• Journal of Physiology & Pathology in Korean Medicine
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• v.37 no.2
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• pp.30-35
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• 2023

Bisphosphonates, estrogen, and calcium supplements are commonly used medications for postmenopausal osteoporosis, but they are associated with various side effects such as vaginal bleeding, deep vein thromembolism, and breast cancer. In this study, we aimed to investigate the potential of a compound isolated from the roots of Oryza sativa L. to improve osteoporosis using an ovariectomized mouse model. We isolated and identified oryzativol A, a lignan compound, through chemical analysis of an ethanol extract using a bioassay-guided fractionation protocol. We also examined the metabolism, clearance, and CYP enzyme activity of oryzativol A, and found that it showed plasma stability of over 80% at all analysis times, and indicating a low likelihood of inactivation or excretion by the CYP3A4 enzyme. Our results showed that the high-dose group of oryzativol A exhibited a significant increase in bone mineral density compared to the control group. Although the ALP concentration did not differ significantly compared to the control group, it showed a tendency to increase in the high-dose group of oryzativol A. Furthermore, the abnormal ratio of serum Ca/P, caused by osteoporosis, was improved to a level closer to that of the normal group as the dosage of oryzativol A increased. Taken together, these findings suggest that oryzativol A is stable in vivo and has potential as a therapeutic agent for osteoporosis, particularly when administered in high doses.

• Journal of Navigation and Port Research
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• v.47 no.2
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• pp.75-84
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• 2023

Ships need to ensure safety during their navigation, which makes route determination highly important. It must be accompanied by a route following controller that can accurately follow the route. This study proposes a method for automatically generating the ship route based on deep reinforcement learning algorithm and following it using a route following controller. To generate a ship route, under keel clearance was applied to secure the ship's safety and navigation chart information was used to apply ship navigation related regulations. For the experiment, a target ship with a draft of 8.23 m was designated. The target route in this study was to depart from Busan port and arrive at the pilot boarding place of the Ulsan port. As a route following controller, a velocity type fuzzy P ID controller that could compensate for the limitation of a linear controller was applied. As a result of using the deep Q network, a route with a total distance of 62.22 km and 81 waypoints was generated. To simplify the route, the Douglas-Peucker algorithm was introduced to reduce the total distance to 55.67 m and the number of way points to 3. After that, an experiment was conducted to follow the path generated by the target ship. Experiment results revealed that the velocity type fuzzy P ID controller had less overshoot and fast settling time. In addition, it had the advantage of reducing the energy loss of the ship because the change in rudder angle was smooth. This study can be used as a basic study of route automatic generation. It suggests a method of combining ship route generation with the route following control.

• Journal of Radiopharmaceuticals and Molecular Probes
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• v.7 no.2
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• pp.79-84
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• 2021

Radiopharmaceuticals are important for tumor diagnosis and therapy. To deliver a radiotracer at the desired target excluding non-targeted tissues is difficult The development of a targeted tracer that has a good clearance profile while maintaining high biostability and biocompatibility is key to optimizing its biodistribution and transport across biological barriers. Improving the hydrophilicity of radiotracers by PEGylation can reduce serum binding, allowing the tracer to circulate without retention and reducing its affinity for non-targeted tissues. In this study, we synthesized a new benzamido tracer (SnBz-PEG₃₆) with the introduction of a low molecular weight polyethylene glycol unit (PEG₃₆, ~2,100 Da). The tumor targeting efficiency and biodistribution of [¹³¹I]-Bz-PEG₃₆ or radiotracer-loaded liposomes were evaluated after their administration to normal mice or mouse tumor models including CT26 (xenograft) and 4T1 (xenograft and orthotopic). Most of the radiotracer was cleared out rapidly (1-24 h post-administration) through the kidney and there was little tumor uptake.

• CELLMED
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• v.13 no.6
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• pp.5.1-5.8
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• 2023

Objectives: Cassia occidentalis L. is a weed belonging to the Caesalpiniaceae family. The root of this medicinal plant is used for the treatment of various ailments, including kidney diseases. The present study was aimed at evaluating the nephroprotective effects of HAE of the roots of Cassia occidentalis L. against gentamicininduced renal toxicity in albino Wistar rats. Methods: The renal toxicity was induced by subcutaneous administration of gentamicin at 100 mg/kg in the rats belonging to the disease control and treatment groups from the 4^th to the 8^th day. The rats in the treatment group received HAE of the roots of Cassia occidentalis L. at 67 mg/kg b. w. orally for 8 days, while no treatment was given to the rats in the disease control and plain control groups. At the end of the experiment, renal biomarkers viz; s. creatinine, b. urea, and s. uric acid, were investigated. The histopathological examination of the kidney specimens was also carried out. Results: The results of the present study revealed that renal function biomarkers such as s. creatinine, b. urea, and s. uric acid were significantly reduced in the rats of the treatment group as compared to those of the disease control group. Moreover, the histoarchitecture reports of the treatment group's kidney specimens showed significant improvements. Conclusion: The results suggested that the HAE of Cassia occidentalis L. roots promisingly prevented kidney injury in gentamicin-induced nephrotoxic rats. This effect might be due to improved clearance of gentamicin from the renal tubule and decreased generation of reactive oxygen species (ROS).

• Nuclear Engineering and Technology
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• v.55 no.1
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• pp.1-11
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• 2023

To protect people and the environment from environmental radiation, the Act on Protective Action Guidelines against Radiation in the Natural Environment was formulated in Korea in 2011. This law regulates matters related to radiation safety that can be encountered in life. In accordance with this law, radiation monitoring equipment is operated at major airports and ports across the country, ensuring radiation monitoring of imported cargo. Currently, six ministries conduct radiation monitoring of imported cargo: the Nuclear Safety and Security Commission; the Korea Customs Service; the Ministry of Food and Drug Safety; the Ministry of Environment; the Ministry of Agriculture, Food and Rural Affairs; and the Korea Forest Service. Each ministry designates the relevant cargo items for radiation monitoring. The objective of this study was to comprehensively review the Korean radiation monitoring system for imported cargo and identify the areas and scopes of improvement. This paper also proposes a new law and an integrated supervision plan, which involves establishing a dedicated department to enhance the efficiency and professionalism of the national radiation monitoring system for imported cargo. The review will contribute to the development of a more sophisticated national radiation monitoring system for imported cargo.

• Korea Trade Review
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• v.43 no.6
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• pp.215-238
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• 2018

Tariff reduction from FTAs are applied to imported goods, but not to traveler's goods. There are difficulties in meeting the FTA's conditions for free tariff application, such as origin of goods and direct transportation. This study suggests the optimal cut-off level of a simple tax rate applied to traveler's goods with respect to traveler' welfare and government tax revenue. Among three different scenarios of simple tax reductions by ordering its weighted magnitude of effects, the optimal tariff was found to be 2% applied to all goods. The effects of a 2% reduction of simple tax rate would increase traveler' welfare by 16.8 billion won and reduce tax revenue by only 0.34 billion won.

• Korea Trade Review
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• v.42 no.2
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• pp.297-318
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• 2017

This study reviews the origin verification system of China via literature research and analyzes cases of Korean exports origin disapproved of Chinese customs clearance, to provide origin verification strategy recommendations for Korean companies exporting to China under Korea-China FTA. We reviewed the provisions of Chinese rules of origin and analyzed origin disapproved cases gathered from various presentations. The main results of the study have the following implications; First, the customs authority needs to establish a consultation channel with the customs authority of China, and origin certification issuing agencies should provide exporters with consulting services in the certificate issuing stage to reduce verification risk. Second, exporters need to pay attention to the formal requirements of the proof of origin, utilize the advance rulings program of differences in classification of items between Korea and China, and monitor regulatory change in China.

• The Journal of the Society of Stroke on Korean Medicine
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• v.18 no.1
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• pp.13-22
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• 2017

■ Objectives This case is to report the effect of Oryeong-san and acupuncture therapy on serum creatinine level of a cerebral infarction patient with diabetic nephropathy. ■ Methods A female Korean patient was treated with Oryeong-san, acupuncture for total 32 days. We observed renal function test, input/output balance, body weight, hand and foot circumferences, and other symptoms like edema, urination, and any adverse event. ■ Results After treatment, serum creatinine level was improved to 2.48mg/dL from 3.45mg/dL at admission, and foot circumference was decreased to 18.5~18.9cm from 22.0~22.5cm without any adverse event. However, we couldn't find any significant differences on input/output balance, body weight, or symptoms of urination. ■ Conclusion This case suggests that Oryeong-san and acupuncture therapy could be effective in improving serum creatinine clearance of cerebral infarction patient with diabetic nephropathy.

• Proceedings of the Korea Water Resources Association Conference
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• 2020.06a
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• pp.210-210
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• 2020

LID (Low Impact Development, 저영향개발)는 산업화 및 도시화 진행 지역에서 비점오염원으로부터 배출되는 오염물질을 제어해 개발지역 내 자연순화 기능을 최대한 유지하고, 물순환 기능증대를 통해 강우 유출수를 지역 내에서 관리하는 것을 목표로 한다. 비점오염원 저감 LID 시설에는 자연형과 장치형 시설이 있다. 자연형 시설에는 저류형, 침투, 식생형 시설 등이 있다. 특히, 침투시설에는 대표적으로 투수블럭이 있으며, 이는 투수성 포장재를 통해 강우 유출수를 지하로 침투시켜 여과나 흡착 등으로 비점오염물질을 제어하는 시설이다. 장치형 시설로는 여과재나 망을 이용해 비점오염물질을 분리하는 여과형 및 스크린형 시설, 응집과 침전을 통해 비점오염물질을 분리하는 응집·침전 시설 등이 있다. 이에 본 연구는 2016년부터 2018년 3년간 전주 서곡지구 지역 내 설치된 필터형 투수블럭, 틈새형 투수블럭에서 진행했다. 각각의 투수블럭에서 총 19회, 20회의 강우 모니터링을 실시했고, 오염물질 유입 및 유출 EMC 등의 분석을 통해 유출 및 오염물질 저감효과를 분석했다. 연구 대상 각 투수블럭의 주요 제원은 시설 용량 14.4㎥, 시설 면적은 14.4㎡이다. 모니터링 결과값을 분석한 결과 필터형 투수블럭의 경우 유출 저감율은 17.4 ~ 100%, 틈새형 투수블럭은 29.6 ~ 100%이었다. 필터형 투수블럭과 틈새형 투수블럭의 단위면적당 유량 저감량은 각각 0.014 ~ 0.583㎥/㎡, 0.035 ~ 0.588㎥/㎡이었다. 오염물질 저감효율을 분석한 결과 유기물 항목(BOD, TOC)의 경우 틈새형 투수블럭에서의 저감효율(BOD 93.59%, TOC 90.39%)이 필터형 투수블럭에서의 저감효율(BOD 89.99%, TOC 86.94%) 보다 다소 높게 나타났다. 영양염류 항목(T-N, T-P)의 경우 필터형, 틈새형 모두 비슷한 저감효율(필터형 T-N 89.02%, 필터형 T-P 98.12%, 틈새형 T-N 90.41%, 틈새형 T-P 98.04%)을 보였다.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.28 no.3A
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• pp.323-330
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• 2008

The ship collision analysis of steel pile group as protection system of bridge in navigable waterways was performed to analyze the structural characteristics of protective structure during ship collision. The analysis encompassed finite element modeling of ship and pile, modeling of material non-linearity, hard impact analysis, displacement-based analysis and soft impact analysis for collision scenarios. Through the analysis of hard impact with a rigid wall, impact load for each collision type of ship bow was estimated. In the displacement-based analysis the estimate of energy which protection system can absorb within its maximum horizontal clearance so as to secure bridge pier from vessel contact during collision was performed. Soft impact analysis for various collision scenarios was conducted and the collision behaviors of vessel and pile-supported protection system were reviewed for the design of protection system. The understanding of the energy dissipation mechanism of pile supported structure and colliding vessel would give us the optimized design of protective structure.