• 대한한방내과학회지
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• 제33권2호
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• pp.126-144
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• 2012

Background : Peripheral nerves more rapidly recover than central nerves. However, it has been known that the degree of reaction of axons of peripheral nerves is affected by distinctive characteristics of axons and environmental factors near the axons. Taxol is a widely used medicine as for ovarian, breast, lung and gastric cancer. However it causes patients difficulties under treatment due to its toxic and side effects, which include persistent pain. Objectives : This study reviewed how SJT extract in vitro and in vivo affects nerve tissues of a sciatic nerve damaged by Taxol. It also studied how SJT extract in vivo affects axons of the sciatic nerve after the sciatic nerve was damaged by pressing. Methods : After vehicle, Taxol, and Taxol plus SJT were treated respectively for tissue of the sciatic nerve in vitro and then tissues were observed using Neurofilament 200, Hoechst, ${\beta}$-tubulin, $S100{\beta}$, caspase-3 and anti-cdc2. SJT was also oral medicated by injecting Taxol into the sciatic nerve of in vivo rats. Tissues of the sciatic nerve and axons of DRG sensory nerves were then observed using Neurofilament 200, Hoechst, ${\beta}$-tubulin, $S100{\beta}$, caspase-3 and p-Erk1/2. After inflicting pressing damage to the sciatic nerve of in vivo rats, tissues of the sciatic nerve and DRG sensory nerve were observed using Neurofilament 200, Hoechst, $S100{\beta}$, caspase-3, anti-cdc2, phospho-vimentin, ${\beta}1$-integrin, Dil reverse tracking and p-Erk1/2. Results : The group of in vitro Taxol plus SJT treatment had meaningful effects after sciatic nerve tissue was damaged by Taxol. The group of in vivo SJT treatment had effects of regenerating Schwann cells and axons which were damaged by Taxol treatment. The group of in vivo SJT had effects of regenerating axons in damaged areas after the sciatic nerve was damaged by pressing, and also had variations of distribution in Schwann cells at DRG sensory nerves and axons. Conclusions : This study confirmed that SJT treatment is effective for growth of axons in the sciatic nerve tissues and improvement of Schwann cells after axons of the sciatic nerve tissues was damaged. After tissues of sciatic nerve was damaged by pressing in vivo, SJT treatment had effects on promoting regeneration of axon in the damaged area and reactional capabilities in axons of DRG sensory nerves.

• 대한두경부종양학회지
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• 제18권1호
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• pp.36-40
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• 2002

Background and Objectives: To determine if laser endoscopic microsurgery is a reliable and appropriate approach in the treatment of laryngeal carcinomas. Materials and Methods: Retrospective study of 62 patients treated with CO2 laser from June 1988 to November 2000 at Seoul National University Hospital for laryngeal squamous cell carcinoma. All patients were treated with curative intention. Fifty three untreated patients with laryngeal carcinoma (39 glottic and 14 supraglottic carcinoma patients) had primary carbon dioxide laser microsurgery. Nine radiation failure patients were treated. Postoperative radiotheray was done for 17 patients. Neck dissection was performed simultaneously for 4 supraglottic cases with cervical nodal metastasis. Mean follow-up duration was 40 months. Results: In primary laser surgery group, distribution of tumors (American Joint Committee on Cancer, 1997) were 38 cases with Tl, 13 cases with T2, 2 cases with T3. Cure rate was 88.7%(47/53) and local control rate was 92.5%(49/53). Larynx was preserved in 94%(50/53) of patients. The overall 5-year survival rate(Kaplan-Meier) was 81.5%. In radiation failure group, 56% of patients were recurred after laser surgery. Conclusion: Laser surgery could be a better treatment modality for early laryngeal cancers and selected advanced cases. Additional radiation therapy should be considered if resection margin is not satisfactory.

• 대한한방내과학회지
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• 제40권6호
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• pp.1122-1135
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• 2019

Purpose: The purpose of this study was to conduct a clinical analysis of patients treated for dizziness with Jeoreongchajeonja-tang, evaluate the effect of Jeoreongchajeonja-tang administration, and present indications of Jeoreongchajeonja-tang in dizziness. Methods: A retrospective study was conducted on 63 patients who were admitted to the Oriental Hospital of Se-Myung University from August 2012 to June 2019, complaining of dizziness, so who took Jeoreongchajeonja-tang. Results: 1) As a result of the analysis of the general characteristics of patients who took Jeoreongchajeonja-tang with dizziness, women were 2.7 times more than men. The age distribution was: patients in their 70s, 36.5%; in their 50s, 20.6%; in their 60s, 15.8%; and in their 80s, 12.6%. Patients had a history of hypertension (46.0%), diabetes (22.2%), stroke (17.4%), lung disease (12.6%), and cancer (11.1%). According to the diagnosis, 48 patients (76.1%) were assigned to the peripheral dizziness group, 7 patients (11.1%) to the central dizziness group, and 8 patients (12.6%) to other dizziness groups. 2) Compared with the peripheral dizziness group, the central dizziness group was older, their history of hypertension 8.4 times greater, their history of stroke 7.8 times greater, and the duration of herbal medicine administration was longer. 3) The vertigo grade was significantly decreased after taking Jeoreongchajeonja-tang (p=0.000). 4) As age increased by one year, odds ratio of improvement in the vertigo grade decreased by 0.924 times after taking Jeoreongchajeonja-tang (p=0.010). 5) Sex, disease duration, past history, diagnosis, the duration of herbal medicine administration, whether or not Yanggyuksanhwa-tang was combined with the Jeoreongchajeonja-tang and whether or not Western medicine was used did not affect improvement in the vertigo grade after taking Jeoreongchajeonja-tang. Conclusions: In patients with dizziness, Jeoreongchajeonja-tang can be used as a treatment without side effects.

• Radiation Oncology Journal
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• 제6권1호
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• pp.93-99
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• 1988

최근에 선형가속기에 대한 제작기술의 발달로 하나의 기계에서 두 가지 X-선이 생성된다. 이러한 기계적 특성을 충분히 이용할 수 있도록 임상적으로 어떠한 장점이 있는지 아는 것은 매우 중요하다. 특히 SAD 방법으로 치료 시 다른 에너지를 사용하여야 될 경우 환자를 다른 에너지가 있는 치료실로 이동시키지 않아도 되는 장점이 있다. 저자는 직장암 환자 15예를 중심으로 6MV와 10MV X-선의 에너지를 복합적으로 사용하여 치료를 하였을 때 단일에너지인 6MV혹은 10MV X-선을 이용했을 때와 등량곡선의 분포도 및 선량률의 차이를 비교하였다. 선량 계산은 치료계획용 Mevaplan 콤퓨터를 이용하였다. 정상조직에 들어가는 방사선량의 차이를 계산하기 위해 방광 및 우측 대퇴부를 임의의 점으로 잡아 콤퓨터에 입력시켜 그 부위의 최대선량 최소선량 및 평균선량을 구하였다. 6MV 및 10MV의 이중에너지 X-선을 이용하였을 때 6MV 단일 에너지 X-선으로 치료시 보다 방광의 평균 방사선량은 $8.1\%$ 감소하였고 방광 평균 방사선량 즉 소장과 근접해 있는 부위는 $7.4\%$의 감소를 보였다. 최대선량치 Dmax는 $1.25\%$감소하였다. 대퇴부위의 평균 방사선량은 $2\%$ 감소하였다. 이중에너지 X-선 치료는 10MV단일에너지와 비교하여 방광의 평균 방사선량은 $8.5\%$ 감소하였고, 소장근접 부위는 $11.8\%$ 감소하였다. 최대선량치 Dmax는 $0.8\%$의 증가로 거의 차이가 없었다. 대퇴부위 방사선량은 $0.8\%$증가로 비슷하였다. 그외 회음부 및 전골전방 부위는 전방조사야에 10MV 대신 6MV를 씀으로써 피부 sparing 효과를 줄여주어 충분한 방사선량을 줄 수 있었다. 위의 결과로 이중에너지 X-선 치료는 정상조직의 손상은 같게 주며 종양부위의 방사선량을 $7\~12\%$정도 올려줄 수 있는 장점이 있음을 알 수 있었다.

• Journal of Nutrition and Health
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• 제33권2호
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• pp.202-215
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• 2000

Intake frequency of one food is often associated with other food items, but few studies examined the relationship of food intake frequency among food items. Finding the relationship among intake frequencies of different food might be useful to understand the food intake patterns of population and correlated foods would be used as an indicators of another food intake. Relationship of food intake can be also applied to make a more simple and useful form of food frequency questionnaire to assess the association between diet and various diseases. The objective of this study was to examine the correlation of intake frequency among food items in food frequency questionnaire (FFQ). A FFQ with 84 food items was administered to 14533 Korean males who 40-65 years of age participating Korean cancer research survey. Data fromm 7647 subjects who completed FFQ were used to examine correlation among food items with three different methods-log linear regression models, Spearman correlation coefficients and cell frequency distribution. To examine the rank correlation, coefficients were calculated by Spearman correlation after scoring the frequency categories. Three most correlated foods were selected in every food intems by three methods each. In most food items, there was positive correlatin, except cooked rice and cooked brown rice, in intake frequency between foods that belonged to similar food groups. But serveral food items-Sausage (processed fish, cheese), Milk (whilte bread, orange juice), Soymilk(other juices), Cheese (pizza, butter), and Coffee(thick beef soup)-showed correlation among totally different food groups. Two sets of food items which were selected by log linear regression model and Sperman correlation coefficients were compared. There were exactly three common foods in 18 food items, 2 common foods in 47 items, 1 common food in 16 items and no common food in 3 items among 3 ranked foods. Three sets of selected food were compared. There were exactly three common foods in 5 food items, 2 common foods in 21 items, 1 common food in 34items and no common food in 24 items among 3 ranked foods. These results indicate that certain patterns exist among intake frequencies of specific food items in the FFQ. More researches are suggested to understand the relationshiops among the intakes of foods so that this information can be used in developing better FFQ or analyzing missing items from self-administered FFQ.

• 대한의용생체공학회:의공학회지
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• 제23권3호
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• pp.197-205
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• 2002

본 연구에서는 잡음이 존재하는 공간에서 획득한 음성신호로부터 후두질환을 감별진단 할 수 있는 분류기를 구현하였다. 이를 위해 후두질환 환자로부터 수집한 /아/ 모음에 잡음을 혼입하여 음성 신호를 획득하였고, 여러 가지 후두질환을 감별진단 할 수 있는 파라미터를 추출하였으며. 이를 입력으로 하는 계층적 신경회로망을 구성하여 후두질환을 감별진단 하도록 하였다. 감별진단용 분류기는 다섯 단계의 계층적 신경회로망으로 구성하였다 첫 번째 신경회로망은 정상 양성 후두질환과 악성 후두질환을. 두 번째 신경회로망은 정상과 양성 후두질환을 감별진단 하도록 하였다 그리고 세 번째 신경회로망은 양성 후두질환 중 후두용. 성대결절 후두마비를 감별진단 하도록 하였으며. 네 번째와 다섯 번째 신경회로망은 성문암 1-4기를 감별진단 하도록 구성하였다. 분류기에 적용된 신경회로망은 다층퍼셉트론 구조로써 역전파 알고리듬으로 학습시켰으며, 선형변환 표준점수변환 등 전처리과정을 적용하여 분류기의 성능을 개선하였다. 후두질환의 감별진단 결과 후두용 88.23%. 정상. 성대결절. 후두마비 100%. 성문암 1기 90%, 성문암 2-4기 100%의 감별진단율을 관찰할 수 있었다.

• 한국방사선학회논문지
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• 제12권2호
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• pp.209-216
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• 2018

혈관조영 및 중재적 방사선학 분야의 경우, 업무 특성상 눈의 방사선 피폭에 대한 위험성이 높다고 알려져 있으나, 현재 구분된 선량평가 및 관리가 이루어지지 않는 실정이다. 이에 본 연구에서는 시술 환경 내 종사자의 눈에 대한 선량평가 및 차폐분석을 위해 첫 번째로, 시술자가 주로 위치하는 지점을 선정하고, 두경부 팬텀 눈의 외안각 지점에 포켓선량계를 부착한 뒤 눈에 대한 피폭선량을 평가하였고, 현재 상용화된 납 안경 착용 시 차폐효과를 산정하였다. 두 번째로, 실측과 동일한 기하학적 구조 내 모의실험을 통해 눈의 피폭선량에 대한 경향성 평가와 차폐효과에 대해 분석하였다. 그 결과, 선량계를 이용한 측정의 경우, 방사선 투시촬영 시간이 증가함에 따라 누적선량이 증가하였고, 또한 시술자의 위치에 따라 각기 다른 양상을 보였다. 모의실험의 경우, 수학적 팬텀 내 눈의 수정체의 경우 각막보다 약 1.1 ~ 1.3배 높은 선량분포를 나타내는 것을 확인하였고, 납 안경의 방호효과는 눈의 각 기관별로 최소 3.7 ~ 최대 21.4% 차폐효과를 보였다.

• 대한핵의학회지
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• 제26권2호
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• pp.371-379
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• 1992

악성종양의 진단 및 치료에 있어서 특정 종양에 대한 항체를 이용하는 연구가 활발히 진행되고 있다. 단세포군항체를 이용한 방사면역신티그라피로 암의 조기 진단 및 영상화가 가능하고 나아가 방사면역치료는 암의 선택적 치료에 도움이 될 수 있다. 위암은 우리나라에서 가장 흔한 악성종양으로 방사면역신티그라피와 방사면역치료법이 새로운 방법으로 모색되고 있다. 이러한 진단 및 치료법의 성공여부를 결정하는 중요한 인자의 하나가 종양조직내에서 종양관련 항원의 농도와 분포이다. 따라서 본 연구에서는 단세포군 항체를 이용한 방사면역학적 방법의 임상 이용을 위한 기초 연구의 일환으로 in vitro quantitative autoradiography를 이용하여 종양 관련항원인 TAG-72와 CEA의 위암조직내 농도 및 분포를 측정하였다. 33예의 위암조직에서 얻은 동결절편을 $1.3\sim83.3$ nmol/liter의 $^{125}I$ 표지 항 TAG-72 단세포군 항체 B-72.3과 항 CEA 단세포군 항체 CEA-79로 반응시킨 후 이 표본들의 자가방사법 디지탈 영상을 H & E 염색과 immunoperoxidase염색 표본과 비교하였으며, 특정 단세포군 항체의 결합에 대한 컴퓨터 분석으로 조직내 항원의 농도와 분포를 측정하였다. TAG-72는 25예(75.7%)의 조직에서 검출되었으며 그 농도는 $8.4\sim525.3$ pmol/gram이었고, CEA는 32예 (96.9%)에서 검출되었으며 그 농도는 $8.8\sim592.9$ pmol/gram 이었다. CEA의 위암 조직내 발현농도는 중앙치가 101.7 pmol/gram 으로 TAG-72의 중앙치인 27.9 pmol/gram 보다 높았다. TAG-72의 조직내 분포는 41.4%에서 병변 부위의 암세포 분포와 일치하였고, CEA의 분포는 병변 부위의 80.5%에서 암세포와 일치하는 소견을 나타내었다. TAG-72의 농도는 점액성 선종(mucinous adenocarcinoma)과 점액함유 선종(mucin containing adenocarcinoma)에서 다른 선종보다 더 높았다. CEA의 농도는 위암의 병리학적 종류에 따른 유의한 차이가 없었다. 이상의 결과로 위암조직에서 TAG-72와 CEA항원이 다양하게 발현됨을 알 수 있었고 CEA는 TAG-72 보다 더 빈번하게 균일한 분포로 발현하는 것으로 나타났다.

• Journal of Preventive Medicine and Public Health
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• 제38권1호
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• pp.107-116
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• 2005

Objectives : We analyzed the changes from 1996 to 2002 in distributive equity of the contribution burden in the Korean National Health Insurance. Methods : The study subjects were a total of 8,923 employee households and a total of 7,296 self-employed households over the period from 1996 to 2002. Those were the households meeting the two criteria as completing each annual survey and having no change in the job of head of the household during that period from the raw data of the Household Income and Expenditure Survey annually conducted by the Korean National Statistical Office. The unit of analysis was a household, and this was the standard for assessing the contribution that is now applied on a monthly basis. Deciles Distribution Ratio, Contribution Concentration Curve and Contribution Concentration Index were estimated as the index of inequality. Multiple regression analysis was conducted to compare the annual ability-to-pay elasticity of the contribution to the reference year of 1996 for three groups (all households, the employee households, and the self-employed households). Results : For the index of inequality, the distributive equity of contribution was improved in all three groups. In particular, the employee group experienced a substantial improvement. Using multiple regression analysis, the ability-to-pay elasticity of the contribution in the employee group significantly increased ($\beta$=0.232, p<0.0001) in the year 2002 as compared to the reference year of 1996. The elasticity in the self-employed group also significantly increased ($\beta$=0.186, p<0.05), although its change was smaller than that in the employee group. Conclusions : The employee group had a greater improvement for the distributive equity of the contribution burden than the self-employed group. Within the observation period, there were two important integration reforms: one was the integration of 227 self-employed societies in 1998 and the other was the integration of 139 employee societies in 2000. We expected that the equity of the contribution burden would be improved for the self-employed group since the integration reform of 1998. However, it was not improved for the self-employed group until the year 2000. This result suggests that capturing exactly the beneficiaries' ability-to-pay such as income is the precedent for distributive equity of the contribution burden, although a more sophisticated imposition standard of contribution is needed.

• International Journal of Automotive Technology
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• 제4권2호
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• pp.77-86
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• 2003

How to compare the environmental damage caused by vehicles with different foe]s and drive trains\ulcorner This paper describes a methodology to assess the environmental impact of vehicles, using different approaches, and evaluating their benefits and limitations. Rating systems are analysed as tools to compare the environmental impact of vehicles, allowing decision makers to dedicate their financial and non-financial policies and support measures in function of the ecological damage. The paper is based on the "Clean Vehicles" research project, commissioned by the Brussels Capital Region via the BIM-IBGE (Brussels Institute for the Conservation of the Environment) (Van Mierlo et at., 2001). The VriJe Universiteit Brussel (ETEC) and the universite Libre do Bruxelles (CEESE) have jointly carried out the workprogramme. The most important results of this project are illustrated in this paper. First an overview of environmental, economical and technical characteristics of the different alternative fuels and drive trains is given. Afterward the basic principles to identify the environmental impact of cars are described. An outline of the considered emissions and their environmental impact leads to the definition of the calculation method, named Ecoscore. A rather simple and pragmatic approach would be stating that all alternative fuelled vehicles (LPG, CNG, EV, HEV, etc.) can be considered as ′clean′. Another basic approach is considering as ′clean′ all vehicles satisfying a stringent omission regulation like EURO IV or EEV. Such approaches however don′t tell anything about the real environmental damage of the vehicles. In the paper we describe "how should the environmental impact of vehicles be defined\ulcorner", including parameters affecting the emissions of vehicles and their influence on human beings and on the environment and "how could it be defined \ulcorner", taking into account the availability of accurate and reliable data. We take into account different damages (acid rain, photochemical air pollution, global warming. noise, etc.) and their impacts on several receptors like human beings (e.g., cancer, respiratory diseases, etc), ecosystems, or buildings. The presented methodology is based on a kind of Life Cycle Assessment (LCA) in which the contribution of all emissions to a certain damage are considered (e.g. using Exposure-Response damage function). The emissions will include oil extraction, transportation refinery, electricity production, distribution, (Well-to-Wheel approach), as well as the emission due to the production, use and dismantling of the vehicle (Cradle-to-Grave approach). The different damages will be normalized to be able to make a comparison. Hence a reference value (determined by the reference vehicle chosen) will be defined as a target value (the normalized value will thus measure a kind of Distance to Target). The contribution of the different normalized damages to a single value "Ecoscore" will be based on a panel weighting method. Some examples of the calculation of the Ecoscore for different alternative fuels and drive trains will be calculated as an illustration of the methodology.