• Asian Pacific Journal of Cancer Prevention
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• v.15 no.5
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• pp.2335-2340
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• 2014

Paclitaxel is hydrophobic in nature and is recognized as a highly toxic anticancer drug, showing adverse effects in normal body sites. In this study, we developed a polymeric nano drug carrier for safe delivery of the paclitaxel to the cancer that releases the drug in a sustained manner and reduces side effects. N-isopropylacrylamide/vinyl pyrrolidone (NIPAAm/VP) nanoparticles were synthesized by radical polymerization. Physicochemical characterization of the polymeric nanoparticles was conducted using dynamic light scattering, transmission electron microscopy, scanning electron microscopy and nuclear magnetic resonance, which confirmedpolymerization of formulated nanoparticles. Drug release was assessed using a spectrophotometer and cell viability assays were carried out on the MCF-7 breast cancer and B16F0 skin cancer cell lines. NIPAAm/VP nanoparticles demonstrated a size distribution in the 65-108 nm range and surface charge measured -15.4 mV. SEM showed the nanoparticles to be spherical in shape with a slow drug release of ~70% in PBS at $38^{\circ}C$ over 96 h. Drug loaded nanoparticles were associated with increased viability of MCF-7 and B16F0 cells in comparison to free paclitaxel. Nano loaded paclitaxel shows high therapeutic efficiency by sustained release action for the longer period of time, i increasing its efficacy and biocompatibility for human cancer therapy. Therefore, paclitaxel loaded (NIPAAm/VP) nanoparticles may provide opportunities to expand delivery of the drug for clinical selection.

• Analytical Science and Technology
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• v.15 no.2
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• pp.120-126
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• 2002

The analytical performance of four commercially-available pneumatic nebulizers(Meinhard, Cross-flow, Babington, ESI PFA) was evaluated using inductively coupled plasma-atomic emission spectrometry (ICP-AES) and ICP-mass spectrometry (ICP-MS) instruments. The performance of an inert concentric nebulizer and a modified conespray nebulizer, made in Korea Research Institute of Standards and Science (KRISS), is compared with that of the four commercial nebulizers. Variation of sample introduction efficiency was investigated as carrier argon pressure and sample uptake rate were changed. Variation of sensitivity, signal stability, blank intensity and oxide/hydride ratios were also studied when the nebulizers were connected to the ICP-MS and ICP-AES instruments. It was found that good analytical result such as high sensitivity, low blank, stable signal and so on can be obtained with judicious selection of the nebulizer depending on the type of sample, sample amount, type of analytical instrument and analyte.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.34 no.11C
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• pp.1076-1084
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• 2009

We propose an ATI (Adaptive Tone Injection) scheme based on clipping noise for PAPR (Peak-to-Average Power Ratio) reduction of OFDM (Orthogonal Frequency Division Multiplexing) signals. The proposed scheme is composed of three steps: clipping, tone selection, and TI procedures. In the first step, the peak samples in the IFFT (Inverse Fast Fourier Transform) outputs are scaled down by clipping. In the second step, the sub-carrier position where the power of the clipping noise is the maximum, is selected. Finally, the generic TI procedure is performed. Simulation results show that the proposed scheme does not require all the possible combinations of the original TI procedures, while maintaining the PAPR reduction performance.

• Journal of the Korea Society of Computer and Information
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• v.15 no.3
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• pp.55-63
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• 2010

On Handoff, existing AP search has chosen one of various APs according to signal strength. However IEEE 802.11 uses Medium Access method with CSMA/CA(Carrier Sensing Multiple Access /Collision Avoidance) that competes to obtain a channel by sharing common medium. For that reason, network performance is heavily affected by the number of nodes and network congestion aside from signal strength. Consequently, in this paper we propose the method that choose one AP which ensures more improved network performance and set up a link, reflecting AP network information in Handoff area, on Handoff in the process of AP selection. We also demonstrate through simulation that it gets maximum performance even in the wireless network which many users concurrently access to, and it has considerable effects on aspects of resources and network management by distribution of users.

• Journal of Microbiology and Biotechnology
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• v.25 no.4
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• pp.511-520
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• 2015

Triclosan, the widely used biocide, specifically targets enoyl-acyl carrier protein reductase (ENR) in the bacterial fatty acid synthesis system. Although the fish pathogen Aeromonas salmonicida subsp. salmonicida exhibits triclosan resistance, the nature of this resistance has not been elucidated. Here, we aimed to characterize the triclosan resistance of A. salmonicida subsp. salmonicida causing furunculosis. The fosmid library of triclosan-resistant A. salmonicida subsp. salmonicida was constructed to select a fosmid clone showing triclosan resistance. With the fosmid clone showing triclosan resistance, a subsequent secondary library search resulted in the selection of subclone pTSR-1. DNA sequence analysis of pTSR-1 revealed the presence of a chromosomal-borne fabV-encoding ENR homolog. The ENR of A. salmonicida (FabVas) exhibited significant homology with previously known FabV, including the catalytic domain YX₍₈₎K. fabVas introduction into E. coli dramatically increased its resistance to triclosan. Heterologous expression of FabVas might functionally replace the triclosan-sensitive FabI in vivo to confer E. coli with triclosan resistance. A genome-wide search for fabVas homologs revealed the presence of an additional fabV gene (fabVas2) paralog in A. salmonicida strains and the fabVas orthologs from other gram-negative fish pathogens. Both of the potential FabV ENRs expressed similarly with or without triclosan supplement. This is the first report about the presence of two potential FabV ENRs in a single pathogenic bacterium. Our result suggests that triclosan-resistant ENRs are widely distributed in various bacteria in nature, and the wide use of this biocide can spread these triclosan-tolerant ENRs among fish pathogens and other pathogenic bacteria.

• The Transactions of the Korean Institute of Power Electronics
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• v.20 no.5
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• pp.456-463
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• 2015

Nowadays, small quantity batch production, which is so-called a flexible manufacturing system, is a major trend in the modern factory automation industry. The demands for new transportation system are increased gradually, with which multiple passive carriers carrying materials and semi-products are precisely and individually controlled along a single closed rail. Thus, a new type of permanent magnet linear synchronous motor (PMLSM), which consists of state coils on a single rail and PM movers as many as carriers, is proposed in this paper. The rail can be segmented as modules with pairs of coils and a current amplifier, which makes the transportation system simple; therefore, the rail can be easily extended and repaired. A design method of the new PMLSM with a single carrier is proposed, which can be thought as a new version of PMLSM, a coil-segmented coreless PMLSM (CS-CLPMLSM). Experimental setup for it is made, and propulsion results show that with the help of a new effective coil selection and switching algorithms, the conventional current-based vector control is sufficient to fulfill the position and velocity control of the new PMLSM. The proposed PMLSM is expected to fulfill seamless servo-control of multiple carriers also in process line, such as a new generation of flat panel display manufacturing line.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.32 no.11B
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• pp.700-708
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• 2007

This paper considers an incentive regulation in the telecommunications industry with respect to the sale of retail and access services. This regulation scheme induces the monopoly carrier who owns bottleneck facilities to adopt socially optimal outcomes when providing access and retail services. It is well known that upstream carriers can realize an integrated level of profit, without integration, by means of a two-part tariff. First, this paper introduces a framework for regulating an access and retail price combined with budget balancing. Second, this paper introduces two-part tariff (price discrimination) scheme for both access (upstream) and retail (downstream) services and discusses the resulting implications for incentive regulation when the regulator has incomplete information about cost functions. By imposing a self-selection mechanism, the regulator can induce firms to adopt socially optimal prices in both access and retail markets.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.11 no.8
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• pp.1465-1471
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• 2007

The electro-magnetic wave propagates through the air in the terrestrial communications, but the acoustic wave propagates through the seawater in the underwater acoustic communication(UAC). It makes the differences between the UAC link and the well hon air communication links. In this paper, we have studied path loss, absorption and ambient noise of the ocean as a medium for UAC. We have analyzed the absorption coefficient and ambient noise level of the coastal area of South Korea and suggested a strategy for the selection of the frequency band by considering the absorption coefficient and ambient noise level. Also, we present an illustrative example of a link budget for the QPSK UAC system which has carrier frequency 25kHz, bit rate 10kbps, range 1km and BER $10^{-3}$ in the shallow water environment with an ideal AWGN assumption.

• Asian-Australasian Journal of Animal Sciences
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• v.31 no.12
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• pp.1852-1862
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• 2018

Objective: The purpose of this study was to investigate a single step genome-wide association study (ssGWAS) for identifying genomic regions affecting reproductive traits in Landrace and Large White pigs. Methods: The traits included the number of pigs weaned per sow per year (PWSY), the number of litters per sow per year (LSY), pigs weaned per litters (PWL), born alive per litters (BAL), non-productive day (NPD) and wean to conception interval per litters (W2CL). A total of 321 animals (140 Landrace and 181 Large White pigs) were genotyped with the Illumina Porcine SNP 60k BeadChip, containing 61,177 single nucleotide polymorphisms (SNPs), while multiple traits single-step genomic BLUP method was used to calculate variances of 5 SNP windows for 11,048 Landrace and 13,985 Large White data records. Results: The outcome of ssGWAS on the reproductive traits identified twenty-five and twenty-two SNPs associated with reproductive traits in Landrace and Large White, respectively. Three known genes were identified to be candidate genes in Landrace pigs including retinol binding protein 7, and ubiquitination factor E4B genes for PWL, BAL, W2CL, and PWSY and one gene, solute carrier organic anion transporter family member 6A1, for LSY and NPD. Meanwhile, five genes were identified to be candidate genes in Large White, two of which, aldehyde dehydrogenase 1 family member A3 and leucine rich repeat kinase 1, associated with all of six reproduction traits and three genes; retrotransposon Gag like 4, transient receptor potential cation channel subfamily C member 5, and LHFPL tetraspan subfamily member 1 for five traits except W2CL. Conclusion: The genomic regions identified in this study provided a start-up point for marker assisted selection and estimating genomic breeding values for improving reproductive traits in commercial pig populations.

• The Journal of the Korea institute of electronic communication sciences
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• v.14 no.5
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• pp.817-824
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• 2019

We propose an ATR (Adaptive Tone Reservation) scheme based on clipping noise for PAPR (Peak-to-Average Power Ratio) reduction of OFDM (Orthogonal Frequency Division Multiplexing) signals. The proposed scheme is composed of three steps: clipping, tone selection, and TR procedures. In the first step, the peak samples in the IFFT (Inverse Fast Fourier Transform) outputs are scaled down by clipping. In the second step, the sub-carrier position where the power of the clipping noise is the maximum, is selected. Finally, the generic TR procedure is performed. Simulation results show that the proposed scheme does not require all the possible combinations for the original TR procedures, while maintaining the PAPR reduction performance.