• 대한화학회지
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• 제46권4호
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• pp.336-345
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• 2002

본 연구에서는 조합화학을 이용하여 $CaO-Gd_2O_3-Al_2O_3$계에서 $Eu^{3+}$와 $Tb^{3+}$활성 적색 및 녹색 PDP용 형광체를 탐색하였으며 탐색된 형광체의 합성온도, 최적조성,발광 특성 등을 조사하였다. $CaO-Gd_2O_3-Al_2O_3$의 삼성분계의 형광특성 라이브러리를 작성하기 위하여 210개의 다른 조성을 가진 시료를 고분자 착체 중합법으로 합성하였다. 합성된 형광체 분말을 VUV PL로 측정하여 형광 특성 라이브러리를 작성하였고 발광특성이 잘 나타난 시료를 XPD를 이용하여 결정 구조를 확인하였다. 적색 형광체로서 탐색된 $Ca_{\alpha}$G$d_{0.95-\alpha-\beta}$$Al_\beta$$O_\delta$ : Eu(0.02< $\alpha+\beta$ <0.04)형광체는 색순도 면에서 상용형광체보다 개선된 특성을 보였으며 녹색 형광체로서 탐색된 $CaGdAl_3O_7$ : Tb, Ca$Al_{12}$$O_{19}$ : Tb, $Gd_4Al_2$$O_9$ : Tb, $Gd_3Al_5$$O_{12}$ : Tb 형광체 중에서 $CaGdAl_3O_7$ : Tb, Ca$Al_{12}$$O_{19}$ : Tb형광체는 상용 형광체에 비해 잔광시간이 짧은 특성을 보였다

• 한국재료학회지
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• 제13권9호
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• pp.572-580
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• 2003

Synthesizing behavior and microstructural evolution of $CaZrO_3$and $m-ZrO_2$in a thermal reaction process of $ZrSiO_4$-$xCaCO_3$mixtures, where x is 7 and 19, were investigated to determine the addition amount of CaO in CaO:$ZrO_2$:$SiO_2$ternary composition. CaZrO$_3$-Ca$_2$SiO$_4$precursor prepared by the mixture of $ZrSiO_4$and CaCO$_3$in aqueous suspending media was controlled to the acidic (pH=4.0) condition with HCI solution to enhance the thermal reaction. The addition amount of dispersant into the $ZrSiO_4$-$xCaCO_3$slip increased with increasing mole ratio of $CaCO_3$, which was associated with the viscosity of slip. Decarbonation reaction was activated with an increase of the addition amount of $CaCO_3$, showing different final temperatures in $ZrSiO_4$-$7CaCO_3$and $ZrSiO_4$-$19CaCO_3$mixtures as about 980 and 116$0^{\circ}C$, respectively, for finishing decarbonation reaction. The grain morphology was changed to spherical shape for all samples with an increase of sintering temperature. The grain size and phase composition of the synthesized composites depended on the mixture ratio of Zrsi04 and CacO3 powders, indicating that the main crystals were m-ZrO2 ($\leq$3 $\mu\textrm{m}$) and $CaZrO_3$ ($\leq$ 7 $\mu\textrm{m}$) in $ZrSiO_4$$>-7CaCO_3$and $ZrSiO_4$-$19CaCO_3$mixtures, respectively.

• 대한화학회지
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• 제36권5호
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• pp.621-626
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• 1992

수용액 중에서 요오드와 $4-(C_9H_{19})C_6H4_O(CH_2CH_2O)_{40} [NP-(EO)_40]$간의 charge transfer(CT) 상호작용에 미치는 $Ca^{2+}$이온의 영향을 UV-visible spectrophotometer를 이용하여 조사하였다. CT 상호작용에 따른 최대 흡수는 390 nm 부근에서 나타났으며, $Ca^{2+}$ 이온 존재하에서는 370 nm 영역으로 이동되었다. 계면활성제 농도를 CMC 이상에서 고정시켰을 때, CT 상호작용에 따른 최대흡수곡선의 강도가 $Ca^{2+}$이온 첨가 농도에 따라 증가하다가 감소하는 변곡점을 보였다. CT 상호작용에 기인한 흡수곡선의 강도가 증가하는 것은 $Ca^{2+}$이온 존재하에서 미셀 구조가 더욱 조밀해진데 다른 요오드와의 donor-acceptor overlap 증가로 볼 수 있다. 이러한 현상들은 수용액 중에서 상대적으로 자유로이 여러가지 배향을 가질 수 있는 비이온성 계면활성제의 선형 oxyethylene(EO) 사슬이 유사 크라운 에테르 구조를 형성하여 $Ca^{2+}$이온과 착물을 형성할 수 있는 가능성을 보여준다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권19호
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• pp.8409-8411
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• 2014

Purpose: To assess the value of multi-tumor marker protein chips in the diagnosis and treatment of ovarian cancer. Materials and Methods: Twelve tumor markers (CA19-9, NSE, CEA, CA242, CK19, ${\beta}$-HCG, AFP, SCC, c-PSA, CA125, CA724 and CA15-3) were detected by protein biochip in 220 patients with ovarian carcinomas, 205 with benign ovarian tumors and 200 healthy subjects. Results: The positivity rate was obviously higher in ovarian cancer (77.7%), than that in the benign cases (26.3%, p<0.01) and healthy subjects (4.5%, p<0.01). Serum levels of tumor markers were furthermore significantly higher in cases with lymph node metastasis (86.8%) than those without metastasis (44.7%), p<0.01. Conclusions: Multi-tumor marker protein chips provide important assistance in the diagnosis and treatment evaluation in ovarian cancers.

• 한국간담췌외과학회지
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• 제26권4호
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• pp.363-374
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• 2022

Backgrounds/Aims: To analyze the results of the neoadjuvant treatment of patients in our center with early pancreatic cancer. Methods: Eighty-four patients with early pancreatic cancer (I-II) were included, of which 59 were considered "bioborderline" (carbohydrate antigen [CA] 19-9 > 37 U/L), and 25 were considered "non-bioborderline" (CA19-9 < 37 U/L). The R0 resection rate, presence of negative nodes, survival, and recurrence rates were analyzed in two groups, the NEO group (neoadjuvant + surgery) and the nonNEO group (upfront surgery). Results: A 28.6% pathologic complete response was observed in the NEO group of the whole sample. The residual R0 was 85.7%, and nodes were negative in 78.6% of the patients in the NEO group of bioborderline patients. All non-bioborderline patients treated with neoadjuvant were R0, and no affected nodes were observed in any of them. The median overall survival (OS) in patients with elevated CA19-9 levels in the NEO group was 31.4 months vs. 13.1 months in the non-NEO (log-rank test p = 0.006), with a 62% relative reduction in the mortality rate (hazard ratio = 0.38, 95% confidence interval: 0.20-0.79; p= 0.008). The median OS in patients with normal CA19-9 levels in the NEO group was 65.9 months vs. 16.2 months in the non-NEO group, without statistically significant differences between the two but with a trend toward significance (log-rank test p = 0.08). Conclusions: A neoadjuvant strategy seemed to improve local control and the survival of patients with early pancreatic cancer, both those with elevated CA19-9 and normal marker levels.

• 원예과학기술지
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• 제19권2호
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• pp.145-148
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• 2001

감귤의 품질에 미치는 CA 저장의 효과를 알아보기 위하여 본 실험을 수행하였다. 1998년 11월 제주도에서 수확된 온주밀감을 공시재료로 사용하였다. 무게감량과 경도는 저온저장구보다 CA 처리에서 저장기간 동안 높게 유지되었고 SSC 값은 저온저장 2개월까지 뚜렷이 증가하다가 그 이후 급격하게 감소한 반면 CA 처리에서는 저장 4개월까지 지속적으로 증가하는 양상을 나타내었다. 유기산은 CA 처리에서 저온저장에서 보다 약간 높게 유지되는 형태로 저장 중 모든 처리에서 크게 감소하였다. 시장성 판정을 위한 품질평가 결과에서도 CA 조건이 저온저장에 비하여 품질유지에 비교적 효과적이었다.

• 한국습지학회지
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• 제14권4호
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• pp.537-545
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• 2012

낙엽활엽수인 상수리나무 낙엽의 지역에 따른 분해율 및 분해과정에 따른 영양염류의 함량 변화를 파악하기 위해 2008년 12월 공주의 상수리나무림과 진주지역의 낙엽-상록침엽수 혼효림 임상에 낙엽주머니를 설치하고 2011년 3월까지 33개월 동안 분해율, 분해상수 (k), 그리고 분해과정에 따른 C/N 비, C/P 비의 변화와 영양염류의 동태를 조사하여 비교하였다. 33개월경과 후 공주와 진주에서 상수리나무 낙엽 잔존률은 각각 $41.2{\pm}0.4%$와 $28.3{\pm}0.6%$, 분해상수 (k)는 각각 0.39와 0.61로 진주지역이 공주지역에 비해 분해가 빠른 것으로 나타났다. 이것은 진주지역이 공주에 비해 연중 기온과 강수량이 높기 때문인 것으로 판단된다. 상수리나무 낙엽의 분해과정에 따른 C/N. C/P 비율은 초기에 각각 46.8, 270.9 이었으나 33개월경과 후에는 공주지역에서 각각 22.0과 106.8, 진주지역에서는 각각 19.2와 170.2로 낮아졌다. 낙엽의 초기 N, P, K, Ca, Mg 함량은 각각 8.31, 0.44, 4.18, 9.38, 1.37 mg/g이었으며, 33개월경과 후 N, P, K, Ca, Mg의 잔존률은 공주지역에서 각각 91.0, 85.4, 30.2, 47.9, 11.7 %, 진주지역에서는 각각 67.0, 54.2, 19.9, 30.0, 40.8%로 Mg을 제외하고 진주지역의 잔존률이 낮았다. 조사기간 동안에 질소와 인은 부동화 후 무기화가, 칼륨, 칼슘, 마그네슘은 지속적인 무기화가 진행되었다.

• Bulletin of the Korean Chemical Society
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• 제19권9호
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• pp.980-985
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• 1998

The excited-state intramolecular proton transfer (ESIPT) emission has been observed for 0.01 mM p-aminosalicylic acid (AS) in nonpolar aprotic solvents as demonstrated by the large Stokes' shifted fluorescence emission around 440 nm in addition to the normal emission at 330 nm. However in aprotic polar solvent such as acetonitrile, the large Stokes' shifted emission band becomes broadened, indicating existence of another emission band originated from intramolecular charge transfer (ICT). It is noteworthy that in protic solvents such as methanol and ethanol the normal and ICT emissions are quenched as the AS concentration decreases, followed by the appearance of new emission at 380 nm. These results are interpreted in terms of ESIPT coupled charge transfer in AS. Being consistent with these steady-state spectroscopic results, the picosecond time-resolved fluorescence study unravelled the decay dynamics of the ESIPT and ICT state ca. 300 ps and ca. 150 ps, respectively with ca. 40 ps for the relaxation time to form the ICT state.

• Journal of Microbiology and Biotechnology
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• 제9권2호
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• pp.168-172
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• 1999

The antifungal mechanism of the antifungal peptide against Aspergillus fumigatus, $K^{18,19}$-CA(l-8)-ME(l-12), derived from cecropin A(l-8)-melittin(l-12) was investigated by confocal laser scanning microscopy, cell wall regeneration, ATPase activity inhibition, and released potassium ion. By confocal laser scanning microscopy, $K^{18,19}$-CA(l-8)-ME(l-12) was detected on the surface of A. fumigatus, while cecropin A used as a negative control peptide was not detected. The protoplast of A. fumigatus treated with$K^{18,19}$-CA(1-8)-ME(1-12) failed to regenerate the fungal cell walls. Compared with cecropin A, the amount of potassium ion released by $K^{18,19}$-CA(l-8)-ME(l-12) was increased. Furthermore, $K^{18,19}$-CA(l-8)-ME(l-12) inhibited the ATPase activity on the plasma membrane. These results suggested that $K^{18,19}$-CA(l-8)-ME(1-12) acts on the plasma membrane of A. fumigatus and its antifungal action is due to the ion channel or pore formation on the plasma membrane.

• Asian Pacific Journal of Cancer Prevention
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• 제16권7호
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• pp.3015-3021
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• 2015

Background: Colorectal cancer (CRC) is a major cause of mortality in developed countries, and it is the third most frequent malignancy in Turkey. There are many biological, genetic, molecular, and tissue-derived prognostic factors for CRCs. In this study, we evaluated prognostic factors in patients who were metastatic at diagnosis or progressed to metastatic disease during follow-up. Patients and Methods: This study included 116 patients with malignancies either in the colon or rectum. Of these, 65 had metastatic disease at diagnosis, and 51 progressed to metastatic disease during the course of the disease. The parameters evaluated were age, gender, comorbidity, performance status and stage of the disease at the beginning, localization, history of surgery, chemotherapy regimen, response to first-line treatment, K-RAS status, site and number of metastases, expression of tumor predictors (CEA, CA19-9), and survival times. A multivariate analysis conducted with factors that considered statistically significant in the univariate analysis. Findings: Median age was 56 (32-82) years and the male/female ratio was 80/36. Eleven patients were at stage II, 40 at stage III, and 65 at stage IV at diagnosis. Twenty three patients had tumor in the right colon, 48 in the left colon, and 45 in the rectum. Ninety seven patients were operated, and 27 had surgical metastasectomy. Ninety three patients received targeted therapy. At the end of follow-up, 61 patients had died, and 55 survived. Metastatic period survival times were longer in the adjuvant group, but the difference did not reach the level of statistical significance (adjuvant group: median 29 months, metastatic group: median 22 months; p=0.285). In the adjuvant group before the metastatic first-line therapy, CEA and CA 19-9 levels were significiantly lower compared to the metastatic group (p<0.005). We also found that patients with elevated tumor predictor (CEA, CA 19-9) levels before the first-line therapy had significiantly poorer prognosis and shorter survival time. Survival was significiantly better with the patients who were younger than 65 years of age, had better initial performance status, a history of primary surgery and metastatectomy, and single site of metastasis. Those who benefitted from the first-line therapy were K-RAS wild type and whose tumor markers (CEA, CA 19-9) were not elevated before the first line therapy. Conclusions: Among the patients with metastatic CRC, those who benefited from first-line therapy, had history of metastasectomy, were K-RAS wild type and had low CA 19-9 levels before the first-line therapy, showed better prognosis independent of other factors.