• Acta Via Serica
• /
• 제4권1호
• /
• pp.1-24
• /
• 2019

Bloody wars between Arab Muslims and Khazar Turks in the Caucasus continued for a more than a hundred years from the mid $7^{th}$ century to the end of the $8^{th}$ century CE. The Khazar state survived but had to withdraw from Caucasian Albania, the present territory of the Republic of Azerbaijan. However, the Khazars managed to expand their political control over the trade routes north-east and north-west of the Caucasian ridge. A trade partnership was established between former rival powers in the region that allows us to call the period after the end of the Arab-Khazar wars up to the time of the collapse of the Khazar state in the middle of the 10th century an era of Arab-Khazar partnership and domination of the Silk Road. This article highlights the impact made by geopolitical shifts in the regions of the time upon international trade tracks and particularly on the development of trade facilities, infrastructure, and local production in Azerbaijan, which became a major transit country of goods from the north to markets in the Muslim Near East.

• Nuclear Engineering and Technology
• /
• 제54권2호
• /
• pp.681-688
• /
• 2022

Dose monitoring in CT patients requires accurate dose estimation but most of the CT dose calculation tools are based on Caucasian computational phantoms. We established a library of organ dose conversion coefficients for Korean adults by using four Korean adult male and two female voxel phantoms combined with Monte Carlo simulation techniques. We calculated organ dose conversion coefficients for head, chest, abdomen and pelvis, and chest-abdomen-pelvis scans, and compared the results with the existing data calculated from Caucasian phantoms. We derived representative organ doses for Korean adults using Korean CT dose surveys combined with the dose conversion coefficients. The organ dose conversion coefficients from the Korean adult phantoms were slightly greater than those of the ICRP reference phantoms: up to 13% for the brain doses in head scans and up to 10% for the dose to the small intestine wall in abdominal scans. We derived Korean representative doses to major organs in head, chest, and AP scans using mean CTDI_vol values extracted from the Korean nationwide surveys conducted in 2008 and 2017. The Korean-specific organ dose conversion coefficients should be useful to readily estimate organ absorbed doses for Korean adult male and female patients undergoing CT scans.

• Asian Pacific Journal of Cancer Prevention
• /
• 제13권11호
• /
• pp.5777-5783
• /
• 2012

Published data on the associations between tumor necrosis factor-alpha (TNF-${\alpha}$) promoter -308G>A and -238G>A polymorphisms and cervical cancer risk are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. Data were collected from MEDLINE and PubMed databases. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated in a fixed/random effect model. 13 separate studies including 3294 cases and 3468 controls were involved in the meta-analysis. We found no association between TNF-${\alpha}$-308G>A polymorphism and cervical cancer in overall population. In subgroup analysis, significantly elevated risks were found in Caucasian population (A vs. G: OR = 1.43, 95% CI = 1.00-2.03; AA vs. GG: OR = 2.09, 95% CI = 1.34-3.25; Recessive model: OR = 2.09, 95% CI = 1.35-3.25) and African population (GA vs. GG: OR = 1.53, 95% CI = 1.02-2.30). An association of TNF-${\alpha}$-238G>A polymorphism with cervical cancer was found (A vs. G: OR = 0.61, 95% CI = 0.47-0.78; GA vs. GG: OR = 0.59, 95% CI = 0.45-0.77; Dominant model: OR = 0.59, 95% CI = 0.46-0.77). When stratified by ethnicity, similar association was observed in Caucasian population (A vs. G: OR = 0.62, 95% CI = 0.46-0.84; GA vs. GG: OR = 0.59, 95% CI = 0.43-0.82; Dominant model: OR = 0.60, 95% CI = 0.44-0.83). In summary, this meta-analysis suggests that TNF-${\alpha}$-238A allele significantly decreased the cervical cancer risk, and the TNF-${\alpha}$-308G>A polymorphism is associated with the susceptibility to cervical cancer in Caucasian and African population.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권20호
• /
• pp.8725-8734
• /
• 2014

The transforming growth factor-${\beta}1$ (TGF-${\beta}1$) gene 29 T/C polymorphism is thought to be associated with breast cancer risk. However, reports are largely conflicting and underpowered. We therefore conducted a meta-analysis of all available case-control studies relating the TGF-${\beta}1$ 29T/C polymorphism to the risk of developing breast cancer by including a total of 31 articles involving 24,021 cases and 31,820 controls. Pooled ORs were generated for the allele contrasts, with additive genetic, dominant genetic and recessive genetic models. Subgroup analysis was also performed by ethnicity for the TGF-${\beta}1$ 29T/C polymorphism. No association was found in the overall analysis (C vs T: OR=1.028, 95% CI=0.949-1.114, p-value 0.500; CC vs TC: OR= 1.022, 95% CI=0.963-1.085, p-value 0.478; CC vs TT: OR= 1.054, 95% CI=0.898-1.236, p-value 0.522; CC vs TT+ TC: OR= 1.031, 95% CI=0.946-1.124, p-value 0.482; TT vs CC+TC: OR= 0.945, 95% CI=0.827-1.080, p-value 0.403). Similarly, in the subgroup analysis by ethnicity, no association was found in Caucasian (C vs T: OR= 1.041, 95% CI=0.932-1.162, p-value 0.475; CC vs TC: OR= 1.031, 95% CI=0.951-1.118, p-value 0.464; CC vs TT: OR= 1.081, 95% CI=0.865-1.351, p-value 0.493; CC vs TT+TC: OR= 1.047, 95% CI=0.929-1.180, p-value 0.453; TT vs CC+TC: OR= 0.929, 95% CI=0.775-1.114, p-value 0.429;) and Asian populations (C vs T: OR= 1.004, 95% CI=0.908-1.111, p-value 0.931; CC vs TC: OR= 0.991, 95% CI=0.896-1.097, p-value 0.865; CC vs TT: OR= 1.015, 95% CI=0.848-1.214, p-value 0.871; CC vs TT+TC: OR= 1.000, 95% CI=0.909-1.101, p-value 0.994; TT vs CC+TC: OR= 0.967, 95% CI=0.808-1.159, p-value 0.720;). No evidence of publication bias was detected during the analysis. No significant association with breast cancer risk was demonstrated overall or on subgroup (Caucasian and Asian) analysis. It can be concluded that TGF-${\beta}1$ 29T/C polymorphism does not play a role in breast cancer susceptibility in overall or ethnicity-specific manner.

• 대한임상약리학회:학술대회논문집
• /
• 대한임상약리학회 1999년도 제8차 추계학술대회 및 정기총회
• /
• pp.52-52
• /
• 1999

• 대한임상약리학회:학술대회논문집
• /
• 대한임상약리학회 1997년도 정기총회 및 추계학술대회
• /
• pp.54-54
• /
• 1997

• 대한예방의학회:학술대회논문집
• /
• 대한예방의학회 2000년도 제52차 추계학술대회 연제집
• /
• pp.60-61
• /
• 2000

• Child Health Nursing Research
• /
• 제1권1호
• /
• pp.47-58
• /
• 1995

This study was performed to test the validity and reliability of the Health Self-Determinism Index for Children(HSDI-C), an instrument designed to measure dimensions and strength of motivation in health behavior, to improve the applicability of the tool through application to the various samples. The convenient sample of 148 (boys=75, girls=72 third grade=42, fourth grade=22, fifth grade=32, sixth grade=52 : Caucasian=72, Asian=30, African=19) comprised the children at a chatholic elementary school in Chicago. The children completed English version of HSDI-C from December 5th, 1994 to January l0th, 1995. The findings were as follows : 1. Four factors of HSDI-C were isolated through the principal component analysis and oblique rotation, and explained 48% of the variance in total score. Low correlations among four factors were anticipated because each factor contributed uniquely, All items of the tool loaded above .30 on one of 4 factors. But items loaded on each factor in this study were very different from those in the previous studies. 2. Cronbach's alpha coefficient for internal consistency was .81 for the total items and .57∼ .81 for 4 subscales. 3. The differences of HSDI-c mean scores between boys and girls and that of among races were not statistically signifcant, but the mean score of girls and the Caucasian were relatively high. The total mean score of the scale was highest at the 3rd grade, decreased at the 4th or 5th grade, and reincreased at the 6th grade. The trend of mean score of four subscales was similar to that of total mean score. According to the results, suggested below : 1. The items loaded on each factor in this study were very different from those in the previous studies. To clear away the problem of the conceptual confusion, HSDI-C needs to be performed to various and large samples. 2. Unexpectedly, the HSDI-C mean score decreased at middle school age. A longitudinal study will be helpful to search for the change trend of the intrinsic motivation. 3. To improve the applicabilty of the HSDI-C, various reliability and validity test methods besides factor analysis or internal consistency are recommended.

• Archives of Plastic Surgery
• /
• 제35권5호
• /
• pp.581-588
• /
• 2008

Purpose: It is generally accepted that anatomical structures of the soft tissue in Asian faces are quite different from those in Caucasian. It is presumed that these differences are due to collagen rich thick dermis and durable superficial musculo-apponeurotic system (SMAS) in Asian. We classified the aging lower eyelids and reviewed the operative procedures according to the types of aging lower eyelids in Asian. Methods: We compared preoperative and postoperative photos of 117 patients over 30 years of age, who underwent lower blepharoplasty at the Kyunghee Medical Center from January 2001 to April 2006. We classified the patients based on the degree of skin laxity, presence of nasojugal groove and malar bag, the extent of aging process. We also reviewed the operative procedures according to each type of classification. Results: We classified our patients into four types as following. Type I patients showed minimal skin-muscle excess confined to lower eyelids regardless of the facial line. For these patients, we performed only transcutaneous or transconjunctival blepharoplasty. In type II patients, nasojugal grooves were shown and skin- muscle laxity was limited to the medial side of imaginary vertical line at lateral margin of pupil. In these cases, we performed free fat graft or fat repositioning on nasojugal groove or fat removal and septal duplication confined to medial side. Type III patients displayed more advanced medial bulging and remarkable laxity over the lateral side, the same operation methods as those of type II were applied at the lateral side of the line. Type IV patients demonstrated extensive midfacial aging changes including malar bags and underwent superficial subciliary cheek lift. Conclusion: The lower eyelid aging of Asian is different from those of Caucasian. We think that our classification is useful in selection of appropriate operative procedure to address specific problems for Asian patients.

• Asian Pacific Journal of Cancer Prevention
• /
• 제16권11호
• /
• pp.4659-4664
• /
• 2015

Background: ABC proteins are one key type of transport superfamilies which undertake majority of drug transport, which affect the osteosarcoma response to chemotherapeutics. Previous studies have suggested the association between ABC polymorphisms and osteosarcoma response. However, the results of previous studies remain controversial. Therefore, we perform a meta-analysis to get a more precise estimation of this association. The association between ABC polymorphisms and osteosarcoma response was assessed by odds ratios (ORs) together with their 95% confidence intervals (CIs). Three polymorphisms of ABC including ABCB1 rs1128503, ABCC3 rs4148416 and ABCC2 rs717620 polymorphism were investigated. Overall, significant association was observed between ABCC3 rs4148416 polymorphism and osteosarcoma response under allele contrast (T vs. C: OR=1.73, 95%CI=1.09-2.74, P=0.019), homozygote comparison (TT vs. CC: OR=2.00, 95%CI=1.25-3.23, P=0.004), recessive genetic model (TT vs. TC/CC: OR=1.80, 95%CI=1.14-2.84, P=0.011) and dominant genetic model (TT/TC vs. CC: OR=1.70, 95%CI=1.20-2.42, P=0.003). Moreover, significant association was also observed in Caucasian population rather than Asian population for ABCB1 rs1128503 polymorphism. We conclude that ABCC3 rs4148416 polymorphism was significantly associated with poor osteosarcoma response and ABCB1 rs1128503 polymorphism was significantly associated with good osteosarcoma response in Caucasian population rather than Asian population.