• 한국식품과학회지
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• 제53권6호
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• pp.739-748
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• 2021

본 연구에서는 가공용 쌀 이용성 향상을 위한 쌀 가공 제품개발과 쌀 생면 제조 기술 확보를 위해 반응표면분석법을 이용하여 글루텐 프리 쌀 우동의 주원료인 쌀가루, 변성전분(아세틸아디핀산이전분), 트레할로스의 함량에 따른 글루텐 프리 쌀 우동의 품질에 미치는 영향을 분석하고 제조 배합비를 Box-Behnken법을 이용하여 최적화하였다. 반응모형에서 쌀가루 함량이 높을수록 수분흡수율, 부피, 황색도, 탄성, 검성, 씹힘성, 응집성이 증가하였으며 변성전분의 함량이 적을수록 황색도, 탄성이 높았다. 수분함량, 명도, 황색도는 linear 모델로 결정되었으며 p-value는 <0.0001, 0.0113, 0.0214로 유의적 차이를 보였다. 글루텐 프리 쌀 우동 주원료의 배합비는 트레할로스의 첨가 없이 쌀가루 60 g, 변성전분 18.81 g 사용하는 것이 바람직한 것으로 나타났다. 반응표면 분석법을 통한 최적 배합비에 따라 글루텐 프리 쌀 우동을 제조한 결과 백색도는 73.09, 수분 흡수율은 59.73%, 부피 32.61 mL, 탁도 0.44, 조리손실율 5.74%, 용출고형분 함량은 1.86%였다. 이 연구 결과는 글루텐 프리 쌀 우동 제조에 기초자료로 제공되어 향후 제품 개발에 도움이 될 것으로 여겨진다.

• International Journal of Fluid Machinery and Systems
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• 제9권2호
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• pp.143-149
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• 2016

In this study, a method for the multi-objective optimization of an impeller for a centrifugal compressor using fluid-structure interaction (FSI) and response surface method (RSM) was proposed. Numerical simulation was conducted using ANSYS CFX and Mechanical with various configurations of impeller geometry. Each design parameter was divided into 3 levels. A total of 15 design points were planned using Box-Behnken design, which is one of the design of experiment (DOE) techniques. Response surfaces based on the results of the DOE were used to find the optimal shape of the impeller. Two objective functions, isentropic efficiency and equivalent stress were selected. Each objective function is an important factor of aerodynamic performance and structural safety. The entire process of optimization was conducted using the ANSYS Design Xplorer (DX). The trade-off between the two objectives was analyzed in the light of Pareto-optimal solutions. Through the optimization, the structural safety and aerodynamic performance of the centrifugal compressor were increased.

• 한국유기농업학회지
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• 제25권1호
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• pp.135-148
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• 2017

본 연구를 통해 논, 시설재배 밭 토양, 쓰레기장, 하천 및 호수의 퇴적 토양 등 22개소에서 분리한 총 6종의 광합성세균 중 호기 암 배양이 가능한 Rhodobacter sphaeroides PS-24를 분리하였다. 형태학적 특징으로는 그람음성의 막대모양으로, 운동성이 있었다. 분리균주의 16S rRNA 염기서열을 분석한 결과 Rhodobacter sphaeroides ATH2.4.1과 99%의 상동성을 나타내었으며, 본 연구에서 Rhodobacter spharoides PS-24로 명명하여 연구를 수행하였다. 선별균주를 modifed Van niel's yeast 배지에서 배양 후 생성된 carotenoid를 추출한 결과 $12.03{\pm}0.15mg/L$의 함량이 측정되었으며, 반응표면분석법 중 Plackett burman 분석방법과 Box-Behnken 분석방법을 통해 carotenoid 생산에 영향을 미치는 요인을 분석하고 농도를 최적화하였다. 분석결과 각각의 독립변수 yeast extract -0.4144 (1.23 g/L), $Na_2CO_3$ 0.8541 (3.71 g/L)와 $MgSO_4$ 1.00 (1.00 g/L)의 농도를 선정하였으며, 이를 바탕으로 배지 조성을 최적화한 결과 yeast extract 1.23 g, sodium acetate 1 g, $NH_4Cl$ 1.75 g, NaCl 2.5 g, $K_2HPO_4$ 2 g, $MgSO_4$ 1.0 g, mono-sodium glutamate 7.5 g, $Na_2CO_3$ 3.71 g, $NH_4Cl$ 3.5 g, $CaCl_2$ 0.01 g/ liter로 선정하였다. 최적배지를 대상으로 5 L, 50 L, 500 L scale-up을 진행한 결과 최종 carotenoid는 각각 17.98 mg/L, 18.03 mg/L, 18.11 mg/L로 조사되었다. 최적배지의 경우 modified Van niel's yeast 배지보다 약 1.5배 많은 carotenoid를 생산하였으며, 대량배양을 통한 scale-up 과정 시 carotenoid의 생산량은 크게 변화하지 않는 것으로 조사되었다. 따라서 본 연구를 바탕으로 산업적으로 다양하게 사용되고 있는 carotenoid를 생산하는 광합성세균 Rhodobacter spharoides PS-24를 개발하였으며, 본 연구를 바탕으로 유기농축산에 사용이 가능한 기능성 미생물제제를 개발하고자 한다.

• 융합정보논문지
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• 제11권2호
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• pp.98-106
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• 2021

본 연구에서는 해양플랜트의 플로트오버 설치작업을 위해 개발된 능동형 갑판 지지 프레임 (Deck support frame, DSF)의 구조설계에 대해 다양한 실험계획법을 이용한 민감도해석의 비교연구를 수행하였다. 능동형 DSF의 주요 구조부재의 두께 치수 변수는 설계인자로 고려하였고, 응답치는 중량과 강도성능으로부터 선정하였다. 민감도해석의 비교연구에 사용한 실험계획법은 직교배열설계법, Box-Behnken 설계법 그리고 Latin hypercube 설계법이다. 실험계획법의 설계공간 탐색의 근사화 성능을 평가하기 위해 반응표면법을 각 실험계획법 별로 생성하여 근사화 정확도 특성을 검토하였다. 또한 최상설계안의 결과로부터 실험계획법의 특성에 따른 수치계산 비용, 중량감소 효과 등과 같은 설계향상 효과를 비교하였다. 능동형 DSF의 구조설계에 대해 직교배열설계법이 가장 향상된 결과를 나타내었다.

• Journal of Welding and Joining
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• 제26권1호
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• pp.63-68
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• 2008

This paper has aimed to prevent excessive heat input by controlling arc distribution and heat input capacity with pulse GTAW in order to improve weld quality in 0.08mm pressure gauge diaphragm and flange welding parts. A design of experiment was designed using Box-Behnken method to optimize a welding process. The pulse GTAW parameters such as pulse current, base current, pulse duty, frequency and welding speed were set to input variables while hydraulic pressure that represents welding characteristics in diaphragm and flange joint were set to output variables. Based on the test result, a second regression equation was obtained between input and output variables and turned out significant. Besides, an influence of parameters has been confirmed through response surface analysis using the second-order regression equation and optimum welding condition was obtained through a grid-search method. The optimum welding condition was set to pulse current 84.4(A), base current 29.6(A), pulse duty 58.8(%), frequency 10(%), and welding speed 596(mm/min). Then, decent bead shape was acquired with no excessive heat input under the $2.3kgf/cm^2$ of hydrostatic pressure.

• 공업화학
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• 제29권3호
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• pp.270-277
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• 2018

반응 표면법(RSM)과 Box-Behnken 설계(BBD) 통계 방법을 사용하여 폐감귤박으로 만든 활성탄(WCAC)에 의한 염료 Eosin Y의 흡착을 검토하였다. 실험은 Eosin Y의 농도(Conc. : 30~50 mg/L), 용액 온도(Temp. : 293~313 K) 및 흡착제 투여량(Dose : 0.05~0.150 g/L)의 3가지 입력 변수를 가진 BBD에 따라 수행하였다. 염료 Eosin Y 제거에 대해 얻어진 2차 다항식 모델의 회귀분석 결정계수($R^2$) 값이 0.9851이고 적합성 결여(Lack of fit)의 p 값은 0.342로 실험 데이터는 2차 다항식 모델에 잘 부합하였다. 염료 농도 50 mg/L, 온도 333 K 및 흡착제 투여량 0.1056 g에서 최적 염료 흡착량 59.3 mg/g이 얻어졌다. WCAC에 의한 Eosin Y의 흡착공정은 유사 2차 속도식에 의해 잘 기술되었으며, 등온 실험결과는 Langmuir 모델식을 따랐다.

• Korean Journal of Chemical Engineering
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• 제35권11호
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• pp.2241-2255
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• 2018

RSM methodology was applied to present mathematical models for the fabrication of polyvinylidene fluoride (PVDF) dual-layer hollow fibers in membrane distillation process. The design of experiments was used to investigate three main parameters in terms of polymer concentration in both outer and inner layers and the flow rate of dope solutions by the Box-Behnken method. According to obtained results, the optimization was done to present the proper membrane with desirable properties. The characteristics of the optimized membrane (named HF-O) suggested by the Box-Behnken (at the predicted point) showed that the proposed models are strongly valid. Then, a morphology study was done to modify the fiber by a combination of three types of a structure such as macro-void, sponge-like and sharp finger-like. It also improved the hydrophobicity of outer surface from 87 to $113^{\circ}$ and the mean pore size of the inner surface from 108.12 to 560.14 nm. The DCMD flux of modified fiber (named HF-M) enhanced 62% more than HF-O when it was fabricated by considering both of RSM and morphology study results. Finally, HF-M was conducted for long-term desalination process up to 100 hr and showed stable flux and wetting resistance during the test. These stepwise approaches are proposed to easily predict the main properties of PVDF dual-layer hollow fibers by valid models and to effectively modify its structure.

• Membrane and Water Treatment
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• 제10권6호
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• pp.417-429
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• 2019

Poly Sulfone nanofibers were electrospun to fabricate membranes of different characteristics. To fabricate the fiber mats, polymer concentration, flowrate, and current density were determined as the most influencing factors affecting the overall performance of the membranes and studied through Response Surface Methodology. The Box-Behnken Design method (three factors at three levels) was used to design, analyze, and optimize the parameters to achieve the best possible performance of the electrospun membranes in forward osmosis process. Also, internal concentration polarization that characterizes the efficiency of the forward osmosis membranes was determined to better assess the overall performance of the fabricated electrospun membranes. Water flux to reverse salt flux was considered as the main response to assess the performance of the membranes. As confirmed experimentally, best membrane performance with the minimal structural parameter value could be achieved when predicted optimal values were used to fabricate the membranes through electrospinning process.

• 한국전산유체공학회:학술대회논문집
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• 한국전산유체공학회 2007년도 추계 학술대회논문집
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• pp.92-99
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• 2007

In this paper, optimization of the vaned centrifugal compressor was carried out at a given mass flow rate condition. Firstly, impeller optimization was conducted using response surface method (RSM) which is one of optimization methods. After the optimization of the impeller was completed, diffuser optimization was performed with the optimized impeller. In these processes, Navier-Stokes solver was used to calculate the flow inside the centrifugal compressor. And the optimization is performed with Box-Behnken design method which is efficient for fitting second-order response surfaces to reduce the number of calculations required. As a result, compared with the reference model, the efficiency and the pressure ratio of the optimized impeller and diffuser are found to be increased. The performance at off-design conditions is presented.

• 품질경영학회지
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• 제29권1호
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• pp.24-40
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• 2001

Response surface designs can be classified, according to the shape of the experimental region, into spherical designs and cuboidal designs. Among the central composite design(CCD)s and the Box-Behnken design(BBD)s that are popular in practice, when the number of factors is k, spherical designs are tile CCDs with the axial value being $\sqrt{\textit{k}}$ and the BBDs, and cuboidal designs are the CCDs with the axial value being 1. With the CCDs having $\sqrt{\textit{k}}$ as the axial value, the radius of the experimental region varies with number of factors, but these designs are the 5-level designs. With the BBDs that are 3-level designs, the radius of the experimental region does not vary with the number of factors. In this article, we propose tile 3-level spherical designs which are constructed so that tile radius of the experimental region varies with the number of factors.