• Korean Journal of Biological Psychiatry
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• v.18 no.4
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• pp.217-224
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• 2011

Subsyndromal bipolar symptoms are common during maintenance treatment and appear to be associated with relapse into an episode of the same polarity. This implies subsyndromal symptoms are an important problem in recurrent bipolar disorder and require more additive and infallible therapeutic intervention. Undetected, untreated subsyndromal states lead patients to have poor prognosis and quality of life. The combination of a long undetected illness and significant psychosocial impairment renders early identification and intervention vital for the treatment of bipolar disorders. Methods for early identification includes finding prodromes, using screening tools such as the HCL-32 (Hypomania Checklist-32) and the BSDS (bipolar spectrum diagnostic scale). Various augmentation treatment methods would be needed to reduce subsyndromal symptoms, especially, psychosocial treatment has the potential to help patients address the multiple psychosocial problems associated with this chronic illness. To overcome difficulties of diagnosing subsyndromal disorder and to treat it appropriately, a staging system was suggested by some researchers. It assumes that earlier stages have better prognosis and require simpler therapeutic regimens. Staging may assist in treatment planning and prognosis of bipolar disorder, and emphasize the importance of early intervention. Further research is required in this exciting and novel area.

• Applied Biological Chemistry
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• v.25 no.3
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• pp.155-160
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• 1982

Claviceps purpurea PRL 1980 produces a fluorescent reddish brown pigment in the alkaloid production medium. When D,L-tryptophan $[side\;chain-3-^{14}C]$ was administered into the production medium, the radioactive pigment and 5-hydroxytryphan were isolated from the cultures. Conversion of tryptophan to 5-hydroxytryptophan in vivo was shown by an isotopic trapping procedure. 5-hydroxytryptophan isolated from the cultures contained appreciable radioactivity and was recrystallized to constant specific radioactivity. The injection of the $^{14}C-labelled$ 5-hydroxytryptophan showed an incorporation of radioactivity into brown pigment significantly higher than that of tryptophan. The brown pigment produced by Claviceps purpurea PRL 1980 seems to be derived from tryptophan through 5-hyrdroxytryptophan.

• Applied Biological Chemistry
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• v.21 no.3
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• pp.137-143
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• 1978

Xanthine oxidase from bovine thyroid glands was found to contain FAD, molybdenum and iron in a ratio 1:0. 36:1. 6. The molecular weight of the thyroid enzyme was similar to that of the milk enzyme when estimated by gel filtration and polyacrylamide gel electrophoresis. The optimum pH for the enzyme activity was 7.8. The pH of the isoelectric point was determined to be 6.2 by electrofocusing. Sodium dodecyl sulfatepolyacrylamide gel electrophoresis experiment indicated that the enzyme was dissociated into subunits and that the molecular weight for the smallest subunit was 65,000 daltons. Absorption spectra were dissimilar between milk and thyroid xanthine oxidase.

• Journal of Applied Biological Chemistry
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• v.56 no.1
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• pp.43-48
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• 2013

In this study, methanol extracts from 25 indigenous Korean corals were prepared and their carotenoid constituents were analyzed by high-performance liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry (HPLC-APCI-MS). Among them, extracts from nine species showed detectable peaks in the HPLC chromatogram at 450 nm and the ultraviolet/visible spectra exhibiting carotenoid-specific characteristics were chosen. The mass data of carotenoid peaks revealed that only peridinin could be identified based on literature comparison and suggested the potential presence of novel carotenoid structures. This is the first reported investigation of indigenous Korean coral carotenoids and further work is needed to explore the carotenoids and their potential roles in the ecosystem of indigenous Korean corals.

• Archives of Pharmacal Research
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• v.16 no.3
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• pp.213-218
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• 1993

($\pm$)-Higenamine is known as a cardiotonic principle of aconite root (root of Aconitum spp., Ranunculaceae). A simple and sensitive detection method for higenamine was developed by using gas chromatography-mass spectrometry (GC/MS). The recovery of higenamine after extraction and concentration with XAD-2 resin column was around 95% from rat biological fluids such as bile, plasma and urine. The limits of detection of higenamine in these biological fluids were approximately 0.1 ng/ml each. It has well been suggested that tetrahydroisoquinolines possessing catechol moiety such as higenamine should be subjected to the catechol-O-methyl transferase (COMT) activity in vivo. We detected two major peaks of presumed metabolites of higenamine in the total ion chromatogram obtained from the rat urine sample after the oral adminstration of ($\pm$)-higenamine. The scan mass spectrum of one of the metabolties coincided with those obtained from coclaurine $(C_6$-O-methyl higenamine) and those of the other metabolite are suggestive of isococlaurine $(C_7$-O-methyl higenamine).

• Applied Biological Chemistry
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• v.38 no.6
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• pp.577-580
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• 1995

During the screening for the antimicrobial agents against multidrug-resistant Staphylococcus aureus, we isolated an active compound produced by strain CNU30122. The active compound was purified from culture broth by HP-20 column chromatography, ethylacetate extraction. silica gel column and Sephadex LH-20 column chromatographies and HPLC. Based on various NMR studies including $^1H-^1H\;COSY$, $^1H-^{13}C\;COSY$ and HMBC experiments. the active compound was identified as fusidic acid.

• Journal of Applied Biological Chemistry
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• v.43 no.1
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• pp.37-43
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• 2000

1,3,2-Dioxaphosphorinanes are suitable compounds for studying the stereochemistry of substitution at phosphorus. Cis- and trans-5-hydroxymethl-5-methyl-2-thiono-2ethoxy-1,3,2-dioxaphosphorinane were prepared, and their structures and stereochemistry unambiguously assigned by NMR and X-ray crystallography with acetoxy and 3,5-dinitrobenzoyloxy derivatives, respectively. Trans isomer gave $^{31}P$ NMR signal at higher field than cis isomer, and the ring proton Spectrum of cis isomer showed characteristic pattern for identifying its geometry. In X-ray crystallography they adopted a chair conformation with the ethoxy groups in the axial positions, and the sulfide groups in the equatorial positions. A flattening of the ring around the phosphorus center was noted, the POC bond angles were about $120^{\circ}$, and the C-O bonds in the ring were significantly longer than the C-O bond for the ethoxy group or the C-O bond for hydroxyl group.

• Applied Science and Convergence Technology
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• v.26 no.6
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• pp.201-207
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• 2017

An electron-excited temperature ($T_{ex}$) is not determined by the Boltzmann plots only with the spectral data of $4p{\rightarrow}4s$ in an Ar-plasma jet operated with a low frequency of several tens of kHz and the low voltage of a few kV, while $T_{ex}$ can be obtained at least with the presence of a high energy-level transition ($5p{\rightarrow}4s$) in the high-voltage operation of 8 kV. The optical intensities of most spectra that are measured according to the voltage and the measuring position of the plasma column increase or decay exponentially at the same rate as that of the intensity variation; therefore, the excitation temperature is estimated by comparing the relative optical-intensity to that of a high voltage. In the low-voltage range of an Ar-jet operation, the electron-excitation temperature is estimated as being from 0.61 eV to 0.67 eV, and the corresponding radical density of the Ar-4p state is in the order of $10^{10}{\sim}10^{11}cm^{-3}$. The variation of the excitation temperature is almost linear in relation to the operation voltage and the position of the plasma plume, meaning that the variation rates of the electron-excitation temperature are 0.03 eV/kV for the voltage and 0.075 eV/cm along the plasma plume.

• Biomaterials and Biomechanics in Bioengineering
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• v.4 no.1
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• pp.9-20
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• 2019

Living beings are formed of advanced biological and mechanical systems which exist for millions of years. It is known that various animals and insects right from small ants to huge whales have different weight carrying capacities, which is generally expressed as a ratio of their own bodyweights i.e., Strength to Bodyweight Ratio (SBR). The puzzle is that when a rhinoceros beetle (scientific name: Dynastinae) can carry 850 times its own bodyweight, why a man cannot accomplish the same feat. There are intrinsic biological and mechanical reasons related to their capacities, as per biomechanics. Yet, there are underlining principles of engineering and structural mechanics which tend to solve this puzzle. The paper attempts to give a plausible answer for this puzzle through structural mechanics and experimental modeling techniques. It is based on the fact that smaller an animal or creature, it has larger value of weight lifting by self-weight ratio. The simple example of steel prism model discussed in this paper, show that smaller the physical model size, larger is its SBR value. To normalize this, the basic length of the model need to be considered and when multiplied with SBR, a constant is arrived. Hence, the aim of the research presented is to derive this constant on a pan-living being spectrum through size/scaling effect.

• Membrane and Water Treatment
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• v.10 no.3
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• pp.223-229
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• 2019

Titania modified by 2-ethylimidazole (2-EI) (denoted as $2-EI-TiO_2$) demonstrated visible light photocatalytic activity for the degradation of organic compounds. $2-EI-TiO_2$ was a bright brown powder that exhibited similar crystallinity and morphology with the control $TiO_2$. A diffuse reflectance spectrum indicated that $2-EI-TiO_2$ absorbs visible light of all wavelengths. X-ray photoelectron spectroscopy (XPS) confirmed the cationic state of nitrogen species (e.g. Ti-O-N) on the surface of $2-EI-TiO_2$. Visible light-illuminated $2-EI-TiO_2$ degraded $10{\mu}M$ 4-chlorophenol (4-CP) by approximately 85% in 4 h. The photochemical activity of $2-EI-TiO_2$ was selective in targeting the organic compound. The repeated use of $2-EI-TiO_2$ decreased the photocatalytic activity for the 4-CP degradation. Experiments using radical scavengers and oxidant probes revealed that the oxidation by photogenerated holes is responsible for the degradation of organic compounds by illuminated $2-EI-TiO_2$ and the role of $^{\bullet}OH$ is negligible.