• 대한임상검사과학회지
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• 제42권3호
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• pp.155-160
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• 2010

Transcranial Doppler ultrasonography (TCD) allows measurement of blood flow velocity to be made from the basal intracerebral vessels. Blood flow velocity in TCD is highly affected not only by blood vessel diameter, blood flow volume, blood viscosity, but also age and sex. Therefore, the study is focused on the correlation between TCD measurement index and sex/age. Subjects were 214 (male 147, famale 67) who had TCD for headache and stroke evaluations at Dongguk University Ilsan Hospital neurology department from December 2009 to April 2010. Sex did not show significant differences with mean flow velocity (MFV), peak systolic flow velocity (PSFV), end diastolic flow velocity (EDFV), pulsatility index (PI) and resistance index (RI) in middle cerebral artery (MCA). Although age also did not show significant differences with MFV and PSFV, EDFV has statistically decreased with age, and PI and RI has statistically increased with age. In addition, age showed significant correlation with MFV, EDFV, PI and RI, but not with PSFV. Therefore, TCD is definitely correlated with age and sex, so that those influencial factors must be considered when being tested.

• 한국자기학회지
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• 제26권4호
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• pp.142-148
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• 2016

자기공명영상에서 위상대조(phase contrast; PC) 기법으로 혈류 속도와 혈류량을 정량적으로 측정하기 위해 VENC(150 cm/s)에서 숙임각의 변화에 따른 혈류 속도와 혈류량을 측정하였다. 1.5T MRI로 지원자 17명(여: 8, 남: 9, 평균연령 $57.9{\pm}15.4$)을 대상으로 non-breath holding 기법을 적용하여 상행대동맥에서 VENC(150 cm/s)로 숙임각을 $20^{\circ}$, $30^{\circ}$, $40^{\circ}$ 변화하여 측정하였다. 혈류는 average velocity, peak velocity, net forward volume, net forward volume/body surface area를 획득하였다. 상행대동맥에서 AV(average velocity)의 평균값은 숙임각 $20^{\circ}$(9.87 cm/s), $30^{\circ}$(9.6 cm/s), $40^{\circ}$(10.05 cm/s)로 측정되었다. 숙임각을 $20^{\circ}$, $30^{\circ}$, $40^{\circ}$에서 peak velocity, average velocity, net forward volume, net forward volume/body surface area는 통계적인 유의한 차이가 없었다(p > .05). 혈류속도와 혈류량 측정은 매개변수를 조정하여 적용하면 심장혈관 질환의 진단 및 치료에 중요한 정보가 되는 혈류량을 정확히 계산하고, 혈류량 측정에 관한 연구에 도움을 줄 수 있다.

• 대한정형도수물리치료학회지
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• 제19권2호
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• pp.31-37
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• 2013

Background: The purpose of this study was to identify the effects of cervical manipulation for improve blood velocity and flow in the subjects with asymmetric vertebral artery. Methods: Twenty-four subjects on asymmetric vertebral artery with right side have less blood flow than left side participated in this study for apply to non-specific cervical manipulation on lower portion. Measurement method were using duplex ultrasound with colour doppler imaging for blood velocity and flow on left and right vertebral artery. Results: Compared changes of blood velocity and flow on unilateral after the cervical manipulation, the left blood velocity decreased significantly (p<.01) and the right blood velocity increased significantly (p<.01). The left blood flow no significant changes and the right blood flow increased significantly (p<.01). Compared changes of blood velocity and flow on bilateral, the left and right blood velocity and flow made significantly difference on pre-manipulation (p<.01). However, both side no significantly difference on post-manipulation. Conclusions: These findings suggest that the non-specific cervical manipulation took effect for improve blood velocity and flow in the subjects with asymmetric vertebral artery. Therefore, therapeutic approaches for improve to asymmetric vertebral artery should be consider non-specific cervical manipulation.

• 전자공학회논문지SC
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• 제44권2호
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• pp.10-17
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• 2007

의료용 초음파 시스템으로 혈류 속도를 측정할 때, 순수한 혈류 신호의 검출이 필요하다. 초음파 트랜스듀서를 통해 들어오는 반사 신호는 체세포 조직(tissue), 혈관 벽(blood wall), 적혈구(red blood cell), 잡음(noise) 등이 혼합된 신호이다. 혼합된 신호에서 체세포 조직과 혈관 벽 신호를 클러터(clutter)라고 한다. 본 논문에서는 ICA(independent component analysis)를 적용하여 클러터 신호와 잡음을 효과적으로 제거하는 방법을 제시하였다. Field II 초음파 시뮬레이션 프로그램을 이용하여 초음파 반사 신호를 생성하고, ICA를 사용하여 각 독립 신호들을 분리, 클러터 신호를 제거하여 혈류 신호를 추출했다. 추출전 혈류신호를 2D 자기상관(autocorrelation) 방법으로 혈류 속도를 측정했다. 그리고 PCA(principal component analysis)방법을 적용한 고유 필터(autocorrelation) 방법으로 클러터를 제거한 결과와 비교하였다. 그 결과 잡음 환경에서의 혈류 속도 측정에 ICA 방법이 우수한 적용 결과를 보였다.

• International Journal of Vascular Biomedical Engineering
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• 제1권2호
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• pp.30-35
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• 2003

Flow characteristics of blood flow in a micro channel were investigated experimentally using a micro-PIV (Particle Image Velocimetry) velocity field measurement technique. The main objective of this study was to understand the real blood flow in micron-sized blood vessels. The Reynolds number based on the hydraulic diameter of micro-channel for deionized (DI) water was about Re=0.34. For each experimental condition, 100 instantaneous velocity fields were captured and ensemble-averaged to get the spatial distributions of mean velocity. In addition, the motion of RBC (Red Blood Cell) was visualized with a high-speed CCD camera. The captured flow images of nano-scale fluorescent tracer particles in DI water were clear and gave good velocity tracking-ability. However, there were substantial velocity variations in the central region of real blood flow in a micro-channel due to the presence of red blood cells.

• 한국정밀공학회지
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• 제24권9호
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• pp.23-31
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• 2007

• 대한전기학회:학술대회논문집
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• 대한전기학회 1988년도 전기.전자공학 학술대회 논문집
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• pp.705-708
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• 1988

Ultrasound Doppler Diagnostic System utilizes the Doppler effect for measurement of blood velocity. The sign of the Doppler frequency shift represents blood flow direction. Pulsed Doppler System uses Phase detector and zerocrossing method to produce simultaneous independent audio and velocity signals for forward and reverse blood flow direction in the time domain, had been fabricated. But time-domain analyzing such as audio evaluation and zerocrossing detection for instantaneous and mean frequency measurement doesn't, provide both an accurate and quantitative result. Therefore, it is necessary to adopt frequency domain technique to improve system performance. In this paper, we describe a unit which is composed of Pulsed Doppler System and real-time spectrum analyzer (installed TMS 32010 DSP Chip). This unit shows time-dependent spectrum variation and mean velocity of blood Signal.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1988년도 전기.전자공학 학술대회 논문집
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• pp.709-712
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• 1988

Ultrasonic Doppler Diagnostic System utilizes the Doppler effect for measurement of blood velocity. The sign of the Doppler frequency shift represents blood flow direction. CW(Continuous-Wave) Doppler System uses quadrature detection and phase rotation method to produce simultaneous independent audio and velocity signals for forward and reverse blood flow direction in the time-domain, had been fabricated. But time-domain analyzing such as audio evaluation and zero- crossing detection for instantaneous and mean frequnecy measurement do not provide both an accurate and quantitative result. Therefore, it is necessary to adopt frequency-domain technique to improve system performance. In this paper, we describe a unit which is composed of CW Doppler System and real-time spectrum analyzer (installed TMS 32010 DSP Chip). This unit shows time-dependent spectrum variation and mean velocity of Blood signal.

• 한국정보통신학회:학술대회논문집
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• 한국해양정보통신학회 2001년도 춘계종합학술대회
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• pp.516-519
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• 2001

환자를 진단하는데 있어 중풍, 고혈압, 동맥경화, 고지혈증 등 혈관 질환에 대해서 혈류에 관한 정보는 매우 중요하다. 초음파를 이용하여 혈류 속도를 측정하는 방법에는 연속 도플러 시스템과 펄스 도플러 시스템으로 나뉘어진다. 펄스 도플러 시스템은 혈류의 위치정보를 얻을 수 있지만, 연속 도플러 시스템에 비해 하드웨어적으로 복잡하고 신호대 잡음비가 낮으므로 본 연구에서는 신뢰적인 정보를 얻을 수 있는 연속 도플러 시스템을 이용하였다. 본 시스템은 크게 아날로그 부와 디지털 부로 나뉘어진다. 아날로그 부는 초음파 신호의 발생부, 초음파 센서로 수신된 신호를 증폭하는 증폭부와 혈류의 도플러 신호를 검출하는 복조부, 잡음 제거를 위한 필터부분으로 구성되어 있다. 디지털 부는 검출된 아날로그 신호를 디지털 신호로 변환하는 부분, 디지털 신호처리 부분 그리고 개인용 컴퓨터(Personal Computer)와 통신하는 부분으로 구성된다. 본 연구에서는 효율적인 초음파 혈류 속도 측정 시스템을 구현함으로써 환자의 혈류 정보를 실시간으로 인을 수 있으므로 뇌혈류 측정 등에 사용되는 전산화 단층 환영장치(Computered Tomography), 자기 공명 영상 촬영장치(Magnetic Resonance Imaging)와 같은 장비와 더불어 보다 정확한 진단을 하는데 유용하다.

• 대한기계학회논문집B
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• 제30권4호
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• pp.314-319
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• 2006

To analyze in-vivo blood flow characteristics in a chicken embryo, in-vivo experiment was carried out using micro-PIV technique. Because endothelial cells in blood vessels are subject to shear stress of blood flow, it is important to get velocity field information of the placental blood flow. Instantaneous velocity fields of an extraembryonic blood vessel using a high-speed camera and intravital microscope. The flow images of RBCs were obtained with a spatial resolution of $20\times20{\mu}m$ in the whole blood vessels. The mean velocity field data confirm that the blood flow does show non-Newtonian fluid characteristic. The blood in a branched vessel merged smoothly without any flow separation into the main blood vessel with the presence of a slight bump. This in-vivo micro-PIV measurement technique can be used as a powerful tool in various blood flow researches.