• Experimental and Molecular Medicine
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• v.50 no.11
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• pp.6.1-6.12
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• 2018

Morphine tolerance remains a challenge in the management of chronic pain in the clinic. As shown in our previous study, the dopamine D2 receptor (D2DR) expressed in spinal cord neurons might be involved in morphine tolerance, but the underlying mechanisms remain to be elucidated. In the present study, selective spinal D2DR blockade attenuated morphine tolerance in mice by inhibiting phosphatidylinositol 3 kinase (PI3K)/serine-threonine kinase (Akt)-mitogen activated protein kinase (MAPK) signaling in a ${\mu}$ opioid receptor (MOR)-dependent manner. Levo-corydalmine (l-CDL), which exhibited micromolar affinity for D2DR in D2/CHO-K1 cell lines in this report and effectively alleviated bone cancer pain in our previous study, attenuated morphine tolerance in rats with chronic bone cancer pain at nonanalgesic doses. Furthermore, the intrathecal administration of l-CDL obviously attenuated morphine tolerance, and the effect was reversed by a D2DR agonist in mice. Spinal D2DR inhibition and l-CDL also inhibited tolerance induced by the MOR agonist DAMGO. l-CDL and a D2DR small interfering RNA (siRNA) decreased the increase in levels of phosphorylated Akt and MAPK in the spinal cord; these changes were abolished by a PI3K inhibitor. In addition, the activated Akt and MAPK proteins in mice exhibiting morphine tolerance were inhibited by a MOR antagonist. Intrathecal administration of a PI3K inhibitor also attenuated DAMGO-induced tolerance. Based on these results, l-CDL antagonized spinal D2DR to attenuate morphine tolerance by inhibiting PI3K/Akt-dependent MAPK phosphorylation through MOR. These findings provide insights into a more versatile treatment for morphine tolerance.

• 한국경영정보학회:학술대회논문집
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• 2007.11a
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• pp.395-401
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• 2007

본 논문은 의료정보시스템 관련 표준인 HL7(Health Level 7)의 정보를 토대로 WS-CDL(Web Service Choreograph Description Language) 웹 서비스를 유도하여 의료정보시스템의 상호운용성을 확보하는데 기여하는 논문으로, 웹 서비스화에 있어 인터페이스 측면만이 아닌 코리오그래피 정보까지도 유도해내는 프레임워크를 제시한다. 또한 현재 HL7에서 다루고 있는 부분 외에도 WS-CDL로 대표되는 코리오그래피 기술 언어의 생성부분을 추가하여 참여자간에 연동 구조를 공유할 수 있게 함으로써, 기술 언어의 생성 부분을 추가하기 전보다 참여자간의 원활한 상호연동이 일어날 수 있도록 돕는 등의, 다양한 웹 서비스 구성요소에 대한 유도를 가능하게 할 수 있는 방향을 제시하였다.

• 한국경영정보학회:학술대회논문집
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• 2007.11a
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• pp.389-394
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• 2007

웹 서비스가 현재 산업에서 주요한 분산 컴퓨팅 기술로 대두되면서, 그에 따른 연구가 활발히 이루어지고 있다. 특히, 비즈니스 프로세스 관점에서 BPEL4WS (Business Process Execution Language for Web Services)와 같은 오케스트레이션의 연구가 많이 이루어지고 있다. 또한, 웹 서비스의 주요 구성 요소중에 하나인 코리오크래피에 대한 부분은 W3C (World Wide Web Consortium)에서 현재 후보 권고안 수준인 WS-CDL (Web Services Choreography Description Language) 관련 연구가 이루어지고 있다. 이런 가운데 DERI (Digital Enterprise Research Institute)에서 WSMX (Web Services Execution Environment) 기반의 시맨틱 웹 서비스 분야의 코리오 그래피 연구를 시작하였고, 코리오그래피 불일치 (Mismatch)를 개념적으로 해결하는 방안인 프로세스 미디에이션 (Process Mediation)의 연구가 있었다. 이러한 연구들을 바탕으로 서로 다른 WS-CDL 상에서 특정 참여자가 코리오그래피 미디에이션을 하기위해서 개발된 XML 언어 WS-CML (Web Services Choreography Mediation Language)을 본 논문에서 제안한다.

• Proceedings of the Korean Information Science Society Conference
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• 2005.11b
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• pp.94-96
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• 2005

지금까지 비즈니스 프로세스 관리에 대한 다양한 연구 활동들이 수행되어 왔지만, 아직까지 범용적인 비즈니스 프로세스 언어 표준이 규정되어 있지 않은 상태이다. 본 연구에서는 대표적인 비즈니스 프로세스 언어들(BPEL4WS, BPML, WSCI, WS-CDL, BPSS 등)의 비교 분석을 통해, 협업 비즈니스 환경에서 비즈니스 프로세스 언어가 가져야 할 필수 요소들을 제안한다. 비즈니스 프로세스 언어의 비교는 세 단계로 구성된다. 첫째, 비즈니스 프로세스를 구성하는 애플리케이션에 따라 조직 내외의 비즈니스 프로세스를 비교한다. 둘째, 협업 비즈니스 프로세스의 모델링 절차에 따라 절차에 필요한 필수 비즈니스 엔터티를 제안한다. 마지막으로, 추출된 필수 비즈니스 엔터티를 이용하여 다양한 비즈니스 프로세스 언어들 사이의 특징을 비교 분석한다.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.23 no.54
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• pp.97-110
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• 2000

As more and more companies pursue ISO 9000 certification, one of the most misconceptions about ISO 9000 is that registration is necessary only for business. ISO 9000 is being driven by commercial requirements, not legal fiat. This registration can be used as evidence of compliance to the ISO 9000 to satisfy specific customer requirements. The primary objective of this research is to provide the efficient implementation process of ISO 9000 certification on the basis of total quality management concerning with ISO/CDl 9001:2000, ISO/CDl 9004:2000 and ISO/CD2 9001:2000. Based on the result of first paper in May 1999, this study has been conducted using the data collected from 312 manufacturing companies which registered ISO 9000 certification. This analysis can be applied to Korean small and medium industrial companies in establishing and maintaining the development of qualify systems. The companies should be able to benefit if they make continuous effort to improve the quality activities based on the factors suggested in this paper.

• Information and Communications Magazine
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• v.28 no.4
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• pp.41-50
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• 2011

미래 전에서는 정보의 중요성이 더욱 부각되고 있으며 정보의 수집 및 전파, 정확한 지휘결심 및 전파, 기동타격체계의 통제 등으로 이어지는 지휘통제의 전 과정을 유기적으로 연결하여, 그 성능을 극대화시키는 것이 네트워크 중심전(NCW: Net-Centric Warfare)의 개념이다. NCW 실현을 위해 개발중인 여러 체계 중 주목 받고 있는 것이 무인기(UAV: Unmanned Aerial Vehicle) 이다. 무인기는 감시정찰, 고정밀 타격, 그리고 전투피해평가 기능 등을 수행하며, 전술적인 상황인식이 가능하게 한다. 무인기가 이러한 임무를 수행하기 위해서는 비행체의 상태정보, 비행체의 조종통제정보, 그리고 임무 탑재체가 획득한 정보의 간단없고 정확한 전달이 요구된다. 이러한 정보를 전송하기 위한 비행체와 지상체간의 제반 통신을 데이터 링크(Data Link)라 하며, NCW 구현에 있어서 가장 핵심이 되는 요소이다. 세계 각국은 영상정보 수집자산으로서 무인기와 데이터링크의 개발에 박차를 가하고 있는 실정이며, 우리 군도 전력화가 계획된 각 제대별 무인기의 통합운용을 위한 영상정보 공용데이터 링크 (MPI-CDL: Multi-Platform Image and Intelligence Commom Data Link)를 개발중에 있으며 지속적인 영상정보 수집자산의 소요증가에 따른 주파수 획득문제와 사업별 독자적인 데이터 링크의 개발을 지양하고 기존체계와의 상호운용 및 단절없는 통신을 보장을 위해 개발과 동시에 국가적 차원에서의 기술구조 표준화가 추진되어야 한다. 이러한 시점에서 본고에서는 먼저 선진국의 (CDL : Commom Data Link) 표준화 동향을 알아보고, 상호운용성과 연동을 위한 한국형 MPI-CDL 기술 표준화방향을 제시하고자 한다.

• The KIPS Transactions:PartD
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• v.13D no.5 s.108
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• pp.671-682
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• 2006

Until now, a variety of the standard and research activities are progressed in the business process management. However, since the common standard of the collaboration process language has not been determined, the research activities could not be well-systemized. We would present the guide-line to select and use the collaboration process language straightly through comparing different collaboration process languages (BPEL4WS, BPML, WSCI, WS-CDL, BPSS, etc). In this regard, we define the implicit and the explicit collaboration as the collaboration method in advance and present the result acquired according to compare and analyze the features of the collaboration process languages. First, the necessary elements the collaboration process languages have are extracted through the framework of the inter-organizational workflow proposed by Bernauer and the collaboration process modeling procedure(CPMP). Second, we analyze the properties of the collaboration process language based the essential elements. Finally, we show the complete example that the collaboration business process really reflects the characteristics of the collaboration business process languages

• Radiation Oncology Journal
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• v.14 no.1
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• pp.53-59
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• 1996

Purpose : Radiation-induced alteration in the immune function is well known phenomenon in cancer patients. Our purpose is to evaluate the extent of immune suppression immediately after mediastinal or pelvic irradiation, which include significant volume of active bone marrow in adults. Materials and Methods'48 cancer patients with mediastinal(N=29) and pelvic irradiation(N=19) were the basis of this analysis. Age ranged from 36 to 76 and mean and median value was 57 years, respectively Sex ratio was 1.3(M: F=27/21). The immunological parameters were the complete blood cell(CBC) with differential cell(D/C) count, T cell subset(CD3, CD4, CD8 CDl9), NK cell test(CDl6, CD56), and serum immunoglobulin(IgG, IgA, IgM) level. Results : The mean value of white blood cell(WBC) was reduced from 7017 to 4470 after irradiation(p=0.0000). In the differential count, the number of lymphocyte, neutrophil, and basophil was markedly reduced with statistical significance(p<0.01) and the number of monocyte was not changed and, on the contrary, that of eosinophil was increased by irradiation. In the lymphocyte subpopulation analysis, the number of all subpopulations, CD3(T cell), CD4(helper T cell), CD8(suppressor T cell), CDl6(NK cell), CDl9(B, cell) was reduced with statistical significance. The mean ratio of CD4 to CD8 in all patients was 1.09 initially and reduced to 0.99 after radiotherapy(p=0.34) , but the proportional percentage of all subpopulations was not changed except CD19(B cell) after irradiation. In the immunoglobulin study, initial values of Ig G, Ig A, and Ig M were relatively above the normal range and the only Ig M was statistically significantly reduced after radiotherapy(p=0.02). Conclusion : Mediastinal and pelvic irradiation resulted in remarkable suppression of lymphocyte count in contrast to the relatively good preservation of other components of white blood cells. But the further study on the functional changes of lymphocyte after radiotherapy may be necessary to conclude the effects of the radiation on the immunity of the cancer Patients.

• Journal of Korea Multimedia Society
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• v.4 no.1
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• pp.13-28
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• 2001

In a VOD(Vide-On-Demand) system, video data are generally stored in magnetic disk array. In order to provide real-time requirement for data retrieval, video streams must be delivered continuously to the clients such that the delivery of continuous media can be guaranteed in a timely fashion. Compared to the increased performance of processors and networks, the performance of magnetic disk systems have improved only modestly. In order to improve the performance of storage system, disk array system is proposed and used. The array system improves I/O performance by placing disks in parallel and retrieving data concurrently. In this paper, two approaches are considered in order to access the video data in a VOD system, which are CTL(Constant Time Length) and CDL(Constant Data Length) access policies. Disk scheduling policies are also classified into the two categories and compared in terms of the maximum allowable video streams with different degrees of disk array synchronization, under the mixed environments in which both data access policy and disk scheduling policy are considered. Among the compared scheduling policies, LOOK was shown to have the best performance. In terms of degree of disk synchronization, more gain was achieved with large degree of synchronization. In comparisons of performance of CTL and CDL, CTL was proved to have a little superior performance in terms of number of maximum allowable streams.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.1
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• pp.311-320
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• 2018

This study was conducted to investigate the relationship among major satisfaction (MS), clinical competence (CC), career decision-making self-efficacy (CDMS), and career decision level (CDL) for undergraduate nursing students. A self-report instrument was used to measure MS, CC, CDMS, and CDL. Questionnaires were completed by 307 nursing students in three nursing colleges, and path analysis was employed to validate the proposed model and analyze the causal relationships among variables. Four constructs (MS, CC, CDMS, and career decision) were analyzed. To build a path model, MS and CC were linked to CDMS and career decision. The initial analysis suggested that the modification needed modification; therefore, a covariance link was added. The overall goodness of fit for indices indicated satisfactory path analysis. The indices were revealed as $x^2=2412$, GFI=0.996, AGFI=0.961, and RMSEA=0.068. As a result, the proposed model was acceptable with a good fit, and there were significant direct and indirect effects of paths in the model. Specifically, MS and CC had a direct influence on CDMS, and MS and CDMS directly affected CDL. Moreover, MS and CC had indirect effects on CDL through CDMS. These results imply that students' CDMS should be seriously considered when designing counseling programs for career guidance, and substantiality of CC education is needed to improve CDMS. These results may provide a practical guideline to provide educational intervention for nursing students.