Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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No Association of the TGF-β1 29T/C Polymorphism with Breast Cancer Risk in Caucasian and Asian Populations: Evidence from a Meta-Analysis Involving 55, 841 Subjects

  • Alqumber, Mohammed A.A. (Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Albaha University) ;
  • Dar, Sajad Ahmad (Division of Gynecology Oncology, Women's Health Services, Henry Ford Health System Detroit) ;
  • Haque, Shafiul (Department of Biosciences, Jamia Millia Islamia University) ;
  • Wahid, Mohd (Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia University) ;
  • Singh, Rohit (Department of Molecular Bioscience, College of Biomedical Science, Kangwon National University) ;
  • Akhter, Naseem (Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Albaha University)
  • Published : 2014.11.06
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Abstract

The transforming growth factor-${\beta}1$ (TGF-${\beta}1$) gene 29 T/C polymorphism is thought to be associated with breast cancer risk. However, reports are largely conflicting and underpowered. We therefore conducted a meta-analysis of all available case-control studies relating the TGF-${\beta}1$ 29T/C polymorphism to the risk of developing breast cancer by including a total of 31 articles involving 24,021 cases and 31,820 controls. Pooled ORs were generated for the allele contrasts, with additive genetic, dominant genetic and recessive genetic models. Subgroup analysis was also performed by ethnicity for the TGF-${\beta}1$ 29T/C polymorphism. No association was found in the overall analysis (C vs T: OR=1.028, 95% CI=0.949-1.114, p-value 0.500; CC vs TC: OR= 1.022, 95% CI=0.963-1.085, p-value 0.478; CC vs TT: OR= 1.054, 95% CI=0.898-1.236, p-value 0.522; CC vs TT+ TC: OR= 1.031, 95% CI=0.946-1.124, p-value 0.482; TT vs CC+TC: OR= 0.945, 95% CI=0.827-1.080, p-value 0.403). Similarly, in the subgroup analysis by ethnicity, no association was found in Caucasian (C vs T: OR= 1.041, 95% CI=0.932-1.162, p-value 0.475; CC vs TC: OR= 1.031, 95% CI=0.951-1.118, p-value 0.464; CC vs TT: OR= 1.081, 95% CI=0.865-1.351, p-value 0.493; CC vs TT+TC: OR= 1.047, 95% CI=0.929-1.180, p-value 0.453; TT vs CC+TC: OR= 0.929, 95% CI=0.775-1.114, p-value 0.429;) and Asian populations (C vs T: OR= 1.004, 95% CI=0.908-1.111, p-value 0.931; CC vs TC: OR= 0.991, 95% CI=0.896-1.097, p-value 0.865; CC vs TT: OR= 1.015, 95% CI=0.848-1.214, p-value 0.871; CC vs TT+TC: OR= 1.000, 95% CI=0.909-1.101, p-value 0.994; TT vs CC+TC: OR= 0.967, 95% CI=0.808-1.159, p-value 0.720;). No evidence of publication bias was detected during the analysis. No significant association with breast cancer risk was demonstrated overall or on subgroup (Caucasian and Asian) analysis. It can be concluded that TGF-${\beta}1$ 29T/C polymorphism does not play a role in breast cancer susceptibility in overall or ethnicity-specific manner.

Keywords

References

  1. Benson JR (2004). Role of transforming growth factor beta in breast carcinogenesis. Lancet Oncol, 5, 229-39. https://doi.org/10.1016/S1470-2045(04)01426-3
  2. Bierie B, Moses HL (2006). Tumour microenvironment: TGFbeta: the molecular Jekyll and Hyde of cancer. Nat Rev Cancer, 6, 506-20. https://doi.org/10.1038/nrc1926
  3. Bouillon R, Carmeliet G, Verlinden L, et al (2008). Vitamin D and human health: lessons from vitamin D receptor null mice. Endocr Rev, 29, 726-76. https://doi.org/10.1210/er.2008-0004
  4. Breast Cancer Association Consortium (2006). Commonly studied single-nucleotide polymorphisms and breast cancer: results from the Breast Cancer Association Consortium. J Natl Cancer Inst, 98, 1382-96. https://doi.org/10.1093/jnci/djj374
  5. Chen XH, Li XQ, Chen Y, et al (2011). Risk of aggressive breast cancer in women of Han nationality carrying TGFB1 rs1982073 C allele and FGFR2 rs1219648 G allele in North China. Breast Cancer Res Treat, 125, 575-82. https://doi.org/10.1007/s10549-010-1032-7
  6. Cox A, Dunning AM, Garcia-Closas M, et al (2007a). A common coding variant in CASP8 is associated with breast cancer risk. Nat Genet, 39, 352-8. https://doi.org/10.1038/ng1981
  7. Cox DG, Penney K, Guo Q, et al (2007b). TGFB1 and TGFBR1 polymorphisms and breast cancer risk in the Nurses' Health Study. BMC Cancer, 7, 175. https://doi.org/10.1186/1471-2407-7-175
  8. DerSimonian R, Laird N (1986). Meta-analysis in clinical trials. Control Clin Trials, 7, 177-88. https://doi.org/10.1016/0197-2456(86)90046-2
  9. Derynck R, Akhurst RJ, Balmain A (2001). TGF-beta signaling in tumor suppression and cancer progression. Nat Genet, 29, 117-29. https://doi.org/10.1038/ng1001-117
  10. Desruisseau S, Palmari J, Giusti C, et al (2006). Determination of TGFbeta1 protein level in human primary breast cancers and its relationship with survival. Br J Cancer, 94, 239-46. https://doi.org/10.1038/sj.bjc.6602920
  11. Dunning AM, Ellis PD, McBride S, et al (2003). A transforming growth factorbeta1 signal peptide variant increases secretion in vitro and is associated with increased incidence of invasive breast cancer. Cancer Res, 63, 2610-5.
  12. Egger M, Davey Smith G, Schneider M, et al (1997). Bias in meta-analysis detected by a simple, graphical test. BMJ, 315, 629-34. https://doi.org/10.1136/bmj.315.7109.629
  13. Feigelson HS, Patel AV, Diver WR, et al (2006). Transforming growth factor beta receptor type I and transforming growth factor beta1 polymorphisms are not associated with postmenopausal breast cancer. Cancer Epidemiol Biomarkers Prev, 15, 1236-7. https://doi.org/10.1158/1055-9965.EPI-06-0163
  14. Ferlay J, Shin HR, Bray F, et al (2010). Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer, 127, 2893-917. https://doi.org/10.1002/ijc.25516
  15. Fujii D, Brissenden JE, Derynck R, et al (1986). Transforming growth factor beta gene maps to human chromosome 19 long arm and to mouse chromosome 7. Somat Cell Mol Genet, 12, 281-8. https://doi.org/10.1007/BF01570787
  16. Gonullu G, Basturk B, Evrensel T, et al (2007). Association of breast cancer and cytokine gene polymorphism in Turkish women. Saudi Med J, 28, 1728-33.
  17. Gonzalez-Zuloeta Ladd AM, Arias-Vasquez A, Siemes C, et al (2007). Transforming-growth factor beta1 Leu10Pro polymorphism and breast cancer morbidity. Eur J Cancer, 43, 371-4. https://doi.org/10.1016/j.ejca.2006.08.021
  18. Grau AM, Wen W, Ramroopsingh DS, et al (2008). Circulating transforming growth factor-beta-1 and breast cancer prognosis: results from the Shanghai Breast Cancer Study. Breast Cancer Res Treat, 112, 335-41. https://doi.org/10.1007/s10549-007-9845-8
  19. Gu D, Zhuang L, Huang H, et al (2010). TGFB1 T29C polymorphism and breast cancer risk: a meta-analysis based on 10,417 cases and 11,455 controls. Breast Cancer Res Treat, 123, 857-61. https://doi.org/10.1007/s10549-010-0766-6
  20. Higgins JP, Thompson SG, Deeks JJ, et al (2003). Measuring inconsistency in meta-analyses. BMJ, 327, 557-60. https://doi.org/10.1136/bmj.327.7414.557
  21. Hishida A, Iwata H, Hamajima N, et al (2003). Transforming growth factor B1 T29C polymorphism and breast cancer risk in Japanese women. Breast Cancer, 10, 63-9. https://doi.org/10.1007/BF02967627
  22. Huang Y, Li B, Qian J, et al (2010). TGF-beta1 29T/C polymorphism and breast cancer risk: a meta-analysis involving 25,996 subjects. Breast Cancer Res Treat, 123, 863-8. https://doi.org/10.1007/s10549-010-0796-0
  23. Jin Q, Hemminki K, Grzybowska E, et al (2004). Polymorphisms and haplotype structures in genes for transforming growth factor beta1 and its receptors in familial and unselected breast cancers. Int J Cancer, 112, 94-9. https://doi.org/10.1002/ijc.20370
  24. Joshi NN, Kale MD, Hake SS, et al (2011). Transforming growth factor beta signaling pathway associated gene polymorphisms may explain lower breast cancer risk in western Indian women. PLoS One, 6, 21866. https://doi.org/10.1371/journal.pone.0021866
  25. Kaklamani VG, Baddi L, Liu J, et al (2005). Combined genetic assessment of transforming growth factor-beta signaling pathway variants may predict breast cancer risk. Cancer Res, 65, 3454-61.
  26. Krippl P, Langsenlehner U, Renner W, et al (2003). The L10P polymorphism of the transforming growth factor-beta 1 gene is not associated with breast cancer risk. Cancer Lett, 201, 181-4. https://doi.org/10.1016/S0304-3835(03)00468-3
  27. Le Marchand L, Haiman CA, van den Berg D, et al (2004). T29C polymorphism in the transforming growth factor beta1 gene and postmenopausal breast cancer risk: the Multiethnic Cohort Study. Cancer Epidemiol Biomarkers Prev, 13, 412-5.
  28. Lee KM, Park SK, Hamajima N, et al (2005). Genetic polymorphisms of TGF-beta1 & TNF-beta and breast cancer risk. Breast Cancer Res Treat, 90, 149-55. https://doi.org/10.1007/s10549-004-3859-2
  29. Lichtenstein P, Holm NV, Verkasalo PK, et al (2000). Environmental and heritable factors in the causation of cancer--analyses of cohorts of twins from Sweden, Denmark, and Finland. N Engl J Med, 343, 78-85. https://doi.org/10.1056/NEJM200007133430201
  30. Liu Y, Lin XF, Lin CJ, et al (2012). Transforming growth factor beta-1 C-509T polymorphism and cancer risk: a metaanalysis of 55 case-control studies. Asian Pac J Cancer Prev, 13, 4683-8. https://doi.org/10.7314/APJCP.2012.13.9.4683
  31. Ma X, Chen C, Xiong H, et al (2010). Transforming growth factorbeta1 L10P variant plays an active role on the breast cancer susceptibility in Caucasian: evidence from 10,392 cases and 11,697 controls. Breast Cancer Res Treat, 124, 453-7. https://doi.org/10.1007/s10549-010-0843-x
  32. Mantel N, Haenszel W (1959). Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst, 22, 719-48.
  33. Massague J (2008). TGFbeta in Cancer. Cell, 134, 215-30. https://doi.org/10.1016/j.cell.2008.07.001
  34. Pardali K, Moustakas A (2007). Actions of TGF-beta as tumor suppressor and pro-metastatic factor in human cancer. Biochim Biophys Acta, 1775, 21-62.
  35. Pooja S, Francis A, Rajender S, et al (2013). Strong impact of TGF-beta1 gene polymorphisms on breast cancer risk in Indian women: a case-control and population-based study. PLoS One, 8, 75979. https://doi.org/10.1371/journal.pone.0075979
  36. Qi X, Zhang F, Yang X, et al (2010). Transforming growth factor-beta1 polymorphisms and breast cancer risk: a metaanalysis based on 27 case-control studies. Breast Cancer Res Treat, 122, 273-9. https://doi.org/10.1007/s10549-010-0847-6
  37. Qiu LX, Yao L, Mao C, et al (2010). TGFB1 L10P polymorphism is associated with breast cancer susceptibility: evidence from a meta-analysis involving 47,817 subjects. Breast Cancer Res Treat, 123, 563-7. https://doi.org/10.1007/s10549-010-0781-7
  38. Quarmby S, Fakhoury H, Levine E, et al (2003). Association of transforming growth factor beta-1 single nucleotide polymorphisms with radiation-induced damage to normal tissues in breast cancer patients. Int J Radiat Biol, 79, 137-43. https://doi.org/10.1080/713865032
  39. Rajkumar T, Samson M, Rama R, et al (2008). TGFbeta1 (Leu10Pro), p53 (Arg72Pro) can predict for increased risk for breast cancer in south Indian women and TGFbeta1 Pro (Leu10Pro) allele predicts response to neo-adjuvant chemoradiotherapy. Breast Cancer Res Treat, 112, 81-7. https://doi.org/10.1007/s10549-007-9821-3
  40. Roberts AB, Wakefield LM (2003). The two faces of transforming growth factor beta in carcinogenesis. Proc Natl Acad Sci USA, 100, 8621-3. https://doi.org/10.1073/pnas.1633291100
  41. Saha A, Gupta V, Bairwa NK, et al (2004). Transforming growth factor-beta1 genotype in sporadic breast cancer patients from India: status of enhancer, promoter, 5'-untranslated-region and exon-1 polymorphisms. Eur J Immunogenet, 31, 37-42. https://doi.org/10.1111/j.1365-2370.2004.00442.x
  42. Scola L, Vaglica M, Crivello A, et al (2006). Cytokine gene polymorphisms and breast cancer susceptibility. Ann N Y Acad Sci, 1089, 104-9. https://doi.org/10.1196/annals.1386.017
  43. Shi HZ, Ren P, Lu QJ, et al (2012). Association between EGF, TGF-beta1 and TNF-alpha gene polymorphisms and hepatocellular carcinoma. Asian Pac J Cancer Prev, 13, 6217-20. https://doi.org/10.7314/APJCP.2012.13.12.6217
  44. Shin A, Shu XO, Cai Q, et al (2005). Genetic polymorphisms of the transforming growth factor-beta1 gene and breast cancer risk: a possible dual role at different cancer stages. Cancer Epidemiol Biomarkers Prev, 14, 1567-70. https://doi.org/10.1158/1055-9965.EPI-05-0078
  45. Shu XO, Gao YT, Cai Q, et al (2004). Genetic polymorphisms in the TGF-beta 1 gene and breast cancer survival: a report from the Shanghai Breast Cancer Study. Cancer Res, 64, 836-9. https://doi.org/10.1158/0008-5472.CAN-03-3492
  46. Vishnoi M, Pandey SN, Modi DR, et al (2008). Genetic susceptibility of epidermal growth factor +61A>G and transforming growth factor beta1 -509C>T gene polymorphisms with gallbladder cancer. Hum Immunol, 69, 360-7. https://doi.org/10.1016/j.humimm.2008.04.004
  47. Watanabe Y, Kinoshita A, Yamada T, et al (2002). A catalog of 106 single-nucleotide polymorphisms (SNPs) and 11 other types of variations in genes for transforming growth factor-beta1 (TGF-beta1) and its signaling pathway. J Hum Genet, 47, 478-83. https://doi.org/10.1007/s100380200069
  48. Wei YS, Zhu YH, Du B, et al (2007). Association of transforming growth factor-beta1 gene polymorphisms with genetic susceptibility to nasopharyngeal carcinoma. Clin Chim Acta, 380, 165-9. https://doi.org/10.1016/j.cca.2007.02.008
  49. Wu R, Li B (1999). A multiplicative-epistatic model for analyzing interspecific differences in outcrossing species. Biometrics, 55, 355-65. https://doi.org/10.1111/j.0006-341X.1999.00355.x
  50. Yamada Y (2001). Association of polymorphisms of the transforming growth factor-beta1 gene with genetic susceptibility to osteoporosis. Pharmacogenetics, 11, 765-71. https://doi.org/10.1097/00008571-200112000-00004
  51. Zhang Y, Liu B, Jin M, et al (2009). Genetic polymorphisms of transforming growth factor-beta1 and its receptors and colorectal cancer susceptibility: a population-based casecontrol study in China. Cancer Lett, 275, 102-8. https://doi.org/10.1016/j.canlet.2008.10.017
  52. Zheng W (2009). Genetic polymorphisms in the transforming growth factor-beta signaling pathways and breast cancer risk and survival. Methods Mol Biol, 472, 265-77. https://doi.org/10.1007/978-1-60327-492-0_11
  53. Ziv E, Cauley J, Morin PA, et al (2001). Association between the T29-->C polymorphism in the transforming growth factor beta1 gene and breast cancer among elderly white women: The Study of Osteoporotic Fractures. JAMA, 285, 2859-63. https://doi.org/10.1001/jama.285.22.2859

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