• Journal of Korean Neurosurgical Society
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• 제49권1호
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• pp.68-70
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• 2011

Neuroblastoma is a common tumor of children. We report a patient with extensive calvarial metastases of a neuroblastoma as an initial presentation. A 2-year-old girl presented with a history of gradually increasing head size and fever. A brain CT showed a multilobulated, large, extra-axial tumor involving both frontotemporoparietal areas with a sunray-spiculated hyperostosis of the skull and marked contrast enhancement. A brain MRI demonstrated extensive calvarial lesions with simultaneous involvement of the orbits. A biopsy was performed and a ganglioneuroblastoma was diagnosed. On systemic evaluation, an enlarged abdominal mass was detected. After neo-adjuvant chemotherapy, most of the tumors disappeared except for a tumor in the left parietal area; there was a corresponding decrease in the circumference of the head. We performed surgery for the remnant mass. Intensive chemotherapy was administered and a bone marrow transplantation was performed. Adequate neo-adjuvant chemotherapy followed by surgery to the neuroblatoma with extensive metastases to the skull and orbit may be helpful.

• 한국식품위생안전성학회지
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• 제11권4호
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• pp.261-271
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• 1996

It has been reported that G009, polysaccharide isolated from Ganoderma lucidum IY009 has various pharmacological effects, such as antinflamatory, antiviral, anticarcinogenic and immunmodulation effects. The purpose of this study was to determine the subacute toxicity of orally administered G009 in Sprague-Dawley rats. Groups of 40 male and 40 female rats were gavaged with 0, 500, 1,000 or 2,000 mg/kg/day for 30 days. No drug-related deaths and clinical morbidities were resulted. There was no drug-related effect on the body weight gain, food consumption and water consumption. Statistically significant changes were observed in several hematological and biochemical parameters of G009-treated groups; however, most of these changes were within normal range and had no relationship to dosage. Urinalysis and bone marrow biopsy showed no remarkable changes in all treated groups. Gross necropsy and hisopathology revealed no evidence of specific toxicity related to G009. Our data indicate that no-observed effect level of G009 is estimated to be above 2,000 mg/kg/day in rats.

• 대한두개안면성형외과학회지
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• 제10권2호
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• pp.138-141
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• 2009

Purpose: Squamous cell carcinoma of the scalp sometimes exhibits unusually aggressive behavior. We report a case of extradordinarily aggressive squamous cell carcinoma of the scalp with invasion into the skull and dura mater. Method: The patient is a 38-year-old man with two cystic masses on the occipital area. He was diagnosed as squamous cell carcinoma in that region and have undergone surgical resections including cortical osteotomy of the skull, several years ago. On this occasion, 3-dimensional computed tomographic imaging revealed an erosive lesion on the occipital bone and magnetic resonance imaging showed two cystic masses invasion into the skull and dura mater. Results: He has undergone wide resection of the masses and cranioplasty with dural repair. Histopathologic examination indicated squamous cell carcinoma with moderate differentiation of the masses, bone marrow and dura mater. Conclusion: Squamous cell carcinoma on the scalp can readily penetrate the full thickness of the cranium and invade the dura mater, sagittal sinus and brain. We suggest wide resection of the scalp and split thickness skin graft with sentinel lymph node biopsy, following by postoperative radiation therapy.

• Tuberculosis and Respiratory Diseases
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• 제41권2호
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• pp.152-157
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• 1994

본 저자들은 양측성으로 반복되는 자연기흉 소견을 보인 21세 남자 환자에서BAL은 시행하여 조직구내 Birbeck granule을 찾음으로써 확진할 수 있었던 골 침범을 동반한 폐 조직구증 1예를 문헌 고찰과 함께 보고하는 바이다.

• Tuberculosis and Respiratory Diseases
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• 제65권5호
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• pp.410-415
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• 2008

폐쇄성 세기관지염은 골수 이식 후 폐에 발생하는 합병증이다. 현재 스테로이드와 면역 억제제를 투여하여 적극적인 치료를 하더라도 폐기능의 호전을 보이는 경우는 일부에 불과하다. 저자들은 기존의 치료에도 불구하고 호전을 보이지 않은 골수 이식 후 발생한 폐쇄성 세기관지염 환자에서 macrolide계 항생제인 azithromycin을 1년간 경구 투여하여 폐기능이 호전됨을 경험하였기에 문헌고찰과 함께 보고하는 바이다.

• 대한두경부종양학회지
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• 제10권2호
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• pp.218-224
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• 1994

Soft tissue sarcoma of the head and neck is not frequent neoplasm, accounting for less than 1% of all malignant neoplasm in the region. The histological varieties include osteogenic sarcoma, malignant fibrous histiocytoma, rhabdomyosarcoma, fibrosarcoma, tenosynovial sarcoma, angiosarcoma and chondrosarcoma. Rhabdomyosarcomas of the head and neck usually occur in children under the age of 10 years (over 70%) and rarely develop in adults over the age of 20 years. The prevalent sites of involvement include the orbit, nasal cavity, external ear, paranasal sinus and soft tissue of mouth and the primary location of tumor is considered to be one of the important prognostic factors. Before the 1960s, when surgical resection was the only method of treatment, the 5-year survival rate was less than 20%, but recently it has been greatly improved by the multimodality treatment, combining surgery with chemotherapy and radiation therapy. Here we treated a rhabdomyosarcoma woman with three cycles of high dose chemotherapy followed by radiation therapy. After the, completion of preoperative treatments, successful result of more than partial response was achieved. Three months later total maxillectomy and radical neck dissection was performed. There was no evidence of tumor infiltration in the resected tumor and regional lymphnodes but metastasized tumor cells in cervical lymphnodes were detected. Tumor cell infiltration was also found on the bone marrow biopsy to evaluate the pancytopenia which occurred during postoperative recovery. Two months later she died of secondary bone marrow failure. We think that this multimodality treatment combining pre-operative chemotherapy, radiotherapy and surgery might play an important role in curative resection and eyeball preservation in patients with rhabdomyosarcoma involving the eyeball.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제10권1호
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• pp.76-80
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• 2007

소아암에서 장관계 악성 종양 특히, 대장암은 극히 드문 질환이다. 그러나, 대장은 소아 장관계 상피세포암이 가장 호발하는 부위이며, 반지세포암은 성인과는 달리 소아 대장암 중에서 가장 흔한 조직형태 중 하나이다. 국내에서는 소아 대장에서 발생한 반지세포암에 대한 보고는 아직 없었다. 반지세포암은 점액이 세포내에 풍부하고 핵이 한쪽으로 치우쳐 있는 특징적 고리모양의 암 세포가 전체 암 세포의 50% 이상을 차지하는 조직 소견으로 진단된다. 저자들은 복통, 체중감소, 요통, 좌측 대퇴부 통증, 혈변으로 내원한 11세 남아에서 내시경 조직검사 소견으로 확진된 복강내 침습, 혈액 및 림프성 전이가 진행된 소아 대장에서의 전이성반지세포암을 경험하였기에 보고하는 바이다.

• Nuclear Medicine and Molecular Imaging
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• 제42권1호
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• pp.29-38
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• 2008

목적: 최근에 세포증식성 PET 방사성의약품으로 소개되고 있는 FLT를 이용하여 국소진행성 유방암 환자에서 FLT-PET 영상을 시행하여 종양 영상으로서의 향후 적용 가능성을 살펴보고, FDG와 FLT의 섭취양상에 대한 비교 및 정상 장기에 대한 섭취분포 양상을 알아보고자 하였다. 대상 및 방법: 본 연구는 2005년 8월부터 2006년 11월까지 총 22명(모두 여성, 평균나이; 42세)의 국소진행성 유방암 진단 받은 환자들을 대상으로 하였으며, 모든 종양의 조직형은 침윤성관상피암이었다. 모든 환자를 대상으로 하여 conventional imaging workup, FLT PET/CT, FDG-PET를 시행하였다. MRI로 측정 한 종양 장경의 평균은 $7.2{\pm}3.4$ cm 이었다. 원발 병소와 림프절 섭취에 대한 육안적인 분석과 반정량적인 분석(SUVmax, $SUV_{75}$, TB ratio)을 하였고, 림프절 섭취에 대한 FDG-PET와 FLT-PET의 일치도를 살펴보았다. 정상장기에서의 FLT와 FDG 분포양상을 비교하기 위해 간과 골수의 SUVmax와 $SUV_{75}$을 측정하였다. 결과: 모든 원발 종양근 FLT-PET와 FDG-PET에서 섭취 증가를 나타냈다. MR로 측정한 종양 장경과 FLT-PET 또는 FDG-PET의 SUVmax간에 유의한 상관관계는 없었다(p>0.05). 종양의 SUVmax (FLT $6.5{\pm}5.2$ vs FDG $8.3{\pm}4.9$, p=0.02)와 $SUV_{75}$ (FLT $5.3{\pm}4.3$ vs FDG $6.9{\pm}4.2$, p=0.02)에서는 FDG가 FLT보다 유의하게 높았으며, 중등도의 유의한 상관관계를 보였다(SUVmax; rho=0.450, p=0.04 / $SUV_{75}$; rho=0.472, p=0.03). 반면, TB 섭취비는 FLT가 FDG보다 현저히 높았다(FLT $11.7{\pm}7.7$ vs FDG $6.3{\pm}3.8$, p=0.001). 림프절 섭취 분포에 대한 비교에서는 FDG와 FLT-PET는 34개 구역에서 33개가 일치하였다. FLT와 FDG의 정상 장기의 섭취분포를 보았을 때 FLT는 간(FLT $4.2{\pm}1.2$ vs FDG $1.8{\pm}0.4$)과 골수(FLT $7.4{\pm}1.2$ vs FDG $1.6{\pm}0.4$)의 섭취가 FDG보다 높고 환자마다 다양하였다. 결론: 국소진행성 유방암에서 FTLT는 FDG보다 종양 섭취도는 낮지만 종양과 전이 림프절 섭취가 PET에서 잘 관찰되었다. FLT-PET는 종양 대 주변섭취의 비가 FDG-PET보다 높았으며, 전이 림프절의 진단에서도 FDG-PET와 높은 일치율을 보여 종양 진단 영상으로 유용할 것으로 생각된다. FLT는 정상 간과 골수 조직의 섭취가 높고 개인차가 커서 이들 장기의 전이를 진단하는 데는 제한적일 것으로 생각된다.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제29권1호
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• pp.85-90
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• 2007

Plasma cell neoplasms are generally categorized into four groups; multiple myeloma(MM), solitary plasmacytoma of the bone(SPB), plasma cell leukemias, and extramedullary plasmacytomas(EMP). These tumors may be further described as localized or diffuse in presentation. Localized plasma cell neoplasms are rare occurrences and include solitary plasmacytomas of the skeletal system, which account for 2-5% of all plasma cell neoplasms and extramedullary plasmacytomas of the soft tissue, which account for approximately 3% of all such neoplasms. A plasmacytoma is defined as any discrete, most likely solitary mass of neoplastic plasma cells either in the bone marrow or in various soft tissue sites. Diffuse lesions include the other two groups, multiple myeloma and plasma cell leukemia. The relationship between these processes has not yet been definitively characterized, but there appears to be a continuum in which both SPB and EMP often progress to MM. The patient was referred who had continuous deep throbbing bone pain and swelling on the left posterior gingival area of the mandible after extraction of the first and second molar. The result of intraoperative excisional biopsy of the lesion was confirmed as a plasmacytoma. And it revealed systemic multiple myeloma through the further diagnostic work-up. It is worth to report because of a rare case of multiple myeloma found in oral cavity as a form of plasmacytoma.

• Childhood Kidney Diseases
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• 제21권1호
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• pp.21-25
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• 2017

Severe hypercalcemia is rarely encountered in children, even though serum calcium concentrations above 15-16 mg/dL could be life-threatening. We present a patient having severe hypercalcemia and azotemia. A 14-year-old boy with no significant past medical history was referred to our hospital with hypercalcemia and azotemia. Laboratory and imaging studies excluded hyperparathyroidism and solid tumor. Other laboratory findings including a peripheral blood profile were unremarkable. His hypercalcemia was not improved with massive hydration, diuretics, or even hemodialysis, but noticeably reversed with administration of calcitonin. A bone marrow biopsy performed to rule out the possibility of hematological malignancy revealed acute lymphoblastic leukemia. His hypercalcemia and azotemia resolved shortly after initiation of induction chemotherapy. Results in this patient indicate that a hematological malignancy could present with severe hypercalcemia even though blast cells have not appeared in the peripheral blood. Therefore, extensive evaluation to determine the cause of hypercalcemia is necessary. Additionally, appropriate treatment, viz., hydration or administration of calcitonin is important to prevent complications of severe hypercalcemia, including renal failure and nephrocalcinosis.