Molecules and Cells

Korean Society for Molecular and Cellular Biology (한국분자세포생물학회)
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Gestational Diabetes Affects the Growth and Functions of Perivascular Stem Cells

  • An, Borim (Department of Internal Medicine, School of Medicine, Kangwon National University) ;
  • Kim, Eunbi (Department of Internal Medicine, School of Medicine, Kangwon National University) ;
  • Song, Haengseok (Department of Biomedical Science, College of Life Science, CHA University) ;
  • Ha, Kwon-Soo (Department of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University) ;
  • Han, Eun-Taek (Department of Medical Environmental Biology and Tropical Medicine, School of Medicine, Kangwon National University) ;
  • Park, Won Sun (Department of Physiology, School of Medicine, Kangwon National University) ;
  • Ahn, Tae Gyu (Department of Obstetrics & Gynecology, School of Medicine, Kangwon National University) ;
  • Yang, Se-Ran (Department of Thoracic & Cardiovascular Surgery, School of Medicine, Kangwon National University) ;
  • Na, Sunghun (Department of Obstetrics & Gynecology, School of Medicine, Kangwon National University) ;
  • Hong, Seok-Ho (Department of Internal Medicine, School of Medicine, Kangwon National University)
  • Received : 2017.03.31
  • Accepted : 2017.05.11
  • Published : 2017.06.30
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Abstract

Gestational diabetes mellitus (GDM), one of the common metabolic disorders of pregnancy, leads to functional alterations in various cells including stem cells as well as some abnormalities in fetal development. Perivascular stem cells (PVCs) have gained more attention in recent years, for the treatment of various diseases. However, the effect of GDM on PVC function has not been investigated. In our study, we isolated PVCs from umbilical cord of normal pregnant women and GDM patients and compared their phenotypes and function. There is no significant difference in phenotypic expression, response to bFGF exposure and adipogenic differentiation capacity between normal (N)-PVCs and GDM-PVCs. However, when compared with N-PVCs, early passage GDM-PVCs displayed decreased initial rates of cell yield and proliferation as well as a reduced ability to promote wound closure. These results suggest that maternal metabolic dysregulation during gestation can alter the function of endogenous multipotent stem cells, which may impact their therapeutic effectiveness.

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References

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