• 대한의용생체공학회:의공학회지
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• 제43권2호
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• pp.71-80
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• 2022

The interaction between dual-ligand decorated particle-based delivery system and target cell under shear flow is predicted using probability model developed. We assumed the two kinds of ligand are decorated on the surface of the particle with 10% length difference. Fixed with other biophysical parameters, a study on the particle-cell interaction for the different non-specific interaction parameter is performed. To induce the firm adhesion, short ligand-receptor should be engaged. Also, it is shown that the rational design of ligand-receptor interaction, including receptor number, specific interaction parameter, kinds of ligand-receptor, etc., should be considered.

• BMB Reports
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• 제56권1호
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• pp.32-42
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• 2023

Heart disease is one of the major life-threatening diseases with high mortality and incidence worldwide. Several model systems, such as primary cells and animals, have been used to understand heart diseases and establish appropriate treatments. However, they have limitations in accuracy and reproducibility in recapitulating disease pathophysiology and evaluating drug responses. In recent years, three-dimensional (3D) cardiac tissue models produced using tissue engineering technology and human cells have outperformed conventional models. In particular, the integration of cell reprogramming techniques with bioengineering platforms (e.g., microfluidics, scaffolds, bioprinting, and biophysical stimuli) has facilitated the development of heart-on-a-chip, cardiac spheroid/organoid, and engineered heart tissue (EHT) to recapitulate the structural and functional features of the native human heart. These cardiac models have improved heart disease modeling and toxicological evaluation. In this review, we summarize the cell types for the fabrication of cardiac tissue models, introduce diverse 3D human cardiac tissue models, and discuss the strategies to enhance their complexity and maturity. Finally, recent studies in the modeling of various heart diseases are reviewed.

• 대한원격탐사학회:학술대회논문집
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• 대한원격탐사학회 2006년도 Proceedings of ISRS 2006 PORSEC Volume I
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• pp.402-405
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• 2006

Radiometric calibration of optical image data is necessary to convert raw digital number (DN) value of each pixel into a physically meaningful measurement (radiance). To extract rather quantitative information regarding biophysical characteristics of the earth surface materials, radiometric calibration is often essential procedure. A sensor detects the radiation of sunlight interacted atmospheric constituents. Therefore, the amount of the energy reaching at the sensor is quite different from the initial amount reflected from the surface. To achieve the target reflectance after atmospheric correct, an initial step is to convert DN value to at-sensor radiance. A linear model, the simplest radiometric model, is applied to averaged spectral radiance for this conversion. This study purposes to analyze the sensitivity of several factors affecting on radiance for carrying out absolute radiometric calibration of panchromatic images from KOMPSAT2 launched at July, 2006. MODTRAN is used to calculate radiance at sensor and reflectance of target is measured by a portable spectro-radiometer at the same time the satellite is passing the target for the radiometric calibration. As using different contents of materials composing of atmosphere, the differences of radiance are investigated. Because the spectral sensitivity of panchromatic images of KOMPSAT2 ranges from 500 to 900 nm, the materials causing scattering in visible range are mainly considered to analyze the sensitivity. According to the verified sensitivity, direct measurement can be recommenced for absolute radiometric calibration.

• 대한원격탐사학회지
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• 제23권1호
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• pp.7-14
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• 2007

Atmospheric correction is one of critical procedures to extract quantitative information related to biophysical variables from hyperspectral imagery. Most atmospheric correction algorithms developed for hyperspectral data have been based upon atmospheric radiative transfer (RT) codes, such as MODTRAN. Because of the difficulty in acquisition of atmospheric data at the time of image capture, the complexity of RT model, and large volume of hyperspectral data, atmospheric correction can be very difficult and time-consuming processing. In this study, we attempted to develop an efficient method for the atmospheric correction of EO-1 Hyperion data. This method uses the pre-calculated look-up-table (LUT) for fast and simple processing. The pre-calculated LUT was generated by successive running of MODTRAN model with several input parameters related to solar and sensor geometry, radiometric specification of sensor, and atmospheric condition. Atmospheric water vapour contents image was generated directly from a few absorption bands of Hyperion data themselves and used one of input parameters. This new atmospheric correction method was tested on the Hyperion data acquired on June 3, 2001 over Seoul area. Reflectance spectra of several known targets corresponded with the typical pattern of spectral reflectance on the atmospherically corrected Hyperion image, although further improvement to reduce sensor noise is necessary.

• 한국농림기상학회지
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• 제12권2호
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• pp.107-121
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• 2010

본 연구에서는 한반도의 주요 생태계인 활엽수림과 농경지에서 지면 모형 JULES(Joint UK Land Environment Simulator)으로 모의한 총일차생산량 (Gross Primary Productivity: GPP)과 생태계 호흡량 (ecosystem respiration: RE)의 수치 모사 결과에 영향을 미치는 주요 모수를 파악하였으며, 민감한 모수에 대해 실측자료를 사용함에 따른 모형 예측력의 개선 정도를 평가하였다. 민감도 실험의 결과, 활엽수림과 농경지에서 모두 JULES로 모의한 GPP는 잎 내부의 질소농도와 리불로오스이인산(RuBP) 카르복실화의 최대 속도에 가장 민감하였다. RE는 활엽수림에서는 목질부 탄소량과 엽면적지수를 연결시켜주는 상수에 가장 민감하였다. 반면에 농경지에서 수치모사된 RE는 GPP와 같이 각각 잎 내부의 질소 농도와 RuBP 카르복실화의 최대 속도에 가장 민감하였다. JULES로부터 제공된 모수의 값으로 모의된 두 지역의 GPP와 RE는 모두 관측값에 비해 과대평가되었다. 특히 활엽수림에서 GPP가 가장 민감하게 반응했던 잎 질소 농도의 실제 관측값이 모형에서 사용하는 기존 설정값의 50% 이하임을 고려할 때 모형에서 설정된 모수의 값으로 탄소 순환을 수치 모사할 경우에 모수의 기존 설정값과 실제값의 차이가 모형의 과다모의에 상당한 영향을 미침을 확인할 수 있었다. 따라서 한반도 탄소순환의 현실적인 모의를 위해서는 모형에서 요구되는 생물리학적 정보가 한반도 다양한 식생 기능 형태를 현실적으로 잘 반영하는지를 확인해야 할 뿐 아니라 지속적인 현장 관측을 통해서 생물리학적 정보와 관련된 자료기반을 마련하는 것이 중요하다.

• 한국농림기상학회지
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• 제1권1호
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• pp.52-59
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• 1999

Vegetation canopy plays an important role in $CO_2$/$H_2$O exchange between the biosphere and the atmosphere by controlling leaf stomata. In this study, rice (Oryza sativa L.), a staple crop in Asia was investigated to formulate its single leaf model of photosynthesis and stomatal conductance. Photosynthesis and stomatal conductance were measured with a portable infrared gas analyzer system. Other plant and meteorological variables were also measured. To evaluate empirical constants in this biochemical leaf model, nonlinear least squares technique was used. The maximum catalytic activity of enzyme and the maximum rate of electron transport were $ 100\mu$㏖ $m^{-2}$ $s^{-1}$ and $140 \mu$㏖ m$^{-2}$ s$^{-1}$ (@ 35$^{\circ}C$), respectively. The empirical constants, m and b, associated with stomatal conductance model were 9.7 and $0.06 m^{-2}$ $s^{-1}$ , respectively. On a leaf scale, agreements between the modeled and the measured values of photosynthesis and stomatal conductance were on average within 20%, and the simulation of diurnal variation was also satisfactory On a canopy scale, the Simple Biosphere model(SiB2) was tested using the derived parameters. The modeled energy fluxes were compared against the micrometeorologically measured fluxes over a rice canopy. Agreements between the modeled and the measured values of net radiation, sensible heat and latent heat fluxes, and $CO_2$ flux (i.e., net canopy photosynthesis) were on average within 25%.

• 한국농림기상학회지
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• 제15권4호
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• pp.282-290
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• 2013

대기와 지표면을 구성하고 있는 토양 및 식생은 생물리학적/생지화학적인 과정을 통해 서로 상호작용을 한다. 이러한 과정을 모의하기 위해 지표모델과 작물 생육모델이 사용되고 있다. 지표모델인 Noah MP 모델과 작물생육모델인 CERES-Rice 모델을 비교하기 위해 해남 플럭스 관측소 인근 지역에서 작물의 생육과 증발산량을 모의하였다. 플럭스 관측자료가 수집된 2003년부터 2012년까지 해남 플럭스 관측소의 주요 식생인 벼를 대상으로 생육과 증발산량을 모의되었다. Noah MP 모델은 단순한 식생 모의 과정으로 인해 개화기를 전후로 하는 벼의 LAI 변화양상을 정확하게 반영하지 못하였다. 벼의 생체중 예측에 있어서도 실제 관측될 수 있는 생체중보다 대략 10분의 1 수준에 해당하는 생체중이 모의되었다. 증발산량 모의의 경우에도, CERES-Rice 모델의 모의값보다 약 21%에 해당하는 증발산량을 모의하였다. 반면, CERES-Rice 모델의 경우 LAI의 변화와 생체중 모의 값은 실제의 벼 생육 양상과 유사할 것으로 추정되었다. 또한, 증발산량의 경우에도 해남 플럭스 관측소에서 측정된 값과 비교하였을 때 Noah-MP모델의 모의값이 CERES-Rice 모델의 모의값에 비해 RMSE 값이 1.8배 높았다. Noah MP 모델이 보이는 높은 오차값들은 Noah MP모델이 논의 지표상태를 적절히 반영하지 못하였기 때문으로 사료되었고, 특히 과소추정된 생체중을 보정하여 증발산량을 예측할 경우 오차를 30%까지 줄일 수 있을 것으로 보인다. 따라서, Noah MP 모델에 논에서의 지표 특성을 반영할 수 있다면 보다 정확한 물질순환과 에너지 교환을 예측할 수 있을 것으로 사료된다.

• 대한원격탐사학회지
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• 제26권6호
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• pp.653-664
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• 2010

The land surface reflectance is a key parameter influencing the climate near the surface. Therefore, it must be determined with sufficient accuracy for climate change research. In particular, the characteristics of the bidirectional reflectance distribution function (BRDF) when using earth observation system (EOS) are important for normalizing the reflected solar radiation from the earth's surface. Also, wide swath satellites like SPOT/VGT (VEGETATION) permit sufficient angular sampling, but high resolution satellites are impossible to obtain sufficient angular sampling over a pixel during short period because of their narrow swath scanning. This gives a difficulty to BRDF model based reflectance normalization of high resolution satellites. The principal objective of the study is to add BRDF modeling of high resolution satellites and to supply insufficient angular sampling through identifying BRDF components from SPOT/VGT. This study is performed as the preliminary data for apply to high-resolution satellite. The study provides surface parameters by eliminating BRD effect when calculated biophysical index of plant by BRDF model. We use semi-empirical BRDF model to identify the BRD components. This study uses SPOT/VGT satellite data acquired in the S1 (daily) data. Modeled reflectance values show a good agreement with measured reflectance values from SPOT satellite. This study analyzes BRD effect components by using the NDVI(Normalized Difference Vegetation Index) and the angle components such as solar zenith angle, satellite zenith angle and relative azimuth angle. Geometric scattering kernel mainly depends on the azimuth angle variation and volumetric scattering kernel is less dependent on the azimuth angle variation. Also, forest from land cover shows the wider distribution of value than cropland, overall tendency is similar. Forest shows relatively larger value of geometric term ($K_1{\cdot}f_1$) than cropland, When performed comparison between cropland and forest. Angle and NDVI value are closely related.

• 한국농공학회논문집
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• 제53권6호
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• pp.31-41
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• 2011

This study was conducted to predict future land-cover changes under climate change scenarios and to cluster analysis of regional land-cover characteristics. To simulate the future land-cover according to climate change scenarios - A1B, A2, and B1 of the Special Report on Emissions Scenarios (SRES), Dyna-CLUE (Conversion of Land Use Change and its Effects) was applied for modeling of competition among land-use types in relation with socioeconomic and biophysical driving factors. Gyeonggi-do were selected as study areas. The simulation results from 2010 to 2040 suggested future land-cover changes under the scenario conditions. All scenarios resulted in a gradual decrease in paddy area, while upland area continuously increased. A1B scenario showed the highest increase in built-up area, but all scenarios showed only slight changes in forest area. As a result of cluster analysis with the land-cover component scores, 31 si/gun in Gyeonggi-do were classified into three clusters. This approach is expected to be useful for evaluating and simulating land-use changes in relation to development constraints and scenarios. The results could be used as fundamental basis for providing policy direction by considering regional land-cover characteristics.

• 한국생물정보학회:학술대회논문집
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• 한국생물정보시스템생물학회 2000년도 International Symposium on Bioinformatics
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• pp.17-20
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• 2000

Structural genomics aims to provide a good experimental structure or computational model of every tractable protein in a complete genome. Underlying this goal is the immense value of protein structure, especially in permitting recognition of distant evolutionary relationships for proteins whose sequence analysis has failed to find any significant homolog. A considerable fraction of the genes in all sequenced genomes have no known function, and structure determination provides a direct means of revealing homology that may be used to infer their putative molecular function. The solved structures will be similarly useful for elucidating the biochemical or biophysical role of proteins that have been previously ascribed only phenotypic functions. More generally, knowledge of an increasingly complete repertoire of protein structures will aid structure prediction methods, improve understanding of protein structure, and ultimately lend insight into molecular interactions and pathways. We use computational methods to select families whose structures cannot be predicted and which are likely to be amenable to experimental characterization. Methods to be employed included modern sequence analysis and clustering algorithms. A critical component is consultation of the presage database for structural genomics, which records the community's experimental work underway and computational predictions. The protein families are ranked according to several criteria including taxonomic diversity and known functional information. Individual proteins, often homologs from hyperthermophiles, are selected from these families as targets for structure determination. The solved structures are examined for structural similarity to other proteins of known structure. Homologous proteins in sequence databases are computationally modeled, to provide a resource of protein structure models complementing the experimentally solved protein structures.