• East Asian mathematical journal
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• 제36권3호
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• pp.389-415
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• 2020

Let M be a semi-invariant submanifold of codimension 3 with almost contact metric structure (𝜙, ξ, η, g) in a complex space form M_n+1(c), c ≠ 0. We denote by R_ξ and R'_X be the structure Jacobi operator with respect to the structure vector ξ and be R'_X = (∇_XR)(·, X)X for any unit vector field X on M, respectively. Suppose that the third fundamental form t satisfies dt(X, Y) = 2𝜃g(𝜙X, Y) for a scalar 𝜃(≠ 2c) and any vector fields X and Y on M. In this paper, we prove that if it satisfies R_ξ𝜙 = 𝜙R_ξ and at the same time R'_ξ = 0, then M is a Hopf real hypersurfaces of type (A), provided that the scalar curvature ${\bar{r}}$ of M holds ${\bar{r}}-2(n-1)c{\leq}0$.

• Korean Journal of Acupuncture
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• 제19권2호
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• pp.97-117
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• 2002

Chiropractic is very similar to Oriental Medicine in philosophy on the cause of diseases and in utilization of spinal articulations for diagnosis and treatment. In this paper the spinal area used to treat liver dysfunction in S.O.T. technique, one of chiropractic techniques, was compared to the acupncture points used to cure the same conditions. Because both Oriental medicine and Chiropractic are dealing with autonomic nervous system in regulating abnormal conditions, also the innervation of spinal nerves to those areas was checked. The spinal area that S.O.T. technique utilizes to correct liver dysfunction is transverse processes of T8, which corresponds to B16. Acupncture points from this level down to T12/L1, which are B16, B17, B18, B19, B20, B21, B45, B46, B47, B48, B49, B50, GV6, GV7, GV8 and GV9, all have been applied to control liver function. Apparent discrepency exists in therapeutic areas for liver malfunction between the two natural healing arts. According to the neurology texts, liver is innervated by sympathetic fibers from the 7th-10th thoracic segments and by parasympathetic fibers from vagus nerve. Sympathetic afferent nerves from the liver reach the 7th-12th thoracic spinal cord segments. It can be said all the 7th-12th thoracic spinal cord segments are related to liver function. Therefore the areas used for liver dysfunction in both natural medicine are appropriately selected. However, B16, the Oriental medical equivalent of the main spinal area which is used for lowered liver function in C.M.R.T. Technique, is not utilized as frequent as in Oriental medicine.

• 수산해양기술연구
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• 제17권2호
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• pp.77-83
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• 1981

하천 오염에서 문제시되고 있는 유기오염 물질인 PCP 와 DDT의 환경기준을 평가하고 담수어 어종간의 독성에 대한 저항성을 연구하였다. 각 어종에 대하여 24, 48, 72 및 96시간의 TL sub(m) 값을 산출하였던 바 오염물질에 대한 저항성은 오염물질의 성상에 따라 상이한 양상을 보여주었다. 실험한 10종의 담수어중 PCP 및 DDT에 저항성이 약한 어종은 N. Chrysophekadion으로 96 h-TL 하(m) 값은 0.065mg/l 과 0.0044mg/l으로 각각 나타났으며 PCP에 저항성이 강한 어종은 T. nilotica로서 96 h-TL 하(m) 값은 0.264mg/l이었으나, DDT에 대해서는 C. Siamensis로서 96 h-TL 하(m) 값은 0.0133mg/l로 평가되었다.

• Journal of Electrochemical Science and Technology
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• 제13권4호
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• pp.431-437
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• 2022

As one of the most hazardous and deadliest pathogens, Listeria monocytogenes (LM) posed various serious diseases to the human being, thus designing effective strategy for its detection is of great significance. In this work, by preparing Ti₃C₂T_x MXenes nanoribbon (Ti₃C₂T_xR) as carrier and selecting thionine (Th) acted simultaneously as signal probe and functional monomer, a LM pathogen-imprinted polymers (PIP) integrated probe electrochemical sensor was design to monitor LM for the first time, that was carried out through the electropolymerization of Th on the Ti₃C₂T_xR/GCE surface in the existence of LM. Upon eluting the templates from the LM imprinted cavities, the fabricated PIP/Ti₃C₂T_xR/GCE sensor can rebound LM cells effectively. By recording the peak current of Th as the response signal, it can be weakened when LM cell was re-bound to the LM imprinted cavity on PIP/Ti₃C₂T_xR/GCE, and the absolute values of peak current change increase with the increasement of LM concentrations. After optimizing three key parameters, a considerable low analytical limit (2 CFU mL^-1) and wide linearity (10-10⁸ CFU mL^-1) for LM were achieved. In addition, the experiments demonstrated that the PIP/Ti₃C₂T_xR sensor offers satisfactory selectivity, reproducibility and stability.

• Biomolecules & Therapeutics
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• 제27권6호
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• pp.577-583
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• 2019

Human cytochrome P450 2C9 is a highly polymorphic enzyme that is required for drug and xenobiotic metabolism. Here, we studied eleven P450 2C9 genetic variants-including three novel variants F69S, L310V, and Q324X-that were clinically identified in Korean patients. P450 2C9 variant enzymes were expressed in Escherichia coli and their bicistronic membrane fractions were prepared The CO-binding spectra were obtained for nine enzyme variants, indicating P450 holoenzymes, but not for the M02 (L90P) variant. The M11 (Q324X) variant could not be expressed due to an early nonsense mutation. LC-MS/MS analysis was performed to measure the catalytic activities of the P450 2C9 variants, using diclofenac as a substrate. Steady-state kinetic analysis revealed that the catalytic efficiency of all nine P450 2C9 variants was lower than that of the wild type P450 2C9 enzyme. The M05 (R150L) and M06 (P279T) variants showed high $k_{cat}$ values; however, their $K_m$ values were also high. As the M01 (F69S), M03 (R124Q), M04 (R125H), M08 (I359L), M09 (I359T), and M10 (A477T) variants exhibited higher $K_m$ and lower $k_{cat}$ values than that of the wild type enzyme, their catalytic efficiency decreased by approximately 50-fold compared to the wild type enzyme. Furthermore, the novel variant M07 (L310V) showed lower $k_{cat}$ and $K_m$ values than the wild type enzyme, which resulted in its decreased (80%) catalytic efficiency. The X-ray crystal structure of P450 2C9 revealed the presence of mutations in the residues surrounding the substrate-binding cavity. Functional characterization of these genetic variants can help understand the pharmacogenetic outcomes.

• Biomolecules & Therapeutics
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• 제30권1호
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• pp.19-27
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• 2022

Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase widely expressed in many cancers such as non-small cell lung cancer (NSCLC), pancreatic cancer, breast cancer, and head and neck cancer. Mutations such as L858R in exon 21, exon 19 truncation (Del19), exon 20 insertions, and others are responsible for aberrant activation of EGFR in NSCLC. First-generation EGFR tyrosine kinase inhibitors (TKIs) such as gefitinib and erlotinib have clinical benefits for EGFR-sensitive (L858R and Del19) NSCLC patients. However, after 10-12 months of treatment with these inhibitors, a secondary T790M mutation at the gatekeeper position in the kinase domain of EGFR was identified, which limited the clinical benefits. Second-generation EGFR irreversible inhibitors (afatinib and dacomitinib) were developed to overcome this T790M mutation. However, their lack of selectivity toward wild-type EGFR compromised their clinical benefits due to serious adverse events. Recently developed third-generation irreversible EGFR TKIs (osimertinib and lazertinib) are selective toward driving mutations and the T790M mutation, while sparing wild-type EGFR activity. The latest studies have concluded that their efficacy was also compromised by additional acquired mutations, including C797S, the key residue cysteine that forms covalent bonds with irreversible inhibitors. Because second- and third-generation EGFR TKIs are irreversible inhibitors, they are not effective against C797S containing EGFR triple mutations (Del19/T790M/C797S and L858R/T790M/C797S). Therefore, there is an urgent unmet medical need to develop next-generation EGFR TKIs that selectively inhibit EGFR triple mutations via a non-irreversible mechanism.

• Kyungpook Mathematical Journal
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• 제62권1호
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• pp.133-166
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• 2022

Let M be a semi-invariant submanifold with almost contact metric structure (𝜙, 𝜉, 𝜂, g) of codimension 3 in a complex space form M_n+1(c) for c ≠ 0. We denote by S and R_𝜉 be the Ricci tensor of M and the structure Jacobi operator in the direction of the structure vector 𝜉, respectively. Suppose that the third fundamental form t satisfies dt(X, Y) = 2𝜃g(𝜙X, Y) for a certain scalar 𝜃 ≠ 2c and any vector fields X and Y on M. In this paper, we prove that if it satisfies R_𝜉𝜙 = 𝜙R_𝜉 and at the same time S𝜉 = g(S𝜉, 𝜉)𝜉, then M is a real hypersurface in M_n(c) (⊂ M_n+1(c)) provided that $\bar{r}-2(n-1)c{\leq}0$, where $\bar{r}$ denotes the scalar curvature of M.

• Journal of Biosystems Engineering
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• 제15권2호
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• pp.143-150
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• 1990

This study was conducted to estimate the ratio of Repair & Maintenance (R&M) costs to purchasing price that is one of the important factors for calculating the management costs of farm machinery. For this purpose, hour of use and R & M costs of power tiller and its attachments utilized results that were investigated with 400 sample units, 50 units by years of use from 1 to 8 years in 1988. The results obtained are summarized as follows; 1. The ratio of R & M costs per hours and annual R & M costs, accumulated R & M costs when sercice life of power tiller is 7 years were 0.017%, 5.50% and 38.52%, respectively. And in case of rotary, these ratio when its service life is 6 years were 0.072%, 7.16% and 43.0%, respectively. 2. The relationship between accumulated hours of use(t) and accumulated R & M costs(Y) of power tiller and its attachments were $Y=19.3t^{1.3}$ in power tiller, $Y=0.03t^{2.09}$ in plow, $Y=48.84t^{1.25}$ in rotary and $Y=7.45t^{1.15}$ in trailer. 3. The ratio of accumulated R & M costs to purchasing price when service life of power tiller is 7 years was 38.5%, and in case of rotary, this ratio when its service life is 6 years was 43.0%.

• 한국전자현미경학회:학술대회논문집
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• 한국현미경학회 1998년도 제29차 춘계학술대회
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• pp.53-55
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• 1998

• 대한수의학회지
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• 제9권2호
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• pp.55-59
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• 1969

For the establishment of simpler and more reliable methods for the diagnosis of Brucellosis, diagnostic antigen for Milk Ring Test (M.R.T.) was prepared according to working document recommended by Ministry of Agriculture U.S.A., and applied in the field for the test of its's applicability. The results are summarized as follows. 1. Of fifty two dairy cattle ranches in the vicinity of Seoul, five ranges were shown positive reaction to M.R.T. 2. Even though one volume of positive milk was mixed with five to ten volumes of negative milk, the positive reactions were also observed. 3. Antigenicity of the antigen was maintained without deteriolation for 13 months at $5^{\circ}C$ and three months at both $22^{\circ}C$ and $37^{\circ}C$. 4. Three positive cows to M.R.T. were also shown suspective reaction by Serum Agglutination Test.