Journal of Radiopharmaceuticals and Molecular Probes (대한방사성의약품학회지)

Korean Society of Radiopharmaceuticals and Molecular Probes (대한방사성의약품학회)
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2D-Covalent organic frameworks for bioimaging and therapeutic applications

  • Chanho Park (Department of Chemistry and Chemical Engineering, Inha University) ;
  • Dong Wook Kim (Department of Chemistry and Chemical Engineering, Inha University)
  • Received : 2020.12.15
  • Accepted : 2020.12.29
  • Published : 2020.12.31
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Abstract

Covalent organic frameworks (COFs) are porous crystalline polymers in which organic units are linked by covalent bonds and have a regular arrangement at the atomic level. Recently, the COFs have been much attention in bio-medical area such as bio-imaging, drug delivery, and therapeutics. These 2D nanoparticles are proving their value in nanomedicine due to their large surface area, functionalization through functional groups exposed on the surface, chemical stability due to covalent bonding, and high biocompatibility. The high ω-electron density and crystallinity of COFs makes it a promising candidate for bioimaging probes, and its porosity and large surface area make it possible to be utilized as a drug delivery vehicle. However, the low dispersibility in water, the cytotoxicity problems of COFs are still challenged to be solved in the future. In this regard, several efforts that increase the degree of dispersion through functionalization on the surface of COFs for the application to the biomedical field have been reported. In this review, we would like to describe the advantages and limitations of COFs for bio-imaging and anti-cancer treatment.

Keywords

Acknowledgement

This work was supported by the Basic Science Research Program (grant code: NRF-2020R1A2C1009017) and by the MOTIE(Ministry of Trade, Industry & Energy (project number: 10080450) and KSRC(Korea Semiconductor Research Consortium) support program for the development of the future semiconductor device.

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