• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1998년도 추계학술대회
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• pp.129-130
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• 1998

In this paper, We designed the ECG-NIBP-$SpO_2$ patient monitor. This production can measure Electrocardiograph, Heart Rate, Noninvasive Blood Pressure, and Oxygen Saturation for Noninvasive Mehod and can display each information. These informations were implemented by the electrodes of ECG part, the cuff of NIBP module and the finger probe with light sensor of $SpO_2$ without injection of needle or catheter. In addition, We developed a new analysis algorithm and measurement technique for NIBP and $SpO_2$ to observe patient's conditions correctly.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2002년도 합동 추계학술대회 논문집 정보 및 제어부문
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• pp.399-402
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• 2002

In this study, we constructed a four-channel impedance measurement system including a two-channel goniometer to analyze human arm movement. Impedances and joint angles were simultaneously measured for wrist and elbow movements. As the impedance changes resulting from wrist and elbow movements depended heavily on electrode placement, we determined the optimal electrode configurations for those movements by searching for high correlation coefficients, large impedance changes, and minimum interferences in ten subjects (age: 29+6). Our optimal electrode configurations showed very strong relationships between the wrist joint angle and forearm impedance (correlation coefficient = 0.95+0.04), and between the elbow joint angle and upper arm impedance (correlation coefficient = -0.98+0.02). Although the measured impedances changes of the wrist (1.1+1.5 ohm) and elbow (-5.0+2.9 ohm) varied among individuals, the reproducibilities of wrist and elbow impedance changes of five subjects were 5.8+1.8 % and 4.6+1.4 % for the optimal electrode pairs, respectively. We propose that this optimal electrode configuration would be useful for future studies involving the measurement of accurate arm movements by impedance method.

• 한국분말재료학회지
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• 제25권2호
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• pp.170-177
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• 2018

Colloidally synthesized luminescent nanocrystals (NCs) have attracted tremendous attention due to their unique nanoscale optical and electronic properties. The emission properties of these NCs can be precisely tuned by controlling their size, shape, and composition as well as by introducing appropriate dopant impurities. Nowadays, these NCs are actively utilized for various applications such as optoelectronic devices including light emitting diodes (LEDs), lasers, and solar cells, and bio-medical applications such as imaging agents and bio-sensors. In this review, we classify luminescent nanomaterials into quantum dots (QDs), upconversion nanoparticles (UCNPs), and perovskite NCs and present their intrinsic emission mechanism. Furthermore, the recently emerging issues of efficiency, toxicity, and durability in these materials are discussed for better understanding of industry demands. As well, the future outlook will be offered for researchers to guide the direction of future research.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2007년도 심포지엄 논문집 정보 및 제어부문
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• pp.469-470
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• 2007

In this paper, we propose a simple and relative electrode contact monitoring method. By exploiting the power line interference, which is regarded as one of the worst noise sources for bio-potential measurement, the relative difference in electrode impedance can be measured without a current or voltage source. Substantial benefits, including no extra circuit components, no degradation of the body potential driving circuit, and no electrical safety problem, can be achieved using this method. Furthermore, this method can be applied to multi-channel isolated bio-potential measurement systems and home health care devices under a steady measuring environment.

• Journal of Ginseng Research
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• 제48권2호
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• pp.140-148
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• 2024

Synthetic biology approaches offer potential for large-scale and sustainable production of natural products with bioactive potency, including ginsenosides, providing a means to produce novel compounds with enhanced therapeutic properties. Ginseng, known for its non-toxic and potent qualities in traditional medicine, has been used for various medical needs. Ginseng has shown promise for its antioxidant and neuroprotective properties, and it has been used as a potential agent to boost immunity against various infections when used together with other drugs and vaccines. Given the increasing demand for ginsenosides and the challenges associated with traditional extraction methods, synthetic biology holds promise in the development of therapeutics. In this review, we discuss recent developments in microorganism producer engineering and ginsenoside production in microorganisms using synthetic biology approaches.

• Macromolecular Research
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• 제17권11호
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• pp.850-855
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• 2009

Keratin is an important protein used in wound healing and tissue recovery. In this study, keratin was modified chemically with iodoacetic acid (IAA) to enhance its solubility in organic solvent. Poly(hydroxybutylate-co-hydroxyvalerate) (PHBV) and modified keratin were dissolved in hexafluoroisopropanol (HFIP) and electrospun to produce nanofibrous mats. The resulting mats were surface-characterized by ATR-FTIR, field-emission scanning electron microscopy (FE-SEM) and electron spectroscopy for chemical analysis (ESCA). The pure m-keratin mat was cross-linked with glutaraldehyde vapor to make it insoluble in water. The biodegradation test in vitro showed that the mats could be biodegraded by PHB depolymerase and trypsin aqueous solution. The results of the cell adhesion experiment showed that the NIH 3T3 cells adhered more to the PHBV/m-keratin nanofibrous mats than the PHBV film. The BrdU assay showed that the keratin and PHBV/m-keratin nanofibrous mats could accelerate the proliferation of fibroblast cells compared to the PHBV nanofibrous mats.

• 대한의용생체공학회:의공학회지
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• 제19권3호
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• pp.261-268
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• 1998

위전도는 피부전극을 이용하여 위에서 발생하는 전기신호를 측정하여 위운동상태를 측정하는 비관혈적인 검사방법이다. 본 연구에서는 임상적으로 유용한 위전도신호 측정 및 분석시스템을 개발하였으며, 개발시스템은 크게 하드웨어(생체증폭기, 필터)와 소프트웨어(유저인터페이스, 분석알고리듬, 환자데이터베이스)로 구성된다. 개발시스템의 생체신호증폭기는 신호분석에 용이하도록 3채널로 구성되어 있으며, 신호의 저장 및 분석은 PC에서 수행하도록 구성되어 있다. 위수축 정보의 획득을 위해서 분석신호는 16Hz로 샘플링하였으며, 위전도신호분석은 임상이용에 유용한 여러 가지 분석 파라메터를 추출할 수 있도록 하였다. 개발된 시스템은 동물실험을 통하여 성능을 평가하였으며, 현재 환자를 대상으로 임상시험이 진행중이다.

• 대한방사성의약품학회지
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• 제6권2호
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• pp.171-176
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• 2020

Covalent organic frameworks (COFs) are porous crystalline polymers in which organic units are linked by covalent bonds and have a regular arrangement at the atomic level. Recently, the COFs have been much attention in bio-medical area such as bio-imaging, drug delivery, and therapeutics. These 2D nanoparticles are proving their value in nanomedicine due to their large surface area, functionalization through functional groups exposed on the surface, chemical stability due to covalent bonding, and high biocompatibility. The high ω-electron density and crystallinity of COFs makes it a promising candidate for bioimaging probes, and its porosity and large surface area make it possible to be utilized as a drug delivery vehicle. However, the low dispersibility in water, the cytotoxicity problems of COFs are still challenged to be solved in the future. In this regard, several efforts that increase the degree of dispersion through functionalization on the surface of COFs for the application to the biomedical field have been reported. In this review, we would like to describe the advantages and limitations of COFs for bio-imaging and anti-cancer treatment.

• Korean Chemical Engineering Research
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• 제57권4호
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• pp.445-454
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• 2019

Layered double hydroxides (LDHs) 나노입자는 특유의 층상형 결정구조에서 기인된 물리화학적 물성 및 생체친화성을 바탕으로 나노-바이오 분야에서 주목을 받고 있다. 바이오 이미징은 질병의 진단과 치료(테라노스틱스, theranostics=therapy+diagnosis)에 다양하게 활용될 수 있는 핵심적인 분야로 차세대 맞춤의학으로의 새로운 패러다임 실현을 위해서 보다 정확하고 빠른 진단기술이 절실히 요구되고 있다. 이를 실현하기 위한 대안으로 나노기술이 접목된 고감도 분자영상 관련 연구들이 활발히 진행되고 있다. 본 총설에서는 LDH 나노입자를 기반으로 하는 바이오 이미징 시스템의 개발동향에 관하여 소개하고 바이오 이미징에 적합한 나노소재의 구조 및 합성 방법에 대하여 설명하였다. 또한 임상 의학에서 현재 많이 사용되고 있는 형광을 이용한 광학영상, 자기공명영상(MRI), 핵의학영상(PET), 컴퓨터 단층 촬영(CT) 등 다양한 분야에서 어떻게 LDH 나노입자를 이용하여 나노 프로브 개발을 할 수 있는지 연구사례를 기술하면서 나노기술과 첨단영상기술이 융합된 획기적인 고감도 나노 바이오 이미징 시스템 개발 및 그 잠재력에 대하여 전망해 보았다.

• Bulletin of the Korean Chemical Society
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• 제32권4호
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• pp.1298-1302
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• 2011

This study describes the development of an electrochemical array immunochip for the detection of IgG. Interdigitated immunochip platforms were fabricated by sputtering gold on a glass wafer by using MEMS process and then were coated with Eudragit S100, an enteric polymer, forming an insulating layer over the working area of immunochips. The breakdown of the polymer layer was exemplified by the catalytic action of urease which, in the presence of urea, caused an alkaline pH change. This subsequently caused an increase of the double layer capacitance of the underlying electrode. Used in conjunction with a competitive immunoassay format, this allowed the ratio of initial to final electrode capacitance to be directly linked with the concentration of analyte, i.e. IgG. Responses to IgG could be detected at IgG concentration as low as $250\;ngmL^{-1}$ and showed good linearity up to IgG concentration as high as $20\;{\mu}gmL^{-1}$.