• 대한의용생체공학회:의공학회지
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• 제34권1호
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• pp.34-39
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• 2013

For the biocompatibility test of implantable devices or for the sensitivity evaluation of biomedical sensors, it is required to understand the mechanism of the protein adsorption and the interaction between the adsorbed proteins and cells. In this study, the adsorption of proteins in a cell culture medium with fetal bovine serum onto an indium tin-oxide electrode was characterized by using linear sweep voltammetry and impedance spectroscopy. We immersed the fabricated ITO electrodes in the culture medium for 30, 60, or 90 min, and then measured the electrochemical properties of electrodes with 10 mM $Fe(CN){_6}^{3-/4-}$ and 0.1 M KCl electrolyte. With an increase of contacting time, the anodic peak current was decreased and the charge transfer resistance was increased. However, both parameters were recovered to the values before contact with the medium after the treatment of Trypsin/Ethylenediaminetetraacetic acid hydrolyzing proteins.

• 대한방사선기술학회지:방사선기술과학
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• 제43권4호
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• pp.243-249
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• 2020

Examination with medical radiography is the most significant advances in medicine in the 21st century. Diagnostic imaging occupies an important position in all medical subjects, surgical and internal medicine, including radiology, orthopedics, and neurosurgery. However, the invention associated with conventional radiography devices has focused only on emphasizing the efficient aspects of the examination or obtaining clearer images without considering the age and disease-induced constraints of the patient's posture. The newly developed X-ray aids to solve this problem can effectively perform X-ray imaging of children's who have difficulty communicating and controlling. It is also thought to be a good way to provide accurate imaging information and minimize radiation exposure for children.

• 대한의용생체공학회:의공학회지
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• 제27권4호
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• pp.197-202
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• 2006

Devices in current market to perform electrical stimulation therapy of the urinary incontinence frequent in aging women are very much impractical to us ε due to the wired configuration. The present study implemented new wireless device to enhance self as well as in-hospital therapy with the easiest and the most convenient application. The therapy system consisted of two modules, called 'master' and 'slave', communicating with each other by the wireless Bluetooth protocol. The patient controls therapy processes on the master module in hand, transmitting the required informations to operate the slave module placed within her pants with the viginal electrode connected, delivering appropriate electrical stimulation. Wireless communication enabled self therapy with clothes on, leading to a great convenience for the patient. The stimulation output signal was comparable to commercialized products in both waveform and stimulation capacity.

• 디지털산업정보학회논문지
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• 제19권2호
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• pp.11-25
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• 2023

With the increasing advancement of VLSI technology, health care system is also developing to serve the humanity with better care. Therefore, biomedical implantable devices are one of the amazing important invention of scientist to collect data from the body cell for the diagnosis of diseases without any pain. This Biomedical implantable transceiver circuit has several important issues. Oscillator is one of them. For the design flexibility and complete transistor-based architecture ring oscillator is favorite to the oscillator circuit designer. This paper represents the design and analysis of the a 9-stage CMOS ring oscillator using cadence virtuoso tool in 180nm technology. It is also designed to generate the carrier signal of 403.5MHz frequency. Ring oscillator comprises of odd number of stages with a feedback circuit forming a closed loop. This circuit was designed with 9-stages of delay inverter and simulated for various parameters such as delay, phase noise or jitter and power consumption. The average power consumption for this oscillator is 9.32㎼ and average phase noise is only -86 dBc/Hz with the source voltage of 0.8827V.

• 전자공학회논문지
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• 제50권3호
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• pp.35-41
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• 2013

$0.18-{\mu}m$ CMOS 반도체 공정을 이용하여 신체에 깊이 이식되어 있는 deep implant 의료 전자기기에서의 무선전력전달을 위한 고효율의 다단 정류기 (multi-stage rectifier)를 구현하였다. 세 개의 단계로 이루어진 정류기는 cross-coupled 된 구조를 이용하여 외부에서 전달되는 작은 AC 입력 신호를 boost하여 1.2-1.5 V의 DC 출력 신호를 implant 전자기기로 전달한다. 설계 된 정류기는 13.56 MHz에서 0.6-Vpp의 작은 RF 입력 신호와 $10-k{\Omega}$의 load 저항이 연결 된 측정 환경에서 최대 70 %의 전력 변환 효율을 달성하였다.

• 한국의학물리학회지:의학물리
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• 제16권3호
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• pp.155-159
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• 2005

생체에 이식되는 장치에 사용하기 위한 무선에너지 전송 시스템을 개발하였다. 이것은 체내에 이식된 장치에 경피적으로 전기에너지를 공급할 수 있는 것이다 경피적으로 결합된 트랜스포머의 권선간의 거리는 인간의 피부 두께를 고려하여 약 10$\~$20 mm이다. 본 연구에서는 Class-E 공진증폭기를 사용하여 높은 효율을 얻고자 하였다. 최대 전류는 각 주파수에서 50 mA 이상의 전류를 얻을 수 있었다. 개발된 시스템은 500 kHz, 1 MHz 및 4 MHz의 서로 다른 주파수에서 정확하게 동작하고 있다는 것을 보여주고 있다.

• Biomaterials and Biomechanics in Bioengineering
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• 제3권1호
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• pp.59-69
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• 2016

A surface resisting protein adsorption and cell adhesion is highly desirable for many biomedical applications such as diagnostic devices, biosensors and blood-contacting devices. In this study, a surface conjugated with sulfobetaine molecules was fabricated via the click reaction for the anti-fouling purpose. An alkyne-containing substrate (Alkyne-PPX) was generated by chemical vapor deposition of 4-ethynyl-[2,2]paracyclophane. Azide-ended mono-sulfobetaine molecules were synthesized and then conjugated on Alkyne-PPX via the click reaction. The protein adsorption from 10% serum was reduced by 57%, while the attachment of L929 cells was reduced by 83% onto the sulfobetaine-PPX surface compared to the protein adsorption and cell adhesion on Alkyne-PPX. In conclusion, we demonstrate that conjugation of mono-sulfobetaine molecules via the click chemistry is an effective way for reduction of non-specific protein adsorption and cell attachment.

• 대한의용생체공학회:의공학회지
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• 제40권3호
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• pp.97-104
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• 2019

To examine different types of influenza diagnostic test kits automatically, automated rapid influenza diagnostic test method based on image recognition is proposed in this paper. First, the proposed methods classify a variety of the rapid influenza diagnostic test kit based on support vector machine that analyzes the kits' feature point. Then, to improve the accuracy of test, the proposed methods match the histogram of both the target image of influenza kit and the input image of influenza kit for minimizing the effect of environment factors, such as lighting and exposure variations. And, to minimize the effect from composition of the hand-helds devices, the proposed methods extract the feature point and match point-by-point between target image of influenza kit and input image of influenza kit. Experimental results of 124 experimental group show that the proposed methods significantly have effectiveness, which shows 90% accuracy in moderate antigen, for the preliminary examination of influenza, and provides the opportunity for taking action against influenza.

• 한국멀티미디어학회논문지
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• 제25권9호
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• pp.1307-1315
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• 2022

In this paper, we proposed and developed a new portable skin elasticity measuring device based on the indentation method using piezoelectric effect. The proposed device is designed to minimize the uncertainty caused by the layer structure of the skin when measuring the elasticity of the skin. And, we developed a piezoelectric-based thin-film pressure sensor that can measure quantitatively and quickly during repeated measurement as a device sensor. To confirm the effectiveness of the proposed measuring device, it was compared with the experimental results of the conventional measuring devices under the same experimental conditions, and statistical correlation analysis was performed between the experimental data of the proposed measuring device and the experimental data of the conventional measuring devices. As a result of the correlation analysis, it was confirmed that the proposed measuring device had a high correlation with the conventional measuring devices. Therefore, it was confirmed that the proposed skin elasticity measuring device was effective.

• 대한의용생체공학회:의공학회지
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• 제29권2호
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• pp.164-171
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• 2008

Recently, many of hospitals have hurried to computerize the resulting data from medical devices, in order to introduce Electric Medical Record(EMR). In terms of the linkage between medical devices and hospital information systems, however, many difficulties have arisen due to some reasons such as the variety of prescription input, the format difference of the resulting data sheet, and the interface difference between medical devices from different companies. To solve these problems, many researches on standardization of the resulting data of medical devices have been performed. In this study, the linkage between hospital information systems and resulting datum in Electrocardiogram(ECG) generating biosignal waveform was tested by applying Medical waveform Format Encoding Rules(MFER) Version 1.02, which has more advantages than existing global standard. MFER viewer, in addition, was made to display the resulting data on a screen. The MFER viewer was tested and compared to the existing Scalable Vector Graphics (SVG) Viewer. The results showed that this method is more effective in the interface the data storage and application, because of simplicity and easiness in data applications. And the results show that the MFER is convenience and effective for physician. It is considered that the role of MFER as the interface in biosignal waveform including Electrocardiogram medical devices would expand in the near future.