• Molecules and Cells
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• v.22 no.3
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• pp.247-253
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• 2006

Protein modification by small ubiquitin-like modifier (SUMO) controls diverse cellular functions of protein targets including transcription factors and coregulators mainly in the nucleus and participates in maintaining cellular homeostasis. In addition, SUMO system plays important roles in DNA damage repair and maintaining genome integrity. Thus, in some cases, the loss of control on SUMOylation or deSUMOylation processes causes a defect in maintaining homeostasis and hence gives a cue to cancer development. Furthermore, recent study showed that SUMO system is also involved in cancer metastasis. In this review, we will summarize and discuss the possible role of SUMO system in cancer development and metastasis.

• Proceedings of the KIEE Conference
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• 1993.07a
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• pp.36-38
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• 1993

This study considers the economic aspect of the distribution automation system, which is the decision-making criteria of the electric utilities for the investment. The feeder automation candidate region is divided into two types of the urban and the rural. The total investment cost of the feeder automation for each type is estimated. The annual cost, is also estimated, by finding the fixed charge rate. To compare the annual cost and the economic effect cost, for the investment decision-making, the costs are quantitatively estimated on the following effects : the manpower replacement, the outage cost saving, the main transformer utilization improvement, the feeder utilization improvement, and the line loss reduction.

• 한국연소학회:학술대회논문집
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• 2015.12a
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• pp.209-211
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• 2015

Evaporation characteristics of a single droplet of carbon nanofluids were investigated in a rapid compression machine(RCM). n-Heptane and carbon black N990 were used to synthesize the carbon nanofluids. RCM is an experimental set-up to simulate a single compression stroke of reciprocating engine. Temperature and pressure in a reaction chamber were measured during the compression stroke. After the piston reaches top dead center(TDC), temperature and pressure decreased due to the heat loss at wall. In that process, a single droplet of carbon nanofluids underwent unsteady condition. A single droplet was put at the center of reaction chamber. Thermocouple whose tip is $50{\mu}m$ was used not only to measure transient bulk temperature, but also to suspend the droplet. The picture of single droplet was taken using high speed camera with a frame rate of 500 fps. From those pictures, the droplet diameter was measured by visual basic program.

• Proceedings of the KIPE Conference
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• 2015.07a
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• pp.361-362
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• 2015

This paper proposes a Direct Power Control (DPC) scheme of improved command tracking capability for Permanent Magnet Synchronous Generator (PMSG) Medium Voltage (MV) Wind Turbines. Benchmarking is performed based on a neutral point clamped three-level back-to-back type voltage source converter. It is introduced to design the DPC modeling and propose DPC scheme of a three-level NPC (3L-NPC) converter. During the fault condition in wind farms, the proposed control scheme directly controls the generated output power to the command value from the hierarchical wind farm controller. The proposed control scheme is compared with conventional control scheme as respect to loss and thermal analysis. The DPC scheme of improved command tracking capability is confirmed through PLECS simulations. Simulation result shows that proposed control scheme achieves a much shorter transient time in a step response of generated output power. The proposed control scheme makes it possible to provide a good dynamic performance for PMSG MV wind turbine to generate a high quality output power under grid fault condition.

• Proceedings of the KIEE Conference
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• 1995.07a
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• pp.156-159
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• 1995

A superconducting power cable is one of the promising ways for transmitting huge electric power efficiently in the future. We performed a conceptual design of 154kV, 3GVA class superconducting power cable. The AC loss of superconductor was estimated by using the Bean model. The cross sectional area of stabilizer was calculated under the adiabatic condition. In this paper, the results of the conceptual design of superconducting power cable is described.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2000.07a
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• pp.794-797
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• 2000

The fabrication of high quality superconducting thin films using pulsed laser deposition (PLD) has been reported to find optimized processing conditions and to make the millimeter-wave devices. High temperature superconducting (HTS) YBCO films were prepared on MgO (10${\times}$10${\times}$0.5mm) substrates by the PLD. The 3 pole bandpass filter with the center frequency of 22 GHz for satellite communication was designed consisting of hairpin coupled-lines to reduce the configuration in size. YBCO films are c-axis oriented and show superconductive transition temperatures of 88∼89 K with the transition widths < 0.5 K. The insertion loss of passband at 70 K was about 5 dB. The measured frequency response of superconducting filter will be compared with the simulation result.

• Journal of Genetic Medicine
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• v.14 no.1
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• pp.31-33
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• 2017

Chromosomal loss in trisomy (trisomy rescue) to generate a disomic fetus can cause confined placental mosaicism and/or feto/placental mosaicism. After trisomy rescue event, there is a risk of fetal uniparental disomy (UPD). Noninvasive prenatal test (NIPT) reflects the genomic constitution of the placenta, not of the fetus itself. Feto-placental discrepancy can therefore cause false-positive (trisomy) NIPT results. These discordant NIPT results can serve as important clues to find UPD associated with confined placental mosaicism. We report a case with maternal UPD of chromosome 20, detected by NIPT of 1,000 high-risk pregnancies, carried out for detecting chromosomal abnormalities in Koreans.

• Anatomy and Cell Biology
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• v.49 no.4
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• pp.223-230
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• 2016

Stroke leads to a variety of pathophysiological conditions such as ischemic infarct, cerebral inflammation, neuronal damage, cognitive decline, and depression. Many endeavors have been tried to find the therapeutic solutions to attenuate severe neuropathogenesis after stroke. Several studies have reported that a decrease in the neuropeptide regulator 'galanin' is associated with neuronal loss, learning and memory dysfunctions, and depression following a stroke. The present review summarized recent evidences on the function and the therapeutic potential of galanin in post-ischemic stroke to provide a further understanding of galanin's role. Hence, we suggest that galanin needs to be considered as a therapeutic factor in the alleviation of post-stroke pathologies.

• Bulletin of the Korean Mathematical Society
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• v.56 no.6
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• pp.1467-1483
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• 2019

This paper analyzes a robust optimal reinsurance and investment strategy for an Ambiguity-Averse Insurer (AAI), who worries about model misspecification and insists on seeking robust optimal strategies. The AAI's surplus process is assumed to follow a jump-diffusion model, and he is allowed to purchase proportional reinsurance or acquire new business, meanwhile invest his surplus in a risk-free asset and a risky-asset, whose price is described by an Ornstein-Uhlenbeck process. Under the criterion for maximizing the expected exponential utility of terminal wealth, robust optimal strategy and value function are derived by applying the stochastic dynamic programming approach. Serval numerical examples are given to illustrate the impact of model parameters on the robust optimal strategies and the loss utility function from ignoring the model uncertainty.

• Journal of Pharmacopuncture
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• v.21 no.4
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• pp.226-240
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• 2018

Neuroprotection or prevention of neuronal loss is a complicated molecular process that is mediated by various cellular pathways. Use of different pharmacological agents as neuroprotectants has been reported especially in the last decades. These neuroprotective agents act through inhibition of inflammatory processes and apoptosis, attenuation of oxidative stress and reduction of free radicals. Control of this injurious molecular process is essential to the reduction of neuronal injuries and is associated with improved functional outcomes and recovery of the patients admitted to the intensive care unit. This study reviews neuroprotective agents and their mechanisms of action against central nervous system damages.