• The Plant Pathology Journal
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• 제30권2호
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• pp.151-158
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• 2014

Three double-stranded RNAs (dsRNAs), approximately 1.85, 1.65 and 1.27 kb in size, were detected in an isolate of Cytospora sacchari from Iran. Partial nucleotide sequence revealed a 1,284 bp segment containing one ORF that potentially encodes a 405 aa protein. This protein contains conserved motifs related to RNA dependent RNA polymerases (RdRp) that showed similarity to RdRps of partitiviruses. The results indicate that these dsRNAs represent a novel Partitivirus that we tentatively designate Cytospora sacchari partitivirus (CsPV). Treatment of the fungal strain by cyclohexamide and also hyphal tip culture had no effect on removing the putative virus. Phylogenetic analysis of putative RdRp of CsPV and other partitiviruses places CsPV as a member of the genus Partitivirus in the family Partitiviridae, and clustering with Aspergillus ochraceous virus 1.

• 한국문헌정보학회지
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• 제6권
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• pp.105-135
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• 1979

This paper is intended to analyze and investigate the versity libraries in Korea. Nineteen national col-present status of four-year national college and unileges and universities based on a number of faculty member, enrollment, department, library staff, volumes in library, academic journals, book budget and facilities of library, and so we have to improve and develop a kind of problems with which national college and university libraries are confronted as follows: 1) Establishment of a position for the INFORMATION SPECIALIST. 2) Reorganization of the organization of college and university library. 3) Securing a position for the EDUCATIONAL RESEARCHER. 4) Upgrading a part of temporary employees. 5) Securing a self-control of library's administration. 6) Revising rules for labor employees in library. 7) Revising a STANDARD STATEMENT FOR ESTABLISHMENT OF UNIVERSITY. (Books and academic journals) 8) ' ( Facilities of library ) 9) Increase of a budget of library and establishing for an article of library budget. 10) Establishment of a new department exclusively responsible for library administration in the Ministry of Education. 11) Giving a leading(proper) role to Seoul National University Library among the other college and university libraries. 12) Establishment of The master course of INFORMATION SCIENCE or THE RESEARCH CENTER FOR INFORMATION SCIENCE in Seoul National University.

• Applied Microscopy
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• 제29권3호
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• pp.275-280
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• 1999

Hypoxylon속은 자낭각을 지닌 갈색이나 진한 갈색의 목질, 또는 탄소질의 자좌를 형성하며, 자낭균류의 대표적인 목재 부후균으로 분류된다. 부후된 목재에서 발견된 국내 미기록종인 본 Hypoxylon moriforme를 국내에서는 최초로 발견하여 국내의 새로운 기록종으로 보고한다. Hypoxylon moriforme는 광학현미경, 주사전자현미경을 이용하여 미세구조학적으로 기술하였다. H. moriforme는 $7.5\sim9.0\times2.5\sim4.0{\mu}m$의 작은 자낭포자와 $75\sim130\times3\sim5{\mu}m$ 자낭을 가지고 있으며, 동북아시아에서 매우 다양하며 근접한 H. truncatum, 열대 및 아열대 지방에서 발견되는 유사한 H. bover 및 H. annulatum과 분류학적으로 비교, 동정하였다.

• Bulletin of the Korean Chemical Society
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• 제28권4호
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• pp.574-580
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• 2007

Full-length chloride intracellular channel protein 1 (CLIC1) is a member of the family of proteins related to bovine chloride intracellular channel p64. Mutations in the SEDL gene cause spondyloepiphyseal dysplasia tarda (SEDT), a rare X-linked chondrodysplasia. The link between the intracellular chloride channels and SEDL is an important step toward understanding their functional interplay. In the present study, CLIC1 protein was subcloned into the pGEX-KG vector and overexpressed in XL-1 blue cells. We developed a large-scale expression system composed of glutathione S-transferase (GST) fused with a 240-amino-acid CLIC1 protein in Escherichia coli. The soluble CLIC1 protein was successfully purified to homogeneity, and its purity, identity, activity and conformation were determined using SDS-PAGE, MALDI-MS, biophotometer and circular dichroism spectroscopic studies. The binding of both CLIC1 and SEDL proteins in vitro was detected by BIAcore biosensor and fluorescence measurements.

• Molecules and Cells
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• 제37권6호
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• pp.441-448
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• 2014

Inflammasomes are specialized signaling platforms critical for the regulation of innate immune and inflammatory responses. Various NLR family members (i.e., NLRP1, NLRP3, and IPAF) as well as the PYHIN family member AIM2 can form inflammasome complexes. These multiprotein complexes activate inflammatory caspases (i.e., caspase-1) which in turn catalyze the maturation of select pro-inflammatory cytokines, including interleukin (IL)-$1{\beta}$ and IL-18. Activation of the NLRP3 inflammasome typically requires two initiating signals. Toll-like receptor (TLR) and NOD-like receptor (NLR) agonists activate the transcription of pro-inflammatory cytokine genes through an NF-${\kappa}B$-dependent priming signal. Following exposure to extracellular ATP, stimulation of the P2X purinoreceptor-7 ($P2X_7R$), which results in $K^+$ efflux, is required as a second signal for NLRP3 inflammasome formation. Alternative models for NLRP3 activation involve lysosomal destabilization and phagocytic NADPH oxidase and /or mitochondria-dependent reactive oxygen species (ROS) production. In this review we examine regulatory mechanisms that activate the NLRP3 inflammasome pathway. Furthermore, we discuss the potential roles of NLRP3 in metabolic and cognitive diseases, including obesity, type 2 diabetes mellitus, Alzheimer's disease, and major depressive disorder. Novel therapeutics involving inflammasome activation may result in possible clinical applications in the near future.

• 대한조선학회논문집
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• 제42권3호
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• pp.276-283
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• 2005

The cooperative production system was proposed as an efficient production system to reduce the ship construction cost and to enhance the competitiveness for small/medium sized shipbuilder in the previous paper. In viewpoint of cooperative production system, the specialization of the FRP ship sizes has already been accomplished to reduce the number of the hull molds by FRP shipbuilders of the Sapjin industrial complex located in Mokpo area in 2003. There also exist lots of effective methods, as a cooperative production system, to cut down the construction cost. In this study, an effective production system in connection with the super structure and outfitting members is proposed such as the standardization of those items and specialized company which intensively produces the super structure and outfitting members at the collectivization area for cooperative work.

• 천문학회보
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• 제41권1호
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• pp.53.3-54
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• 2016

We present a preliminary result of the Fornax cluster survey as a part of the KMTNet Intensive Nearby Southern Galaxy Group Survey (KINGS). We discovered about 200 new dwarf galaxy candidates from the survey of the $8^{\circ}{\times}6^{\circ}$ area around the Fornax cluster. They have magnitudes ranging from V=17.5 to 22 mag (Mv = -13.8 to -9.3), and they are almost complete to V = 20 mag. Surface brightness profiles of most of these galaxies are fit well by a Sersic law with n ~ 1.0. Structural parameters of these galaxies follow well the scaling relations of dwarf galaxies in the fundamental plane. The color-magnitude diagram of these galaxies shows that they are mostly located at the faint end of the red sequence, indicating that they are the probable member of the Fornax cluster. We also derive a luminosity function of the Fornax cluster by combining the new galaxies with the known galaxies in the previous catalogs. We will discuss the future of the KINGS-Fornax.

• Steel and Composite Structures
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• 제17권6호
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• pp.851-865
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• 2014

Full penetration welded steel moment-resisting frame (SMRF) structures with welded box sections are widely employed in steel bridges, where a large number of steel bridges have been in operation for over fifty years in Japan. Welding defects such as incomplete penetration at the beam-column connections of these existing SMRF steel bridge piers were observed during inspection. Previous experiments conducted by the authors' team indicate that gusset stiffeners (termed fillets in this study) at the beam-web-to-column-web joint of the beam-column connections may play an important role on the seismic performance of the connections. This paper aims to experimentally study the effect of the fillet radius on seismic performance of the connections with large welding defects. Four specimens with different sizes of fillet radii were loaded under quasi-static incremental cyclic loading, where different load-displacement relations and cracking behaviors were observed. The experimental results show that, as the size of the fillet radius increases, the seismic performance of the connections can be greatly improved.

• 농촌의학ㆍ지역보건
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• 제37권4호
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• pp.195-214
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• 2012

The New Public Health(NPH) is a comprehensive approach to protecting and promoting the health status of each individual member and society as a whole. NHP is not so much a philosophy to broaden the understanding of public health as it is an action plan to address current public health system. This paper's objectives include increasing public and professional awareness of the significant changes in the national public health systems of developed countries and contributing to more effective delivery of public health services in Korea. This paper reviews articles and documents concerning NPH and the public health system, and outlines of the achievements in developed countries since NPH movement began. These include the change in the definition and function of public health, expansion of public health networks, strengthening of public health policy, reorientation of public health delivery systems, promotion of workforce capacity, and the implementation of evidence-based management. To overcome the challenges facing the public health system of Korea, we must prioritize the value of population-based approach, expand the notion of a public health system to encompass all sectors that can influence health, promote a "Health in All Policies" approach, focus on an evidence-based health policy and program, develop core competencies for public health workers, and establish performance standards for public health organizations based on the core functions of public health.

• 한국공간구조학회논문집
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• 제14권2호
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• pp.69-78
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• 2014

The purpose of this study is to increase applicability of high strength steel, HSA800 to the structure. Selected study of structure is to consider high strength steel, and following parts, 1) Tensile member with no consider of buckling, 2) Truss existing both tension and compression members with small slenderness ratio. This studied structure is included tension column hang on to the upper bridge truss. The structure element quantity with apply HSA800 instead of SM570 is reduced about 38.9% of tension column and 29.7% of bridge truss. In addition, the number of element's division is reduced about two sections due to reduction of self weight that the crane is able to lift up. This improves to reduce erection sequence and construction period which can save about a month. All connections are reviewed as welding and bolt. Also, the cost of welding is reduced about 41.3% due to apply HSA800. In conclusion, applying HSA800 to the hanging structure aggressively can secure economic and constructability.