• Biomolecules & Therapeutics
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• v.32 no.1
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• pp.104-114
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• 2024

Licochalcone C (LCC; PubChem CID:9840805), a chalcone compound originating from the root of Glycyrrhiza inflata, has shown anticancer activity against skin cancer, esophageal squamous cell carcinoma, and oral squamous cell carcinoma. However, the therapeutic potential of LCC in treating colorectal cancer (CRC) and its underlying molecular mechanisms remain unclear. Chemotherapy for CRC is challenging because of the development of drug resistance. In this study, we examined the antiproliferative activity of LCC in human colorectal carcinoma HCT116 cells, oxaliplatin (Ox) sensitive and Ox-resistant HCT116 cells (HCT116-OxR). LCC significantly and selectively inhibited the growth of HCT116 and HCT116-OxR cells. An in vitro kinase assay showed that LCC inhibited the kinase activities of EGFR and AKT. Molecular docking simulations using AutoDock Vina indicated that LCC could be in ATP-binding pockets. Decreased phosphorylation of EGFR and AKT was observed in the LCC-treated cells. In addition, LCC induced cell cycle arrest by modulating the expression of cell cycle regulators p21, p27, cyclin B1, and cdc2. LCC treatment induced ROS generation in CRC cells, and the ROS induction was accompanied by the phosphorylation of JNK and p38 kinases. Moreover, LCC dysregulated mitochondrial membrane potential (MMP), and the disruption of MMP resulted in the release of cytochrome c into the cytoplasm and activation of caspases to execute apoptosis. Overall, LCC showed anticancer activity against both Ox-sensitive and Ox-resistant CRC cells by targeting EGFR and AKT, inducing ROS generation and disrupting MMP. Thus, LCC may be potential therapeutic agents for the treatment of Ox-resistant CRC cells.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.32 no.6A
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• pp.519-536
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• 2007

In this paper, we combine the Hybrid-Automatic Repeat reQuest (HARQ) algorithm with joint Tx and Rx antenna selection based on the reliability of the individual antennas links. The cyclic redundancy check (CRC) is applied on the data before being encoded using the Turbo encoder. In the receiver the CRC is used to detect errors of each antenna stream and to decide whether a retransmission is required or not. The receiver feeds back the transmitter with the Tx antennas ordering and the acknowledgement of each antenna (ACK or NACK). If the number of ACK antennas is higher than the NACK antennas, then the retransmission takes place from the ACK antennas using the Chase Combining (CC). If the number of the NACK antennas is higher than the ACK antennas then the ACK antennas are used to retransmit the data streams using the CC algorithm and additional NACK antennas are used to retransmit the remaining streams using Incremental Redundancy (IR, i.e. the encoder rate is reduced). Furthermore, the HARQ is used with the I-BLAST (Iterative-BLAST) which grantees a high transmission rate.

• Proceedings of the IEEK Conference
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• 2008.06a
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• pp.771-772
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• 2008

In this paper, we analyze the characterization of Mibench, an embedded system benchmark program, using simplescalar simulator. The experimental results show Mibench generally is formed by lots of integer and memory access instructions. Especially, IPC of rijndael decoding is effected by cache size largely, but IPC of CRC32 is few effected by cache size or branch predicting algorithm.

• Proceedings of the IEEK Conference
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• 2003.07b
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• pp.799-802
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• 2003

In this paper a FPGA implementation of WEP protocol is described. IEEE 802.11 specifies a wired LAN equivalent data confidentiality algorithm. WEP(Wired Equivalent Privacy) is defined as protecting authorized users of a wireless LAN from casual eavesdropping. WEP use RC4 algorithm for data encryption and decryption, also it use CRC-32 algorithm for error detection. The WEP protocol is implemented using Xilinx VirtexE XCV1000E-6HQ240C FPGA chip with PCI bus interface.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2002.11a
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• pp.265-269
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• 2002

본 논문에서는 무선랜 시스템에서 보안상의 취약점을 해소하기 위해 적용되고 있는 보안 기법들에 관해 분석하였다. WLAN에서 적용되고 있는 보안규정 WEP는 RC4 스트림 키퍼의 특징에서 오는 IV Reuse 문제 및 ICV를 생성하는 CRC-32의 선형특성에 따른 문제를 분석하고 현재 사용되는 보안기법인 액세스컨트롤의 강화와 WEP 키관리 및 VPN에서의 사용자 인증알고리즘 및 데이터 암호화기술을 분석하고, 802.11a에서 보안모델의 나아갈 방향을 제시하였다.

• Aerospace Engineering and Technology
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• v.7 no.1
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• pp.83-90
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• 2008

The next generation LID satellite has 64KB PROM which contains the boot loader and the monitor software, and two 4MB NVMEMs which are used for flight software storage. The boot loader has two operation modes which are the flight software mode and the monitor mode. In the flight software mode, it checks CRC checksum of selected NVMEM and copies flight software image from NVMEM to RAM And then it starts VxWorks RTOS in RAM, creates flight software tasks, and starts execution of flight software. In the monitor mode, it activates monitor software which performs NVMEM reprogramming and board-level testing on the ground. This paper is to present the design of Boot ROM software and verification method using simulator.

• Journal of Ginseng Research
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• v.39 no.3
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• pp.230-237
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• 2015

Background: Colorectal cancer (CRC) is a leading cause of death worldwide. Chronic gut inflammation is recognized as a risk factor for tumor development, including CRC. American ginseng is a very commonly used ginseng species in the West. Methods: A genetically engineered $Apc^{Min/+}$ mouse model was used in this study. We analyzed the saponin composition of American ginseng used in this project, and evaluated its effects on the progression of high-fat-diet-enhanced CRC carcinogenesis. Results: After oral ginseng administration (10-20 mg/kg/d for up to 32 wk), experimental data showed that, compared with the untreated mice, ginseng very significantly reduced tumor initiation and progression in both the small intestine (including the proximal end, middle end, and distal end) and the colon (all p < 0.01). This tumor number reduction was more obvious in those mice treated with a low dose of ginseng. The tumor multiplicity data were supported by body weight changes and gut tissue histology examinations. In addition, quantitative real-time polymerase chain reaction analysis showed that compared with the untreated group, ginseng very significantly reduced the gene expression of inflammatory cytokines, including interleukin-$1{\alpha}$ (IL-$1{\alpha}$), IL-$1{\beta}$, IL-6, tumor necrosis factor-${\alpha}$, granulocyte-colony stimulating factor, and granulocyte-macrophage colony-stimulating factor in both the small intestine and the colon (all p < 0.01). Conclusion: Further studies are needed to link our observed effects to the actions of the gut microbiome in converting the parent ginsenosides to bioactive ginseng metabolites. Our data suggest that American ginseng may have potential value in CRC chemoprevention.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.2
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• pp.627-633
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• 2015

Background: To study the effect of parecoxib, a novel cyclooxygenase-2 selective inhibitor, on the radiation response of colorectal cancer (CRC) cells and its underlying mechanisms. Materials and Methods: Both in vitro colony formation and apoptosis assays as well as in vivo mouse xenograft experiments were used to explore the radiosensitizing effects of parecoxib in human HCT116 and HT29 CRC cells. Results: Parecoxib sensitized CRC cells to radiation in vitro with a sensitivity enhancement ratio of 1.32 for HCT116 cells and 1.15 for HT29 cells at a surviving fraction of 0.37. This effect was partially attributable to enhanced apoptosis induction by parecoxib combined with radiation, as illustrated using an in vitro apoptosis assays. Parecoxib augmented the tumor response of HCT116 xenografts to radiation, achieving growth delay more than 20 days and an enhancement factor of 1.53. In accordance with the in vitro results, parecoxib combined with radiation resulted in less proliferation and more apoptosis in tumors than radiation alone. Radiation monotherapy decreased microvessel density (MVD) and microvessel intensity (MVI), but increased the hypoxia level in xenografts. Parecoxib did not affect MVD, but it increased MVI and attenuated hypoxia. Conclusions: Parecoxib can effectively enhance radiation sensitivity in CRC cells through direct effects on tumor cells and indirect effects on tumor vasculature.

• Journal of the Semiconductor & Display Technology
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• v.21 no.1
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• pp.85-90
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• 2022

In this paper, an asynchronous nonvolatile memory module using a self-diagnosis function was designed. For the system to work, a lot of data must be input/output, and memory that can be stored is required. The volatile memory is fast, but data is erased without power, and the nonvolatile memory is slow, but data can be stored semi-permanently without power. The non-volatile static random-access memory is designed to solve these memory problems. However, the non-volatile static random-access memory is weak external noise or electrical shock, data can be some error. To solve these data errors, self-diagnosis algorithms were applied to non-volatile static random-access memory using error correction code, cyclic redundancy check 32 and data check sum to increase the reliability and accuracy of data retention. In addition, the possibility of application to an asynchronous non-volatile storage system requiring reliability was suggested.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.3
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• pp.1819-1823
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• 2013

Objective: Microarray data were analyzed to explore key genes and their functions in progression of colorectal cancer (CRC). Methods: Two microarray data sets were downloaded from Gene Expression Omnibus (GEO) database and differentially expressed genes (DEGs) were identified using corresponding packages of R. Functional enrichment analysis was performed with DAVID tools to uncover their biological functions. Results: 631 and 590 DEGs were obtained from the two data sets, respectively. A total of 32 common DEGs were then screened out with the rank product method. The significantly enriched GO terms included inflammatory response, response to wounding and response to drugs. Two interleukin-related domains were revealed in the domain analysis. KEGG pathway enrichment analysis showed that the PPAR signaling pathway and the renin-angiotensin system were enriched in the DEGs. Conclusions: Our study to systemically characterize gene expression changes in CRC with microarray technology revealed changes in a range of key genes, pathways and function modules. Their utility in diagnosis and treatment now require exploration.