• Atmosphere
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• v.29 no.5
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• pp.627-637
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• 2019

Severe and long-lasting heat waves over Korea and many regions in the Northern Hemisphere (NH) during the 2016 summer, have been attributed to global warming and atmospheric teleconnection coupled with tropical convective activities. Yet, what controls subseasonsal time scale of heat wave has not been well addressed. Here we show a critical role of two dominant boreal summer intraseasonal oscillation (BSISO) modes, denominated as BSISO1 and BSISO2, on modulating temporal structure of heat waves in the midst of similar climate background. The 2016 summer was characterized by La Nina development following decay of strong 2015/2016 El Nino. The NH circumglobal teleconnection pattern (CGT) and associated high temperature anomalies and heat waves were largely driven by convective activity over northwest India and Pakistan during summer associated with La Nina development. However, the heat wave event in Korea from late July to late August was accompanied by the phase 7~8 of 30~60-day BSISO1 characterized by convective activity over the South China Sea and Western North Pacific and anticyclonic circulation (AC) anomaly over East Asia. Although the 2010 summer had very similar climate anomalies as the 2016 summer with La Nina development and CGT, short-lasting but frequent heat waves were occurred during August associated with the phase 1~2 of 10~30-day BSISO2 characterized by convective activity over the Philippine and South China Sea and AC anomaly over East Asia. This study has an implication on importance of BSISO for better understanding mechanism and temporal structure of heat waves in Korea.

• Journal of Physiology & Pathology in Korean Medicine
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• v.33 no.2
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• pp.116-122
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• 2019

The aim of this study is to evaluate the anti-inflammatory effect of Hataedock treatment using Coptidis Rhizome and Glycyrrhiza Uralensis (CG) mixed extract in allergic rhinitis induced NC/Nga mice. We divided NC/Nga mice into 3 groups as follows; allergic rhinitis-induced group after CG Hataedock treatment (CGT, n=10), no treatment group (Ctrl), allergic rhinitis elicited group (ARE). To induce allergic rhinitis, NC/Nga mice of 3 weeks age were sensitized on 7, 8 and 9week by Ovalbumin (OVA) antigen in intranasal space. Hataedock using CG extract was administered on week 3 in allergic rhinitis-induced group (CGT) after Hataedock treatment. To identify distribution of Interlukin (IL)-4, Cluster of differentiation 40 (CD40), high-affinity IgE receptor ($Fc{\varepsilon}RI$), substance P, Matrix metallopeptidase 9 (MMP-9), Nuclear $factor-{\kappa}B$ ($NF-{\kappa}B$) p65, Inducible nitric oxide synthase (iNOS) and Cycloxygenase-2 (COX-2), we used histological examination. CGT significantly inhibited IL-4 and CD40 response compared with ARE. The reduction of Th2 cytokine expression decreased inflammatory mediators such as $Fc{\varepsilon}RI$, substance P, MMP-9, $NF-{\kappa}B$ p65, iNOS and COX-2. Such immunological improvement induced reduction of respiratory epithelial damage and mucin secretion in goblet cell. These results indicate that Hataedock treatment suppresses allergic rhinitis through modulating of Th2 responses and diminishing various inflammatory mediators in nasal mucosal tissue. It might have potential applications for prevention and treatment of allergic rhinitis.

• Journal of Astronomy and Space Sciences
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• v.38 no.4
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• pp.217-227
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• 2021

In this study, we describe an analytical process for designing a low Earth orbit constellation for discontinuous regional coverage, to be used for a surveillance and reconnaissance space mission. The objective of this study was to configure a satellite constellation that targeted multiple areas near the Korean Peninsula. The constellation design forms part of a discontinuous regional coverage problem with a minimum revisit time. We first introduced an optimal inclination search algorithm to calculate the orbital inclination that maximizes the geometrical coverage of single or multiple ground targets. The common ground track (CGT) constellation pattern with a repeating period of one nodal day was then used to construct the rest of the orbital elements of the constellation. Combining these results, we present an analytical design process that users can directly apply to their own situation. For Seoul, for example, 39.0° was determined as the optimal orbital inclination, and the maximum and average revisit times were 58.1 min and 27.9 min for a 20-satellite constellation, and 42.5 min and 19.7 min for a 30-satellite CGT constellation, respectively. This study also compares the revisit times of the proposed method with those of a traditional Walker-Delta constellation under three inclination conditions: optimal inclination, restricted inclination by launch trajectories from the Korean Peninsula, and inclination for the sun-synchronous orbit. A comparison showed that the CGT constellation had the shortest revisit times with a non-optimal inclination condition. The results of this analysis can serve as a reference for determining the appropriate constellation pattern for a given inclination condition.

• Proceedings of the Korea Society of Design Studies Conference
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• 2004.05a
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• pp.224-225
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• 2004

• Journal of the Korea Society of Computer and Information
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• v.10 no.1 s.33
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• pp.53-58
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• 2005

Interfaces comprising menu and icons of web-based application programs should comply pertinently with user's cognitive system. In Particular, since the application Program's specific function in this study aimed at the purpose of child's effective idea, with respect to that, it is necessary to constitute a rational web use environment through careful research and analysis of user interface. The purpose of this study was to enhance elementary students to modify the CGTS with the menu arrangement. icon types and preferable terms for their use of professionally letter-based screen structure of CGTS developed to help the designer's idea.

• Journal of Korea Port Economic Association
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• v.28 no.2
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• pp.155-177
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• 2012

This paper aims at measuring the changes of Malmquist productivity and technical efficiency of Korean shipbuilding Industry and examinig their determinants utilizing the panel analysis. The increase of the technological progress was greater than technical efficiency, resulting in the increase of the total factor productivity for the period of 2004-2010. This study also employs the panel technique to analyse the effects of Employee, Dock, and Length on the changes of Malmquist productivity and technical efficiency. The dependent variables are obtained from three combinations, which are (Employee, Dock, and CGT), (Employee, Length, and CGT), and (Dock, and Length, and CGT). The empirical results show that all of the explanatory variables have a positive effect on the change of Malmquist productivity and technical efficiency.

• The Journal of Pediatrics of Korean Medicine
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• v.31 no.2
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• pp.48-56
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• 2017

Objectives Hataedock is a treatment that dispels toxic heat and meconium which has been accumulated to the fetus from a pregnant mother via orally administering herbal extracts to a newborn baby. This study was conducted to compare the efficacy of Hataedock, with using the extract of Coptis japonica & Glycyrrhiza uralensis, to the early administration of probiotics for immunomodulation in the intestinal mucosa. Methods NC/Nga mice were divided into three groups; Control group (no treatment), CGT group (3-week-old mice given the extract of Coptis japonica & Glycyrrhiza uralensis), and MBT group (3-week-old mice given a Bifidobacterium). After 2 weeks, the intestinal mucosa tissues of each group of mice were observed. Immunohistochemical staining for IL-4, IL-13, CD40, $Fc{\varepsilon}RI$, $p-I{\kappa}B$, EGF, and VEGF in the intestinal mucosa was performed. Results CGT group showed 65% decrease in IL-4, 67% decrease in IL-13, 58% decrease in CD40, 72% decrease in $Fc{\varepsilon}RI$, 76% decrease in $p-I{\kappa}B$, 41% increase in EGF and 100% increase in VEGF compared to the control group. MBT group also showed 50% decrease in IL-4, 63% decrease in IL-13, 33% decrease in CD40, 53% decrease in $Fc{\varepsilon}RI$, 46% decrease in $p-I{\kappa}B$, 23% increase in EGF and 151% increase in VEGF compared to the control group. Conclusions These results suggest that both Hataedock, with using the extract of Coptis japonica & Glycyrrhiza uralensis, and early administration of probiotics were effective in regulating Th2, relieving inflammation and developing intestinal mucosal tissues. Hataedock with extract of Coptis japonica & Glycyrrhiza uralensis may be more effective for immunomodulation in intestinal mucosa than probiotics.

• Atmosphere
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• v.28 no.3
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• pp.325-336
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• 2018

This study investigates robust features of interdecadal changes in the Northern hemisphere summer tropical-extratropical teleconnection occurred around the mid-to-late 1990s by analyzing four different reanalysis data for atmospheric circulation and temperature, two precipitation reconstructions, and two sea surface temperature (SST) data during the satellite observation era of 1980~2017. For the last 38 years, there has been a significant increasing trend in anticyclonic circulation at lower and upper troposphere and 2 m air temperature with wavenumber-5 Rossby wave structure in the Northern Hemisphere (NH) extratropics. The increase has been accompanied with the significant weakening and northward shift of jet stream over Eurasia and the North Pacific. It is further found that there has been a significant interdecadal shift occurred around the mid-to-late 1990s in the two distinct modes of tropical-extratropical teleconnection: Western Pacific-North America (WPNA) and circumglobal teleconnection (CGT) pattern. After mid-to-late 1990s, the WPNA has played more important role in modulating the extratropical atmospheric circulation and surface climate, which has been preferentially occurred during the El $Ni{\tilde{n}}o$-Southern Oscillation (ENSO) decaying or transition summer such as 1998, 2010 and 2016. During these summers, severe heat waves were occurred over many parts of the NH extratropics due to the combined effect of the increasing trend in the barotropic anticyclonic circulation and the significant WPNA across the NH. Although weakened, the CGT also contributed to some of hot summers over many parts of the NH extratropics such as 1999, 2000, 2008, 2011, and 2012 when weak to moderate La $Ni{\tilde{n}}o$ was persisted.

• Korean Journal of Veterinary Research
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• v.54 no.1
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• pp.39-48
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• 2014

The prevalence of thermophilic Campylobacter (C.) spp. in stray, breeding, and household dogs was 25.2, 12.0, and 8.8%, respectively. C. jejuni and C. upsaliensis were the predominant Campylobacter spp. from household dogs. cdtA, cdtB, and cdtC were detected by PCR in all isolates. Despite the high cytolethal distending toxin (CDT) gene prevalence, only 26 (31%) C. jejuni strains and one (15.3%) C. coli strain showed evidence of CDT production in HEp-2 cell cytotoxicity assays. Virulence-associated genes detected in the C. jejuni and C. coli isolates were cadF, dnaJ, flaA, racR, ciaB, iamA, pldA, virB11, ceuE, and docC. cadF, dnaJ, flaA, and ceuE were found in all C. jejuni and C. coli isolates. When detecting Guillain-Barr$\acute{e}$ syndrome-associated genes (galE, cgtB, and wlaN), galE was identified in all isolates. However, cgtB and wlaN were more prevalent in C. jejuni isolates from humans than those from dogs. Adherence and invasion abilities of the C. jejuni and C. coli strains were tested in INT-407 cells. A considerable correlation (adjusted $R^2$= 0.678) existed between adherence and invasion activities of the Campylobacter spp. isolates.

• The Journal of Pediatrics of Korean Medicine
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• v.33 no.2
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• pp.22-31
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• 2019

Objective This study is to learn the effects of Hataedock method using Coptidis rhizoma and Glycyrrhiza uralensis mixed extract on inflammatory response in allergic rhinitis-induced obese NC/Nga mice. Materials and Methods The mice were fed with high fat-diet to be obese, and were divided into 3 groups as follows; allergic rhinitis-induced obese mice group with Hataedock method (CGT, n=10), no treatment group (Ctrl), allergic rhinitis elicited obese mice group (ARE). To induce allergic rhinitis, NC/Nga mice of 3 weeks age were sensitized on 7, 8 and 9 weeks by ovalbumin antigen in intraperitoneal space. After 7 days of final sensitization, allergic rhinitis was initially induced in mice through nasal cavities for 5 days. After 1-week, allergic rhinitis was induced again by the same method. Histological examination was used to identify distribution of IL-4, CD40, STAT6, $Fc{\varepsilon}RI$, substance P, MMP-9, NF-${\kappa}B$ p65, iNOS and COX-2. Results Hataedock method significantly reduced IL-4, STAT6 and CD40 response (p<0.05). In CGT, the inhibition of Th2 differentiation decreased inflammatory mediators such as $Fc{\varepsilon}RI$, substance P, MMP-9, NF-${\kappa}B$ p65, iNOS and COX-2 (all p<0.05). The immunological improvement led reduction of respiratory epithelial damage and mucin secretion in goblet cell. Conclusion The results of this study show that the Hataedock method suppresses the expression of allergic rhinitis by decreasing the inflammatory mediators through the regulation of Th2 differentiation even when the inflammation reaction is increased by obesity. Therefore, Hataedock may have potential preventive measure of allergic rhinitis accompanied by obese.