• Korean Journal of Agricultural and Forest Meteorology
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• v.12 no.4
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• pp.217-224
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• 2010

This study was carried out to quantify potential effects of the surrounding ocean on the observed air temperature at coastal weather stations in the Korean Peninsula. Daily maximum and minimum temperature data for 2001-2009 were collected from 66 Korea Meteorological Administration (KMA) stations and the monthly averages were calculated for further analyses. Monthly data from 27 inland sites were used to generate a gridded temperature surface for the whole Peninsula based on an inverse distance weighting and the local temperature at the remaining 39 sites were estimated by recent techniques in geospatial climatology which are widely used in correction of small - scale climate controls like cold air drainage, urban heat island, topography as well as elevation. Deviations from the observed temperature were regarded as the 'apparent' sea effect and showed a quasi-logarithmic relationship with the distance of each site from the nearest coastline. Potential effects of the sea on daily temperature might exceed $6.0^{\circ}C$ cooling in summer and $6.5^{\circ}C$ warming in winter according to this relationship. We classified 25 sites within the 10 km distance from the nearest coastline into 'coastal sites' and the remaining 15 'fringe sites'. When the average deviations of the fringe sites ($0.5^{\circ}C$ for daily maximum and $1.0^{\circ}C$ for daily minimum temperature) were used as the 'noise' and subtracted from the 'apparent' sea effects of the coastal sites, maximum cooling effects of the sea were identified as $1.5^{\circ}C$ on the west coast and $3.0^{\circ}C$ on the east and the south coast in summer months. The warming effects of the sea in winter ranged from $1.0^{\circ}C$ on the west and $3.5^{\circ}C$ on the south and east coasts.

• The Journal of Internal Korean Medicine
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• v.24 no.2
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• pp.337-347
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• 2003

This study investigated the effect of Yanggyuksanhwa-tang on cerebral ischemia of the rats. Considering age-related impact on cerebral ischemia, aged rats (18 months old) were used for this study. Ischemic damage was induced by the transient occlusion of bilateral common carotid arteries(BCAO) under the hypotension. Yanggyuksanhwa-tang was administered twice orally. Then changes of immunohistochemical expression of c-fos and c-jun in ischemic damaged hippocampus were observed. The BCAO in aged rats led significant increase of c-fos expression in CA1 and DG of hippocampus. While the treatment of Yanggyuksanhwa-tang significantly attenuated the increase of c-fos expression in CA1 hippocampus following BCAO ischemia. Depending on changes of the normalized optical density(NOD) of immunohistochemical c-fos expression, the treatment of Yanggyuksanhwa-tang significantly attenuated the increase of NOD in CA1 and DG of hippocampus. And there was not changes in CA2 and CA3 hippocampus with respect to the control BCAO group. The BCAO in aged rats led significant increase of c-jun expression in CA1 hippocampus. While the treatment of Yanggyuksanhwa-tang significantly attenuated the increase of c-jun expression in CA1 hippocampus following BCAO ischemia. Depending on changes of the NOD of immunohistochemical c-jun expression, the treatment of Yanggyuksanhwa-tang significantly attenuated the increase of NOD in CA1 hippocampus. And there was not changes in CA2, CA3 and DG of hippocampus with respect to the control BCAO group.

• Journal of agriculture & life science
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• v.44 no.3
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• pp.31-40
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• 2010

This study was carried out to offer a basis data for conservation and application of effective management of Camellia japonica stand in Hakdong, Geoje Island. Field survey was conducted at C. japonica stand, mixed stand, Chamaecyparis obtusa plantation, and Pinus thunbergii stand. Importance value of C. japonica at tree layer was highest in C. japonica stand and mixed stand, and that of C. obtusa and P. thunbergii were highest in C. obtusa plantation and P. thunbergii stand, respectively. At subtree layer, C. japonica, Callicarpa dichotoma, Neolitses serices, and Styrax japonica had the highest importance value in C. japonica stand, mixed stand, C. obtusa plantation, and P. thunbergii stand, respectively. The species diversity ranged from 0.121 to 1.589 in C. japonica stand, 0.543 to 1.540 in mixed stand, 0.276 to 1.321 in C. obtusa plantation, and 0.764 to 1.523 in P. thunbergii stand, respectively. Soil pH was 5.72 in C. japonica stand, 5.26 in mixed stand, 5.21 in C. obtusa plantation, and 5.32 in P. thunbergii stand. The content of organic matter and total N were 5.77, 0.48% in C. japonica stand, 4.41, 0.30% in mixed stand, 3.28, 0.33% in C. obtusa plantation, and 5.32, 0.28% in P. thunbergii stand.

• Journal of the Korean Wood Science and Technology
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• v.47 no.3
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• pp.299-310
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• 2019

This study was carried out to investigate the effect of heat-treatment and particle size on the crystalline properties of the wood cellulose. The color of wood flours was changed from light yellow in control sample to dark yellow or deep brown by heat treatment at $100^{\circ}C$ to $200^{\circ}C$. Relative crystallinity of the heat treated wood cellulose decreased with decreasing particle size from wood chips to 200 mesh, and there was little change in the crystal width. As the temperature was increased, relative crystallinity of the wood increased and crystal width was not changed. As a result of the FT-IR analysis, it was confirmed that the peaks were gradually decreased at -OH elongation as the heat-treated temperature was increased. The lignin C-H bending of $1425cm^{-1}$ and the hemicellulose C-H bending of $1370cm^{-1}$ did not change with the increase of the heat treatment temperature. In addition, it was revealed that C-C stretching of carbohydrate near $1031cm^{-1}$ decreased with increasing heat treatment temperature. Consequently, it is suggested that particle size and heat treatment affected the crystalline properties of wood cellulose.

• Korean Journal of Agricultural and Forest Meteorology
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• v.11 no.4
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• pp.206-212
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• 2009

We investigated the patterns of freeze injury in dormant 'Changhowon Hwangdo' peach fruit by observing the extent of browning and germination of the branches that were treated with freezing temperature sets simulating the process of natural freezing incidences in orchards. Under the treatment of freezing temperature of $-15^{\circ}C$, the browning ratios were 15% for flower bud and less than 3% for both leaf bud and cambium. Under the $-20^{\circ}C$ treatment, the browning ratios were 40% for both flower and leaf buds and 1% for cambium. The browning ratios were 86%, 68% and 40% respectively for flower bud, leaf bud, and cambium under the $-25^{\circ}C$ treatment. All the samples showed 100% browning ratio under the $-30^{\circ}C$ treatment. The budburst ratios of leaf buds were 85%, 66%, 32%, and 0% under the -15, -20, -25 and $-30^{\circ}C$ treatments, respectively. The branches of peach fruit treated with the same freezing temperature showed different responses depending on the sampling date. In January the browning ratio was low and the budburst ratio was high whereas in February the opposite was the case, showing vulnerability of peach trees to low temperature after endo-dormancy release.

• Journal of the Korean Ceramic Society
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• v.39 no.11
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• pp.1074-1082
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• 2002

Nanocomposite PMN-PT-BT/Ag/MgO was prepared by sintering at $950{\circ}C$ with addition of $AgNO_3$ and MgO sol to the PMN-PT-BT powder sinterable at $1200{\circ}C$. The low-temperature-sinterable PMN-PT-BT/Ag powder prepared by the modified mixed oxide method was calcined at $600{\circ}C$ for 1h and surface modified with the MgO sol of 0-10 wt% and then subjected to consolidation at $850-950{\circ}C$ for 4h under a flowing oxygen. The nanocomposite PMN-PT-BT/Ag/MgO(0.5wt%) sintered at $950{\circ}C$ showed the microstructure with grains of $1-3{\mu}m$, the second phase of MgO of $0.1-0.3{\mu}m$ by SEM and Ag of << $1{\mu}m$ qualitatively by SIMS. It showed the sintered relative density of 99%, the room temperature dielectric constant of 17200, the dielectric loss of 2.1% and the specific resistivity of $5.46{\times}10^{12}{\Omega}{\cdot}cm$. But the PMN-PT-BT/Ag/MgO(0 wt%) nanocomposite sintered at $950{\circ}C$ showed a little better properties : the sintered relative density of 99.5%, the room temperature dielectric constant of 19500, the dielectric loss of 2.1% and the specific resistivity of $7.30{\times}10^{12}{\Omega}{\cdot}cm$.

• Korean Journal of Clinical Laboratory Science
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• v.44 no.1
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• pp.24-30
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• 2012

In this study, we have examined the effects of the storage time and temperature on DNA quality and have also studied the effects of the hydration buffer in which DNA is dissolved. This study was performed using 160 human blood samples collected with informed consent from 2007 to 2008 in the hospital where this cohort study was performed. The DNA extracted was dissolved using distilled water (DW) or Tris-EDTA (TE) buffer, and stored in the deep freezer or refrigerator for up to 10 weeks at $-70^{\circ}C$, $-20^{\circ}C$, $4^{\circ}C$, and $25^{\circ}C$, respectively. DNA integrity was determined by the degree of smearing of DNA on the gel. After four weeks, all of the 20 DNA samples dissolved in DW and stored at $25^{\circ}C$ were entirely degraded. After 10 weeks, 6 of the 20 DNA samples dissolved in TE buffer and stored at $25^{\circ}C$ were fairly degraded, and 4 of the 20 DNA samples dissolved in DW and stored at $4^{\circ}C$ were fairly degraded. The 20 DNA samples dissolved in TE buffer and stored at $4^{\circ}C$ were stable for 10 weeks. DNA samples stored at $-20^{\circ}C$ and $-70^{\circ}C$ did not appear to degrade in either DW or TE buffer, even at the 10-week point. We suggest that TE buffer should use for DNA elution, in order to protect against degradation and to preserve DNA for a long period of time, and the samples should be stored at $-20^{\circ}C$ or $-70^{\circ}C$.

• Clinical and Experimental Pediatrics
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• v.58 no.11
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• pp.421-426
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• 2015

Purpose: The vancomycin dosage regimen is regularly modified according to the patient's glomerular filtration rate (GFR). In the present study, we aimed to assess the usefulness of serum cystatin C (Cys-C) concentration, compared with serum creatinine (SCr) concentration, for predicting vancomycin clearance (CLvcm) in neonates. Methods: We retrospectively analyzed the laboratory data of 50 term neonates who were admitted to the neonatal intensive care unit and received intravenous vancomycin, and assessed the pharmacokinetic profiles. Creatinine clearance (CLcr) and GFR based on Cys-C (GFRcys-c) were estimated using the Schwartz and Larsson formulas, respectively. Results: The mean CLvcm (${\pm}$standard deviation) was $74.52{\pm}31.17L/hr$, the volume of distribution of vancomycin was $0.67{\pm}0.14L$, and vancomycin half-life was $9.16{\pm}17.42hours$. The SCr was $0.46{\pm}0.25mg/dL$ and serum Cys-C was $1.43{\pm}0.34mg/L$. The peak and trough concentrations of vancomycin were $24.65{\pm}14.84$ and $8.10{\pm}5.35mcg/mL$, respectively. The calculated GFR based on serum creatinine concentration (GFR-Cr) and GFRcys-c were $70.2{\pm}9.45$ and $63.6{\pm}30.18mL/min$, respectively. The correlation constant for CLvcm and the reciprocal of Cys-C (0.479, P=0.001) was significantly higher than that for CLvcm and the reciprocal of SCr (0.286, P=0.044). GFRcys-c was strongly correlated with CLvcm (P=0.001), and the correlation constant was significantly higher than that for CLvcm and CLcr (0.496, P=0.001). Linear regression analysis showed that only GFRcys-c was independently and positively correlated with CLvcm (F=41.9, P<0.001). Conclusion: The use of serum Cys-C as a marker of CLvcm could be beneficial for more reliable predictions of serum vancomycin concentrations, particularly in neonates.

• Journal of agriculture & life science
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• v.46 no.2
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• pp.139-149
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• 2012

Black garlic and Gaeddongssuk (Artemisia annua L.) were extracted using central composite design by response surface methodology (RSM) in 11 conditions (A~K) with $110{\sim}130^{\circ}C$ and 2~4 hr, and then each extracts were monitored for the total phenol, flavonoid contents and antioxidant activities. The optimum extraction conditions for black garlic and Gaeddongssuk are selected 3 conditions ($130^{\circ}C$, 4 hr; $120^{\circ}C$, 3 hr; $130^{\circ}C$, 3 hr) and 1 condition ($120^{\circ}C$, 3 hr), respectively. They were mixed according to the following ratio; 1:0.5, 1:1, 1:1.5 and 1:2 (black garlic: Gaeddongssuk extract, w/w), and then these composites were tested to the total phenol, flavonoid contents and antioxidant activities. Antioxidant activities of black garlic and Gaeddongssuk extracts by $120^{\circ}C$, 3 hr condition were higher. And the optimal mixture ratio of black garlic and Gaeddongssuk was 1:1.5 (w/w).

• International Journal of Stem Cells
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• v.16 no.2
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• pp.191-201
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• 2023

Background and Objectives: O-cyclic phytosphingosine-1-phosphate (cP1P) is a synthetic chemical and has a structure like sphingosine-1-phosphate (S1P). S1P is known to promote cell migration, invasion, proliferation, and anti-apoptosis through hippocampal signals. However, S1P mediated cellular-, molecular mechanism is still remained in the lung. Acute lung injury (ALI) and its severe form acute respiratory distress syndrome (ARDS) are characterized by excessive immune response, increased vascular permeability, alveolar-peritoneal barrier collapse, and edema. In this study, we determined whether cP1P primed human dermal derived mesenchymal stem cells (hdMSCs) ameliorate lung injury and its therapeutic pathway in ALI mice. Methods and Results: cP1P treatment significantly stimulated MSC migration and invasion ability. In cytokine array, secretion of vascular-related factors was increased in cP1P primed hdMSCs (hdMSC^cP1P), and cP1P treatment induced inhibition of Lats while increased phosphorylation of Yap. We next determined whether hdMSC^cP1P reduce inflammatory response in LPS exposed mice. hdMSC^cP1P further decreased infiltration of macrophage and neutrophil, and release of TNF-α, IL-1β, and IL-6 were reduced rather than naïve hdMSC treatment. In addition, phosphorylation of STAT1 and expression of iNOS were significantly decreased in the lungs of MSC^cP1P treated mice. Conclusions: Taken together, these data suggest that cP1P treatment enhances hdMSC migration in regulation of Hippo signaling and MSC^cP1P provide a therapeutic potential for ALI/ARDS treatment.