• Journal of Satellite, Information and Communications
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• v.12 no.4
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• pp.162-165
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• 2017

In an effort to compensate the rising of the data throughput demand nowadays, there have been many research works to optimize the radio resource and increase the capacity of the network. At the present, small cell network, mmWave band and beamforming technology are leading the trend and becoming the core solutions of the fifth generation (5G) cellular networks. Since the propagation characteristics of radio wave in the mmWave band is quite different from the conventional bands, the communication systems which work in these bands have to be redesigned. In this paper, a 3D simulation model is discussed for cellular network at 60 GHz in outdoor environments. Coverage analysis and system performance is carried out for a small cell system in the typical urban environment including street canyon simulation scenario. In addition, the beamforming technique is considered to evaluate the throughput improvement. Simulation results show that the mmWave small cell systems is expected to be one of the major candidate technologies to satisfy the requirements of 5G in terms of data rate.

• The Korean Journal of Physiology and Pharmacology
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• v.17 no.4
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• pp.331-338
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• 2013

AMP-activated protein kinase (AMPK), an important regulator of energy metabolism, is activated in response to cellular stress when intracellular levels of AMP increase. We investigated the neuroprotective effects of AMPK against scopolamine-induced memory impairment in vivo and glutamate-induced cytotoxicity in vitro. An adenovirus expressing AMPK wild type alpha subunit (WT) or a dominant negative form (DN) was injected into the hippocampus of rats using a stereotaxic apparatus. The AMPK WT-injected rats showed significant reversal of the scopolamine induced cognitive deficit as evaluated by escape latency in the Morris water maze. In addition, they showed enhanced acetylcholinesterase (AChE)-reactive neurons in the hippocampus, implying increased cholinergic activity in response to AMPK. We also studied the cellular mechanism by which AMPK protects against glutamate-induced cell death in primary cultured rat hippocampal neurons. We further demonstrated that AMPK WT-infected cells increased cell viability and reduced Annexin V positive hippocampal neurons. Western blot analysis indicated that AMPK WT-infected cells reduced the expression of Bax and had no effects on Bcl-2, which resulted in a decreased Bax/Bcl-2 ratio. These data suggest that AMPK is a useful cognitive impairment treatment target, and that its beneficial effects are mediated via the protective capacity of hippocampal neurons.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.32 no.3A
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• pp.247-260
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• 2007

This paper solves the problem of finding a suitable sub-channel and power joint allocation method for multiple users in 802.16e OFDMA/TDD cellular systems. The joint allocation is thatfirstly the sub-channel is allocated to the users and then suitable power is allocated. We propose a FASA (Fairness insured Aggressive Sub-channel Allocation) algorithm which is a dynamic channel allocation algorithm considering all users' channel state information conditionally to maximize fairness and throughput. The improved CHC algorithm, which is dynamic power allocation algorithm, is also proposed in this paper The Improved CHC algorithm collects the extra of the downlink transmit power and then re-allocates it to other users. Simulation results show that the proposed improved CHC algorithm additionally increases the fairness and sector throughput.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.21 no.4
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• pp.718-723
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• 2017

We propose a pilot hopping scheme that improves the limited system capacity due to pilot contamination in multi-cell environment with large-scale antenna arrays at a base station, assuming the infinite number of antennas. In the conventional fixed pilot scheme, each user obtains the same signal-to-interference ratio (SIR) over a long period of time. Therefore, a user with strong interference has continuously low SIR which degrades its service quality. In the proposed pilot hopping scheme, different pilot signals are used for each time slot, and different amounts of interference are received every time. When such a pilot hopping technique is applied, the SIR fluctuates at every time slot. When the Hybrid Automatic Repeat & reQuest (HARQ) technique is applied in such a channel, the outage probability and transmission rate are improved. We show that there is the performance gain of the proposed scheme over the conventional scheme through computer simulations.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.32 no.11A
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• pp.1120-1127
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• 2007

In this paper, we propose a generalized processor sharing - dynamic resource allocation (GPS-DRA) scheme which allocates the required amount of resources to each hop dynamically in cellular-based multi-hop systems. In the hybrid-distributed system considered in this paper, a central controller such as a base station (BS) should allocate resources properly to each hop. However, due to changing channel condition with time, it is difficult to allocate as much amount of resources as each hop needs for transmission. GPS-DRA scheme allocates the required amount of resources dynamically to each hop based on the amount of resources used in previous frames by each hop. The amount of control overhead generated by GPS-DRA scheme can be very small because a central controller doesn't need to collect all link information for resource allocation. Our simulation results show that channel utilization increased about 16% and cell capacity increased about 65% compared to those of fixed resource allocation (FRA) scheme.

• Molecules and Cells
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• v.40 no.6
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• pp.434-439
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• 2017

Gestational diabetes mellitus (GDM), one of the common metabolic disorders of pregnancy, leads to functional alterations in various cells including stem cells as well as some abnormalities in fetal development. Perivascular stem cells (PVCs) have gained more attention in recent years, for the treatment of various diseases. However, the effect of GDM on PVC function has not been investigated. In our study, we isolated PVCs from umbilical cord of normal pregnant women and GDM patients and compared their phenotypes and function. There is no significant difference in phenotypic expression, response to bFGF exposure and adipogenic differentiation capacity between normal (N)-PVCs and GDM-PVCs. However, when compared with N-PVCs, early passage GDM-PVCs displayed decreased initial rates of cell yield and proliferation as well as a reduced ability to promote wound closure. These results suggest that maternal metabolic dysregulation during gestation can alter the function of endogenous multipotent stem cells, which may impact their therapeutic effectiveness.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.17
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• pp.7641-7651
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• 2015

It has been shown previously that nutritional supplements rich in polyphenolic compounds play a significant role in prostate cancer chemoprevention. Propolis is a natural, resinous hive product that has several pharmacological activities including antimicrobial, antioxidant, anti-inflammatory, and antitumoral activities. The aim of this study was to compare the cytotoxic, antioxidant and antitumoral activities of an ethanolic extract of Egyptian propolis (EEP) in vitro with an established chemotherapeutic drug such as doxorubicin (DOX), and the effects of their combination against the PC3 human prostate cancer cell line. Cellular viability and $IC_{50}$ levels with EEP, DOX and their (v/v) combination were detected by sulphorhodamine-B (SRB) assay after incubation of PC3 cells for 72h with different doses (0, 0.01, 0.1, 1, 10 and $100{\mu}g/ml$). Two selected doses of $IC_{50}$ and $IC_{25}$ were applied to cells for 24h for antitumor evaluation assay of treatment compounds. EEP and its (v/v) combination with DOX showed significant antitumor potential besides high antioxidant properties of superoxide dismutase (SOD), total antioxidant capacity (TAC), catalase (CAT), nitric oxide (NO) and reduced glutathione (GSH) levels when compared with the control untreated cells. DNA fragmentation assay and semi quantitative RT-PCR analyses for p53 and Bax genes showed that EEP activated cellular apoptosis and increased the mRNA expression levels more than other treatment. In conclusion, EEP alone or in combination with DOX at both doses used here showed greater antioxidant, antiproliferative and apoptotic effects against the PC3 cell lines as compared to treatment with DOX alone. Therefore, EEP could be considered as a promising candidate for prostate cancer chemotherapy.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.40 no.8
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• pp.1532-1541
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• 2015

D2D(Device-to-Device) communication is a promising technology to improve the system capacity and spectral efficiency. By sharing the same radio resources with cellular user equipments, D2D communications can significantly enhance the overall spectral efficiency. However, it may cause interference between D2D link and cellular link. So, careful resource allocation and interference coordination between them are very important and need to be properly handled. This paper proposes a radio resource allocation scheme that decreases interference through the use of area grouping and D2D pair grouping. Simulations results are provided to verify the performance improvement of the proposed scheme in terms of the number of assigned resource blocks and computational complexity.

• Journal of Biosystems Engineering
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• v.39 no.3
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• pp.244-252
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• 2014

Purpose: The development of an efficient in vitro cell culture device to process various cells would represent a major milestone in biological science and engineering. However, the current conventional macro-scale in vitro cell culture platforms are limited in their capacity for detailed analysis and determination of cellular behavior in complex environments. This paper describes a microfluidic-based culture device that allows accurate control of parameters of physical cues such as pressure. Methods: A microfluidic device, as a model microbioreactor, was designed and fabricated to culture Saccharomyces cerevisiae and Chlamydomonas reinhardtii under various conditions of physical pressure stimulus. This device was compatible with live-cell imaging and allowed quantitative analysis of physical cue-induced behavior in yeast and microalgae. Results: A simple microfluidic-based in vitro cell culture device containing a cell culture channel and an air channel was developed to investigate physical pressure stress-induced behavior in yeasts and microalgae. The shapes of Saccharomyces cerevisiae and Chlamydomonas reinhardtii could be controlled under compressive stress. The lipid production by Chlamydomonas reinhardtii was significantly enhanced by compressive stress in the microfluidic device when compared to cells cultured without compressive stress. Conclusions: This microfluidic-based in vitro cell culture device can be used as a tool for quantitative analysis of cellular behavior under complex physical and chemical conditions.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.33 no.2A
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• pp.98-106
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• 2008

To reduce the outage probability and to increase the transmission capacity, the importance of repeaters in cellular systems keeps increasing. Unlike optical repeaters which require wireline connections, RF repeaters are easy to install, have low limitations in location and also have a reduced operational expense such as the optical fiber maintenance cost. On the other hand, RF repeaters suffer the interference due to the feedback signals between the transmitter and receiver antennas, hence require an extra interference cancellation method when the amount of the feedback signal reduction by using the shielding is not sufficient. In this paper, a channel estimation method for two-path feedback interference signals in the ICS (Interference Cancellation System) repeaters using baseband signal processing is proposed and its performance is evaluated. When compared with the conventional method which estimates each multipath individually, the proposed method achieves 10 dB performance gain in terms of the normalized mean-squared-error.