• Parasites, Hosts and Diseases
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• v.53 no.3
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• pp.265-270
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• 2015

Hemoglobinopathy and malaria are commonly found worldwide particularly in malaria endemic areas. Thalassemia, the alteration of globin chain synthesis, has been reported to confer resistance against malaria. The prevalence of thalassemia was investigated in 101 malaria patients with Plasmodium falciparum and Plasmodium vivax along the Thai-Myanmar border to examine protective effect of thalassemia against severe malaria. Hemoglobin typing was performed using low pressure liquid chromatography (LPLC) and ${\alpha}$-thalassemia was confirmed by multiplex PCR. Five types of thalassemia were observed in malaria patients. The 2 major types of thalassemia were Hb E (18.8%) and ${\alpha}$-thalassemia-2 (11.9%). There was no association between thalassemia hemoglobinopathy and malaria parasitemia, an indicator of malaria disease severity. Thalassemia had no significant association with P. vivax infection, but the parasitemia in patients with coexistence of P. vivax and thalassemia was about 2-3 times lower than those with coexistence of P. falciparum and thalassemia and malaria without thalassemia. Furthermore, the parasitemia of P. vivax in patients with coexistence of Hb E showed lower value than coexistence with other types of thalassemia and malaria without coexistence. Parasitemia, hemoglobin, and hematocrit values in patients with coexistence of thalassemia other than Hb E were significantly lower than those without coexistence of thalassemia. Furthermore, parasitemia with coexistence of Hb E were 2 times lower than those with coexistence of thalassemia other than Hb E. In conclusion, the results may, at least in part, support the protective effect of thalassemia on the development of hyperparasitemia and severe anemia in malaria patients.

• Journal of the East Asian Society of Dietary Life
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• v.7 no.2
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• pp.181-198
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• 1997

The purpose of this study was to investigated relationship between heath status and food preference of male and fermale adults who live in Iksan City, Cheonbuk, Korea. The subjects consisted of 96 male and 93 fermale adults were aged 20 to 70 years old. Each subject was interviewed to get information of food preference. Blood samples were taken concentration of serum in hemoglobin, glucose, total cholesterol, GOT(glutamic oxaloacetic transaminase), GPT(glutamic pyruvic transaminase) were measured. The results obtained were as follows: Among the food preference were like, dislike and ordinary answered to male and fermale adults the normal average of serum concentration with hemoglobin level showed 15.4, 14.2, 15.5, 12.9, 15.8 and 13.2g/dl, glucose level showed 85.8, 86.1, 87.5, 88.1, 87.9 and 86.1mg/dl, total cholesterol level showed 183.1, 185.0, 172.4, 193.5, 181.2 and 184.0mg/dl, GOT level showed 4.8, 23.4, 24.8, 23.9, 24.9 and 21.7ppm, GPT level showed 22.7, 20.2, 26.3, 18.5, 22.5 and 18.4ppm respectively. The abnormal average of serum concentration with hemoglobin level showed 11.1, 10.8, 12.2, 11.3, 12.5 and 11.0g/dl, abnormal glucose level showed 155.7 168.5, 166.2, 134.1, 124.1, 130.1, abnormal total cholesterol level showed 260.3, 273.7, 255.2, 286.5, 255.9 and 251.8mg/dl, abnormal GOT level showed 58.8, 66.8, 51.8, 50.3, 51.2 and 51.0ppm abnormal GPT level showed 54.3, 48.6, 51.3, 50.2, 53.2 and 45.5ppm respectively.

• Korean Journal of Veterinary Research
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• v.25 no.1
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• pp.19-25
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• 1985

한국(韓國), 대만(臺灣), 일본(日本)에서 사육(飼育)하고 있는 꽃사슴(Cervus nippon) 129두(頭)와 물사슴(Cervus unicolor) 7두(頭)에서 hemoglobin, transferrin, albumin carbonic anhydrase, slow-${\alpha}_2$ 및 amylase형(型)을 전기영동(電氣泳動)에 의(依)하여 분석(分析)한 결과(結果) 다음과 같은 결론(結論)을 얻었다. 1. cellulose acetate에 의(依)한 전기영동(電氣泳動)이 starch gel에 의(依)한 전기영동(電氣泳動)보다 hemoglobin형(型) 분리(分離)에 있어서 더 간편하며 시간이 적게 걸리고, 선명(鮮明)할 뿐만 아니라 영구보존(永久保存)이 가능(可能)하다. 2. 꽃사슴의 hemoglobin형(型)은 $Hb^F$, $Hb^{FS}$, $Hb^S$형(型)으로 분리(分離)되었으나 물사슴에 있어서는 전부(全部) $Hb^F$형(型)으로 나타났다. 3. hemoglobin ${\beta}$ chain은 4가지형(型) 즉 ${\beta}$-1, ${\beta}$-2, ${\beta}$-3 및 ${\beta}$-4로 분리(分離)되었다. 4. hemoglobin ${\alpha}$ chain은 ${\alpha}_1$과 ${\alpha}_1{\alpha}_2$형(型)으로 분리(分離)되었다. 5. slow-${\alpha}_2$형(型)은 A형(型)과 AB형(型)으로 분리(分離)되었으며, 꽃사슴에 있어서는 AB형(型)이 12% 출현(出現)하였으나 물사슴에서는 전부(全部) A형(型)으로 AB형(型)은 없었다. 6. albumin형(型)에서는 F형(型)과 S형(型)으로 분리(分離)되었으며 꽃사슴은 전부(全部) F형(型)이였고, 물사슴은 전부(全部) S형(型)이였다. 7. transferrin형(型), carbonic anhydrase형(型) 및 amylase형(型)은 전부(全部) 각각(各各) 1종류(種類)의 형(型)이였다.

• Korean Journal of Community Nutrition
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• v.8 no.2
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• pp.160-170
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• 2003

Pregnant women in South Korea are a highly risk group fur iron deficiency anemia. Previous studies indicated that the 24-hour recall method was insensitive in distinguishing iron deficiency anemic women from normal women. This method is also impractical to when used at community health centers where no public health dietitians are employed. The objective of this study was to develop a convenient tool to evaluate the usual iron (Fe) intake of pregnant women. The study participants were 115 pregnant women (age 23 to 37 years) at gestational stage of 13 to 24 weeks. Anemic subjects were classified on the basis of their serum ferritin < 12.0 ${\mu}$g/L and hemoglobin < 12.0 g/dL levels. Food frequency questionnaires with 46, 29, and 15 commonly consumed food items were used to measure the usual intake of iron of the subjects. Hemoglobin and serum ferritin were measured from fasting blood samples. Nutrients intake was assessed on three consecutive days using the 24-hour recall method and the food record method. The iron index score calculated using the food frequency method showed a significantly positive correlation with iron intake for the three days dietary intake. The iron index showed a significantly difference (p < 0.05) between the normal and anemic groups. However, there was no significant difference in the iron intake between the anemic and the normal women as measured by the 24-hour recall and food record method. Our study indicated that the 29-food items questionnaire could be used as a screening tool to identify poor dietary intake of iron. (Korean J Community Nutrition 8(2) : 160170, 2003)

• Korean Journal of Acupuncture
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• v.26 no.1
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• pp.111-123
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• 2009

Objective : The purpose of this study is to observe the effect of high frequency electro-acupuncture (hf-EA) at Yanglingquan(GB34) on $CCl_4$-induced liver damage in rats. Methods : The author performed several experimental items, including measurements of body weight and liver weight, hematological analysis for RBC, WBC, PLT, hemoglobin, lymphocytes, neutrophils, monocytes and biochemical assays for ALT, AST, ALP and total cholesterol in serum, and histological analysis of liver tissue. Results & Conclusion : 1. WBC level in blood was slightly reduced by acupuncture and hf-EA at GB34. 2. Lymphocyte level in blood was decreased by $CCl_4$-intoxication and significantly increased by acupuncture and hf-EA at GB34. 3. Neutrophils level in blood was slightly reduced by acupuncture and hf-EA at GB34. 4. ALT and AST in serum were reduced significantly by acupuncture and hf-EA at GB34. 5. The pathological changes of liver tissue induced by $CCl_4$ was reduced by hf-EA at GB34. 6. No significant difference was found between the effects of acupuncture and hf-EA on CCl4-induced liver damage in rats.

• Journal of Nutrition and Health
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• v.27 no.10
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• pp.1058-1069
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• 1994

This study was performed to study the effects of dietary factors on breast and cervical cancer incidence in female Koreans. The subjects were 60 breast and 109 cervical cancer patients recruited from five general hospitals in Seoul. Food intake, anthropometric measurement, and blood compositions were studied through personal interview and using medical records, from August 1991 to September 1992. Body weight, body mass index, triceps skinfold thickness and body muscle mass were at upper limit of normal value, which suggest that these patients had a tendency of overweight. The levels of hemoglobin and hematocrit of the patients were below the normal values. The values of serum protein, albumin, and calcium were in the normal range but close to the lower bound. Therefore the nutritional status assessed by blood composition seems to be marginal. The results of diet history showed that most of the nutrient intake of the subjects met with RDA. The fat intake were 22.9-36.9g/day which supplies about 15-16% of total calories. The results of this study do not agree with those reports of western societies which showed the positive correlation between calorie and fat intake and the incidence of breast and cervical cancer. Even through the calories and fat intake of the subjects were not high, it was higher than national average, especially in breast cancer patients. From this study, dietary factors does not seem to be a major risk factor in cancer incidence in Korea. However, the tendency of the increasing consumption of fat could be a contributing risk factor together with overweight.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.41 no.3
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• pp.182-187
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• 2008

Nine biochemical characteristics of female Oncorhynchus keta subpopulations that migrate to three streams (Namdaechun, Myeongpachun, Oshipchun) in Gangwon, Korea, were evaluated during November 2006: aspartate aminotransferase, alanine aminotransferase, creatine kinase, triglyceride, cholesterol, glucose, hemoglobin, and urea in the blood and RNA/DNA in muscle. The three subpopulations were identical morphologically, but differed in their biochemical characteristics. The RNA/DNA ratio could be useful for distinguishing the subpopulations. RNA/DNA ratios of the Namdaechun and the Myeongpachun and Oshipchun subpopulations were $3.52{\pm}0.7$ and $2.9{\pm}0.7$ and $2.4{\pm}0.8$, respectively. The difference was statistically significant (P<0.05). By contrast, the blood parameters were somewhat ambiguous.

• Korean Journal of Veterinary Service
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• v.23 no.1
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• pp.9-17
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• 2000

Epidemic malaria is prevalent in the demilitarized zone and the northern area of Kyonggi province in Korea. Malaria has broken out in Gangwha-Gun since 1997 due to geographical condition. The results obtained from an epidemiological surveillance for the malaria that happened in 1999 were as follows ; Anopheles sinensis collected in UV-light traps in the barn in Wolgogri and Dangsanri of Songhaemyon showed the distribution of 27,156 of 49,280 figures, corresponding to 55.1%, between July and August. The numbers of patients with malaria were 48(32.4%) in July, 36(24.3%) in August, and 38(25.7%) in September with a prevalence with the ages of the twenties to the seventies. Of a total 154 patients, the male were 86(58.1%) and the female were 68(41.8%). The annual parasite index(API) were 6.44, 5.89 and 4.45 in Songhaemyon, Yangsamyon and Kyodongmyon, respectively. A high infection rate was found Particularly in the areas within 2km from the Han river. By the immunofluorescence assays(IFA), 26 cases were positive with an antibody titers of $\geq$ 1 : 32, of 220 residents in Songhaemyon and 336 ones with a potential case and contacted with the patients. By the blood test, there was no significance in alkaline phosphatase, alanine aminotransferase, total cholesterol, glucose, hemoglobin, hematocrit, white blood cell, red blood cell, and platelet between residents with an antibody titers of $\geq$ 1 : 32 and < 1 : 32 in Songhaemyon.

• Journal of Chest Surgery
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• v.23 no.6
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• pp.1049-1056
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• 1990

The OXYREX hollow fiber membrane oxygenator developed by joint work of KIST and Green Cross Medical company has been evaluated by experimental investigation and clinical application, In this oxygenator gas exchanges occur through small pores of 0.1pm size which are distributed on 70% of surface of polypropylene hollow fiber. The Oxyrex membrane oxygenator consists of 36 thousand hollow fibers and it has 3.3m2 of gas exchange surface. The Oxyrex membrane oxygenator has unique blood flow path: blood enters the oxygenator passes between the hollow fibers and exits through outlet ports, that provides low transmembrane pressure drop. In the animal experiment and in vitro investigations of Oxyrex oxygenator, it showed low transmembrane pressure difference, effective heat exchanger performance, stable gas transfer function and less blood trauma. The Oxyrex oxygenator been used from March, 1990, to October, 1990, in 40 patients undergoing open heart operations. In the clinical applications of Oxyrex, adequate oxygenation[PaO2, 283$\pm$70mmHg] and carbon dioxide removal[PaCO2, 27\ulcorner6mmHg]were maintained under the condition of FiO2: below 0.6, Hct; 25%, perfusion flow; 2.4 L/min, gas flow: 2.1 L/min. During maximum 365 minutes of cardiopulmonary bypass[CPB] time period, the Oxyrex oxygenator maintained stable condition of PaO2, PaCO2 respectively and it also kept low plasma hemoglobin level. The complement proteins C3 and CH50 were not significantly changed pre to post CPB. There were no complications related to the oxygenator during and after the CPB.

• Korean Journal of Veterinary Research
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• v.27 no.1
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• pp.93-99
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• 1987

A study was conducted to observe the effects of dexamethasone sodium 21 phosphate injection in different amounts, intervals and times on the fluctuation of the parasitized erythrocytes in the peripheral blood of the T. sergenti carrier calves. A total of 31 calves including 15 Holstein and 16 Korean native male calves aged 6-12 months (125-300kg) was used. Results observed were as follows. 1. The calves injected 0.2mg/kg body weight two and three times in 48 hour intervals and 5 times in 24 hour intervals observed that 2 out of 2 heads, 3 out of 6 heads, and 4 out of 5 heads, respectively were substantially increased parasitized erythrocytes in the blood for 3-11 days after the first injection and continued to 2-10 days. 2. However, the calves injected once with 0.1mg/kg body weight and all control calves showed no visible change of the parasitized erythrocytes in the blood during the experimental period. 3. The animals injected over 2 times with 0.2mg/kg body weight tended to be decreased the number of erythrocytes, hemoglobin concentration and PCV for 2-3 days after first injection and continued about one week. 4. All animals injected the dexamethasone were observed the neutrophilic leukocytosis, eosinopenea and lymphopenea until 48 hours after injection.