• 제목/요약/키워드: Biomechanical property

검색결과 21건 처리시간 0.028초

연골세포의 기계적 물성치 측정 (Measurement of Biomechanical Property of Chondrocyte)

  • 이권용;;박상국;김병수;박종철
    • 한국정밀공학회:학술대회논문집
    • /
    • 한국정밀공학회 2002년도 춘계학술대회 논문집
    • /
    • pp.154-157
    • /
    • 2002
  • A cyto-indentation technique was used to obtain the biomechanical compressive compliance property of an chondrocyte cell attached to glass surface, which was tried to generate joint cartilage by tissue engineering. Piezo-transducer system and dual photo-diode system were used to conduct mechanical indentation through displacement-controlled testing and the measurement of corresponding cell reaction force. The Poisson's ratio of 0.37 was quoted from other report. The compressive compliance of chondrocyte, that was determined by elastic contact theory, was 1.38${\pm}$0.057 kPa. This value is 30% higher than that of MG63 osteoblast-like cell. The cyto-indentation technique employed in this study is so precise that it can quantify the biomechanical property of single cell.

  • PDF

대퇴골 전자간부 해면골의 미세구조적 특성과 생역학적 특성에 관한 연구 (A study on the micro-structural and biomechanical properties of trabecular bone in intertrochanteric region)

  • 백명현;원예연;최문권;김광균;김한성
    • 한국정밀공학회:학술대회논문집
    • /
    • 한국정밀공학회 2005년도 춘계학술대회 논문집
    • /
    • pp.923-926
    • /
    • 2005
  • To investigate the relationship between BMD, micro-structural and mechanical properties in intertrochanteric trabecular bone, the PIXI-mus2 system, micro-CT and FE model were used. The purpose of this study were (1) to apply high-resolution imaging techniques (micro-CT imaging) in combination with new computer modeling techniques (FEA) to quantify 3D microstructural and biomechanical properties of trabecular bone in the intertrochanteric region, and (2) determine if the prediction of bone elastic constant can be improved with structural index.

  • PDF

척추성형술 시술에서 요추의 생체역학적 특성 변화 (Biomechanical Property Change of Vertebral body in Vertebroplasty)

  • 이준형;전성재;채수원;이태수;서중근;박정율;김상돈;이관행
    • 한국정밀공학회:학술대회논문집
    • /
    • 한국정밀공학회 2003년도 춘계학술대회 논문집
    • /
    • pp.1324-1327
    • /
    • 2003
  • The compressed fracture of spine caused by osteoporosis is one of the most frequent diseases in bone fracture. Recently the vertebroplasty has drawn much attention as a medical treatment for the compressed fracture of spine, which strengthens the vertebral body and corrects deformity, and relieves pain in patients by injecting bone cement. The finite element analysis is used to investigate the vertebroplasty quantitatively. Previous works with finite element analysis have drawbacks in their simplified models geometry of vertebral body and with material properties of bone. In this paper the exact geometry of vertebral body has been constructed from medical image data and the biomechanical property changes of vertebral body in vertebroplasty have been investigate by using three dimensional finite element analysis.

  • PDF

성인 대퇴골두 제 1압박 골소주군의 미세구조와 생역학적 특성의 상관관계 및 유한요소해석법의 유용성 평가 (Evaluation of the Usefulness of Finite Element Analysis and Statistical Correlation of Micro-structural and Biomechanical Property of the Primary Compressive Trabecular System In Adult Femur)

  • 백명현;원예연;최문권;윤태봉
    • 한국정밀공학회:학술대회논문집
    • /
    • 한국정밀공학회 2006년도 추계학술대회 논문집
    • /
    • pp.555-556
    • /
    • 2006
  • PDF

Biomechanical Properties of the Cornea Using a Dynamic Scheimpflug Analyzer in Healthy Eyes

  • Lee, Hun;Kang, David Sung Yong;Ha, Byoung Jin;Choi, Jin Young;Kim, Eung Kweon;Seo, Kyoung Yul;Kim, Tae-im
    • Yonsei Medical Journal
    • /
    • 제59권9호
    • /
    • pp.1115-1122
    • /
    • 2018
  • Purpose: To investigate biomechanical properties of the cornea using a dynamic Scheimpflug analyzer according to age. Materials and Methods: In this prospective, cross-sectional, observational study, participants underwent ophthalmic investigations including corneal biomechanical properties, keratometric values, intraocular pressure (IOP), and manifest refraction spherical equivalent (MRSE). We determined the relationship of biomechanical parameters and ocular/systemic variables (participant's age, MRSE, IOP, and mean keratometric values) by piecewise regression analysis, association of biomechanical parameters with variables by Spearman's correlation and stepwise multiple regression analyses, and reference intervals (RI) by the bootstrap method. Results: This study included 217 eyes of 118 participants (20-81 years of age). Piecewise regression analysis between Corvis-central corneal thickness (CCT) and participant's age revealed that the optimal cut-off value of age was 45 years. No clear breakpoints were detected between the corneal biomechanical parameters and MRSE, IOP, and mean keratometric values. Corneal velocity, deformation amplitude, radius, maximal concave power, Corvis-CCT, and Corvis-IOP exhibited correlations with IOP, regardless of age (all ages, 20-44 years, and over 44 years). With smaller deformation amplitude and corneal velocity as well as increased CorvisIOP and Corvis-CCT, IOP became significantly increased. We provided the results of determination of confidence interval from RI data using bootstrap method in three separate age groups (all ages, 20-44 years, and over 44 years). Conclusion: We demonstrated multiple corneal biomechanical parameters according to age, and reported that the corneal biomechanical parameters are influenced by IOP.

인조고막용 키토산 패치 지지체의 생체역학적 특성 및 독성 평가 (Biomechanical Properties and Cytotoxicity of Chitosan Patch Scaffold for Artificial Eardrum)

  • 정종훈;김장호;정연훈;임애리;임기택;홍지향;정필훈
    • Journal of Biosystems Engineering
    • /
    • 제32권1호
    • /
    • pp.57-62
    • /
    • 2007
  • The objectives of this study were to prepare a new artificial eardrum patch using water-insoluble chitosan for healing the tympanic membrane perforations and to investigate biomechanical properties and cyotoxicity of the chitosan patch scaffold (CPS). Tensile strength and elongation at the rupture point of CPSs were 2.49-74.05 MPa and 0.11-107.06%, respectively. As the biomechanical properties or CPSs varied with the concentration of chitosan and glycerol, the proper conditions for the CPS were found out. SEM analysis showed very smooth and uniform surface of CPSs without pores at x1000. The result of MTT test showed that CPSs had no cytotoxicity.

Comparison of Biomechanical Properties of Dura Mater Substitutes and Cranial Human Dura Mater : An In Vitro Study

  • Kizmazoglu, Ceren;Aydin, Hasan Emre;Kaya, Ismail;Atar, Murat;Husemoglu, Bugra;Kalemci, Orhan;Sozer, Gulden;Havitcioglu, Hasan
    • Journal of Korean Neurosurgical Society
    • /
    • 제62권6호
    • /
    • pp.635-642
    • /
    • 2019
  • Objective : The aim of this study was to investigate the biomechanical differences between human dura mater and dura mater substitutes to optimize biomimetic materials. Methods : Four groups were investigated. Group I used cranial dura mater (n=10), group II used $Gore-Tex^{(R)}$ Expanded Cardiovascular Patch (W.L. Gore & Associates Inc., Flagstaff, AZ, USA) (n=6), group III used $Durepair^{(R)}$ (Medtronic Inc., Goleta, CA, USA) (n=6), and group IV used $Tutopatch^{(R)}$ (Tutogen Medical GmbH, Neunkirchen am Brand, Germany) (n=6). We used an axial compression machine to measure maximum tensile strength. Results : The mean tensile strengths were $7.01{\pm}0.77MPa$ for group I, $22.03{\pm}0.60MPa$ for group II, $19.59{\pm}0.65MPa$ for group III, and $3.51{\pm}0.63MPa$ for group IV. The materials in groups II and III were stronger than those in group I. However, the materials in group IV were weaker than those in group I. Conclusion : An important dura mater graft property is biomechanical similarity to cranial human dura mater. This biomechanical study contributed to the future development of artificial dura mater substitutes with biomechanical properties similar to those of human dura mater.

백서에서 치아회분과 석고 매식 후 두개 결손부의 생물물리적 성질에 관한 실험적 연구 (BIOMECHANICAL STUDY OF THE CALVARIAL DEFECTS AFTER IMPLANTATION OF THE TOOTHASH AND PLASTER IN THE RAT)

  • 김영균;고영무
    • Maxillofacial Plastic and Reconstructive Surgery
    • /
    • 제19권1호
    • /
    • pp.45-54
    • /
    • 1997
  • The purpose of this investigation was to determine the biomechanical property of calvarial defects reconstructed using toothash, plaster and tooth-plaster mixture. Full-thickness bony defects were made on the rat calvaria with size of $10mm{\times}10mm$. Group 1 was filled with toothash only, group 2 : toothash-plaster mixture, and group 3 : plaster only. The defects were allowed to heal for 12 and 20 weeks before killing the animals. Light microscopic examinations vas taken after 12 week after operation. The hardness was evaluated for test of mechanical property. The following results were obtained : 1. In light microscopic examination 12 week after operation, there were no inflammatory and foreign body reaction. Implanted particles were resorbed gradually or united directly with newly formed bone. 2. In hardness test, the hardness of newly formed bone was lower than that of normal bone and there was significant difference(P<0.01). The site of new bone formation has enough hardness to resist the mechanical stress. These results suggest that toothash and plaster are biocompatible and osteoconductive material.

  • PDF

인공추간판 적용 시 인접 운동 분절에서의 변화 분석 (Analysis of biomechanical change of adjacent motion segment of the lumbar spine with an implanted artificial disc)

  • 김영은;윤상석
    • 한국정밀공학회:학술대회논문집
    • /
    • 한국정밀공학회 2005년도 추계학술대회 논문집
    • /
    • pp.244-247
    • /
    • 2005
  • Although several artificial disc designs have been developed for the treatment of discogenic low back pain and used clinically, biomechanical change with its implantation seldom studied. To evaluate the effect of artificial disc implantation on the biomechanics of lumbar spinal unit, nonlinear three-dimensional finite element model of L1-L5, S1 was developed and strain and stress of vertebral body and surrounding spinal ligaments were predicted. Intact osteoligamentous L1-L5, S1 model was created with 1-mm CT scan of a volunteer and known material property of each element were applied. This model also includes the effect of local muscles which was modeled with pre-strained spring elements. The intact model was validated with reported biomechanical data. Two models implanted with artificial discs, SB Charite or Prodisc, at L4/5 via anterior approach were also developed. The implanted model predictions were compared with that of intact model. Angular motion of vertebral body, force on spinal ligaments, facet joint contact force with $2\sim12$ Nm flexion-extension moment.

  • PDF

Effects of Caponization on Bone Characteristics and Histological Structure in Chickens

  • Chen, Kuo-Lung;Chang, Ming-Huang;Tsay, Shiow-Min;Hurng, Huaang-Youh;Chiou, Peter Wen-Shyg
    • Asian-Australasian Journal of Animal Sciences
    • /
    • 제19권2호
    • /
    • pp.245-251
    • /
    • 2006
  • The aim of this study was to investigate the effects of caponization on the bone characteristics, biomechanical property and histology in Taiwan country chickens fed to market age of 26 wks. Male Taiwan country chickens $D{\times}L_2$ were caponized or sham-operated at 8 wks of age, and selected healthy sham-operated and completely caponized chickens (prominent degenerated comb) were selected at 16 wks old and fed to 26 wks old for the trials. Fifteen intact male chickens (Intact), sham-operated chickens (Sham) and caponized chickens (Capon) were assigned for trial 1, and sixteen Intact and Capon were assigned for trial 2. Results in trial 1 showed that the abdominal fat and relative abdominal fat weights of Capon were significantly heavier than Intact and Sham (p<0.05), while the tibia weight and relative weight were the lightest (p<0.05). The tibia breaking strength, bending moment and stress of Capon were the poorest among groups (p<0.05). The trial 2 produced the similar observation that Capon were significantly lighter than Intact (p<0.05) in the tibia weight, relative tibia weight and their biomechanical properties. On histological determinations, Capon showed a thinner cartilage end and fewer chondrocytes (about 50%) and trabecular, and bigger marrow cavity; while decreased hemopoietic cells number with increased adipocytes than Intact observed by H&E stain and at low magnification. At high magnification, Capon showed a decrease in the chondrocyte size by 33 to 50%, with smaller nucleus located near the cell membrane, and exhibited monocellular form chondrocytes. Capon also showed a less strongly acidic sulfated mucosubstance with weaker dyeing property within cartilage zone, and smaller chondrocytes size by Alcian blue stain.