Annals of Hepato-Biliary-Pancreatic Surgery (한국간담췌외과학회지)

The Korean Association of Hepato-Biliary-Pancreatic Surgery (한국간담췌외과학회)
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The link between Helicobacter pylori infection and gallbladder and biliary tract diseases: A review

  • Klay Puay Khim Lim (Lee Kong Chian School of Medicine, Nanyang Technological University) ;
  • Aaron Jia Loong Lee (Lee Kong Chian School of Medicine, Nanyang Technological University) ;
  • Xiuting Jiang (Lee Kong Chian School of Medicine, Nanyang Technological University) ;
  • Thomas Zheng Jie Teng (Lee Kong Chian School of Medicine, Nanyang Technological University) ;
  • Vishal G. Shelat (Department of General Surgery, Tan Tock Seng Hospital)
  • Received : 2022.07.25
  • Accepted : 2023.03.08
  • Published : 2023.08.31
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Abstract

Helicobacter pylori is a gram-negative pathogen commonly associated with peptic ulcer disease and gastric cancer. H. pylori infection has also been reported in cholelithiasis, cholecystitis, gallbladder polyps, and biliary tract cancers. However, the association between H. pylori and gallbladder and biliary tract pathologies remains unclear due to the paucity of literature. In response to the current literature gap, we aim to review and provide an updated summary of the association between H. pylori with gallbladder and biliary tract diseases and its impact on their clinical management. Relevant peer-reviewed studies were retrieved from Medline, PubMed, Embase, and Cochrane databases. We found that H. pylori infection was associated with cholelithiasis, chronic cholecystitis, biliary tract cancer, primary sclerosing cholangitis, and primary biliary cholangitis but not with gallbladder polyps. While causal links have been reported, prospective longitudinal studies are required to conclude the association between H. pylori and gallbladder pathologies. Clinicians should be aware of the implications that H. pylori infection has on the management of these diseases.

Keywords

References

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