• Clinical and Experimental Pediatrics
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• 제64권10호
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• pp.504-510
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• 2021

Population screening of newborns is an extremely important and informative diagnostic approach that allows early identification of babies who are predisposed to the development of a number of serious diseases. Some of these diseases are known and have effective treatment methods. Neonatal screening enables the early diagnosis and subsequent timely initiation of therapy. This helps to prevent serious complications and reduce the percentage of disability and deaths among newborns and young children. Primary immunodeficiency diseases and primary immunodeficiency syndrome (PIDS) are a heterogeneous group of diseases and conditions based on impaired immune system function associated with developmental defects and characterized by various combinations of recurrent infections, development of autoimmune and lymphoproliferative syndromes (genetic defects in apoptosis, gene mutation Fas receptor or ligand), granulomatous process, and malignant neoplasms. Most of these diseases manifest in infancy and lead to serious illness, disability, and high mortality rates. Until recently, it was impossible to identify children with PIDS before the onset of the first clinical symptoms, which are usually accompanied by complications in the form of severe coinfections of a viral-bacterial-fungal etiology. Modern advances in medical laboratory technology have allowed the identification of children with severe PIDS, manifested by T- and/or B-cell lymphopenia and other disorders of the immune system. This review discusses the main existing strategies and directions used in PIDS screening programs for newborns, including approaches to screening based on excision of T-cell receptors and kappa-recombination excision circles, as well as the potential role and place of next-generation sequencing technology to increase the diagnostic accuracy of these diseases.

• 한국정보디스플레이학회:학술대회논문집
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• 한국정보디스플레이학회 2004년도 Asia Display / IMID 04
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• pp.903-906
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• 2004

A ${\pi}$ cell is initially in splay state. Before driving a ${\pi}$ cell, transition from splay to bend state is always necessary which originates from nucleation. We propose a novel technique to make bend transition fast and effectively by forming transition cores around the pixels with the technique of multi-domain alignment, where domain boundaries play a crucial role in splay to bend transition. This noble technique enables the splay to bend transition to occur within less than 2 seconds with a low applied voltage.

• Food Science and Biotechnology
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• 제17권5호
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• pp.1102-1105
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• 2008

The structural change and leakage of cellular substances of Saccharomyces cerevisiae attributed by high hydrostatic pressure (HHP) treatment were observed with scanning electron microscopy (SEM). S. cerevisiae (ATCC16664) was inoculated in apple juice for 10 min at $23^{\circ}C$ and the apple juice treated at 138, 207, 276, 345, and 414 MPa pressure for 30 sec at $23^{\circ}C$. Increased of roughness, elongation, wrinkling, and pores on yeast cell surfaces, the yeast cell walls were severely damaged by HHP treatment from 276 to 414 MPa. Inactivation of S. cerevisiae by HHP is dependent on structural changes on the cell walls observed with SEM.

• Industrial Engineering and Management Systems
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• 제15권2호
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• pp.131-142
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• 2016

We consider a multi-server queueing system without buffer and with two types of customers as a model of operation of a mobile network cell. Customers arrive at the system in the marked Markovian arrival flow. The service times of customers are exponentially distributed with parameters depending on the type of customer. A part of the available servers is reserved exclusively for service of first type customers. Customers who do not receive service upon arrival, can make repeated attempts. The system operation is influenced by random factors, leading to a change of the system parameters, including the total number of servers and the number of reserved servers. The behavior of the system is described by the multi-dimensional Markov chain. The generator of this Markov chain is constructed and the ergodicity condition is derived. Formulas for computation of the main performance measures of the system based on the stationary distribution of the Markov chain are derived. Numerical examples are presented.

• Biotechnology and Bioprocess Engineering:BBE
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• 제6권5호
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• pp.311-325
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• 2001

Tissue engineering scaffolds play a critical role in regulating the reconstructed human tissue development. Various types of scaffolds have been developed in recent years, including fibrous matrix and foam-like scaffolds. The design of scaffold materials has been investigated extensively. However, the design of physical structure of the scaffold, especially fibrous matrices, has not received much attention. This paper compares the different characteristics of fibrous and foam-like scaffolds, and reviews regulatory roles of important scaffold properties, including surface geometry, scaffold configuration, pore structure, mechanical property and bioactivity. Tissue regeneration, cell organization, proliferation and differentiation under different microstructures were evaluated. The importance of proper scaffold selection and design is further discussed with the examples of bone tissue engineering and stem cell tissue engineering. This review addresses the importance of scaffold microstructure and provides insights in designing appropriate scaffold structure for different applications of tissue engineering.

• 한국세라믹학회지
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• 제38권6호
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• pp.499-505
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• 2001

The behaviour of ionic compound crystals under combined chemical and externally applied electrical potential gradients is discussed. Firstly, a systematic overview is given. Then a formal analysis follows. The transport equations of the ions and the electric defects predict that even with reversible electrodes demixing, and in particular decomposition of the compound will occur if the applied d.c. current density is sufficiently high. These predictions are illustrated by appropriate experiments. With the help of the solid solution (Me, Fe)O, where Fe-ions are the dilute species, we investigate experimentally the behaviour of a ternary ionic crystal under a d.c. electric current load. All the compounds were placed in a galvanic cell, and the internal reactions which then could be observed were driven by the electric field in this cell. In addition, we discuss the influence of the electric field on the classical solid state reaction AX+BX=ABX$_2$, if again the reaction couple is placed in a galvanic cell.

• Journal of Information Display
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• 제5권2호
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• pp.19-22
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• 2004

A ${\pi}$ cell is initially in splay state. Before driving a ${\pi}$ cell, transition from splay to bend state is always necessary which originates from nucleation. We propose a novel technique to make bend transition fast and effectively by forming transition cores around the pixels with the technique of multi-domain alignment, where domain boundaries play a crucial role in splay to bend transition. This noble technique enables the splay to bend transition to occur within less than 2 seconds with a low applied voltage.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2013년도 제45회 하계 정기학술대회 초록집
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• pp.310.2-310.2
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• 2013

For enhancement of dye-sensitized solar cell performance, TiO2 blocking layer has been used to prevent recombination between electron and hole at the conducting oxide and electrolyte interface. In solid state dye-sensitized solar cells, it is necessary to fabricate pin-hole free TiO2 blocking layer. In this work, we deposited the TiO2 blocking layer on conducting oxide by atomic layer deposition and compared the efficiency. To compare the efficiency, we fabricate solid state dye-sensitized solar cell with using CuSCN as hole transport material. We see the efficiency improve with 40nm TiO2 blocking layer and the TiO2 blocking layer morphology was characterized by SEM. Also, we used this blocking layer in TiO2/Sb2S3/ CuSCN solar cell.

• 한국정보통신학회:학술대회논문집
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• 한국해양정보통신학회 2009년도 춘계학술대회
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• pp.441-445
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• 2009

본 논문에서는 Self-Programmable Cellular Automata(SPCA)를 기반으로 하여 최대주기수열을 생성하는 방법을 제안한다. 최근 긴 주기의 수열을 생성하기 위해서 CA의 차원을 증가시키거나, 상태전이 단계마다 각 셀의 전이규칙을 바꾸는 PCA를 사용하여 왔다. 본 논문에서는 셀의 전이 규칙에 역동성을 부여하기 위하여 각 셀의 상태전이 규칙을 각 시간 단계마다 바꿈으로써 더 긴 주기의 수열을 생성하고 생성된 수열의 랜덤성을 높이고자 한다.

• Journal of the Optical Society of Korea
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• 제5권2호
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• pp.39-42
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• 2001

A new method of switching mode in AFLC cell is proposed for faster switching time and higher contrast ratio. In this mode the ″dark″ state is obtained by applying negative full voltage while the ″bright″ state is achieved by applying positive full voltage to the cell. The switching time is reduced to 100 $mutextrm{s}$ for the cell whose switching time is 22 ms when operated in conventional mode. The contrast ratio is also improved vastly with this method. The possibility of achieving gray scale was shown in this mode of operation.