• Dementia and Neurocognitive Disorders
• /
• v.23 no.2
• /
• pp.95-106
• /
• 2024

Background and Purpose: Ventricle enlargement has been implicated in the pathophysiology of Alzheimer's disease (AD). We studied the relationship between ventricular size and cognitive function in patients with AD. We focused on the effect of the initial ventricle size on the rate of cognitive decline in patients with AD. Methods: A retrospective analysis of probable clinical AD participants with more than 2 magnetic resonance imaging images was performed. To measure ventricle size, we used visual rating scales of (1) Cardiovascular Health Study (CHS) score and (2) conventional linear measurement method. Results: Increased clinical dementia rating (CDR) was correlated with a decreased Mini-Mental Status Examination (MMSE) score, and increased medial temporal lobe atrophy (MTLA) and global ventricle size (p<0.001, p<0.001, p=0.021, respectively). There was a significant correlation between the change in cognitive function in the group (70%-100%ile) with a large initial ventricle size (p=0.021 for ∆CDR, p=0.01 for ∆MMSE), while the median ventricle size (30%-70%ile) showed correlation with other brain structural changes (MTLA, frontal atrophy [FA], and white matter) (p=0.036 for initial MTLA, p=0.034 for FA). Conclusions: In this study, the initial ventricle size may be a potential new imaging biomarker for initial cognitive function and clinical progression in AD. We found a relationship between the initial ventricle size and initial AD-related brain structural biomarkers.

• Journal of the Korean Society of School Health
• /
• v.36 no.3
• /
• pp.103-112
• /
• 2023

Purpose: The COVID-19 pandemic, which emerged in late 2019, had a profound impact on global public health and disrupted the daily lives of people worldwide. Particularly, university students faced a challenging situation as their university life underwent a drastic transformation due to long-term remote learning and isolation measures. This study aimed to investigate the relationship between changes in daily life during the 2020 COVID-19 pandemic and depressive symptoms among university students aged between 19 and 29 in Korea. Methods: We analyzed data from the nationally representative 2020 Community Health Survey (CHS). Among the 229,269 participants, 9,279 university students aged 19-29, either enrolled or on leave, were selected. After excluding 401 cases with missing values, the final sample comprised 8,878 individuals. Using multivariate logistic regression with a complex sample design, we explored the association between daily life changes during the COVID-19 pandemic and depressive symptoms. Results: Changes in daily life during the COVID-19 pandemic was associated with depressive symptoms in Korean university students aged 19 to 29, even after adjusting for sociodemographic characteristics, health-related factors, and COVID-19-related aspects (OR=1.28, 95% CI=1.09~1.50). Conclusion: Our study suggests that when examining the impact of COVID-19 on health issues, it is crucial to consider the changes in daily life caused by the pandemic. These findings can provide insights into the psychological well-being of university students during times of crisis.

• The Plant Pathology Journal
• /
• v.40 no.5
• /
• pp.425-437
• /
• 2024

A large number of species in the genus Colletotrichum have been reported as causal agents of anthracnose on crops and wild plants in Korea. Many Colletotrichum isolates from the country preserved in the Korean Agricultural Culture Collection (KACC) were previously identified based on host plants and morphological characteristics, and it may lead to species misidentification. Thus, accurate fungal species identification using multilocus sequence analyses is essential for understanding disease epidemiology and disease management strategies. In this study, combined DNA sequence analyses of internal transcribed spacer, gapdh, chs-1, his3, act, tub2, and gs were applied to re-identify 27 Colletotrichum isolates in KACC. The phylogenetic analyses showed that the isolates resulted in 11 known species, they belong to the C. dematium species complex (C. hemerocallidis, C. jinshuiense, and C. spinaciae), the C. magnum complex (C. kaifengense and C. cf. ovatense), the C. orchidearum complex (C. cattleyicola, C. plurivorum, C. reniforme, and C. sojae) and the C. orbiculare complex (C. malvarum and C. orbiculare). Of them, C. cattleyicola, C. hemerocallidis, C. kaifengense, and C. reniforme were unrecorded species in Korea. In the view of host-fungus combinations, 10 combinations are newly reported in the world and 12 are new reports in Korea, although their pathogenicity on the host was not confirmed.

• The Korean Journal of Mycology
• /
• v.52 no.1
• /
• pp.55-60
• /
• 2024

In August 2023, leaf spot disease was observed in peanuts in Cheongju-si, Korea. Leaf spots occurred at the leaf margins and the lesions gradually expanded. Diseased leaf areas were light or dark brown and irregular in shape. A fungal isolate was obtained from symptomatic leaf and cultured on potato dextrose agar (PDA) medium at 25℃. An isolate was identified as Colletotrichum sojae based on morphological characteristics and sequences of the internal transcribed spacers, glyceraldehyde-3-phosphate dehydrogenase, chitin synthase-1, actin, and 𝛽-tubulin genes. Pathogenicity tests were performed on peanut seedlings in a conidial suspension (1×10⁶ conidia/mL). Lesions were observed on the peanut leaf 5 d after inoculation. The pathogen was re-isolated from the lesions of the inoculated leaves. To the best of our knowledge, this is the first report of anthracnose on peanut caused by C. sojae in Korea.

• Journal of Life Science
• /
• v.18 no.2
• /
• pp.234-240
• /
• 2008

Anthocyanin synthesis in strawberry (Fragaria x ananassa cv Maehyang) begins approximately 26 days postflowering and continued throughout fruit ripening. A set of cDNA clones encoding the anthocyanin biosynthetic enzymes were isolated from strawberry. A pair of primers were designed for polymerase chain reaction (PCR) through the comparison of the nucleotide sequences of homologous genes from diverse plants. Reverse transcriptase-PCRs were performed using cDNA synthesized from ripe fruit total RNA and the primers corresponding to each gene. Eight genes of the anthocyanin pathway were cloned and confirmed by sequencing to code for phenylalanine ammonia lyase (PAL), 4-cummarate CoA ligase (4CL), chalcone synthase (CHS), chalcone isomerase (CHI), flavanone-3-hydroxylase (F3H), dihydroflavonol 4-reductase (DFR), anthocyanidine synthase (ANS), UDP-glucose:flavonoid-3-O-glucosyl-transferase (UFGT). Northern analyses showed that the corresponding genes were differentially expressed during the fruit development process. All genes except PAL were predominantly expressed in fruit. Expression of PAL, DFR and ANS was detected 10 days postflowering at the early stage of fruit development, declined for a while and sharply increased 22 days postflowering then showed a peak 34 days postflowering. The other genes, however, were not expressed up to 22 or 30 days postflowering when the initial fruit ripening events occur at the time of initiation of anthocyanin accumulation. The onset of anthocyanin synthesis in ripening strawberry coincides with a coordinated induction of the anthocyanin pathway genes, suggesting the involvement of regulatory genes. We propose that at least two different regulatory mechanisms playa role in the biosynthesis of anthocyanin during color development of strawberry.

• Journal of The Korean Society of Grassland and Forage Science
• /
• v.27 no.2
• /
• pp.93-100
• /
• 2007

This study was conducted to determine the effects of different levels (10, 12 and 15%) of crude protein (CP) in total mixed ration (TMR) on dry matter intake, digestibility and nitrogen balance of Korean black goats in the stage of early pregnancy and to obtain information on their optimal dietary levels of CP. In the present study, 12 Does of Korean black goats in the early pregnancy were allotted to four unreplicated groups by dietary level of CP and then they were housed in individual metabolism cages with completely randomized design throughout 30 days with 20 days adaptation and 10 days collection periods. Does in Control were fed a conventional diet and does in TMR10, TMR12 and TMR15 were fed a diet adjusted to about 10, 12 and 15% CP, respectively. Dry matter(DM) contents ranged from 89 to 91% in treatments. There were no differences fur fiber contents among three CP levels of TMR, showing that ADF and NDF had 18.57 to 19.85, and 53.41 to 54.80, respectively. Crude protein contents for three TMR treaements had 10.61, 12.15 and 14.97%, respectively. However, non-fibrous carbohydrate (NFC) contents decreased with increasing CP levels in treatments. Meanwhile, Intakes of DM, nutrients and digestible nutrients were significantly (p<0.05) higher in TMR15 and control than in TMR10 and TMR12. Moreover, DM intake per metabolic body weight and theit ratio per body weight was significantly (p<0.05) higher for control and TMR15 than other treatments. DM digestibility was not significantly different among treatments, but ether extract digestibility of treatments was significantly (p<0.05) higher than that of control, but there was no significant difference among treatments. Nitrogen retention significantly (p<0.05) increased with increasing CP levels in TMR, and TMR15 was highest among treatments. Our results showed that the increasing CP levels in TMR increased DM intake and nitrogen retention and suggested that the optimal dietary CP levels under TMR feeding system in early pregnant Korean black goats could be estimated for at least 15%.

• The Journal of the Korea Contents Association
• /
• v.20 no.4
• /
• pp.244-253
• /
• 2020

This study aimed to assess the factors affecting the level of happiness and a sense of happiness among senior men and women, including sociodemographic characteristics, health behavior, subjective health level, and healthcare utilization, using the 2017 Community Health Survey (CHS). A total of 67,835 older adults were enrolled for the study, 27,979 males and 39,856 females. The results showed that education level and total household income affected the happiness in female elderly, while having a spouse increased happiness in male elderly. In addition, both male elderly and female felt a great of happiness when they had good health behaviors, perceived themselves to be in good health, and had no restrictions with healthcare utilization. Subjective health status and healthcare utilization seem to have a substantial impact on happiness because older adulthood is a period marked with increased physical vulnerability compared to other age groups due to diminished physiological functions. Based on these results, the government should expand subsidies for welfare for the aged to provide lifelong education opportunities and the existing elderly education and programs in health-related organizations should reflect the characteristics of the elderly. Furthermore, social service systems and programs related to the elderly should be re-evaluated so as to develop services and programs tailored to the elderly to promote their happiness more effectively.

• Annual Conference on Human and Language Technology
• /
• 2003.10d
• /
• pp.246-251
• /
• 2003

한국어의 언어적 특성에 의해 빈번하게 등장하는 명사와 기능어의 나열은 기능어나 연결 구문의 잦은 생략현상에 의해 복합 명사의 출현을 발생시킨다. 따라서, 한국어 분석에서 복합 명사의 처리 방법은 매우 중요한 문제로 인식되었으며 활발한 연구가 진행되어 왔다. 복합 명사의 의미 결정은 복합 명사구 내 단위 명사간의 의미적인 수식 관계를 고려하여 머리어의 선택과 의미를 함께 결정할 필요가 있다. 본 논문에서는 정보 검색의 색인어 추출 방법에서 사용되는 복합 명사구 내의 서술성 명사 처리를 이용하여 복합 명사의 의미 결정을 인접 명사의 의미 공기 정보가 아닌 구문관계에 따른 의미 공기 정보를 사용하여 분석하는 방법을 제시한다. 복합 명사구 내에서 구문적인 관계는 명사구 내에 서술성 명사가 등장하는 경우 보-술 관계에 의한 격 결정 문제로 전환할 수 있다. 이러한 구문 구조는 명사 의미를 결정할 수 있는 추가적인 정보로 활용할 수 있으며, 이때 구문 구조 파악을 위해 구축된 의미 제약 조건을 활용하도록 한다. 구조 분석에서 사용되는 격틀 정보는 동사와 공기하는 명사의 구문 관계를 분석하기 위해 의미 정보를 제약조건으로 하여 구축된다. 이러한 의미 격틀 정보는 단문 내 명사들의 격 결정과 격을 채우는 명사 의미를 결정할 수 있는 정보로 활용된다. 본 논문에서는 현재 개발중인 한영 기계 번역 시스템 Tellus-KE의 단문 단위 대역어 선정을 위해 구축된 의미 대역패턴인 동사구 패턴을 사용한다. 동사구 패턴에 기술된 한국어의 단문 단위 의미 격 정보를 사용하는 경우, 격결정을 위해 사용되는 의미 제약 조건이 복합 명사의 중심어 선택과 의미 결정에 재활용 될 수 있으며, 병렬말뭉치에 의해 반자동으로 구축되는 의미 대역 패턴을 사용하여 데이터 구축의 어려움을 개선하고자 한다. 및 산출 과정에 즉각적으로 활용될 수 있을 것이다. 또한, 이러한 정보들은 현재 구축중인 세종 전자사전에도 직접 반영되고 있다.teness)은 언화행위가 성공적이라는 것이다.[J. Searle] (7) 수로 쓰인 것(상수)(象數)과 시로 쓰인 것(의리)(義理)이 하나인 것은 그 나타난 것과 나타나지 않은 것들 사이에 어떠한 들도 없음을 말한다. [(성중영)(成中英)] (8) 공통의 규범의 공통성 속에 규범적인 측면이 벌써 있다. 공통성에서 개인적이 아닌 공적인 규범으로의 전이는 규범, 가치, 규칙, 과정, 제도로의 전이라고 본다. [C. Morrison] (9) 우리의 언어사용에 신비적인 요소를 부인할 수가 없다. 넓은 의미의 발화의미(utterance meaning) 속에 신비적인 요소나 애정표시도 수용된다. 의미분석은 지금 한글을 연구하고, 그 결과에 의존하여서 우리의 실제의 생활에 사용하는 $\ulcorner$한국어사전$\lrcorner$ 등을 만드는 과정에서, 어떤 의미에서 실험되었다고 말할 수가 있는 언어과학의 연구의 결과에 의존하여서 수행되는 철학적인 작업이다. 여기에서는 하나의 철학적인 연구의 시작으로 받아들여지는 이 의미분석의 문제를 반성하여 본다.반인과 다르다는 것이 밝혀졌다. 이 결과가 옳다면 한국의 심성 어휘집은 어절 문맥에 따라서 어간이나 어근 또는 활용형 그 자체로 이루어져 있을 것이다.으며, 레드 클로버 + 혼파 초지가 건물수량과 사료가치를 높이는데 효과적이었다.\ell}$ 이었으며 , yeast extract 첨가(添加)하여 배양시(培養時)는 yeast extract 농도(濃度)가 증가(增加)함에 따라 단백질(蛋白質) 함량(含量)도 증가(增加)하였다. 7. CHS-13 균주(菌株)의 RNA 함량(

• The KIPS Transactions:PartC
• /
• v.14C no.6
• /
• pp.519-524
• /
• 2007

One of the most important issues on the sensor network with resource limited sensor nodes is prolonging the network lifetime by effectively utilizing the limited node energy. The most representative mechanism to achieve a long lived sensor network is the clustering mechanism which can be further classified into the single hop mode and the multi hop mode. The single hop mode requires that all sensor nodes in a cluster communicate directly with the cluster head(CH) via single hop md, in the multi hop mode, sensor nodes communicate with the CH with the help of other Intermediate nodes. One of the most critical factors that impact on the performance of the existing multi hop clustering mechanism is the cluster size and, without the assumption on the uniform node distribution, finding out the best cluster size is intractable. Since sensor nodes in a real sensor network are distributed non uniformly, the fixed size mechanism may not work best for real sensor networks. Therefore, in this paper, we propose a new dynamic size multi hop clustering mechanism in which the cluster size is determined according to the distance from the sink to relieve the traffic passing through the CHs near the sink. We show that our proposed scheme outperforms the existing fixed size clustering mechanisms by carrying out numerical analysis and simulations.

• Journal of the Korea Convergence Society
• /
• v.11 no.6
• /
• pp.401-410
• /
• 2020

The purpose of this study was to investigate predictors and mediating effects of physical activity and nourishment regulation on well-being among young and middle aged patients on DM medication and to compare between those with non-pharmacological treatment and those without. Data were obtained from 2017 community health survey including 1,480 DM patients with oral medication in the age between 20 and 49. Using SPSS 25.0 and AMOS 25.0, path analysis was performed to explore the association between personal factors (socio-economic status, health habit, eating habit and compliance of health examination) and well-being, along with mediating effects of physical activity. Results demonstrated the different mediating role of physical activity. In medication only group, there was no direct effect of physical activity and no indirect effect of personal factors. Direct effect of physical activity and indirect effects of predictors were found in those with non-pharmacological treatment group. When developing strategies to enhance well-being of young and middle aged diabetic patients, proper reflection of their age specific traits and disease management capability are essential.