• Journal of Technologic Dentistry
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• v.26 no.1
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• pp.49-58
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• 2004

Two diketones, 1-phenyl-1,2-propanedione(PD) and 2,3-butanedione (BD) were investigated as new visible light photosensitizers for a dental resin composite of bis-GMA in order to improve photopolymerization effect. And the photopolymerization efficiency of mixed photosensitizers, PD-CQ and DA-CQ, was studied. Photopolymerization effect of photosensitizers were compared with that of camphorquinone(CQ), the most widely used photosensitizer. The photopolymerization efficiency of bis-GMA containing the photosensitizer increased with irradiation time. The increase was in the order: BD < CQ < PD. The photopolymerization efficiency of this mixture was not so efficient as CQ or PD.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.8
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• pp.4651-4654
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• 2013

Choroquine (CQ) and valproic acid (VPA) have been extensively studied for biological effects. Here, we focused on efficacy of combined CQ and VPA on osteosarcoma cell lines. Viability of osteosarcoma cell lines (U20S and HOS) was analyzed by MTT assay. Apoptotic assays and colony formation assays were also applied. ROS generation and Western Blotting were performed to determine the mechanism of CQ and VPA combination in the process of apoptosis. The viability of different osteosarcoma cell lines significantly decreased after CQ and VPA combination treatment compared with either drug used alone, and apoptosis was increased significantly. ROS generation was triggered leading to expression of apoptosis related genes being increased and of antiapoptotic related genes being decreased. From our data shown here, CQ and VPA combination treatment in vitro enhanced cytotoxicy to osteosarcoma cells.

• Journal of applied mathematics & informatics
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• v.29 no.1_2
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• pp.293-309
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• 2011

The purpose of this article is to prove strong convergence theorems for weak relatively nonexpansive mapping which is firstly presented in this article. In order to get the strong convergence theorems for weak relatively nonexpansive mapping, the monotone CQ iteration method is presented and is used to approximate the fixed point of weak relatively nonexpansive mapping, therefore this article apply above results to prove the strong convergence theorems of zero point for maximal monotone operators in Banach spaces. Noting that, the CQ iteration method can be used for relatively nonexpansive mapping but it can not be used for weak relatively nonexpansive mapping. However, the monotone CQ method can be used for weak relatively nonexpansive mapping. The results of this paper modify and improve the results of S.Matsushita and W.Takahashi, and some others.

• Journal of applied mathematics & informatics
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• v.27 no.3_4
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• pp.763-771
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• 2009

T.H. Kim, H.K. Xu, [Convergence of the modified Mann's iteration method for asymptotically strict pseudo-contractions, Nonlinear Anal.(2007),doi:l0.l016/j.na.2007.02.029.] proved the strong convergence for asymptotically strict pseudo-contractions by the classical CQ iterative method. In this paper, we apply the monotone CQ iterative method to modify the classical CQ iterative method of T.H. Kim, H.K. Xu, and to obtain the strong convergence theorems for asymptotically strict pseudo-contractions. In the proved process of this paper, Cauchy sequences method is used, so we complete the proof without using the demi-closedness principle, Opial's condition or others about weak topological technologies. In addition, we use a ingenious technology to avoid defining that F(T) is bounded. On the other hand, we relax the restriction on the control sequence of iterative scheme.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.22 no.5
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• pp.1097-1106
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• 1997

Most works on importance sampling (IS) as an efficient evaluation technique havd been done in an additibe white gaussian noise channel (Awgn). In this paper we propose a CQ(conventional importance sampling and quasi-translantion) IS technique for the mobile radio channel modeled as Rician fading, and analyze the IS estimator's variance to determine optimum IS parameters and the minimum number of run times. Reference showed that CIS technique has a poor performance for systems with meories, but it is shown that the CIS technique can be improved by combining with quasi-translation technique even for systems with memories. Here the CQ IS technique modifies the variance of additive noise and also performs quasi-translation for the fading distribution. We determine the optimum IS parameters of the proposed CQ IS estimator and whow that the simulation gains are about 10$^{3}$~10$^{6}$ for the mobile communication systems with memories in case of the expected BERs 10$^{-5}$ ~10$^{-8}$ .

• Journal of Technologic Dentistry
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• v.35 no.4
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• pp.313-320
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• 2013

Purpose: The purpose of this study was to know the physical properties of UDMA dental composite resins containing two photosensitizers, PD, DA, as a photosensitizer instead of CQ. We want to know Remaining Double Bond(RDB) of UDMA unfilled resin and diametral tensile strength and flexural strength of composite resin containing PD and DA were compared with those of CQ, most widely used photosensitizer for dental composite resins. Methods: The RDB of UDMA studied by FT-IR spectroscopy increased with irradiation time. The composite resins were tested for their physical properties. The dental composite resins were made with UDMA as a monomer, silanized silica as filler, N,N-dimethylaminoethyl methacrylate (DAEM) as amine initiator, and one of the two kinds of new photosensitizers. Results: The relative RDB of UDMA was in the order: DA > CQ > PD but the physical properties of the composite resins show PD and DA with higher results compared with that containing CQ. The reason for the results is that PD and DA serve not only as a photosensitizer but also as a photo-crosslinking agent. Conclusion: PD and DA show as effective photosensizers, suitable for UDMA dental composite resin compare with a higher efficiency than CQ.

• Journal of Ginseng Research
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• v.42 no.4
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• pp.470-475
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• 2018

Background: It was previously found that Korean Red Ginseng water extract (KRGE) inhibits the histamine-induced itch signaling pathway in peripheral sensory neurons. Thus, in the present study, we investigated whether KRGE inhibited another distinctive itch pathway induced by chloroquine (CQ); a representative histamine-independent pathway mediated by MrgprA3 and TRPA1. Methods: Intracellular calcium changes were measured by the calcium imaging technique in the HEK293T cells transfected with both MrgprA3 and TRPA1 ("MrgprA3/TRPA1"), and in primary culture of mouse dorsal root ganglia (DRGs). Mouse scratching behavior tests were performed to verify proposed antipruritic effects of KRGE and ginsenoside Rg3. Results: CQ-induced $Ca^{2+}$ influx was strongly inhibited by KRGE ($10{\mu}g/mL$) in MrgprA3/TRPA1, and notably ginsenoside Rg3 dose-dependently suppressed CQ-induced $Ca^{2+}$ influx in MrgprA3/TRPA1. Moreover, both KRGE ($10{\mu}g/mL$) and Rg3 ($100{\mu}M$) suppressed CQ-induced $Ca^{2+}$ influx in primary culture of mouse DRGs, indicating that the inhibitory effect of KRGE was functional in peripheral sensory neurons. In vivo tests revealed that not only KRGE (100 mg) suppressed CQ-induced scratching in mice [bouts of scratching: $274.0{\pm}51.47$ (control) vs. $104.7{\pm}17.39$ (KRGE)], but also Rg3 (1.5 mg) oral administration significantly reduced CQ-induced scratching as well [bouts of scratching: $216.8{\pm}33.73$ (control) vs.$115.7{\pm}20.94$ (Rg3)]. Conclusion: The present study verified that KRGE and Rg3 have a strong antipruritic effect against CQ-induced itch. Thus, KRGE is as a promising antipruritic agent that blocks both histamine-dependent and -independent itch at peripheral sensory neuronal levels.

• Restorative Dentistry and Endodontics
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• v.36 no.3
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• pp.219-230
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• 2011

Objectives: The aim of this study was to evaluate the optical characteristics such as color and translucency changes before and after light curing, to quantify the CQ and to measure refractive indices of body and opaque shade of resin composites materials. Materials and Methods: Resin composites used in this study were A2 body and A2 opaque shade of Esthet-X, Filtek supreme, Gradia Direct, Clearfil Majesty and Beautifil II. Color and translucency changes before and after light curing were evaluated by colorimeter, the CQ was quantified by GC-MS and refractive index changes were measured by spectroscopic ellipsometer. Results: Translucency parameter (TP) was significantly increased after curing. The CQ content of body shades are higher than that of opaque shades in all resin composites. Refractive index increased after polymerization in all materials and significant difference in ${\Delta}$refractive index was found between body and opaque shade (significance level 0.05). Conclusions: For an accurate shade match, direct shade matching of resin composite should be performed by using the cured material.

• Restorative Dentistry and Endodontics
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• v.36 no.4
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• pp.313-323
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• 2011

Objectives: This study investigated the optimal combination of 3-component photoinitiation system, consisting of CQ, p-octyloxy-phenyl-phenyl iodonium hexafluoroantimonate (OPPI), and 2-dimethylaminoethyl methacrylate (DMAEMA) to increase the degree of conversion of resin monomers, and analyze the effect of the ratio of the photoinitiator to the co-initiator. Materials and Methods: Each photoinitiators (CQ and OPP) and co-initiator (DMAEMA) were mixed in three levels with 0.2 wt.% (low concentration, L), 1.0 wt.% (medium concentration, M), and 2.0 wt.% (high concentration, H). A total of nine groups using the Taguchi method were tested according to the following proportion of components in the photoinitiator system: LLL, LMM, LHH, MLM, MMH, MHL, HLH, HML, HHM. Each monomer was polymerized using a quartz-tungsten-halogen curing unit (Demetron 400, USA) for 5, 20, 40, 60, 300 sec and the degree of conversion (DC) was determined at each exposure time using FTIR. Results: Significant differences were found for DC values in groups. MMH group and HHM group exhibited greater initial DC than the others. No significant difference was found with the ratio of the photoinitiators (CQ, OPPI) to the co-initiator (DMAEMA). The concentrations of CQ didn't affect the DC values, but those of OPPI did strongly. Conclusions: MMH and HHM groups seem to be best ones to get increased DC. MMH group is indicated for bright, translucent color and HHM group is good for dark, opaque colored-resin.

• Phonetics and Speech Sciences
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• v.1 no.2
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• pp.163-171
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• 2009

This study attempted to investigate vocal characteristics and differences in gender and voice classification among classical singers. Twenty-three female singers (M = 23.1 yrs, SD = 3.6 yrs, average 6.3 yrs singing experience, all classified as sopranos) and twenty male singers (M = 25.2 yrs, SD= 3.6 yrs, average 6. 3 yrs singing experience, 8 tenors, 12 baritones) were recruited to participate in the present study. Speaking fundamental frequency (FO), closed quotient (CQ), MPT (Maximum Phonation Time), breathing types, maximum inspiratory pressure (MIP), maximum expiratory pressure (MEP), and singers' formants were measured. In addition, vibratory patterns were observed using stroboscopy. Sfo, singing CQ, breathing types, formant frequency in singers' formants, MIP, MEP, and MPT were significantly different from gender to gender. Generally, singers' formants were observed in male singers and also the pattern of singers' formants was different between tenors and baritones. Lower singing CQ values were observed than speaking CQ values in the female singers (P<.001). Furthermore, MEP, MIP, and singing CQ were significantly lower for female singers than for males singers (P<.001). MPT and speaking FO, however, were not significantly different between tenors and baritones.