• BMB Reports
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• v.46 no.11
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• pp.533-538
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• 2013

The expression of matrix metalloproteinases (MMPs) produced by cancer cells has been associated with the high potential of metastasis in several human carcinomas, including breast cancer. Several pieces of evidence demonstrate that protein tyrosine phosphatases (PTP) have functions that promote cell migration and metastasis in breast cancer. We analyzed whether PTP inhibitor might control breast cancer invasion through MMP expression. Herein, we investigate the effect of 4-hydroxy- 3,3-dimethyl-2H benzo[g]indole-2,5(3H)-dione (BVT948), a novel PTP inhibitor, on 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced MMP-9 expression and cell invasion in MCF-7 cells. The expression of MMP-9 and cell invasion increased after TPA treatment, whereas TPA-induced MMP-9 expression and cell invasion were decreased by BVT948 pretreatment. Also, BVT948 suppressed NF-${\kappa}B$ activation in TPA-treated MCF-7 cells. However, BVT948 didn't block TPA-induced AP-1 activation in MCF-7 cells. Our results suggest that the PTP inhibitor blocks breast cancer invasion via suppression of the expression of MMP-9.

• Molecules and Cells
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• v.43 no.4
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• pp.350-359
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• 2020

Pathogenic aminoacyl-tRNA synthetases (ARSs) are attractive targets for anti-infective agents because their catalytic active sites are different from those of human ARSs. Mupirocin is a topical antibiotic that specifically inhibits bacterial isoleucyl-tRNA synthetase (IleRS), resulting in a block to protein synthesis. Previous studies on Thermus thermophilus IleRS indicated that mupirocin-resistance of eukaryotic IleRS is primarily due to differences in two amino acids, His581 and Leu583, in the active site. However, without a eukaryotic IleRS structure, the structural basis for mupirocin-resistance of eukaryotic IleRS remains elusive. Herein, we determined the crystal structure of Candida albicans IleRS complexed with Ile-AMP at 2.9 A resolution. The largest difference between eukaryotic and prokaryotic IleRS enzymes is closure of the active site pocket by Phe55 in the HIGH loop; Arg410 in the CP core loop; and the second Lys in the KMSKR loop. The Ile-AMP product is lodged in a closed active site, which may restrict its release and thereby enhance catalytic efficiency. The compact active site also prevents the optimal positioning of the 9-hydroxynonanoic acid of mupirocin and plays a critical role in resistance of eukaryotic IleRS to anti-infective agents.

• Journal of IKEEE
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• v.10 no.1 s.18
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• pp.22-29
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• 2006

In this paper, we present the efficient way of SDRAM accessing through the DMA(Direct Memory Access) when a microprocessor and peripheral blocks are sharing a SDRAM. The microprocessor is able to access a memory through the AMBA which is the system bus provided by ARM Corporation and DMAs are able to access a memory through their own bus. Peripheral block's reading and writing on the SDRAM memory are realized by the intermediate DMA in order to minimize times of access and addressing the memory. While the microprocessor doesn‘t access to the SDRAM aproaching other registers or occurring a hit signal for fetching program or data, the DMAs may read/write the data in the SDRAM without an interference of the AMBA. This way increases the efficient of the system and performance is more by 16.8%.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.21 no.4
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• pp.399-407
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• 2010

SC-FDMA system uses DFT-spreading method for reducing the PAPR of OFDM signal, which improves the power efficiency. Block type pilot is used in SC-FDMA system. However, there are ICI due to the inevitable phase noise and frequency offset that can be generated from the Doppler frequency and inaccuracy between the transceiver oscillators. This ICI definitely degrades the BER performance. To overcome this problem and estimate the channel efficiently, we like to propose ICI compensation algorithm for the SC-FDMA system with comb type pilot. SLM method is additionally included for the PAPR reduction when pilot is assigned in comb type. Finally, it is confirmed that the ICI due to the phase noise and frequency offset is efficiently compensated by the suggested algorithm.

• Journal of the Korean Geosynthetics Society
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• v.10 no.3
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• pp.43-51
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• 2011

This paper describes the results of pullout tests in the laboratory, which are conducted to assess the pullout performance of recently developed geosynthetic strip reinforcement with rounded band anchor. The geosynthetic strip can be used as reinforcements in reinforced soil wall with concrete block facing. The pullout resistance of the geosynthetic strip with rounded band anchor is mobilized by the combination of the interface friction between soil-reinforcement surface and the passive soil resistance caused by the rounded band anchor. Therefore, both the friction resistance and the passive resistance have to be considered in design. From the pullout test results, when the rounded band anchor are formed in the end part of the geosynthetic strip, pullout strength increases about from 10% to 65%. The passive resistance can be evaluated based on the pullout test results.

• Journal of the Korean Geosynthetics Society
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• v.11 no.1
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• pp.65-75
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• 2012

Since the modem reinforced soil wall technology was introduced in domestic civil engineering society in the year 1980, the reinforced soil walls have been extensively used because these technologies have advantages such as economical efficiency, graceful appearance, and easy construction. This paper describes the application of reinforced soil wall, design criteria, and construction problems. Many cases of troubles, which include a severe deformation of facing, cracks of facing block, overall sliding failure and so on, have been reported. Inappropriate design and construction management mainly induce these problems. The technological level of design and quantity control for reinforced soil wall is not sufficiently supported to cope with the growth quantity of reinforced soil wall construction market and the increasing number of construction companies. The unified standard design and construction criteria of reinforced soil wall should be established with the detail consideration of overall performance and stability. The quality control of design and construction, and cost of construction must be seriously executed to construct a high quality of reinforced soil wall.

• Asian-Australasian Journal of Animal Sciences
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• v.15 no.2
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• pp.195-204
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• 2002

The objective of this study was to examine the impact of three categories of supplements on intake and diet induced difference on degradation of straw substrates. Sixteen crossbred cattle fitted with rumen cannula were randomly divided into 4 equal groups. Animals were fed on wheat straw ad libitum without any supplement except mineral mixture (control; $T_1$) or supplemented with concentrate mixture (CS; $T_2$) or green Lucerne (GLS; $T_3$) or urea-molasses block lick (ULS; $T_4$). Total dry matter intake in $T_2$, $T_3$ and $T_4$ was increased by 70, 54 and 49%, respectively compared to $T_1$ which was only 1.55 kg/100 kg B.Wt. Other than control animals, straw intake was less on $T_3$ than $T_2$ or $T_4$. In Sacco degradation of untreated and urea treated wheat or paddy straw in different treatments indicated that the supplements had a significant (p<0.01) impact on rapidly soluble (A) and insoluble but potentially degradable (B) fractions of straw. Urea treatment increased fraction-A but, provision of supplement improved fraction-B also. Effective degradation (ED) of OM was better on $T_2$. Rate of degradation (C) of OM and CWC was dependent on diet and type of straw but hemicellulose and cellulose were related to latter factor only. ED of cell wall carbohydrates (CWC) was similar in $T_2$ and $T_4$ but higher than $T_3$. CS was more effective in improving the degradation of both untreated and urea treated straw while ULS was effective on the former only. CS had more impact on superior quality straw while contrary was true with ULS. Although GLS improved intake and degradability of untreated and urea treated straws, its bulkiness affected the straw intake compared to other supplements.

• Asian-Australasian Journal of Animal Sciences
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• v.21 no.11
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• pp.1592-1598
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• 2008

An experiment was carried out to study the effect of cattle slurry on maize fodder (Zea mays) production. Maize fodder was produced at 4 cattle slurry levels $T_0$ (0 ton/ha), $T_1$ (10 ton/ha), $T_2$ (12 ton/ha) and $T_3$ (14 ton/ha) in a randomized block design. Agronomic characteristics, plant heights, circumference of stems, number of leaves, leaf area and dry matter yield of maize fodder were measured. Maize plant height and stem circumference were significantly (p<0.01) influenced by the increasing rate of cattle slurry at 15, 30, 45 and 56 days after sowing. Number of leaves of fodder plants was not significant but leaf area was significant (p<0.05) among the treatment groups. The highest biomass yield (p<0.01) of maize fodder was observed in $T_2$ (44.0 ton/ha). For crude protein content, a significant difference (p<0.01) was observed in the treatment groups and the highest value was observed in $T_2$ (11.99%). Organic matter content of maize fodder showed a significant difference but ash, ADF and NDF contents showed no significant differences among treatment groups. From this study it may be concluded that the application of 12 tons of cattle slurry/ha was optimal for production of biomass and nutrient content of maize fodder.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.37 no.1
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• pp.30-35
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• 2011

Introduction: Dental implants are used routinely with high success rates in generally healthy individuals. By contrast, their use in patients with diabetes mellitus is controversial because altered bone healing around implants has been reported. This study examined the bone healing response around titanium implants placed immediately in rats with controlled and uncontrolled diabetes. Materials and Methods: Twenty rats were divided into the control, insulin-treated and diabetic groups. The rats received streptozotocin (60 mg/kg) to induce diabetes; animals in the insulin-treated group also received three units of subcutaneous slow-release insulin. A titanium implant ($1.2{\times}3\;mm$) was placed in the extraction socket of the maxillary first molar and bone block was harvested at 1, 2 and 4 weeks. Results: Bone formation around the implants was consistently (from 1 to 4 week post-implantation) slower for the diabetic group than the control and insulin-treated group. Bone morphogenesis in the diabetic rats was characterized by fragmented bone tissues and extensive soft tissue intervention. Conclusion: The immediate placement of titanium implants in the maxilla of diabetic rats led to an unwanted bone healing response. These results suggest that immediate implant insertion in patients with poorly controlled diabetes might be contraindicated.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2003.10a
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• pp.369-372
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• 2003

This paper describes a design of OFDM (Orthogoanl Frequency Division Multiplexing) based wireless LAN system receiver, defined in IEEE 802.11a standards. Because OFDM system uses several orthogonal sequence sets, it ran avoid selective fading of fast data transfer problem when it is used with error correction code. But if the receiver is not synchronized, the orthogonal of between sub-ralliers will be destroyed and the data interruption will be generated. So it makes error property get worse very murk. For improving the noise error, we use the relationship of phasor between sub-carriers and make system synchronization using one tab equalizer. The designed OFDM block is described by Verilog HDL for the efficient and small size hardware. And we preform the functional verification and evaluation using the vector of standards.