• Molecules and Cells
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• v.40 no.4
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• pp.271-279
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• 2017

Ran-binding protein family member, RanBP9 has been reported in various basic cellular mechanisms and neuropathological conditions including schizophrenia. Previous studies have reported that RanBP9 is highly expressed in the mammalian brain and retina; however, the role of RanBP9 in retinal development is largely unknown. Here, we present the novel and regulatory roles of RanBP9 in retinal development of a vertebrate animal model, zebrafish. Zebrafish embryos exhibited abundant expression of ranbp9 in developing brain tissues as well as in the developing retina. Yeast two-hybrid screening demonstrated the interaction of RanBP9 with Mind bomb, a component of Notch signaling involved in both neurogenesis and neural disease autism. The interaction is further substantiated by co-localization studies in cultured cells. Knockdown of ranbp9 resulted in retinal dysplasia with defective proliferation of retinal cells, downregulation of neuronal differentiation marker huC, elevation of neural proliferation marker her4, and alteration of cell cycle marker p57kip2. Expression of the $M{\ddot{u}}ller$ glial cell marker glutamine synthase was also affected in knockdown morphants. Our results suggest that Mind bomb-binding partner RanBP9 plays a role during retinal cell development of zebrafish embryogenesis.

• Journal of the Korea institute for structural maintenance and inspection
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• v.21 no.5
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• pp.74-82
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• 2017

Localized corrosions damages in their structural sections can be occurred affected by installed environment conditions with high temperature as near the coastline and humidity or their poor maintenance situation. In bearing supports of steel bridges, especially, lower web and vertical stiffener in end girder support can be easily corroded because of relatively higher humidity due to the narrow space in the end of girder and the wetted accumulated sediments affected by rain water or antifreezing admixture leaked from expansion joint. It can be related to change in their structural performance. In this study, thus, bearing strength test specimens were fabricated considering corrosion damage in the web and vertical stiffeners and the change in their bearing strengths were experimentally evaluated. From the test results, localized corrosion damage of structural members in the end girder affected the bearing strength of end girder support, especially, localized corrosion damage of the vertical stiffener relatively highly affected their bearing strengths.

• Steel and Composite Structures
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• v.21 no.5
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• pp.1031-1043
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• 2016

Optimization of the construction scheme of the cable-strut tensile structure based on error sensitivity analysis is studied in this paper. First, the element length was extracted as a fundamental variable, and the relationship between element length change and element internal force was established. By setting all pre-stresses in active cables to zero, the equation between the pre-stress deviation in the passive cables and the element length error was obtained to analyze and evaluate the error effects under different construction schemes. Afterwards, based on the probability statistics theory, the mathematical model of element length error is set up. The statistical features of the pre-stress deviation were achieved. Finally, a cable-strut tensile structure model with a diameter of 5.0 m was fabricated. The element length errors are simulated by adjusting the element length, and each member in one symmetrical unit was elongated by 3 mm to explore the error sensitivity of each type of element. The numerical analysis of error sensitivity was also carried out by the FEA model in ANSYS software, where the element length change was simulated by implementing appropriate temperature changes. The theoretical analysis and experimental results both indicated that different elements had different error sensitivities. Likewise, different construction schemes had different construction precisions, and the optimal construction scheme should be chosen for the real construction projects to achieve lower error effects, lower cost and greater convenience.

• Journal of the Korean Geographical Society
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• v.37 no.4
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• pp.442-459
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• 2002

With the formation of European Union, the frontier function which was existed among the member nations was vanished. The European Union, each national government, and local or regional self-government search actively for the transfrontier development strategies in order to make the underdeveloped transfrontiers an united internal region of European Union with an augmentation of mutual activities inter-transfrontier and a cooperative development of transfrontier. On the transfrontier among France-Belgium-Luxemburg which was the iron industry center of Europe, the cooperative development strategies(P.E.D.) of the inter-government and inter-local are executing for the restructuring of the stable regional economic on the basis of the INITRREG program of the European Union. In recent years, the locals self-govemments transfrontier are executing not only restructuring of regional economic but formation of urban community with the unification of the urban and regional planning, administration, and society.

• BMB Reports
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• v.43 no.2
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• pp.97-102
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• 2010

Clenbuterol, a $\beta_2$-adrenoceptor agonist, has been proven to be a powerful repartition agent that can decrease fat deposition. Based on results from our previous cDNA microarray experiment of pig clenbuterol administration, a novel up-regulated EST was full-length cloned (4859 bp encoding 1041 amino acids) and found to be the pig homolog of large tumor suppressor 2 (Lats2). We mapped pig Lats2 to chromosome 11p13-14 by using FISH, and western blotting demonstrated that pig Lats2 protein was most abundant in adipose. In Drosophila, Lats2 ortholog was reported as a key component of the Hippo pathway which regulates cell differentiation and growth. Here, we show that pig Lats2 exhibit inverted expression to YAP1, another member of the Hippo pathway which positively regulates cell growth and proliferation, during the differentiation of 3T3-L1 preadipocytes. Our results suggested that Lats2 may involve in Hippo pathway regulating the fat reduction by inhibiting adipocyte differentiation and growth.

• Journal of Korean Society of Steel Construction
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• v.25 no.4
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• pp.347-357
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• 2013

Recently, In recognition of outstanding structural performance the use of Concrete Filled steel Tube(CFT) columns has been increased. Research is ongoing that effective use of cross-sectional because steel strength development and rising prices. In this Lab, suggests new shape by Thin steel plates bent to be L-channel welded to form square steel tube to maximize efficiency of the cross section. In addition, since the rib placed at the center of the tube width acts as an anchor; higher load capacity of buckling is acceptable. we have developed New shape welded built-up square tube for broader usability which were bent to be L-shaped and thin Plate each unit member were welded. In order to apply the new shape built-up square columns, we predicted structure behavior, stress distribution with parameter Width thickness ratio. The experimental results presented in standards and even exceed the b/t of the rib anchors installed in the role due to exert enough strength and deformation to improve performance was favorable.

• Research in Community and Public Health Nursing
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• v.11 no.1
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• pp.184-198
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• 2000

This descriptive correlational study was conducted to identify the variables related to a health promoting lifestyle in college female students. Participants were 232 female college student living in chinju city who selected by convenience sampling method. The data were collected by self-reported questionnaires from May to December. 1999. The data were analyzed by using descriptive statistics. pearson correlation coefficient. t-test. ANOVA. Duncan verification and stepwise multiple regression with an SAS program. The result to this study were as follows; 1) The average score of a health promoting lifestyle performance was 97.19, the average score of each item was 2.37. among the each items. self-actualization was obtained the most high score(31.10) and stress management was obtained the low score(14.74). 2) The result of compare health promoting lifestyle performance with related variables was follows; (1) In intervention factor, school lifestyle level showed significant positive correlations with teaching relationship level. (2) In Analysis of relationship of health definition. self-efficacy, perceived health status. and perceived benefit & barriers of health that is recognition-perception factors. health promoting lifestyle performance showed significant positive correlations with health definition (r = .2948. p = .001) and self-efficacy (r= .4587. p = .001). (3) A health promoting lifestyle showed significant positive correlations with school lifestyle(9.9%), family support (12.8%), and relationship with teacher (14.6%). This result indicate that; 1) need to development the health promoting model that suitable to our situation. 2) need to development the health promoting model that include family member and application and test to women. 3) need to development of the health promotion program and health education to women. 4) need to study for find out variables that have a influence to stress management. exercise. nutrition. and health promoting performance with low score in test.

• Geotechnical Engineering
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• v.13 no.3
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• pp.33-52
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• 1997

A three dimensional nonlinear finite element analysis is used to study the influence of various design decisions for tieback walls. The numerical model simulates the soldier piles and the tendon bonded length of the anchors with beam elements, the unbonded tendon with a spring element, the wood lagging with the shell elements, and the soil with solid 3D nonlinear elements. The soil model used is a modified hyperbolic model with unloading hysteresis. The complete sequence of construction is simulated including the excavation, and the placement and stressing of the anchors. The numerical model is calibrated against a full scale instrumented tieback wall at the National Geotechnical Experimentation Site (NGES) on the Riverside Campus of Texas A&M University. Then a parametric study is conducted. The results give information on the influence of the following factors on the wall behavior : location of the first anchor, length of the tendon unbonded zone, magnitude of the anchor forces, embedment of the soldier piles, stiffness of the wood lagging, and of the piles. The implications in design are discussed.

• Korean Journal of Health Education and Promotion
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• v.27 no.5
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• pp.73-78
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• 2010

Background: Although collaboration for community health is emphasized, the concept and process of collaboration are rather unclear. International research has classified the types of collaboration and focused on the factors influencing successful collaboration. Greater attention is needed for collaboration practice and research domestically. Findings: By the level of intensity, the types of collaboration range from simpler networking to more formal and sophisticated collaboration. A 4-stage collaboration development consists of formation, implementation, maintenance, and institutionalization stages. Influential factors for collaboration development include: shared goals; operational structure and process; sufficient resources; member and leadership characteristics; environment and climate for collaboration; and information exchange and communication. Discussion: Most of collaboration research so far has dealt with partnerships and coalition building with community-based organizations, and much attention is given to private-public partnership for health. Contextual understanding and collaborative environment are the foremost tasks for us to enhance collaboration for community health in our centralized public health system.

• Magazine of the Korea Concrete Institute
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• v.6 no.1
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• pp.89-100
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• 1994

The current test procedure for transfer length, which determine transfer length by measuring concrete strain, has an actual bond stress state in the prestressed pretensioned member : however, it is difficult to determine the bond properties of maximum bond stress and bond stiffness with this method. It is also difficult for design engineer to understand and select a correct safety criterion from the widely distributed results of such a ransfer test alone. An alternative testing procedure is provided here to determine the bond properties without measuring the concrete strain. In this test the bond stress is measured directly by creating a similar boundary condition within the transfer length in a real beam during the transfer of prestressing force. The prestressing force was released step by step by step from the unloading side. The release of force induces a swelling of the strand at the unloading side of concrete block, bonding force in the block, and a bond slip of the strand toward the other side of the block. Two center-hole load cells are used to record the end loads until the point of general bond slip(maximum bond stress). It is suggested that this test procedure be performed with the ordinary transfer test when determining the transfer length in a prestressed, pretensioned concrete beam.