• Journal of Applied Biological Chemistry
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• v.64 no.4
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• pp.383-389
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• 2021

Obesity is associated with impaired intestinal epithelial barrier function, which contribute to host systemic inflammation and metabolic dysfunction. Korean traditional foods, fiber-rich bean products, have been various biological activities in anti-inflammatory responses, but has not reported the large intestinal health. In this study, we investigated the intestinal health promoting effect of cooked soybeans (CSB) on high fat diet (HFD)-induced obesity model. SD rat were fed either a HFD or HFD supplemented with 10.6% CSB (HFD+CSB) for animal experimental period. CSB treatment significantly decreased the HFD-induced weights of body and fat. Also, CSB treatment improved HFD-reduced tight junction components (ZO-1, Claudin-1, and Occludin-1) mRNA expression in large intestine tissue. Additionally, histopathological evaluation showed that CSB treatment attenuated the HFD-increased inflammatory cells infiltration and epithelial damages in large intestine tissue. At the genus level, effects of CSB supplement not yet clear, while dietary effects showed differential abundance of several genera including Lactobacillus, Duncaniella, and Alloprevotella. NMDS analysis showed significant microbial shifts by HFD, while CSB did not shift gut microbiota. CSB increased the abundance of the genera Anaerotignum, Enterococcus, Clostridium sensu stricto, and Escherichia/Shigella by linear discriminant analysis effect size analysis, while reduced the abundance of Longicatena and Ligilactobacillus. These findings indicate that CSB supplement improves HFD-deteriorated large intestinal health by the amelioration of tight junction component, while CSB did not shift gut microbiotas.

• Journal of the Korea institute for structural maintenance and inspection
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• v.27 no.2
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• pp.8-16
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• 2023

This study evaluated a shear capacity of confined socket-bolt (CSB) shear connector developed for utilizing cast in placed pile (CIP) as a permanent underground wall. The push-out tests were performed in the specimens with different CIP types, CSB shear connector types, L/d, and concrete compressive strengths of concrete pile, and with or without waterproofing at interfaces between CIP and underground wall. Test results showed that the specimens with a H-shaped pile were fractured in the CSB shear connector, while the fracture concentrated in the concrete part of the specimens with a reinforced concrete pile was alleviated as the compressive strength of the concrete pile increased, resulting in the severe fracture of CSB shear connector. The maximum shear capacities of the specimens with high strength bolts and reinforcing bars used as CSB shear connector were approximately 1.22 and 1.20 times higher than those of the specimens with a H-shaped pile, respectively, and 1.10 and 1.16 times higher than those of the specimens with a reinforced concrete pile, respectively. Meanwhile, the maximum shear capacity was not significantly affected by the embedding length of the CSB shear connector and overlapping length of reinforcing bar. The predicted shear capacities calculated from the KDS standards were lower than the measured values of all specimens tested in this study.

• Journal of Digital Convergence
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• v.13 no.2
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• pp.1-11
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• 2015

The growing company that provides high quality service to every customer by introducing a cloud-system organization. However, the information needs of diverse and different, so every cloud system, and acts as a barrier to entry for cloud services provide appropriate. Cloud services are becoming complicated and diversified depending on concerns about cloud security continues, the growing need of professionalism held by the cloud service(Cloud Service Brokerage) CSB companies. Thus, to analyze the various services, find my support legislation, security and compatibility issues, the services of the best new business through service offerings tailored to the environment, and will implement the necessary management services which brokerage (CSB) is. This study presents a brokerage(CSB) development model, and suggested policy measures that apply to the co-op that I am having difficulties in cloud services business models.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.19 no.2
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• pp.1-18
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• 2006

Objective : Although management of asthma has become increasingly effective, its cure remains elusive, necessitating a new modality to prevent or eliminate causes triggering clinical progress. Based in the clinical experiences, a novel decoration Cheongsangbiyeum (CSB), has been developed to treat asthma, which consists of Polyporus, Semen Myristicae, Pericarpium citri Reticulatae, Rhizoma Cimicifugae, Cortex Albizziae, Fructus Rubi, Rhizoma Zedoariae, and Rhizoma Rhei. In the current study, its anti-asthmatic efficacy was evaluated using a mouse model of asthma. Methods : Experimental allergic asthma was induced by repeated intraperitioneal sensitization and intranasal challenge of ovalbumin (OVA). Water extract of CSB (1 mg/mouse/day) was administrated orally whereas control mice on given with identical volume of phosphate-buffered saline (PBS) for 5 days during the course of antigen challenge. When airway hyperreactivity(AHR) measured by ${\bata}-methacoline-induced$ airflow obstruction was compared, AHR of CSB-treated mice was significantly lower than those of control mice, indicating that CM extract can attenuate an asthmatic symptom. Airway recruitment of leukocytes and eosinophils was also markedly reduced by CSB treatment suggesting that oral treatment of CSB can alleviate the airway inflammation. For a better understanding of possible mechanisms underlying anti-asthmatic effet of CSB, cytokine (IL-4, IL-5, IL-13 and $IFN{\gamma}$ levels in bronchoalveola lavage fluid (BALF) and lung tissues were determined. Results : The results showed that cytokine levels were significantly lowered by CSB treatment. Additionally, number of draining lymph node cells was significantly lower than those of control mice. These data indicate that CSB suppress in vivo allergen-specific response. However, notably, levels of type 2 cytokines such as IL-5 and IL-13 were more profoundly influenced. Moreover, in vitro OVA-specific proliferative response and type 2 cytokine (IL-4, IL-5 and IL-13) production lymph node cells was markedly decreased in CSB-treated mice, whereas their $IFN{\gamma}$ production was not significantly altered Thrse data clearly showed a preferential inhibition of type 2 T cell (Th2) response by CSB treatment. This finding was also supported by serum antibody data showing that levels of OVA-specific type 2 antibodies, IgE and IgG1, in CSB-treated mice were significantly lower than in control mice, while type 1 antibody, IgG2a level m rather higher than controls, although the difference was in significant. Conclusions : In conclusion, oral administration of CSB attenuates asthmatic manifestations including AHR ad airway recruitment of eosinophils in a mouse model which possibly results from selective inhibition of Th2 cell response to allergen. Our data suggest a potential clinical application of CSB for control of allergic asthma.

• The Plant Pathology Journal
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• v.27 no.1
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• pp.68-77
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• 2011

Fifty five species of medicinal plant materials were tested for their antifungal activity in vitro against Rhizoctonia solani AG 2-1 and Trichoderma harzianum to select plant species that can be used to improve the biocontrol efficacy of T. harzianum. Six species were effective against R. solani AG 2-1 but were also antagonistic to T. harzianum, except for Cinnamomum loureirii stem bark (CSB). CSB inhibited mycelial growth of R. solani AG 2-1 by 73.7% but showed an inhibitory effect on mycelial growth of T. harzianum by only 2.2%. Scanning electron microscophs showed that the CSB treatment resulted in deformed R. solani AG 2-1 hyphal cells, and transmission electron microscophs revealed degenerated cell structures such as degenerated cytoplasm and disentangled cell wall and the accumulation of electron-dense inclusions (asterisks) in the CSB treatment. The biocontrol efficacy of radish damping-off increased greatly following the combined treatments of T. harzianum and CSB and the combined treatment increased efficacy from 6.4-23.1% to 37.1-87.3% compared with either treatment alone. CSB did not affect T. harzianum population growth, as it was almost the same in rice-bran peat medium (culture) amended with 0.1% and 1.0% CSB powder as in non-amended medium. The formulation of T. harzianum in rice-bran peat medium amended with CSB powder reduced the severity of radish damping-off by 80.6%, suggesting that T. harzianum and CSB can be formulated as a biocontrol product for the control of R. solani AG 2-1.

• Journal of KIISE
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• v.42 no.9
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• pp.1090-1099
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• 2015

The concept of Cloud Service Brokerage (CSB) has been introduced as a result of the expansion of the cloud-computing paradigm. Cloud services that provide similar functionality are registered with a CSB. A CSB intermediates cloud services between cloud users and providers. However, there are differences in the price and performance offered by each of the cloud providers. Thus, cloud users have difficulty in finding suitable services to use. Therefore, a CSB is required in order to provide an approach for cloud services to fulfill the requirements of cloud users. In this paper, we propose a virtual cloud bank architecture that includes both a Service Analysis Model (SAM) that can be used to specify and analyze various cloud services and a requirement analysis method that can be used to collect and analyze the cloud user requirements. The VCB architecture that is herein proposed can be used as a reference architecture to provide user-centric cloud services.

• Nuclear Engineering and Technology
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• v.29 no.5
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• pp.399-405
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• 1997

In this study a new phase separated spectral analysis algorithm is proposed to identify CSB vibration mode directly from ex-core neutron signals. Ex-core neutron signals can be decomposed into the global, core support barrel (CSB) beam mode, and CSB shell mode components by the new phase separation algorithm based on the characteristics of Fourier transform. By using the proposed algorithm and the conventional spectral analysis the vibration mode of the CSB and the fuel assembly of Ulchin-1 NPP were identified from measured ex-core neutron signals.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.10
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• pp.5839-5842
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• 2013

Aim: We assessed the association between genetic variants of XPG, XPA, XPD, CSB, XPC and CCNH in the nucleotide excision repair (NER) pathway and risk of prostate cancer. Methods: We genotyped the XPG, XPA, XPD, CSB, XPC and CCNH polymorphisms by a 384-well plate format on the MassARRAY(R) platform. Multivariate logistical regression analysis was used to assess the associations between the six gene polymorphisms and risk of prostate cancer. Results: Individuals carrying the XPG rs229614 TT (OR=2.01, 95%CI=1.35-3.27) genotype and T allele (OR=1.73, 95%CI=1.37-2.57) were moderately significantly associated with a higher risk of prostate cancer. Subjects with XPD rs13181 G allele had a marginally increased risk of prostate cancer, with adjusted OR(95%CI) of 1.53 (1.04-2.37). Moreover, individuals carrying with CSB rs2228526 GG genotype (OR=2.05, 95% CI=1.23-3.52) and G allele (OR=1.56, 95%CI=1.17-2.05) were associated with a higher increased risk of prostate cancer. The combination genotype of XPG rs2296147 T and CSB rs2228526 G allele had accumulative effect on the risk of this cancer, with an OR (95% CI) of 2.23(1.37-3.59). Conclusions: Our study indicates that XPG rs2296147 and CSB rs2228526 polymorphisms are significantly associated with increased risk of prostate cancer, and that combination of XPG rs2296147 T allele and CSB rs2228526 G allele is strongly associated with an increased risk.

• Journal of the Korean Society of Food Science and Nutrition
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• v.43 no.6
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• pp.829-835
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• 2014

This study investigated the neuroprotective effects of bread containing extract from Cirsium setidens (CS) or Aster scaber (AS) against $H_2O_2$-induced death of human brain neuroblastoma SK-N-SH cells. Treatment with bread containing extract from CS (CSB) or AS (ASB) reduced $H_2O_2$ cytotoxicity in SK-N-SH cells, the intracellular ROS level, and the phospho-p38 mitogen-activated protein kinase (MAPK) level. In the sensory evaluation, wild vegetable flavor scores of CSB were higher than those of ASB and bread containing 0% CS or AS (NB). In terms of appearance, color, flavor, softness, and overall acceptability, CSB and ASB showed higher scores than NB, but no differences were observed between CSB and ASB. These results indicate that CSB and ASB have potent health benefits in terms of neuroprotection against oxidative stress mediated through antioxidant activity and inhibition of p38 phosphorylation in brain neural cells. Thus, CS and AS could be considered as a health functional material.

• Proceedings of the Korea Information Processing Society Conference
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• 2017.04a
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• pp.637-640
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• 2017

최근 클라우드 기술이 확산되면서 여러 기업이 자신만의 클라우드를 다양하게 제공하고 있으며 세계 각지에 흩어져 있는 다양한 클라우드 공급자들과 여러 프라이빗 클라우드를 연결하여 하나의 서비스를 제공하는 클라우드 서비스 브로커리지(Cloud Services Brokerage) 기술이 등장하게 되었다. 하지만 현재의 CSB 기술은 가상 자원 관리, 가상 머신 라이프 사이클 관리에 초점이 맞추어져 있으며 CSB에서 제공되는 모니터링 요소는 사용자의 복잡한 요구를 만족하기에는 부족한 실정이다. 또한 추가 모니터링 도구를 사용하는 경우도 CSB의 데이터와의 일관성을 만족하지 않는 문제가 있다. 따라서 본 논문에서는 이종 CSB와 연동이 가능한 실시간 모니터링 시스템을 제안한다. 본 논문에서 제안하는 모니터링 기술은 Scalr 및 CompatibleOne을 사용하여 주기적으로 메타데이터 동기화를 진행하며 데이터 일관성을 충족시키고 다양한 모니터링 데이터를 실시간으로 수집하여 사용자에게 제공한다.