• 약학회지
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• 제43권5호
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• pp.659-664
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• 1999

To investigate the difference of contractile mechanism between KCI and phenylephrine-induced contraction, we observed effects of $Ca^{2+}$ antagonists and protein kinase inhibitors on aorta contraction of rats. Verapamil dose-dependently inhibited the contraction induced by KCI and phenylephrine, the inhibitory effect of verapamil was more potent in KCI-induced contraction than phenylephrine-induced contraction. Econazole and TMB-8 significantly inhibited CKI-induced contraction but did not inhibit phenylephrine-induced contraction. Staurosporine dose-dependently inhibited both KCI and phenylephrine-induced contraction. Genistein and calmodulin antagonists (W-7 and trifluoperazine) also inhibited both contraction in a dose dependent manner. However, the inhibitory effects of genistein and calmodulin antagonists were more potent in phenylephrine-induced contraction than KCI-induced contraction. These results suggest that involvements of $Ca^{2+}$ channel and protein kinase in rat aorta contraction were dependent on agonist causing aorta smooth muscle contraction.

• Journal of Oral Medicine and Pain
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• 제20권2호
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• pp.269-281
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• 1995

To study the characteristics of EMG power spectrum of masticatory muscles during sustained isometric contraction and recovery at various contraction times, the author analysed the EMG signals of anterior temporal and masseter muscles before, during, and after sustained isometric contraction at 50% level of maximum voluntary contraction (MVC) for 15,30,60 seconds. Twelve normal subjects were included in this study. The author came to following conclusions from the results. 1. MMF of anterior temporal muscle in the contraction period was significantly higher than that of masseter muscle during sustained isometric contraction regardless of isometric contraction times (p<0.05). 2. MMF in the contraction period decreased as the contraction time increased during sustained isometric contraction in both temporal and masseter muscles(p<0.05). 3. SMF in the contraction period increased as the contraction tie increased during sustained isometric contraction in both temporal and masseter muscles(p<0.01). 4. MMF in the first part of recovery period (20 seconds) decreased as the contraction time increased during sustained isometric contraction(p<0.05). However, MMF in the later parts of recovery period (20-120 seconds) showed no significant differences. 5. MMF of anterior temporl muscle in the recovery period was significantly higher than that of masseter muscle after sustained isometric contraction regardless of isometric contraction times (p<0.05). 6. The recovery rate of MF reached 100% in 100 seconds after the isometric contraction regardless of isometric contraction times.

• The Korean Journal of Physiology
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• 제29권2호
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• pp.225-232
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• 1995

The present study was conducted to evaluate the effect of phorbol 12,13-dibutyrate (PDBu) on the contraction of rabbit jugular vein in vitro. PDBu concentrations of greater than 10 nM induced a periodic contraction which was composed of rapid contraction, plateau and slow relaxation. The frequency of periodic contraction increased as PDBu concentration increased. The PDBu-induced contraction was inhibited by staurosporine (100 nM), it was not changed by tetrodotoxin $(1\;{\mu}M).$ In $Ca^{2+}$-free medium, PDBu induced a sustaining contraction, but not periodic contraction. Addition of $Ca^{2+}$ to medium evoked periodic contraction which was inhibited by nifedipine, PDBu concentrations of greater than $0.1\;{\mu}M$ increased ^{45}Ca^{2+}$ uptake without changing $^{45}Ca^{2+}$ efflux. Charybdotoxin and apamin, $Ca^{2+}$-activated K^{+}$ channel blockers, did not affect the PDBu-induced periodic contraction, whereas tetraethylammonium (TEA) abolished the periodicity. Pinacidil $(10\;{\mu}M).$, a potassium channel activator, blocked PDBu induced periodic contraction, which was recovered by glybenclamide $(10\;{\mu}M).$. In high potassium solution, PDBu did not produce the periodic contraction. These results suggest that the PDBu-induced periodicity of contraction is modulated by voltage dependent $Ca^{2+}$ channel and ATP-sensitive $K^{+}$ channel.

• Physical Therapy Rehabilitation Science
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• 제5권1호
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• pp.40-46
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• 2016

Objective: The purpose of this study was to examine the effect on multifidus and external oblique abdominis muscle activation during hip contraction of three types (concentric, isometric, eccentric) in standing position. Design: Cross-sectional study. Methods: Twenty healthy adult men volunteered to participate in this study. Muscle activation was recorded from gluteus maximus, both multifidus, and both external oblique abdominis by surface electromyography (EMG) while holding position in the type of gluteus maximus contraction. EMG values were normalized by maximum muscle contractions (% maximum voluntary isometric contraction). All subjects performed hip extension with three contraction methods. The type of gluteus maximus contraction using Thera-band was composed of concentric contraction (type 1), isometric contraction (type 2), and eccentric contraction (type 3). To measure muscle activation on the gluteus maximus contraction type, each position were maintained for 5 seconds with data collection taken place during middle three seconds. Muscle activation was measured in each position three times. Results: For the results of this study, there was no significant difference within three contraction patterns of the gluteus maximus (concentric, isometric, and eccentric) each both multifidus, both external oblique abdominis, and gluteus maximus. And there was no significant difference among both multifidus, both external oblique abdominis, and gluteus maximus each hip extension contraction type. Conclusions: These findings suggest that specific contraction types of the gluteus maximus does not lead to a more effective activation of the multifidus, external oblique abdominis, and gluteus maximus.

• The Journal of Korean Physical Therapy
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• 제14권4호
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• pp.260-265
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• 2002

There are many methods for muscle strengthening. Muscle strengthening with eccentric contraction work is the best way by researcher's report. Also, eccentric contraction need proper resistance for muscle strengthening. Combination of isotonic in PNF is a muscle strengthening method with manual resistance. It makes concentric contraction $\rightarrow$ eccentric contraction $\rightarrow$ concentric contraction with continually and without muscle relaxation. Combination isotonic technique use with PNF pattern. Therefore, it will make development and increasing of active control motion, coordination, actual range of motion, strengthen and functional training in eccentric control of movement. Concentric contraction have the 3rd lever system and eccentric contraction have the 2nd lever system with combination of isotonic. Serial concentric contraction $\rightarrow$ eccentric contraction $\rightarrow$ concentric contraction make strong SEC and PEC. It will be increase elasticity of SEC, PEC and contractile components either.

• 한국수학교육학회지시리즈B:순수및응용수학
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• 제29권4호
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• pp.335-352
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• 2022

In this paper, we give an extended version of fixed point results for 𝜃-contraction and 𝜃-𝜙-contraction and define a new type of contraction, namely, cyclic 𝜃-contraction and cyclic 𝜃-𝜙-contraction in a complete metric space. Moreover, we prove the existence of best proximity point for cyclic 𝜃-contraction and cyclic 𝜃-𝜙-contraction. Also, we establish best proximity result in the setting of uniformly convex Banach space.

• 한국전문물리치료학회지
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• 제12권3호
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• pp.46-55
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• 2005

The purpose of this study was to evaluate the effect of concurrent and reciprocal isometric contraction and angle of ankle joint on fatigue of concentrically contracting contralateral dorsiflexor and plantar flexor. Seventeen able-bodied subjects participated in the study. Concurrent and reciprocal isometric contraction were performed under three different ankle joint angles (dorsiflexion, neutral position, plantar flexion). During concurrent or reciprocal isometric contraction. fatigue of concentrically contracting contralateral tibialis anterior, gastrocnemius, and soleus was investigated and compared. There was no interaction between different ankle joint angles and direction of isometric contraction (p<.05). No significant differences were found among three different ankle joint angles (p<.05). Contralateral muscle fatigability was lower in reciprocal isometric contraction than that in concurrent isometric contraction (p<.05). Therefore, the findings of this study suggest that reciprocal isometric contraction is more beneficial than concurrent isometric contraction inducing less fatigability during contralateral concentric contraction.

• The Korean Journal of Physiology and Pharmacology
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• 제17권2호
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• pp.139-147
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• 2013

Lysolipids such as LPA, S1P and SPC have diverse biological activities including cell proliferation, differentiation, and migration. We investigated signaling pathways of LPA-induced contraction in feline esophageal smooth muscle cells. We used freshly isolated smooth muscle cells and permeabilized cells from cat esophagus to measure the length of cells. Maximal contraction occurred at $10^{-6}M$ and the response peaked at 30s. To identify LPA receptor subtypes in cells, western blot analysis was performed with antibodies to LPA receptor subtypes. LPA1 and LPA3 receptor were detected at 50 kDa and 44 kDa. LPA-induced contraction was almost completely blocked by LPA receptor (1/3) antagonist KI16425. Pertussis toxin (PTX) inhibited the contraction induced by LPA, suggesting that the contraction is mediated by a PTX-sensitive G protein. Phospholipase C (PLC) inhibitors U73122 and neomycin, and protein kinase C (PKC) inhibitor GF109203X also reduced the contraction. The PKC-mediated contraction may be isozyme-specific since only $PKC{\varepsilon}$ antibody inhibited the contraction. MEK inhibitor PD98059 and JNK inhibitor SP600125 blocked the contraction. However, there is no synergistic effect of PKC and MAPK on the LPA-induced contraction. In addition, RhoA inhibitor C3 exoenzyme and ROCK inhibitor Y27632 significantly, but not completely, reduced the contraction. The present study demonstrated that LPA-induced contraction seems to be mediated by LPA receptors (1/3), coupled to PTX-sensitive G protein, resulting in activation of PLC, PKC-${\varepsilon}$ pathway, which subsequently mediates activation of ERK and JNK. The data also suggest that RhoA/ROCK are involved in the LPA-induced contraction.

• Korean Journal of Mathematics
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• 제31권3호
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• pp.373-383
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• 2023

The aim of this paper is to prove some new approximate best proximity pair theorems on metric spaces using contraction mappings such as P-Bianchini contraction, P - B contraction and so on. A few examples are provided to exemplify our findings. Finally, we discuss some applications that are related to the main results.

• Korean Journal of Mathematics
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• 제31권2호
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• pp.123-131
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• 2023

In this paper, we prove existence of best proximity points for 2-convex contraction, 2-sided contraction, and M-weakly cyclic 2-convex contraction mappings in the setting of complete strongly regular generalized modular metric spaces that generalize many results in the literature.