• Smart Media Journal
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• v.12 no.4
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• pp.59-59
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• 2023

• Journal of KIISE:Software and Applications
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• v.37 no.10
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• pp.723-735
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• 2010

Evaluating the level of achievement and providing the knowledge which is appropriate at the evaluated level have great influence in studying of the human beings. This shows the importance of the order of training and the training order should be considered in machine learning. In this research, to assess the influence of the order of training, we propose a method of controlling the order of training samples utilizing the experience of supervisor in the training of MLP. The supervisor finds out the current state of MLP using teaching experience and student evaluation, and then selects the most instructive sample for MLP in that state. We use CRF to represent and utilize the experience of supervisor. While the proposed method is similar to active learning in selecting samples, it is basically different in that selection is not to reduce the number of samples to be used but to assist the learning progress. The result from classification problem shows that the method is usually effective in terms of time taken in training in contrast to random selection.

• The Korean Journal of Physiology and Pharmacology
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• v.16 no.1
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• pp.17-24
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• 2012

The hypothalamus-pituitary-adrenocortex (HPA) axis is the central mediator of the stress response. The supramammillary (SuM) region is relatively unique among the hypothalamic structures in that it sends a large, direct projection to the hippocampal formation. It has been shown that mild stress could activate the SuM cells that project to the hippocampus. However, the role of these cell populations in modulating the stress response is not known. The present study examined the effect of stress on different populations of SuM cells that project to the hippocampus by injecting the fluorescent retrograde tracer, fluorogold (FG), into the hippocampus and utilizing the immunohistochemistry of choline acetyltransferase (ChAT), corticotrophin releasing factor (CRF), serotonin (5-HT), glutamate decarboxylase (GAD), tyrosine hydroxylase (TH) and NADPH-d reactivity. Immobilization (IMO) stress (2 hr) produced an increase in the expression of ChAT- immunoreactivity, and tended to increase in CRF, 5-HT, GAD, TH-immunoreactivity and nitric oxide (NO)-reactivity in the SuM cells. Fifty-three percent of 5-HT, 31% of ChAT and 56% of CRF cells were double stained with retrograde cells from the hippocampus. By contrast, a few retrogradely labeled cells projecting to the hippocampus were immunoreactive for dopamine, ${\gamma}$-aminobutyric acid (GABA) and NO. These results suggest that the SuM region contains distinct cell populations that differentially respond to stress. In addition, the findings suggest that serotonergic, cholinergic and corticotropin releasing cells projecting to the hippocampus within the SuM nucleus may play an important role in modulating stress-related behaviors.

• Journal of Veterinary Clinics
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• v.25 no.4
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• pp.236-240
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• 2008

Parathyroid hormone (PTH) regulates calcium (Ca) and phosphate transport. Secondary hyperparathyroidism usually occur in chronic renal failure (CRF), and it is a common complication of CRF in dogs and cats. Twenty one dogs with renal failure were enrolled in this study. Plasma Ca, inorganic phosphorus (iP) and PTH concentrations were measured. Dogs were divided into two groups by the ratio of Ca to iP (Ca/iP$\leq$1; Group I, Ca/iP$\leq$1.5; Group II). The PTH level between sexes ages were not significantly different. The PTH level and Ca/iP between two groups were significantly different (p < 0.0001). In conclusion, The ratio of Ca to iP may be considered as useful surrogator to predict PTH level of dogs with renal failure.

• Journal of KIISE:Software and Applications
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• v.36 no.1
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• pp.82-91
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• 2009

Sign language spotting is the task of detecting and recognizing the signs in a signed utterance. The difficulty of sign language spotting is that the occurrences of signs vary in both motion and shape. Moreover, the signs appear within a continuous gesture stream, interspersed with transitional movements between signs in a vocabulary and non-sign patterns(which include out-of-vocabulary signs, epentheses, and other movements that do not correspond to signs). In this paper, a novel method for designing a threshold model in a conditional random field(CRF) model is proposed. The proposed model performs an adaptive threshold for distinguishing between signs in the vocabulary and non-sign patterns. A hand appearance-based sign verification method, a short-sign detector, and a subsign reasoning method are included to further improve sign language spotting accuracy. Experimental results show that the proposed method can detect signs from continuous data with an 88% spotting rate and can recognize signs from isolated data with a 94% recognition rate, versus 74% and 90% respectively for CRFs without a threshold model, short-sign detector, subsign reasoning, and hand appearance-based sign verification.

• Korea-Australia Rheology Journal
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• v.17 no.3
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• pp.117-123
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• 2005

Background: Reduced deformability of red blood cells (RBCs) may play an important role on the pathogenesis of chronic vascular complications of diabetes mellitus. However, available techniques for measuring RBC deformability often require washing process after each measurement, which is not optimal for day­to-day clinical use at point of care. The objectives of the present study are to develop a device and to delineate the correlation of impaired RBC deformability with diabetic nephropathy. Methods: We developed a disposable ektacytometry to measure RBC deformability, which adopted a laser diffraction technique and slit rheometry. The essential features of this design are its simplicity (ease of operation and no moving parts) and a disposable element which is in contact with the blood sample. We studied adult diabetic patients divided into three groups according to diabetic complications. Group I comprised 57 diabetic patients with normal renal function. Group II comprised 26 diabetic patients with chronic renal failure (CRF). Group III consisted of 30 diabetic subjects with end-stage renal disease (ESRD) on hemo-dialysis. According to the renal function for the diabetic groups, matched non-diabetic groups were served as control. Results: We found substantially impaired red blood cell deformability in those with normal renal function (group I) compared to non-diabetic control (P = 0.0005). As renal function decreases, an increased impairment in RBC deformability was found. Diabetic patients with chronic renal failure (group II) when compared to non-diabetic controls (CRF) had an apparently greater impairment in RBC deformability (P = 0.07). The non-diabetic cohort (CRF), on the other hand, manifested significant impairment in red blood cell deformability compared to healthy: control (P = 0.0001). Conclusions: The newly developed slit ektacytometer can measure the RBC deformability with ease and accuracy. In addition, progressive impairment in cell deformability is associated with renal function loss in all patients regardless of the presence or absence of diabetes. In diabetic patients, early impairment in RBC deformability appears in patients with normal renal function.

• The Korea Journal of Herbology
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• v.25 no.2
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• pp.117-128
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• 2010

Objectives : In this study the antidepressant effects of mixture of Citri Peticulatae Viride Pericarpium and Lycii Radicis Cortex on the change of HPA-Axis and Catecholamic system was investigated Methods : The forced swimming test(FST) was performed. The expression of corticotropin-releasing factor(CRF), c-Fos in the paraventricular nucleus(PVN), and tyrosine hydroxylase(TH) in the ventral tegmental area(VTA) and locus coeruleus(LC) was measured with immunohistochemical method and the concentration of seum adrenocorticotropic hormone(ACTH) was measured with ELISA method. And the experimental groups were divided into the extraction after mixing(A) and mixture after extraction(B). The effects of both group were compared. Results : The duration of immobility in the forced swimming test was significantly decreased in the A400 group(P<0.01). The expression of CRF in PVN were significantly reduced in the A100, A400, B100, B400groups(P<0.001). but the expression of c-fos in PVN weren't reduced in all groups. And the concentration of ACTH in Plasma were significantly reduced in the A 100 group(P<0.01). The expression of TH in LC were significantly reduced in the A 400, B 100 and B400 groups(P<0.05~P<0.01). Conclusion : Mixture of Citri Peticulatae Viride Pericarpium and Lycii Radicis Cortex has antidepressant effects. But the difference between mixing and extracting methods was not shown.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.10 no.3
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• pp.625-633
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• 2009

This study was conducted to assess the distribution of coronary risk factors(CRF) and evaluate the risk profile of coronary heart disease by the clustering of the CRF in health checkup examinees. The study sample consists of 3,345 adults aged 30s-60s years(1,917 males, 1,428 females), not recognized as taking medicines for or having cardiovascular diseases, who underwent health package check-up at the health examination center of a university-affliated hospital in Daejon City. The proportion of subjects with 1, 2, 3, 4 and or more risk factors were 27.6%, 26.5%, 16.9% and 9.1%, respectively, therefore, the 80.0% of total subjects had at least one more risk factor. From these findings, this study concluded that the prevalence rates of CRF were relatively high. These data provide further evidence that the early intervention for coronary health prevention and promotion in general adult population is necessary at the population level.

• Journal of Korea Society of Industrial Information Systems
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• v.27 no.1
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• pp.49-62
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• 2022

Online customer review data can be easily collected on the Internet and also they describe sentimental evaluation of a product in different aspects. Previous sentiment analysis studies evaluate the degree of sentiment with review data, which may have multiple sentences describing different product aspects. Since different aspects of a product can be described in a sentence, the proposed method suggested analyzing a sentence to build a pair of a product aspect terms and sentimental terms. Bidirectional LSTM and CRF algorithms were used in this paper. A pair of aspect terms and sentimental terms are evaluated by pre-defined evaluation rules. The paper suggested using the result of evaulation as inputs of QFD, so that the quantified customer voices effect on the requirements of a new product. Online reviews for a hair dryer were used as an example showing that the proposed approach can derive reasonable sentiment analysis results.

• Nutrition Research and Practice
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• v.18 no.2
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• pp.210-222
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• 2024

BACKGROUND/OBJECTIVES: Chronic renal failure (CRF) is a complex pathological condition that lacks a cure. Certain Chinese medicines, such as melittin, a major component in bee venom, have shown efficacy in treating CRF patients. On the other hand, the mechanisms underlying the therapeutic effects of melittin are unclear. MATERIALS/METHODS: A 5/6 nephrectomy model (5/6 Nx) of renal failure was established on rats for in vivo assays, and mouse podocyte clone 5 (MPC5) mouse podocyte cells were treated with angiotensin II (AngII) to establish an in vitro podocyte damage model. The 24-h urine protein, serum creatinine, and blood urea nitrogen levels were evaluated after one, 2, and 4 weeks. Hematoxylin and eosin staining, Masson staining, and periodic acid-Schiff staining were used to examine the pathological changes in kidney tissues. A cell counting kit 8 assay was used to assess the cell viability. Reverse transcription polymerase chain reaction and Western blot were used to assess the mRNA and protein levels in the cells, respectively. RESULTS: In the rat 5/6 Nx, melittin reduced the 24-h urinary protein excretion and the serum creatinine and blood urea nitrogen levels. Furthermore, the renal pathology was improved in the melittin-treated 5/6 Nx rats. Melittin promoted podocin, nephrin, Beclin 1, and the LC3II/LC3I ratio and inhibited phosphorylated mammalian target of rapamycin (mTOR)/mTOR in 5/6 Nx-induced rats and AngII-induced MPC5 mouse podocyte cells. Moreover, inhibiting autophagy with 3-MA weakened the effects of melittin on podocin, nephrin, and the LC3II/LC3I ratio in podocytes. CONCLUSION: Melittin may offer protection against kidney injury, probably by regulating podocyte autophagy. These results provide the theoretical basis for applying melittin in CRF therapy.