• The Korean Journal of Applied Statistics
• /
• v.28 no.2
• /
• pp.295-308
• /
• 2015

We have experienced a substantial improvement in and cost-drop for genotyping that enables genetic epidemiological studies with large-scale genetic data. Genome-wide association studies have identified more than ten thousand causal variants. Many statistical methods based on linear mixed models have been developed for various goals such as estimating heritability and identifying disease susceptibility locus. Empirical results also repeatedly stress the importance of linear mixed models. Therefore, we review the statistical methods related with to linear mixed models and illustrate the meaning of their estimates.

• Annals of Hepato-Biliary-Pancreatic Surgery
• /
• v.27 no.3
• /
• pp.241-250
• /
• 2023

Helicobacter pylori is a gram-negative pathogen commonly associated with peptic ulcer disease and gastric cancer. H. pylori infection has also been reported in cholelithiasis, cholecystitis, gallbladder polyps, and biliary tract cancers. However, the association between H. pylori and gallbladder and biliary tract pathologies remains unclear due to the paucity of literature. In response to the current literature gap, we aim to review and provide an updated summary of the association between H. pylori with gallbladder and biliary tract diseases and its impact on their clinical management. Relevant peer-reviewed studies were retrieved from Medline, PubMed, Embase, and Cochrane databases. We found that H. pylori infection was associated with cholelithiasis, chronic cholecystitis, biliary tract cancer, primary sclerosing cholangitis, and primary biliary cholangitis but not with gallbladder polyps. While causal links have been reported, prospective longitudinal studies are required to conclude the association between H. pylori and gallbladder pathologies. Clinicians should be aware of the implications that H. pylori infection has on the management of these diseases.

• Journal of Korean Society of Occupational and Environmental Hygiene
• /
• v.17 no.1
• /
• pp.1-12
• /
• 2007

We have reviewed all cases and epidemiological studies that have reported the association between worker's exposure to metalworking fluids(MWF) and non-malignant respiratory diseases. The followings are main conclusions we critically reviewed. Exposure to MWF was believed to be significantly related to the risk of cough and phlegm. Relative risk caused by straight MWF was found to be higher in exposure to straight MWF than water-soluble MWF. We also found that exposure to water-soluble MWF significantly caused hypersensitivity pneumonitis (HP) and occupational asthma. The main culprits that cause the development of HP and asthma are believed to be microbes contaminated in MWF, ethanolamine and biocides. HP and asthma could be developed at even exposure to lower than $0.5mg/m^3$, exposure level recommended by NIOSH. Most epidemiological studies have reported that relationship between chronic bronchitis and exposure to MWF was significant. Although there were several studies that suggested the significant association between exposure to MWF and the development of rhinitis and sinusitis, we could not conclude the causal relationship because of lack of evidences.

• Biomedical Science Letters
• /
• v.20 no.4
• /
• pp.221-226
• /
• 2014

High-density lipoprotein (HDL) cholesterol levels are associated with decreased risk of coronary artery disease. Several genome-wide association studies (GWAS) for HDL cholesterol levels have implicated Lipoprotein lipase (LPL) as possibly being causal. Herein, the association between single nucleotide polymorphism (SNP) rs10503669 in the LPL gene and HDL cholesterol levels and triglyceride levels was tested in the Korean population. A total of 994 subjects from Seoul City were included in a replication study with LPL SNP rs10503669. SNP rs10503669 in the LPL gene was associated with mean HDL cholesterol levels (effect per allele 3.13 mg/dL, P<0.0001) and triglyceride levels (effect per allele -18.0 mg/dL, P=0.0026). Subjects with the CA/AA genotype had a 0.42-fold (range 0.23~0.77-fold) lower risk of having abnormal HDL cholesterol levels (<40 mg/dL) than subjects with the CC genotype. When analyzed by gender, the association of LPL was stronger in men than in women. This study clearly demonstrates that genetic variants in LPL influence HDL cholesterol levels and triglyceride levels in Korean adults.

• Nutrition Research and Practice
• /
• v.16 no.1
• /
• pp.94-105
• /
• 2022

BACKGROUND/OBJECTIVES: The purpose of this study was to investigate the association between socioeconomic status and chewing discomfort and identify the role of food insecurity in the association's causal pathway in a representative sample of Korean elders. MATERIALS/METHODS: We conducted cross-sectional analyses of the Korea National Health and Nutrition Examination Survey (2013-2015) data for elders aged ≥ 65 years. Socioeconomic status indicators used included household income and education level. Chewing discomfort was assessed according to the self-reported presence of chewing problems. Food security was surveyed using a questionnaire based on the US Household Food Security Survey Module. RESULTS: The odds ratios of chewing discomfort in the 1st and 2nd income quartiles were 1.55 (95% confidence interval [CI], 1.15-2.10) and 1.40 (95% CI, 1.03-1.90), respectively, compared to participants in the highest income quartile. Participants with the lowest education level were 1.89 (95% CI, 1.30-2.75) times more likely to have chewing discomfort than those without chewing discomfort. After including food security in the final model, the logistic coefficients were attenuated in the income and education quartiles. CONCLUSIONS: Low socioeconomic status was associated with chewing discomfort. In addition, the results confirm that food insecurity can mediate the association between socioeconomic inequalities and chewing discomfort among the elderly.

• Journal of the Korean Society of Safety
• /
• v.35 no.4
• /
• pp.64-73
• /
• 2020

As Korean government and safety-related organizations make continuous efforts to reduce the number of industrial accidents, accident rate has steadily declined since 2010, thereby recording 0.48% in 2017. However, the number of fatalities due to industrial accidents was 1,987 in 2017, which means that more efforts should be made to reduce the number of industrial accidents. As an essential activity for enhancing the system safety, accident analysis can be effectively used for reducing the number of industrial accidents. Accident analysis aims to understand the process of an accident scenario and to identify the plausible causes of the accident. Accident analysis offers useful information for developing measures for preventing the recurrence of an accident or its similar accidents. However, it seems that the current practice of accident analysis in Korean manufacturing companies takes a simplistic accident model, which is based on a linear and deterministic cause-effect relation. Considering the actual complexities underlying accidents, this would be problematic; it could be more significant in the case of human error-related accidents. Accordingly, it is necessary to use a more elaborated accident model for addressing the complexity and nature of human-error related accidents more systematically. Regarding this, HFACS(Human Factors Analysis and Classification System) can be a viable accident analysis method. It is based on the Swiss cheese model and offers a range of causal factors of a human error-related accident, some of which can be judged as the plausible causes of an accident. HFACS has been widely used in several work domains(e.g. aviation and rail industry) and can be effectively used in Korean industries. However, as HFACS was originally developed in aviation industry, the taxonomy of causal factors may not be easily applied to accidents in Korean industries, particularly manufacturing companies. In addition, the typical characteristics of Korean industries need to be reflected as well. With this issue in mind, we developed HFACS-K as a method for analyzing accidents happening in Korean industries. This paper reports the process of developing HFACS-K, the structure and contents of HFACS-K, and a case study for demonstrating its usefulness.

• Journal of Families and Better Life
• /
• v.11 no.2
• /
• pp.55-68
• /
• 1993

The purpose of this study were to investigate the allocation of time for housework and leisure and the causal relations between management satisfaction and all variables affecting it. for this purposes the data were collected through the questionnaire whose respondnet were 448 housewives. The major results of this study were as follows; 1`) The housework time was affected by the number of family member the age of wife and income. And leisure time was affected by the work status and age of wife educational level and income. The satisfaction level of management were affected by the wife's work status and educational level and income. 2) The relation between housework time and time management strategies was negative And the relations between satisfaction level of management and time planning time management strategies were positive. 3) Among all variables affcting the satisfaction level of management the educational level income time planning time management strategies and leisure time had direct effect And the work status had indirect effect.

• English Language & Literature Teaching
• /
• v.16 no.1
• /
• pp.61-80
• /
• 2009

This study investigates the effects of different types of genre and tasks on college students' English listening comprehension. 104 college students were assigned to Argumentative (AG), Causal and Evaluation (CE), and Narrative (NA) group. They report their listening comprehension through gap-filling (GF), summary (ST), and multiple-choice comprehension task (MC). Results showed that different genre groups were significantly different on overall tasks. Moreover, results from each group also presented that different mean scores on each task indicated a statistical significance. Proficiency levels, higher and lower level group, showed a significant effect for the task on listening comprehension. The results of the statistical analysis, using One-way ANOVA indicated that genre significantly affects Korean college students' listening comprehension, and implied that listening comprehension sores for each genre were also substantially different. Different genre groups resented significant different in overall listening comprehension tasks.

• The Research Journal of the Costume Culture
• /
• v.7 no.3
• /
• pp.58-71
• /
• 1999

The purposes of this study were to investigate the differences inbrand identification ability, opinions on purchasing imported casual wears and purchase behaviors among the high school students grouped by the attitudes toward imported casula wears. Data were obtained from 452 high school students in Seoul by using self-administered questionnaires. Chi-Square Analysis and ANOVA by SAS statistical package were used for data analysis. The subject with favorable toward imported casual wears suggested higher price levels as appropriate price levels of jeans, were more positive about purchasing imported causal wears than the less favorable. Those with more favorable attitudes tended to purchase at individual stores and to have more experiences in purchasing imported brands, spent higher amount of monthly clothing expenditures, searched information mostly through the conversation with peers, and indicated design as the most important evaluative criteria used when purchase clothing. Most of the high school students relied on their parents as the sources of allowances to purchased clothing.

• The Research Journal of the Costume Culture
• /
• v.8 no.6
• /
• pp.864-870
• /
• 2000

The purpose of this study were to investigate clothing design preference (style, color, fabric print, kinds of fabrics) & satisfaction with the fit of ready-to-wear clothing for older Men. For this study, the questionnaires were administered to 650 older men in seoul from June to August, 1998. Employing a sample of 504 data were analyzed by mean, frequency and percent. With respect to clothing design preference, they prefer suit the style of outdoor clothing on going-out. On distinguish clothing into formal wear & casual wear, the color preference due to seasons has difference in spring clothing. Regarding the degree of fabric pattern preference, nonpattern single color fabric has occupied in formal wear, pattern in casual wear. Regarding the degree of fabric preference, they take a serious view of shape preservation in formal wear, utility (washing, sweat absorption) in causal wear. Suit has the lowest satisfaction in the fit of ready-to-wear clothing. Sleeve length the lowest in the degree of satisfaction for each part.