• The Korean Journal of Health Service Management
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• v.6 no.2
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• pp.111-119
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• 2012

The purpose of the study were to investigate the effect of the neuro-feedback program which improves brain function and stress reduction effect. The research design is one group pretest-posttest survey. 121 nursing students of a college in the Busan region took part in the study. Training involving the neuro-feedback program was conducted twice a week, 30 minutes per session, for a total of 10 weeks. The collected data was encoded and analyzed using SPSS 12.0 Version. The brain function and stress levels of the subjects were analyzed through the before-and-after results of the training were analyzed using a paired t-test. The results of the study showed that the BQ and SQ were enhanced as a result of the neuro-feedback. In particular, there were significant increases in the SRQ, ATQ, ACQ, and EQ of the BQ. SQ is correlated with the prevalence rate and resistance to disease, meaning not only psychological anxiety, uneasiness and excitement, but also physical anxiety and response to disease. Based on the study, by using the neuro-feedback training as a program for stress reduction, it is expected that nursing students will receive less stress from internal and external factors, and their ability to cope with stress will be enhanced.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.5
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• pp.2655-2661
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• 2014

This study is analized with how Dance as a healing art influence to elderly women's brain function measured by 2 channel system EEG(Electroencephalogram). The objects in this study are 60 aged over 65years in K city. The study started from March to July in 2013. The treatment was conducted by ones a week, 60minutes a time for 16 weeks. Participants are 30 of the experimental group and 30 of the control group checked by EEG before and after treatment. The result in experimental group is indicated as followed. The Basic Rhythm Quotient Lt(79.11/89.56, p<.015), wave length Rt((8.33/9.37, p<.003), amplitude Lt(39.87/47.19, p<.006), amplitude Rt(40.09/49.87, p<.000) did show statistically higher score after treatment. Therefore, dance as a healing art is to be proved the value and efficiency of the practical use for activating elderly women's brain function.

• Journal of Oriental Neuropsychiatry
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• v.15 no.2
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• pp.181-190
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• 2004

Tremor is the common symptom clinically and often be continuous with the brain cortex function. Scalp Acupuncture was designed by connecting the Meridian theory with brain cortex functional theory. We carried out four patients with tremor. We operated Scalp Acupuncture on the chorea-tremor area in connection with precentral gyrus which is in charge of the motion of the opposite part of body about 20 minutes. Herbal medication and the other oriental medical treatments were performed. After our treatments, tremor and some other symptoms were improved.

• BMB Reports
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• v.49 no.5
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• pp.255-262
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• 2016

The disease known as cerebral cavernous malformations mostly occurs in the central nervous system, and their typical histological presentations are multiple lumen formation and vascular leakage at the brain capillary level, resulting in disruption of the blood-brain barrier. These abnormalities result in severe neurological symptoms such as seizures, focal neurological deficits and hemorrhagic strokes. CCM research has identified 'loss of function' mutations of three ccm genes responsible for the disease and also complex regulation of multiple signaling pathways including the WNT/β-catenin pathway, TGF-β and Notch signaling by the ccm genes. Although CCM research is a relatively new and small scientific field, as CCM research has the potential to regulate systemic blood vessel permeability and angiogenesis including that of the blood-brain barrier, this field is growing rapidly. In this review, I will provide a brief overview of CCM pathogenesis and function of ccm genes based on recent progress in CCM research.

• Applied Microscopy
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• v.46 no.2
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• pp.100-104
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• 2016

Electron microscopy is currently the only available technique with a spatial resolution sufficient to identify fine neuronal processes and synaptic structures in densely packed neuropil. For large-scale volume reconstruction of neuronal connectivity, serial block-face scanning electron microscopy allows us to acquire thousands of serial images in an automated fashion and reconstruct neural circuits faster by reducing the alignment task. Here we introduce the whole reconstruction procedure of synaptic network in the rat hippocampal CA1 area and discuss technical issues to be resolved for improving image quality and segmentation. Compared to the serial section transmission electron microscopy, serial block-face scanning electron microscopy produced much reliable three-dimensional data sets and accelerated reconstruction by reducing the need of alignment and distortion adjustment. This approach will generate invaluable information on organizational features of our connectomes as well as diverse neurological disorders caused by synaptic impairments.

• Sleep Medicine and Psychophysiology
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• v.3 no.1
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• pp.25-30
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• 1996

Personality can be understood in terms of cognitive and informational modulation. Augmenting and reducing evoked potential (AREP) has been known as the one of method to test this cognitive characteristic. Especially, many studies have been performed on the relationship between AREP and the Zuckerman Sensation Seeking Scale (SSS) and the Eysenck Personality Questinnaire (EPQ), which are well known as the psychological tests of personality. Generally sensation seekers tend to be augmenters and low sensation seekers tend to the rend to be reducers of EP. However, there are some reports that EP reducers are more extraverted on the EPQ and more sensation-seeking on the SSS than EP augmenters. These results may imply regulatory function of brain can be different depending on brain areas. According to the result of author's studies it can be assumed that frontocentral area works consistently with personality trend whereas right posterior temporal area performs inhibitory regulation against personality trend.

• Child Health Nursing Research
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• v.17 no.4
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• pp.281-287
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• 2011

Purpose: The study was done to explore growth variation in head circumference (HC) in extremely premature infants (EPI) with brain injury. Methods: A retrospective cohort study was conducted with 79 cohort samples from the archives of the catch-up growth project. Mean age of the infants was 29.2 weeks of gestation and mean HC, 27.1 cm at birth. Their HC measurements were retrieved from the archives up to 6 month of corrected age (CA) and analyzed against history of brain injury during hospitalization. Results: Overall growth retardation in HC was observed in the cohort sample compared to longer gestation premature infants. EPI with brain injury showed decreased HC compared to infants without brain injury, and resulting growth variation across 6 month of CA. Highest retardation in HC growth was observed in male infants with brain injury. Conclusion: Extreme preterm birth itself may function as a major obstacle against HC growth toward term age in EPI. Sustainability of brain injury could be observed with higher HC growth retardation after term. Evolutionary favor to female infants may exist in HC growth of EPI. Intensive education on HC monitoring is highly suggested for parents of EPI, particularly with children with brain injury.

• Archives of Pharmacal Research
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• v.29 no.4
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• pp.265-275
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• 2006

In the developing brain, capillaries are differentiated and matured into the blood-brain barrier (BBB), which is composed of cerebral endothelial cells, astrocyte end-feet, and pericytes. Since the BBB regulates the homeostasis of central nervous system (CNS), the maintenance of the BBB is important for CNS function. The disruption of the BBB may result in many brain disorders including brain tumors. However, the molecular mechanism of BBB formation and maintenance is poorly understood. Here, we summarize recent advances in the role of oxygen tension and growth factors on BBB development and maintenance, and in BBB dysfunction related with brain tumors.

• Molecules and Cells
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• v.42 no.11
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• pp.739-746
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• 2019

Significant knowledge about the pathophysiology of Alzheimer's disease (AD) has been gained in the last century; however, the understanding of its causes of onset remains limited. Late-onset AD is observed in about 95% of patients, and APOE4-encoding apolipoprotein E4 (ApoE4) is strongly associated with these cases. As an apolipoprotein, the function of ApoE in brain cholesterol transport has been extensively studied and widely appreciated. Development of new technologies such as human-induced pluripotent stem cells (hiPSCs) and CRISPR-Cas9 genome editing tools have enabled us to develop human brain model systems in vitro and readily manipulate genomic information. In the context of these advances, recent studies provide strong evidence that abnormal cholesterol metabolism by ApoE4 could be linked to AD-associated pathology. In this review, we discuss novel discoveries in brain cholesterol dysregulation by ApoE4. We further elaborate cell type-specific roles in cholesterol regulation of four major brain cell types, neurons, astrocytes, microglia, and oligodendrocytes, and how its dysregulation can be linked to AD pathology.

• Korean Journal of Biological Psychiatry
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• v.22 no.2
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• pp.40-46
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• 2015

Neuroglial cells are fundamental for brain homeostasis and defense to intrinsic or extrinsic changes. Loss of their function and over-reactivity to stimuli contribute to the aging of brain. Alzheimer's disease (AD) could be caused by more dramatic response in neuroglia associated with various chemokines and cytokines. Neuroglia of the AD brain shares some phenotypes with aging neuroglia. In addition, neuroglial activation and neuroinflammation are commonly showed in neurodegeneration. Thus neuroglia would be a promising target for therapeutics of AD.