• The Korean Journal of Physiology and Pharmacology
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• v.17 no.1
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• pp.37-42
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• 2013

Taxifolin glycoside is a new drug candidate for the treatment of atopic dermatitis (AD). Many drugs cause side effects such as long QT syndrome by blocking the human ether-a-go-go related gene (hERG) $K^+$ channels. To determine whether taxifolin glycoside would block hERG $K^+$ channels, we recorded hERG $K^+$ currents using a whole-cell patch clamp technique. We found that taxifolin glycoside directly blocked hERG $K^+$ current in a concentration-dependent manner ($EC_{50}=9.6{\pm}0.7{\mu}M$). The activation curve of hERG $K^+$ channels was negatively shifted by taxifolin glycoside. In addition, taxifolin glycoside accelerated the activation time constant and reduced the onset of the inactivation time constant. These results suggest that taxifolin glycoside blocks hERG $K^+$ channels that function by facilitating activation and inactivation process.

• The Journal of the Korea Contents Association
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• v.4 no.4
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• pp.71-78
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• 2004

Dedicated Short Range Communications(DSRC) as a prominent communications candidate for Intelligent Transportation Systems(ITS) have been developed to support ITS applications such as value-added information service, e-commerce, electronic toll payment, etc. These various applications associated with electronic payment through unsecure communication channel of DSRC suffer from security threats. To ensure secure payment, we have adopted appropriate cryptographic mechanisms including encipherment, authentication exchange and digital signature. The cryptographic mechanisms require to use cryptographic keys established between two communication entities. In this paper, we propose a secure electronic payment system which is designed to have some functions for strong authentication, encryption, key agreement, etc. Especially, we adopt domestic developed cryptographic algorithms such as EC-KCDSA and SEED for digital signature and block cipher, respectively. We can show those mechanisms are appropriate for the secure electronic payment system for ITS services under the DSRC wireless environment in aspects of constrained computational resource use and processing speed.

• The Korean Journal of Physiology and Pharmacology
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• v.1 no.5
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• pp.485-493
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• 1997

We investigated the effect of ${\alpha}-adrenergic$ and cholinergic receptor agonists on $Ca^{2+}$ current in adult rat trigeminal ganglion neurons using whole-cell patch clamp methods. The application of acetylcholine, carbachol, and oxotremorine ($50\;{\mu}M\;each$) produced a rapid and reversible reduction of the $Ca^{2+}$ current by $17{\pm}6%,\;19{\pm}3%,\;and\;18{\pm}4%$, respectively. Atropine, a muscarinic antagonist, blocked carbachol- induced $Ca^{2+}$ current inhibition to $3{\pm}1%$. Norepinephrine ($50\;{\mu}M$) reduced $Ca^{2+}$ current by $18{\pm}2%$, while clonidine ($50\;{\mu}M$), an ${\alpha}2-adrenergic$ receptor agonist, inhibited $Ca^{2+}$ current by only $4{\pm}1%$. Yohimbine, an ${\alpha}2-adrenergic$ receptor antagonist, did not block the inhibitory effect of norepinephrine on $Ca^{2+}$ current, whereas prazosin, an ${\alpha}1-adrenergic$ receptor antagonist, attenuated the inhibitory effect of norepinephrine on $Ca^{2+}$ current to $6{\pm}1%$. This pharmacology contrasts with ${\alpha}2-adrenergic$ receptor modulation of $Ca^{2+}$ channels in rat sympathetic neurons, which is sensitive to clonidine and blocked by yohimbine. Our data suggest that the modulation of voltage dependent $Ca^{2+}$ channel by norepinephrine is mediated via an α1-adrenergic receptor. Pretreatment with pertussis toxin (250 ng/ml) for 16 h greatly reduced norepinephrine- and carbachol-induced $Ca^{2+}$ current inhibition from $17{\pm}3%\;and\;18{\pm}3%\;to\;2{\pm}1%\;and\;2{\pm}1%$, respectively. These results demonstrate that norepinephrine, through an ${\alpha}1-adrenergic$ receptor, and carbachol, through a muscarinic receptor, inhibit $Ca^{2+}$ currents in adult rat trigeminal ganglion neurons via pertussis toxin sensitive GTP-binding proteins.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.36 no.5A
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• pp.473-484
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• 2011

In this paper, we analyze and propose the Joint Call Admission Control(JCAC) scheme to combine network selection scheme and radio resource reservation based Call Admission Control(CAC) in LTE-WLAN heterogeneous networks. First, We propose the JCAC system that uses network decision rate to select a network for terminal and radio resource reservation scheme in overlaying LTE-WLAN network environment. And we analyze the performance of a proposed system using markov chain model. The performance is presented in terms of the new call blocking probability, handoff call dropping probability, and channel utilization of each network. As a performance result of the our research, the system using JCAC is better than the system using non-JCAC. We found a suitable resource reservation rate that is 10% in the system using JCAC. Our work may be useful as a guideline of resource reservation rate to introduce JCAC system using resource reservation scheme in overlaying LTE-WLAN network environment.

• Journal of the Institute of Electronics and Information Engineers
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• v.50 no.1
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• pp.9-14
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• 2013

In this paper, we propose a low complexity bilateral search SIC for OFDM in fast time-varying channels. Due to the possibility of error propagation in SIC, symbol detection ordering within the block of symbols has a significant effect on the overall performance. In this paper, the first symbol to be detected is determined based on CSEP values, and then the next symbol to be detected is selected according to the updated CSEP while bilaterally searching from the boundary of the detected symbol group. Through computer simulations, we show that the proposed method has performance improvements with almost the same computation complexity over the conventional methods in the high SNR region. It has a performance approaching the MFB, known as the performance upper bound, within 2dB at the BER of $10^{-5}$.

• The Journal of the Korea institute of electronic communication sciences
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• v.9 no.12
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• pp.1365-1372
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• 2014

In recent, the LTE(Long-Term Evolution) mobile communication system has been commercialized and a variety of service is being provided. Comparing to the old wireless access systems such as 3G mobile communications, in particular, the LTE system supports a service requiring a high transmission rate by providing broadband wireless access. In order to understand the possibility of successful support of a multimedia service such as IPTV(Internet Protocol Television) through the LTE system, it is necessary to understand the mechanism that decides the transmission rate supported by the LTE system. This paper, therefore, discusses on the relationship between a number of metrics such as CQI and BLER that affects the transmission rate with the measurement results from the field tests.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.31 no.1A
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• pp.1-10
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• 2006

The Home Phoneline Networking Alliance(HomePNA) 2.0 technology can establish a home network using existing in-home phone lines, which provides a channel rate of 4-32 Mbps. HomePNA 2.0 Medium Access Control(MAC) protocol adopts an IEEE 802.3 Carrier Sense Multiple Access with Collision Detection(CSMA/CD) access method, Quality of Service(QoS) algorithm, and Distributed Fair Priority Queuing(DFPQ) collision resolution algorithm. In this paper, we describe some performance analysis results of HomePNA 2.0 MAC protocol and the requirements of HomePNA 2.0 MAC controller. Then, we propose the architecture of HomePNA 2.0 MAC controller circuit, show the simulation result of each block included in HomePNA 2.0 MAC controller, and present the HomePNA 2.0 transceiver chip that we have implemented.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2010.10a
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• pp.722-725
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• 2010

In this paper, BER performance and error convergence speed of layered LDPC(Low Density Parity Check) decoder which supports IEEE 802.16e WiMAX standard is analyzed, and optimal design conditions for hardware implementation are derived. A LDPC decoder is modeled and simulated at AWGN channel with QPSK modulation by Matlab. The parity check matrix(PCM) for IEEE 802.16e standard which has block lengths of 576, 1440, 2304 and code rates of 1/2, 2/3A, 2/3B, 3/4A, 3/4B, 5/6 are used. Fixed-point simulation results show that fixed-point bit-width should be more than 8 bits for acceptable decoding performance.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.47 no.2
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• pp.1-8
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• 2010

Multi antenna techniques using space-time codes can achieve diversity gains in a multi-path environment without additional bandwidth requirement. Most of the 4G candidate standards including the IEEE 802.16e adopt multi-input multi-output (MIMO) schemes to achieve either high throughput performance or diversity gains. In these 4G candidate standards, turbo codes using an iterative decoder with soft input soft output are used to overcome serious channel fading. For this reason, the estimated signal values from MIMO detectors should be soft decision detection values. In this paper, we propose efficient methods to estimate soft decision detection values for various space time coding schemes, and provide the simulation results of turbo coded space time coding scheme over an IEEE 802.16e link.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.46 no.4
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• pp.64-71
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• 2009

This paper presents an efficient frame synchronizer architecture using the common autocorrelator for Digital Video Broadcasting via Satellite, Second generation(DVB-S2). To achieve the satisfactory performance under severe channel conditions and the efficient hardware resource utilization of functional synchronization blocks which have been implemented, we propose a new efficient common autocorrelator structure. The proposed architecture can improve the performance of the frame and frequency synchronizer since each block operates jointly in parallel and significantly reduce the complexity of the frame synchronizer. Hence, The proposed architecture can ensure the decrease by about 92% multipliers and 81% adders compared with the direct implementation. Moreover, it has been thoroughly verified with an FPGA board and R&STM SFU broadcast test equipment and consists of 29,821 LUTs with XilinxTM Virtex IV LX200.