히 세계문화유산이나 기록 유산의 등재 활동은 풍부한 자원을 가지고 있음에도 상당히 미약하여 향후 이런 분야에 대한 협력을 강화해야할 것이다. 근래에 문화유산과 관광을 결합한 새로운 형태의 정책 수립과 연구방향이 시도되고 있다. 다소의 부정적 측면이 있음에도 중앙아시아 및 실크로드 국가들은 이런 시도를 환영하고 있다. 향후 우리나라는 이들 국가들과 연구네트워크를 형성하여 문화유산 정책과 연구활동의 많은 분야에서 협력을 강화할 것이 기대된다.

• 대한본초학회지
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• 제26권3호
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• pp.75-82
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• 2011

Objectives : In this study, we evaluated the effect of Chungganhaeju-hwan(CGHJH) on hydrogen peroxide($H_2O_2$)-induced and ethanol(EtOH)-induced neuronal damage in vitro and in vivo, respectively. Methods:We carried out the anti-oxidant effects of CGHJH against hydrogen peroxide($H_2O_2$)-induced toxicity in HT22 and PC12 cells using thiazolyl blue tetrazolium bromide. Then, to investigate the protective effect on CGHJH against EtOH-induced memory impairment and hippocampal cell damage in male ICR mice, we performed novel object recognition test(NORT), and analysed the brain tissues after immunohistochemistry and western blotting. Results:CGHJH showed protective effect from $H_2O_2$-induced cell toxicity at doses of $1\sim100{\mu}g$/mL in both HT22 and PC12 cells. CGHJH had also recovery effect from EtOH-induced memory impairment in ICR mice from NORT and it protected hippocampal cells against EtOH toxicity in the result of cresyl violet and NeuN immunoreactivity. Conclusion : These results demonstrate that CGHJH has protective effect in neuronal cells against $H_2O_2$ and EtOH toxicities and this effect could be a main role of recovery effect on EtOH-induced memory loss.

• 문화기술의 융합
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• 제9권4호
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• pp.351-356
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• 2023

본 연구는 영화 <자산어보>(2021)가 19세기 성리학적 질서가 흔들리며 서서히 몰락해가는 조선을 어떤 방식으로 재현하고 있는지를 분석을 통해 살펴보기 위해 기획되었다. 분석에 앞서 역사극의 내레이션 특성을 고려하여 역사극의 분석틀을 제시하였다. 우리는 역사극의 분석틀을 활용하여 <자산어보>가 유배 서사의 플롯 구조를 기반으로 정약전, 장창대가 시대의 한계와 가능성 사이에서 주체적 개인으로 자신의 삶을 살아가는 모습을 재현하고 있음을 확인하였다. 흑백과 컬러 이미지의 대비, 보이스 오버 내레이션의 적극적 활용, 한시 자막과 음악 등으로 만들어낸 중심기억과 잉여기억을 통해 영화는 주체적 개인으로 살아가기 위해 필요한 것이 무엇인지에 관한 보편적인 질문을 우리에게 던지고 있다.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2006년도 하계종합학술대회
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• pp.667-668
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• 2006

Radio Frequency Identification (RFID) is an automatic identification method, relying on storing and remotely retrieving data using devices called RFID tags or transponders. RFID systems is coming into increasing use in industry and logistics. This paper discuses implementation of multi-protocol RFID reader SoC. The SoC contains multi-protocol RFID RFID reader, CPU, UART, memory.

• Journal of Ginseng Research
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• 제18권3호
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• pp.165-174
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• 1994

To investigate the significant indicators Improving the undisturbed memory in animal behavior, we employed several behavioral methods (learning, relearning in radial maze, and active avoidance) with ginseng components. Results showed that the repeated intranasal administration of $Rb_1$ and total saponins from Korean red ginseng induced direct effects on the brain mechanisms in rats, and improved the spatial memory during the learning, relearning and retention in the 12-arm radial maze test. The intranasal treatment of the total saponins also effectively improved the disturbed memory (amnesia) by pentylentetrazole, and simultaneously protected the brain by decreasing the severity of motor epileptic seizures. The intraperitonial administration of polysaccharide fraction of Korean red ginseng could improve avoidance behavior (amount of the total ecapes) in the active-avoidance test. In addition, local changes of the temperature and resistance of skin observed after Rb, administration were suggested to reflect some action of sympathetic nerve Key words Memory, intranasal administration, pentylenetetrazole, Korea red ginseng.

• 생물정신의학
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• 제16권4호
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• pp.238-245
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• 2009

Objectives : Mild Alzheimer's disease(AD) is uncertain to be related to visuospatial working memory subsystem dysfunction. We used the self ordered pointing test(SOPT) to find the characteristics of visuospatial working memory in mild AD. Methods : We compared the visuospatial working memory abilities of 20 patients with mild AD and 20 normal elderly controls(NC) using SOPT, of which stimuli consisted of two stimuli types(A : abstract, C : concrete) and two stimuli numbers(8 and 12). Therefore, working memory was tested using C8, C12, A8, and A12 stimuli conditions in SOPT. Mixed-model ANOVA was conducted with the AD and NC groups as between-subjects factor, with stimuli types and stimuli numbers as the within-subjects factors and with SOPT error rates as the dependent variable. Results : The AD group showed higher error rates in SOPT than the NC group. The NC group showed low error rates in concrete stimuli than in abstract stimuli and in small stimuli numbers than in large stimuli numbers. And the AD group showed no differences between stimuli types or stimuli numbers. Conclusion : AD patients showed a poor performance in visuospatial working memory using concrete stimuli. The result suggests that there is a non-transformation from visual input to phonological working memory in AD. Patients with AD showed a poor performance although in small stimuli number condition of SOPT. It suggests that in AD, visuospatial working memory is not working well although in low central executive loads.

• Korean Journal of Radiology
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• 제1권1호
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• pp.19-24
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• 2000

Objective: In order to investigate the functional brain anatomy associated with verbal and visual working memory, functional magnetic resonance imaging was performed. Materials and Methods: In ten normal right handed subjects, functional MR images were obtained using a 1.5-T MR scanner and the EPI BOLD technique. An item recognition task was used for stimulation, and during the activation period of the verbal working memory task, consonant letters were used. During the activation period of the visual working memory task, symbols or diagrams were employed instead of letters. For the post-processing of images, the SPM program was used, with the threshold of significance set at p < .001. We assessed activated brain areas during the two stimulation tasks and compared the activated regions between the two tasks. Results: The prefrontal cortex and secondary visual cortex were activated bilaterally by both verbal and visual working memory tasks, and the patterns of activated signals were similar in both tasks. The superior parietal cortex was also activated by both tasks, with lateralization to the left in the verbal task, and bilaterally without lateralization in the visual task. The inferior frontal cortex, inferior parietal cortex and temporal gyrus were activated exclusively by the verbal working memory task, predominantly in the left hemisphere. Conclusion: The prefrontal cortex is activated by two stimulation tasks, and this is related to the function of the central executive. The language areas activated by the verbal working memory task may be a function of the phonological loop. Bilateral prefrontal and superior parietal cortices activated by the visual working memory task may be related to the visual maintenance of objects, representing visual working memory.